Aliases &
Descriptions
for GPER gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| G protein-coupled estrogen receptor 11 2 | | Lymphocyte-derived G-protein coupled receptor2 3 | | DRY121 2 3 | | mER2 3 | | CEPR1 2 3 | | G-protein coupled receptor 302 3 | | FEG-11 2 3 | | IL8-related receptor DRY122 3 | | GPR302 3 5 | | OTTHUMP000002000792 | | CMKRL22 3 5 | | constitutively expressed peptide-like receptor2 | | LyGPR1 2 | | G-protein coupled estrogen receptor 12 | | GPCR-Br1 2 | | heptahelix receptor2 | | LERGU1 2 | | leucine rich protein in GPR30 3'UTR2 | | G protein-coupled receptor 301 2 | | MGC996782 | | LERGU21 2 | | chemokine receptor-like 22 | | Membrane estrogen receptor2 3 | | LYGPR3 | | Flow-induced endothelial G-protein coupled receptor 12 3 | | GPCR-BR3 | | Chemoattractant receptor-like 22 3 | | |
Export aliases for GPER gene to outside databasesPrevious GC identifers: GC07P001093 GC07P001121 |
Summaries
for GPER gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GPER:
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein thatlocalizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilizationand synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in therapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternatetranscriptional splice variants which encode the same protein have been characterized. (provided by RefSeq)
UniProtKB/Swiss-Prot: GPER_HUMAN, Q99527Function: Receptor for estrogen
 summary
for GPER: The GPR30 receptor is an orphan G-protein-coupled receptor that has recently been shown to bind estrogen and
cause estrogen-mediated adenylyl cyclase stimulation. GPR30 is widely distributed in neural, breast cancer,
placental, heart, ovarian, prostate, hepatic, vascular epithelial and lymphoid tissue. The receptor acts
independently of ERalpha and ERbeta and triggers ER-dependent EGFR action.
Gene Wiki entry for GPER (GPR30) |
Genomic Views
for GPER gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for GPER
Other transcription factors
Search SABiosciences Chromatin IP Primers for GPER
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GPER  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p22.3 Ensembl cytogenetic band: 7p22.3 HGNC cytogenetic band: 7p22GPER Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P001041: view genomic region
(about GC identifiers)
Start:
|
1,041,713 bp from pter |
End:
|
1,048,693 bp from pter |
Size:
|
6,981 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+ 1,121,844-1,133,451 |
RefSeq DNA sequence:- NC_000007.13 NT_007819.17 NT_079592.2
|
Proteins
for GPER gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: GPER_HUMAN, Q99527 (See
protein sequence)Recommended Name: G-protein coupled estrogen receptor 1 Size: 375 amino acids; 42248 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membraneprotein (By similarity). Golgi apparatus membrane; Multi-pass membrane protein (By similarity). Note=Protein has beendetected in the cell membrane, endoplasmic reticulum and Golgi apparatus. It is currently unclear whether this is acell surface or intracellular receptor
Secondary accessions: A8K6C5 B5BUJ1 O00143 O43494 Q13631 Q6FHL1 Q96F42 Q99981Explore the universe of human proteins at neXtProt for GPER: NX_Q99527
REFSEQ proteins (3 alternative transcripts):
NP_001035055.1 NP_001091671.1 NP_001496.1
ENSEMBL proteins: ENSP00000380281 ENSP00000341512 ENSP00000380277 ENSP00000346586 ENSP00000410487 ENSP00000385151 ENSP00000297469
Human Recombinant Proteins
5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7): About this table
GPER for ontologies About GeneDecksing
Antibodies for GPER:
Assays for GPER: |
Protein
Domains/
Families
for GPER gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GPER for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q99527ProtoNet protein and cluster: Q99527 UniProtKB/Swiss-Prot: GPER_HUMAN, Q99527Similarity: Belongs to the G-protein coupled receptor 1 family |
Gene Function
for GPER gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: GPER_HUMAN, Q99527Function: Receptor for estrogen
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
IEA | -- | | GO:0004930 | G-protein coupled receptor activity |
IEA | -- |
About this table
GPER for ontologies About GeneDecksing
Animal Models: 11 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Gpr30):
GPER for phenotypes About GeneDecksing
|
Pathways & Interactions
for GPER gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
GPER for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for GPER
SABiosciences Pathway-Focused PCR Array including GPER: PAHS-3009A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GPER
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GPER
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor protein signaling pathway |
TAS | 8920907 |
About this table
GPER for ontologies About GeneDecksing
|
Drugs & Compounds
for GPER gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
GPER for compounds About GeneDecksing
Compounds for GPER available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| beta-Estradiol | Endogenous ER agonist | [50-28-2] | | Tamoxifen citrate | Estrogen receptor partial agonist/antagonist | [54965-24-1] | | ICI 182,780 | Estrogen receptor antagonist | [129453-61-8] | | G-15 | High affinity and selective GPR30 antagonist | [1161002-05-6] |
About this table
6  Novoseek chemical compound relationships for GPER gene
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| estrogen |
74.6 |
77 |
18467441 (5), 11043579 (4), 18420744 (4), 19749156 (4) (see all 27) |
| progestin |
62.6 |
16 |
12193550 (8), 12446589 (2), 15539556 (1), 16289637 (1) |
| estradiol |
48.4 |
1 |
