Aliases &
Descriptions
for GPRC5C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| G protein-coupled receptor, family C, group 5, member C1 2 | | orphan G-protein coupled receptor2 | | RAIG-31 2 3 | | retinoic acid responsive gene protein2 | | RAIG32 3 5 | | G-protein coupled receptor family C group 5 member C2 | | Retinoic acid-induced gene 3 protein2 3 | | OTTHUMP000000708802 | | MGC1318202 | | |
Export aliases for GPRC5C gene to outside databasesPrevious GC identifers: GC17M072433 GC17P075486 GC17P072891 GC17P073025 GC17P073024 GC17P069938 GC17P072427 |
Summaries
for GPRC5C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GPRC5C:
The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of thissuperfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein isunknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transductioncascade. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq)
UniProtKB/Swiss-Prot: GPC5C_HUMAN, Q9NQ84Function: This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction betweenretinoid and G-protein signaling pathways (By similarity)
Gene Wiki entry for GPRC5C |
Genomic Views
for GPRC5C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GPRC5C gene promoter:
YY1 SREBP-1b SREBP-1c SREBP-1a Chx10 STAT5A p53 Egr-1 Pax-2 ER-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for GPRC5C
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GPRC5C  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25GPRC5C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P067838: view genomic region
(about GC identifiers)
Start:
|
67,836,934 bp from pter |
End:
|
67,852,782 bp from pter |
Size:
|
15,849 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr17+ 72,427,052-72,446,719 |
RefSeq DNA sequence:- NC_000017.10 NT_010783.15
|
Proteins
for GPRC5C gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: GPC5C_HUMAN, Q9NQ84 (See
protein sequence)Recommended Name: G-protein coupled receptor family C group 5 member C precursor Size: 441 amino acids; 48193 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membraneprotein. Note=Localized in the plasma membrane and perinuclear vesicles
Sequence caution: Sequence=AAH16860.2; Type=Erroneous initiation; Sequence=AAI10849.1; Type=Erroneous initiation;Sequence=AAI25081.1; Type=Erroneous initiation; Sequence=AAI25082.1; Type=Erroneous initiation; Sequence=BAG54752.1;Type=Erroneous initiation; Sequence=CAC00633.1; Type=Erroneous initiation;
Secondary accessions: B5BUN4 Q2NL85 Q9NZG5Alternative splicing: 2 isoforms: Q9NQ84-1 Q9NQ84-2 Explore the universe of human proteins at neXtProt for GPRC5C: NX_Q9NQ84
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_061123.3 NP_071319.2
ENSEMBL proteins: ENSP00000376403 ENSP00000376405 ENSP00000376404 ENSP00000340595 ENSP00000392190 ENSP00000262616 ENSP00000402339
Human Recombinant Proteins
5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6): About this table
GPRC5C for ontologies About GeneDecksing
Antibodies for GPRC5C:
Assays for GPRC5C: |
Protein
Domains/
Families
for GPRC5C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GPRC5C for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NQ84ProtoNet protein and cluster: Q9NQ84 UniProtKB/Swiss-Prot: GPC5C_HUMAN, Q9NQ84Similarity: Belongs to the G-protein coupled receptor 3 family |
Gene Function
for GPRC5C gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: GPC5C_HUMAN, Q9NQ84Function: This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction betweenretinoid and G-protein signaling pathways (By similarity)Induction: By all-trans retinoic acid (ATRA)
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
GPRC5C for ontologies About GeneDecksing
|
Pathways & Interactions
for GPRC5C gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Pathway-Focused PCR Array including GPRC5C: PAHS-3009A
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPRC5C
1 Interacting protein for GPRC5C (Q9NQ841) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor protein signaling pathway |
TAS | 10783259 |
About this table
GPRC5C for ontologies About GeneDecksing
|
Drugs & Compounds
for GPRC5C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for GPRC5C
|
Transcripts
for GPRC5C gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for GPRC5C gene (2 alternative transcripts): NM_018653.3 NM_022036.2 Additional cDNA sequence: AB451470.1 AF207989.1 AJ276102.1 AK000249.1 AK075397.1 AK131210.1 AK222909.1 BC004925.1 BC016860.1 BC069202.1 BC110848.1 BC125080.1 BC125081.1 BT007435.1 CR592340.1 CR595715.1 CR597806.1 CR622350.1 11 DOTS entries: DT.97847878 DT.305116 DT.91939475 DT.95073294 DT.86854667 DT.95073292 DT.120949167 DT.95073303 DT.92050869 DT.95073302 DT.100782887 24/207 AceView cDNA sequences (see all 207): BI916185 BM756107 CR622350 BC004925 BM744405 BI764504 AI016010 NM_018653 BE907718 AL546406 AL047143 AA303063 BE350498 W69470 BC069202 NM_022036 AI075186 CR597806 BF727094 CD246153 CR595715 BE464116 BM768096 BM830675
 highest scoring ESTs for GPRC5C:AI130916 AA004699 AA055383 AA055934 AA178961 AA224166 AA453173 AA877534 AA995462 AF207989 Unigene Cluster for GPRC5C: G protein-coupled receptor, family C, group 5, member C Hs.446438 [show with all ESTs]Unigene Representative Sequence: AK131210
