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GPX1 Gene

protein-coding   GIFtS: 63

GC03M049369
glutathione peroxidase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
glutathione peroxidase 11 2     OTTHUMP000002107662
Cellular glutathione peroxidase2 3     MGC143992
GSHPx-12 3     MGC882452
GPx-12 3     EC 1.11.1.93
GSHPX12     

External Ids:    HGNC: 45531   Entrez Gene: 28762   Ensembl: ENSG000002332767   UniProtKB: P072033   

Export aliases for GPX1 gene to outside databases

Previous GC identifers: GC03P048736 GC03P048542 GC03M049249 GC03M049353


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPX1:
This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification
of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a
few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione
peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein
is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with
five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly
associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been
found for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: GPX1_HUMAN, P07203
Function: Protects the hemoglobin in erythrocytes from oxidative breakdown

Gene Wiki entry for GPX1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GPX1 gene promoter:
         AP-1   c-Jun   c-Fos   NF-kappaB   NF-kappaB1   GR-alpha   GR-beta   PPAR-gamma1   PPAR-gamma2   CUTL1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for GPX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GPX1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

GPX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPX1 gene location

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049369:  view genomic region     (about GC identifiers)

Start:
49,394,609 bp from pter
End:
49,396,033 bp from pter
Size:
1,425 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: GPX1_HUMAN, P07203 (See protein sequence)
Recommended Name: Glutathione peroxidase 1  
Size: 203 amino acids; 22088 Da
Subunit: Homotetramer
Subcellular location: Cytoplasm
PDB structures from and Proteopedia :
2F8A (3D)    
Secondary accessions: Q7Z5H1 Q9BW12

Explore the universe of human proteins at neXtProt for GPX1: NX_P07203 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_000572.2  NP_958799.1  


    ENSEMBL proteins: 
    ENSP00000391316 ENSP00000407375 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for GPX1
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for GPX1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: GPX1
    GenScript Custom Purified and Recombinant Proteins Services for GPX1 
    Novus Biologicals Protein for GPX1
    Novus Biologicals Lysate for GPX1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IDA10833429
    GO:0005739 mitochondrion IDA10833429
    GO:0005829 cytosol EXP8428933
    About this table

    GPX1 for ontologies           About GeneDecksing



    Antibodies for GPX1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for GPX1
    R&D Systems Antibodies for GPX1 (Glutathione Peroxidase 1/GPX1)
    Cell Signaling Technology (CST) Antibodies for GPX1 
    OriGene Antibodies (see all 3): GPX1
    GenScript Custom Superior Antibodies Services for GPX1 
    Novus Biologicals Antibodies for GPX1
    Epitomics antibodies for GPX1

    Assays for GPX1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GPX1 
    Enzo Life Sciences assays for GPX1
    Uscn ELISAs and CLIAs for GPX1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GPX1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR012336 Thioredoxin-like_fold
     IPR012335 Thioredoxin_fold
     IPR000889 Glutathione_peroxidase

    Graphical View of Domain Structure for InterPro Entry P07203

    ProtoNet protein and cluster: P07203

    1 Blocks protein family: IPB000889 Glutathione peroxidase

    UniProtKB/Swiss-Prot: GPX1_HUMAN, P07203
    Similarity: Belongs to the glutathione peroxidase family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: GPX1_HUMAN, P07203
    Function: Protects the hemoglobin in erythrocytes from oxidative breakdown
    Catalytic activity: 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O
    Enzyme Number (IUBMB): EC 1.11.1.9 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and siRNA for GPX1
    Sigma-Aldrich shRNA Panels and shRNA for GPX1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): GPX1
    OriGene shRNA RFP (see all 2): GPX1
    OriGene basic RS shRNA (see all 2): GPX1
    OriGene siRNA (see all 2): GPX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GPX1 
    miRNA:Sigma-Aldrich microRNA Mimics for GPX1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GPX1 
    Search SABiosciences for Assays for microRNAs that regulate GPX1

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): GPX1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): GPX1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): GPX1
    OriGene 3'-UTR clone (see all 2): GPX1 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): GPX1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for GPX1 

    Genatlas biochemistry entry for GPX1:
    glutathione peroxidase 1,selenium dependent,cellular,catabolic pathway of activated oxygen species,free radical
    detoxification

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004602 glutathione peroxidase activity IDA12829378
    GO:0004866 endopeptidase inhibitor activity IDA12751788
    GO:0016491 oxidoreductase activity IEA--
    GO:0017124 SH3 domain binding IPI12893824
    About this table

    GPX1 for ontologies           About GeneDecksing

    Animal Models: 12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Gpx1):

    cellulardigestive/alimentaryendocrine/exocrine glandgrowth/sizehearing/vestibular/ear
    hematopoietic systemhomeostasis/metabolismimmune systemlife span-post-weaning/agingnervous system
    no phenotypic analysisvision/eye

