Aliases &
Descriptions
for GPR125 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| G protein-coupled receptor 1251 2 | | TEM5L2 | | PGR211 2 | | OTTHUMP000002192952 | | FLJ385471 | | probable G-protein coupled receptor 1252 | | TEM5-like2 | | |
Export aliases for GPR125 gene to outside databasesPrevious GC identifers: GC04M022472 GC04M022077 GC04M022139 GC04M022065 GC04M022346 |
Summaries
for GPR125 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: GP125_HUMAN, Q8IWK6Function: Orphan receptor
Gene Wiki entry for GPR125 |
Genomic Views
for GPR125 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GPR125 gene promoter:
MEF-2A c-Myc Max TGIF Nkx2-2 HSF1 (long) LUN-1 FOXJ2 (long isoform) Arnt STAT1beta
Other transcription factors
Search SABiosciences Chromatin IP Primers for GPR125
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GPR125  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p15.2 Ensembl cytogenetic band: 4p15.2 HGNC cytogenetic band: 4p15.31GPR125 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M021733: view genomic region
(about GC identifiers)
Start:
|
21,733,692 bp from pter |
End:
|
21,862,148 bp from pter |
Size:
|
128,457 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr4- 22,346,694-22,517,677 |
RefSeq DNA sequence:- NC_000004.11 NT_006316.16
|
Proteins
for GPR125 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: GP125_HUMAN, Q8IWK6 (See
protein sequence)Recommended Name: Probable G-protein coupled receptor 125 precursor Size: 1321 amino acids; 146151 Da
Subunit: Interacts with DLG1
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAH35645.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence;
Secondary accessions: Q6UXK9 Q86SQ5 Q8TC55Alternative splicing: 4 isoforms: Q8IWK6-1 Q8IWK6-2 Q8IWK6-3 Q8IWK6-4 Explore the universe of human proteins at neXtProt for GPR125: NX_Q8IWK6
REFSEQ proteins: NP_660333.2
ENSEMBL proteins: ENSP00000424927 ENSP00000371563 ENSP00000422606 ENSP00000334952 ENSP00000421006 ENSP00000425223
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
GPR125 for ontologies About GeneDecksing
Antibodies for GPR125:
Assays for GPR125: |
Protein
Domains/
Families
for GPR125 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GPR125 for domains About GeneDecksing
5/11 InterPro domains/families (see all 11):Graphical View of Domain Structure for InterPro Entry Q8IWK6ProtoNet protein and cluster: Q8IWK6 4 Blocks protein families: IPB000203 GPS domain IPB000483 Cysteine-rich flanking region IPB000832 G-protein coupled receptors family 2 (secretin-like) IPB001611 Leucine-rich repeat signature
UniProtKB/Swiss-Prot: GP125_HUMAN, Q8IWK6Domain: Binds to DLG1 through its PDZ-binding motif (By similarity)Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamilySimilarity: Contains 1 GPS domainSimilarity: Contains 1 Ig-like (immunoglobulin-like) domainSimilarity: Contains 5 LRR (leucine-rich) repeats |
Gene Function
for GPR125 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: GP125_HUMAN, Q8IWK6Function: Orphan receptor
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004888 | transmembrane receptor activity |
-- | -- | | GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0005515 | protein binding |
IEA | -- |
About this table
GPR125 for ontologies About GeneDecksing
Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Gpr125):
GPR125 for phenotypes About GeneDecksing
|
Pathways & Interactions
for GPR125 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Pathway-Focused PCR Array including GPR125: PAHS-3009A
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR125
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007166 | cell surface receptor linked signaling pathway |
-- | -- | | GO:0007186 | G-protein coupled receptor protein signaling pathway |
TAS | 15203201 | | GO:0007218 | neuropeptide signaling pathway |
IEA | -- |
About this table
GPR125 for ontologies About GeneDecksing
|
Drugs & Compounds
for GPR125 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for GPR125
|
Transcripts