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GPRC5C (see all 7)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | | | | | - | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | |
| SP3: | | | | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for GPRC5C
9 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000392627(uc002jkp.2 uc002jkq.2 uc002jkr.2 uc002jks.2)
ENST00000481232 ENST00000392629 ENST00000392628(uc002jkt.2) ENST00000482723(uc002jku.2)
ENST00000342648 ENST00000420926 ENST00000262616 ENST00000417745
|
Expression
for GPRC5C gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| GPRC5C expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching GPRC5C gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 47316_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.87 |
1.12 |
AI130916 |
1.00 |
1.00 |
1.00 |
1 |
| 87629_at*2, 3
|
U95-E |
6 |
0.31 |
0.17 |
0.66 |
0.88 |
AI970895 |
0.60 |
1.00 |
0.82 |
1 |
| 219327_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_022036 |
0.60 |
1.00 |
0.82 |
1 |
| 230907_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AK000249 |
0.80 |
1.00 |
0.91 |
1 |
| 219327_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 230907_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
GPRC5C for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.446438
UniProtKB/Swiss-Prot: GPC5C_HUMAN, Q9NQ84Tissue specificity: Expression is highest in the periphery, particularly in the stomach, but also in the kidney, liver,pancreas, and prostate. In brain, levels of expression are generally lower than in the periphery, with the exceptionof cerebellum, spinal cord, and dorsal root ganglia (DRG)
SABiosciences Expression via Pathway-Focused PCR Array including GPRC5C: PAHS-3009A
|
Orthologs
for GPRC5C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GPRC5C gene from 5/9 species (see all 9)
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
dog
(Canis familiaris) |
GPRC5C1 |
-- |
G protein-coupled receptor, family C, group 5, member more |
86.82(n)
87.78(a) |
483288 XM_540407.2 XP_540407.2 |
chimpanzee
(Pan troglodytes) |
GPRC5C1 |
-- |
G protein-coupled receptor, family C, group 5, member more |
98.95(n)
98.74(a) |
468316 XM_523705.2 XP_523705.2 |
cow
(Bos taurus) |
GPRC5C1 |
-- |
G protein-coupled receptor, family C, group 5, member more |
85.91(n)
84.55(a) |
535664 XM_873143.2 XP_878236.2 |
rat
(Rattus norvegicus) |
Gprc5c1 |
-- |
G protein-coupled receptor, family C, group 5, member more |
85.92(n)
88.2(a) |
287805 XM_213518.4 XP_213518.3 |
mouse
(Mus musculus) |
Gprc5c1 , 5 |
11 (80.54 cM)5
|
G protein-coupled receptor, family C, group 5, member more1, 5 |
86.74(n)1
89.55(a)1 |
703551 NM_147217.21 NP_671750.11
AA0331315 AI4484485 (see all 23) |
About this table Species with no ortholog for GPRC5C
ENSEMBL Gene Tree for GPRC5C (if available) |
Paralogs
for GPRC5C gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for GPRC5C gene
- GPRC5A2 GPRC5B2 GPRC5D2
GPRC5C for paralogs About GeneDecksing
|
Genomic Variants
for GPRC5C gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for GPRC5C (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for GPRC5C
5 CNVs: 34522 8852 53066 5336 7171 | | QIAGEN SeqTarget long-range PCR primers for resequencing GPRC5C |
|
Disorders & Mutations
for GPRC5C gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GPRC5C for disorders About GeneDecksing
OMIM: 605949
Export disorders and mutations for GPRC5C gene to outside databases
|
Medical News
for GPRC5C gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for GPRC5C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/15 PubMed articles for GPRC5C gene, integrated from 7 sources (see all 15):
(articles sorted by number of sources associating them with GPRC5C)- Molecular cloning and characterization of two novel retinoic acid- inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). (PubMed id 10945465)1, 2, 3, 7 Robbins M.J.... Pangalos M.N. (2000)
- Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. (PubMed id 11311935)1, 2, 7 Braeuner-Osborne H.... O'Hara P. (2001)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Human protein factory for converting the transcriptome into an in vitro-expressed proteome. (PubMed id 19054851)2 Goshima N.... Nomura N. (2008)
- Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. (PubMed id 18083107)2 Rikova K....Comb M.J. (2007)
- Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks. (PubMed id 17389395)2 Wolf-Yadlin A.... White F.M. (2007)
- ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
|
External Searches for GPRC5C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GPRC5C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GPRC5C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GPRC5C gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for GPRC5C gene:
Search GeneIP for patents involving GPRC5C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GPRC5C gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for GPRC5C |
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