    GPX1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    GPX1 for pathways           About GeneDecksing

    2 Millipore Pathways for GPX1
        HETE and HPETE biosynthesis and metabolism
    Glutathione metabolism

    3 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  GPX1
        Glutathione Metabolism
    Arachidonic Acid Metabolism
    Amyotrophic Lateral Sclerosis Signaling

    4 Kegg Pathways  (Kegg details for GPX1):
        hsa00480 Glutathione metabolism
    hsa00590 Arachidonic acid metabolism
    hsa05014 Amyotrophic lateral sclerosis (ALS)
    hsa05016 Huntington's disease

        SABiosciences Pathway-Focused PCR Arrays including GPX1 (see all 7): PAHS-002A PAHS-003A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GPX1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GPX1

    5/48 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 48):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000302 response to reactive oxygen species ----
    GO:0001659 temperature homeostasis IEA--
    GO:0001836 release of cytochrome c from mitochondria IMP12221075
    GO:0001885 endothelial cell development IEA--
    GO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA--
    About this table

    GPX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    GPX1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GPX1
    10/50 Novoseek chemical compound relationships for GPX1 gene (see all 50)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenium 82.2 102 18940188 (8), 19415410 (7), 17625244 (4), 17052796 (3) (see all 36)
    selenocysteine 80.9 20 9488664 (2), 10970865 (2), 16354666 (2), 16764674 (1) (see all 10)
    selenite 73.7 8 19033020 (3), 17150329 (2), 12896980 (1), 17115890 (1) (see all 5)
    manganese superoxide 71.3 16 16538174 (1), 15496407 (1), 16945136 (1), 18379781 (1) (see all 12)
    h2o2 60.4 42 8824885 (3), 17886026 (2), 8597083 (1), 18853169 (1) (see all 18)
    superoxide 58.2 55 14633623 (2), 14573732 (2), 14962293 (2), 20083859 (2) (see all 34)
    oxygen 57.6 17 12398936 (2), 14633623 (1), 15082714 (1), 19415410 (1) (see all 13)
    12-hpete 54.1 3 17608719 (1), 11115402 (1)
    gsts 48 3 12140174 (1), 18449862 (1), 18664505 (1)
    8-oxo-dg 44.3 3 16615267 (1), 16448453 (1), 10657953 (1)
    About this table

    2 PharmGKB drug compound relationships for GPX1 gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    estradiolFA  14514655
    tamoxifenFA  14514655
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and siRNA for GPX1
    Sigma-Aldrich shRNA Panels and shRNA for GPX1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): GPX1
    OriGene shRNA RFP (see all 2): GPX1
    OriGene basic RS shRNA (see all 2): GPX1
    OriGene siRNA (see all 2): GPX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GPX1 
    miRNA: Sigma-Aldrich microRNA Mimics for GPX1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GPX1 
    Search SABiosciences for Assays for microRNAs that regulate GPX1
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): GPX1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): GPX1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): GPX1
    OriGene 3'-UTR Clone (see all 2): GPX1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): GPX1 
    Primers: OriGene genome-wide validated SYBR primer pairs: GPX1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for GPX1: PPH00154A

    REFSEQ mRNAs for GPX1 gene (2 alternative transcripts): 

    NM_000581.2  NM_201397.1  

    Additional cDNA sequence: 

    AK130160.1 AK225835.1 BC000742.2 BC007865.2 BC070258.1 CR595371.1 CR601795.1 CR614747.1 
    CR620255.1 CR626479.1 M21304.1 X13709.1 X13710.1 Y00433.1 

    24/26 DOTS entries (see all 26):

    DT.100695209  DT.95377672  DT.120904358  DT.453375  DT.120904697  DT.120904391  DT.95377397  DT.100660428 
    DT.419998  DT.100660424  DT.120904690  DT.100853695  DT.100878930  DT.40133618  DT.120904525  DT.120904753 
    DT.100660420  DT.100660421  DT.120904378  DT.120904805  DT.95376893  DT.100660426  DT.101986123  DT.120904496 

    24/2393 AceView cDNA sequences (see all 2393):

    BF968073 BM457182 BQ431815 BQ670305 BM799554 BE906974 BU075925 BM751450 
    BQ423912 AL548314 BI258857 AA195163 BM849484 BM556509 CR601531 AU125345 
    W94542 BU151682 F02985 AU143571 BX091260 AA315468 BG249486 BM770359 

    highest scoring ESTs for GPX1:

    AA147790 AA157154 AA157493 AA187407 AA224081 AA300266 AA310925 AA312505 AA313224 AA314246 

    Unigene Cluster for GPX1:

    Glutathione peroxidase 1
    Hs.76686  [show with all ESTs]
    Unigene Representative Sequence: BM478682


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419349(uc011bcm.1) ENST00000419783(uc011bcl.1) ENST00000496791