for GPR125 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for GPR125 gene: NM_145290.2 Additional cDNA sequence: AK027494.1 AK095866.1 AK129664.1 AK299168.1 AL832257.1 AY181243.1 AY358306.1 AY360366.1 BC026009.1 BC035645.1 BX648287.1 CR592300.1 21 DOTS entries: DT.75122690 DT.40251780 DT.100887085 DT.97809846 DT.121230364 DT.100829638 DT.121230535 DT.86838316 DT.100887087 DT.121098185 DT.202836 DT.97784105 DT.100680796 DT.100711378 DT.102826076 DT.121230358 DT.121230388 DT.121230518 DT.95224381 DT.100887088 DT.92453674 24/241 AceView cDNA sequences (see all 241): CD644477 BU741713 AA709153 CB162498 BU622172 BM755109 BU741930 AI879479 AW132109 CK430589 BC035645 BE385344 CA311287 CR592300 CD672827 AK027494 AI004005 BM975214 AW207087 AY358306 AI961383 AI878977 BM712960 AW151549
 highest scoring ESTs for GPR125:AY358306 BC035645 BX416923 AA009429 AA009430 AA029272 AA031830 AA031831 AA033817 AA120826 Unigene Cluster for GPR125: G protein-coupled receptor 125 Hs.99195 [show with all ESTs]Unigene Representative Sequence: NM_145290
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for GPR125 (see all 9)
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for GPR125
14 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000506133 ENST00000511051 ENST00000382129 ENST00000514749 ENST00000506346
ENST00000282943 ENST00000508133(uc003gqn.1) ENST00000499527(uc003gql.1)
ENST00000334304(uc010ieo.1 uc003gqm.1) ENST00000502482(uc003gqo.2)
ENST00000504617 ENST00000506155 ENST00000513385 ENST00000514129
|
Expression
for GPR125 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| GPR125 expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching GPR125 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 33299_at2, 3
|
U95-A |
1 |
0.75 |
1.00 |
1.00 |
1.00 |
M37712 |
0.20 |
0.50 |
0.38 |
1 |
| 210473_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
M37712 |
0.20 |
0.50 |
0.38 |
1 |
| 210473_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1555122_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
GPR125 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.99195
SABiosciences Expression via Pathway-Focused PCR Array including GPR125: PAHS-3009A
|
Orthologs
for GPR125 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GPR125 gene from 5/9 species (see all 9)
About this table Species with no ortholog for GPR125
ENSEMBL Gene Tree for GPR125 (if available) |
Paralogs
for GPR125 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for GPR125 gene
- GPR1242 GPR1232
GPR125 for paralogs About GeneDecksing
|
Genomic Variants
for GPR125 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 4 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for GPR125 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for GPR125
1 CNV: 0274
1 Indel: 41524 | | QIAGEN SeqTarget long-range PCR primers for resequencing GPR125 |
|
Disorders & Mutations
for GPR125 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GPR125 for disorders About GeneDecksing
OMIM: 612303
Human Genome Epidemiology (HuGE) Navigator: GPR125 (2 documents)
Export disorders and mutations for GPR125 gene to outside databases
|
Medical News
for GPR125 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for GPR125 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/12 PubMed articles for GPR125 gene, integrated from 7 sources (see all 12):
(articles sorted by number of sources associating them with GPR125)- There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PubMed id 12565841)1, 2, 3 Fredriksson R....Schioeth H.B. (2003)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. (PubMed id 15021905)1, 2 Yamamoto Y.... Takai Y. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1 Shimada M....Tokunaga K. (2010)
- Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia. (PubMed id 17457313)1 Christoforou A....Evans K.L. (2007)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- The human and mouse repertoire of the adhesion family of G-protein- coupled receptors. (PubMed id 15203201)1 Bjarnadottir T.K.... Schioeth H.B. (2004)
|
External Searches for GPR125 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GPR125 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GPR125 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GPR125 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for GPR125 gene:
Search GeneIP for patents involving GPR125
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GPR125 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for GPR125 |
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