18566127 (1) |
| steroid |
44.2 |
7 |
20228382 (1), 17640985 (1), 18420744 (1), 15511221 (1) (see all 5) |
| progesterone |
35 |
2 |
20228382 (1), 12193550 (1) |
| calcium |
17.9 |
2 |
19131510 (1) |
About this table
|
Transcripts
for GPER gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for GPER gene (3 alternative transcripts): NM_001039966.1 NM_001098201.1 NM_001505.2 Additional cDNA sequence: AB451427.1 AF015257.1 AK289588.1 AY265807.1 AY265808.1 AY265809.1 BC011634.1 BC067849.1 BC082766.1 CR541655.1 CR541741.1 U58828.1 U63917.1 X98510.1 Y08162.1 6 DOTS entries: DT.100691243 DT.101963730 DT.95371254 DT.112109 DT.91758727 DT.100790769 24/75 AceView cDNA sequences (see all 75): BQ278731 CB106598 BU732605 BU857553 BU857973 BX101291 BC082766 U63917 Y08162 BI820958 X98510 AA810225 CD558521 BM016871 AY265807 BM680243 CB995575 BF941220 CF994734 AY265809 BX956912 CB991744 BE874882 BE677759 Unigene Cluster for GPER: G protein-coupled estrogen receptor 1 Hs.20961 [show with all ESTs]Unigene Representative Sequence: NM_001039966
GeneLoc Exon Structure
7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397092(uc010ksd.1 uc003sjz.1 uc003ska.1) ENST00000342452
ENST00000397088(uc003skb.2) ENST00000354575 ENST00000413368 ENST00000401670
ENST00000297469
|
Expression
for GPER gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| GPER expression in normal and diseased human tissues
1 / 2 5 probe-sets matching GPER gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 37447_at2
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
| 210640_s_at2
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 211829_s_at2
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 210640_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 211829_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
GPER for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGCGGAAAAA
SOURCE GeneReport for Unigene cluster: Hs.20961
UniProtKB/Swiss-Prot: GPER_HUMAN, Q99527Tissue specificity: Ubiquitously expressed, but is most abundant in placenta. In brain regions, expressed as a 2.8 kbtranscript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen
SABiosciences Expression via Pathway-Focused PCR Array including GPER: PAHS-3009A
|
Orthologs
for GPER gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GPER gene from 5/7 species (see all 7)
About this table Species with no ortholog for GPER
ENSEMBL Gene Tree for GPER (if available) |
Paralogs
for GPER gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for GPER gene
- GPR1462
GPER for paralogs About GeneDecksing
|
Genomic Variants
for GPER gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for GPER
2 CNVs: 0093 4519 | | QIAGEN SeqTarget long-range PCR primers for resequencing GPER |
|
Disorders & Mutations
for GPER gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GPER for disorders About GeneDecksing
OMIM: 601805
4 Novoseek disease relationships for GPER gene
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| breast cancer |
48.8 |
26 |
18467441 (3), 12027886 (2), 18768737 (2), 19342448 (2) (see all 12) |
| ovarian cancer |
22.1 |
3 |
17308128 (3), 19395996 (1) |
| tumors |
15.2 |
7 |
18467441 (2), 11043579 (1), 19951611 (1), 19749156 (1) (see all 5) |
| cancer |
0.465 |
5 |
19951611 (1), 19749156 (1), 17308128 (1), 19432902 (1) |
About this table
Human Genome Epidemiology (HuGE) Navigator: GPER (2 documents)
Export disorders and mutations for GPER gene to outside databases
|
Medical News
for GPER gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for GPER gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/86 PubMed articles for GPER gene, integrated from 7 sources (see all 86):
(articles sorted by number of sources associating them with GPER)- Discovery of three novel G-protein-coupled receptor genes. (PubMed id 9479505)1, 2, 3 O'Dowd B.F.... George S.R. (1998)
- Identification of a gene (GPR30) with homology to the G-protein- coupled receptor superfamily associated with estrogen receptor expression in breast cancer. (PubMed id 9367686)1, 2, 7 Carmeci C.... Weigel R.J. (1997)
- Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans- activation of the epidermal growth factor receptor through release of HB-EGF. (PubMed id 11043579)1, 2, 7 Filardo E.J.... Frackelton A.R. Jr. (2000)
- Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. (PubMed id 15539556)1, 2, 7 Thomas P.... Dong J. (2005)
- Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30. (PubMed id 17655271)1, 3 Revankar C.M....Prossnitz E.R. (2007)
- A transmembrane intracellular estrogen receptor mediates rapid cell signaling. (PubMed id 15705806)1, 2 Revankar C.M....Prossnitz E.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- Cloning of cDNAs encoding G protein-coupled receptor expressed in human endothelial cells exposed to fluid shear stress. (PubMed id 9398636)1, 2 Takada Y.... Ando J. (1997)
- A novel putative G-protein-coupled receptor expressed in lung, heart and lymphoid tissue. (PubMed id 9141481)1, 2 Kvingedal A.M. and Smeland E.B. (1997)
|
External Searches for GPER gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GPER gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GPER gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GPER gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for GPER gene:
Search GeneIP for patents involving GPER
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GPER gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
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 |  |  |  | |
| |  | Tocris compounds for GPER |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for GPER |
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