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Aliases & Descriptionsfor GPR182 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions G protein-coupled receptor 1821 2 AMR2 AM-R1 2 7TMR2 adrenomedullin receptor1 2 gamrh2 hrhAMR1 2 MGC343992 G10D1 2 G-protein coupled receptor 1822 ADMR2 3
Export aliases for GPR182 gene to outside databases Previous GC identifers: GC12P055675 GC12P057388
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Summariesfor GPR182 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for GPR182 : Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. (provided by RefSeq) UniProtKB/Swiss-Prot: GP182_HUMAN, O15218 Function : Orphan receptorGene Wiki entry for GPR182
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Genomic Viewsfor GPR182 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for GPR182 Other transcription factors Search SABiosciences Chromatin IP Primers for GPR182 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13.3 GPR182 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P054428: view genomic region
(about GC identifiers )
Start:
54,427,154 bp from pter
End:
54,444,914 bp from pter
Size:
17,761 bases
Orientation:
plus strand
1 alternative location : Chr 12+ 57,388,230-57,390,468
RefSeq DNA sequence: NC_000012.11 NT_029419.12
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Proteinsfor GPR182 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: GP182_HUMAN, O15218 (See
protein sequence )Recommended Name: G-protein coupled receptor 182 Size : 404 amino acids; 45323 Da
Subcellular location : Cell membrane; Multi-pass membrane protein
Caution : Was originally (PubMed:9367907) thought to be a receptor for adrenomedullinExplore the universe of human proteins at neXtProt for GPR182: NX_O15218 Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_009195.1 ENSEMBL proteins: ENSP00000300098 Human Recombinant Proteins 2 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005886 plasma membrane
IEA -- GO:0016021 integral to membrane
IEA --
About this table
GPR182 for ontologies About GeneDecksing Antibodies for GPR182: Assays for GPR182:
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Protein
Domains/ Familiesfor GPR182 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
GPR182 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O15218 ProtoNet protein and cluster: O15218
1 Blocks protein family : IPB001350 G10D orphan receptor signature UniProtKB/Swiss-Prot: GP182_HUMAN, O15218 Similarity : Belongs to the G-protein coupled receptor 1 family
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Gene Functionfor GPR182 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: GP182_HUMAN, O15218 Function : Orphan receptor
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0001605 adrenomedullin receptor activity
IEA -- GO:0004888 transmembrane receptor activity
TAS 9367907 GO:0004930 G-protein coupled receptor activity
IEA --
About this table
GPR182 for ontologies About GeneDecksing
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Pathways & Interactionsfor GPR182 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section
GPR182 for pathways About GeneDecksing 1 Millipore Pathway for GPR182 SABiosciences Pathway-Focused PCR Array including GPR182 : PAHS-3009A Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPR182 3 Gene Ontology (GO) biological process terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0001666 response to hypoxia
IEA -- GO:0007166 cell surface receptor linked signaling pathway
TAS 9367907 GO:0007186 G-protein coupled receptor protein signaling pathway
-- --
About this table
GPR182 for ontologies About GeneDecksing
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Drugs & Compoundsfor GPR182 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section
GPR182 for compounds About GeneDecksing Browse Tocris compounds for GPR182 4 Novoseek chemical compound relationships for GPR182 gene
About this table
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Transcriptsfor GPR182 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for GPR182 gene: NM_007264.3
Additional cDNA sequence: BC034761.1 Y13583.1
2 DOTS entries : DT.92416997 DT.121199001
18 AceView cDNA sequences :
BM919720 NM_007264 BC034761 AI433867 BI759854 AI962628 AI379917 BX114393 CD246170 BM091055 BI830122 AW135380 AI243295 AA704594 Y13583 BM091360 T90363 BP340154 Unigene Cluster for GPR182:
G protein-coupled receptor 182 Hs.483909 [show with all ESTs ] Unigene Representative Sequence: BC034761 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000300098 (uc001smk.2 )
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Expression for GPR182 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section GPR182 expression in normal and diseased human tissues 1 / 2
4 probe-sets matching GPR182 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
36429_at2
U95-A
1
0.88
1.00
1.00
1.00
--
--
--
--
--
214506_at2
U133-A
1
0.36
1.00
--
--
--
--
--
--
--
214506_at2
U133Plus2
1
0.36
1.00
--
--
--
--
--
--
--
1552440_at2
U133Plus2
1
0.36
1.00
--
--
--
--
--
--
--
About this table
GPR182 for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.483909 UniProtKB/Swiss-Prot: GP182_HUMAN, O15218 Tissue specificity : Highly expressed in heart, skeletal muscle, immune system, adrenal gland and liver
SABiosciences Expression via Pathway-Focused PCR Array including GPR182 : PAHS-3009A
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Orthologsfor GPR182 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for GPR182 gene from 5/7 species (see all 7 )
About this table Species with no ortholog for GPR182 ENSEMBL Gene Tree for GPR182 (if available)
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Paralogsfor GPR182 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for GPR182 gene CXCR7 2 XCR1 2 CX3CR1 2 CCBP2 2
GPR182 for paralogs About GeneDecksing
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Genomic Variantsfor GPR182 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 12 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for GPR182 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for GPR182: --
QIAGEN SeqTarget long-range PCR primers for resequencing GPR182
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Disorders & Mutationsfor GPR182 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
GPR182 for disorders About GeneDecksing
OMIM: 605307 8 Novoseek disease relationships for GPR182 gene
About this table Export disorders and mutations for GPR182 gene to outside databases
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Medical Newsfor GPR182 gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor GPR182 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/97 PubMed articles for GPR182 gene, integrated from 7 sources (see all 97 ): (articles sorted by number of sources associating them with GPR182) Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response. (PubMed id 9535752) 1 , 2 , 3, 7 Kennedy S.P.... Hill R.J. (1998) Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system. (PubMed id 9367907) 1 , 2 , 3, 7 Haenze J.... Rascher W. (1997) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Localization and distribution of adrenomedullin receptor in the human placenta: changes with gestational age. (PubMed id 17939601) 1 , 7 Marinoni E....Di Iorio R. (2007) [Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease] (PubMed id 14720432) 1 , 7 Xu P....Song W.D. (2003) Adrenomedullin receptor expression in human lung and in pulmonary tumors. (PubMed id 9016306) 1 , 7 Martinez A....Cuttitta F. (1997) The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review). (PubMed id 11956648) 1 , 7 Fowler D.E. and Wang P. (2002) Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia. (PubMed id 11883938) 1 , 7 Haenze J.... Fischer A. (2002) Receptors for adrenomedullin in human vascular endothelial cells. (PubMed id 7621913) 1 , 7 Kato J....Eto T. (1995) The ADMR receptor mediates the effects of adrenomedul lin on pancreatic cancer cells and on cells of the tumor microenvironment. (PubMed id 19847298) 1 Ramachandran V....Logsdon C.D. (2009)
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External Searches for GPR182 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing GPR182 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing GPR182 gene
(According to HUGE )
About This Section --
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Specialized Databases showing GPR182 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for GPR182 gene: Search GeneIP for patents involving GPR182 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor GPR182 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for GPR182
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