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    GPX1 expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching GPX1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    37033_s_at2, 3 U95-A 2 1.00 0.91 1.00 1.00 X13710 0.80 0.75 0.78 1
    200736_s_at2, 3 U133-A 3 1.00 0.71 -- -- NM_000581 0.60 1.00 0.82 1
    200736_s_at2 U133Plus2 3 1.00 0.71 -- -- -- -- -- -- --
    About this table

    GPX1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    GPX1 gene expression
    GPX1 gene electronic northern expression
    GPX1 gene sage expression
    About these images

    CGAP SAGE TAG: CTCTTCGAGA

    SOURCE GeneReport for Unigene cluster: Hs.76686

    Expression variation in blood from EXPOLDB for GPX1

    Primers: OriGene genome-wide validated SYBR primer pairs: GPX1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for GPX1: PPH00154A
        SABiosciences Expression via Pathway-Focused PCR Arrays including GPX1 (see all 7): PAHS-002A PAHS-003A  


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for GPX1 gene from 5/7 species (see all 7)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    GPX11   -- glutathione peroxidase 1 88.57(n)
    94.29(a)
    442961  XM_533828.2  XP_533828.2 
    cow
    (Bos taurus)
    GPX11   -- glutathione peroxidase 1 85.07(n)
    89.55(a)
    281209  NM_174076.2  NP_776501.1 
    rat
    (Rattus norvegicus)
    Gpx11   -- glutathione peroxidase 1 82.75(n)
    84.92(a)
    24404  NM_030826.2  NP_110453.2 
    mouse
    (Mus musculus)
    Gpx11 , 5 9 (59.24 cM)5
    glutathione peroxidase 11, 5 85.71(n)1
    88.27(a)1
    147751  NM_008160.51  NP_032186.21 
     AI1950245  AK0022455  (see all 24)
    zebrafish
    (Danio rerio)
    wufd42f122   -- Transcribed sequence with weak similarity to protein more 77.57(n)  57057448 
    About this table        Species with no ortholog for GPX1

    ENSEMBL Gene Tree for GPX1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for GPX1 gene
    GPX62  GPX52  GPX22  GPX42  GPX72  GPX82  GPX32  

    GPX1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/15 NCBI SNPs in GPX1 are shown (see all 15)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 3 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs18006681,2
    C,F,49395757(-) CCTTAC/TAGTGC 2 -- ut5125Minor allele frequency- T:0.15MN NS NA EA 3132
    rs49914481,2
    --49395695(-) TCGGCC/TAgcgg 4 P L mis1 ref10--------
    rs81791671,2
    F,H49395816(-) ACTGCC/GTGTGC 2 -- ng515Minor allele frequency- G:0.00NS EA 592
    rs81791681,2
    --49395724(-) TTCTTG/AGACAA 2 -- ut511Minor allele frequency- A:0.01NS 172
    rs81791691,2
    C,F49395698(-) TGCTCG/CGCTAg 4 /P /R mis1 ref11Minor allele frequency- C:0.02NS 180
    rs178387621,2
    C,F49395674(-) GCGGC-/GGCCCAGT 6 A AA AAA fra1 ref12Minor allele frequency- GGC:0.10EA NA 202
    rs283625881,2
    --49395686(+) CCGCC-/GCCGCTAG 6 A AA AAA fra1 ref10--------
    rs358109661,2
    --49395837(+) TGAGG-/GTCCCG 2 -- ng510--------
    rs412765391,2
    --49395752(+) AACAAG/TCACTG 2 -- ut510--------
    rs560412431,2
    --49395688(+) GCCGC-/CGCCGC
            
    TAGCC
    4 A AAA fra1 ref10--------
    About this table

    HapMap Linkage Disequilibrium images for GPX1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GPX1: --

    QIAGEN SeqTarget long-range PCR primers for resequencing GPX1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GPX1 for disorders           About GeneDecksing

    OMIM: 138320

    10/29 Novoseek disease relationships for GPX1 gene (see all 29)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenium deficiency 72.2 4 18940188 (3)
    cancer 28.4 18 16317164 (2), 9792801 (2), 15203190 (2), 19826042 (2) (see all 10)
    hyperhomocysteinemia 26.6 4 18237028 (1), 14656025 (1), 17822368 (1)
    atherosclerosis 26.3 18 17350371 (4), 17420349 (3), 15331559 (1), 17255533 (1) (see all 6)
    hepatitis acute viral 26.2 1 1803152 (1)
    cardiovascular diseases 19.7 3 17822368 (1), 19327385 (1), 18541150 (1)
    insulinoma 19.1 1 14962293 (1)
    cancer lung 15.5 14 16615267 (5), 17052796 (2), 8001233 (1), 14744747 (1) (see all 6)
    breast carcinoma 13.5 3 11502879 (1), 12398936 (1), 12810669 (1)
    breast cancer 11.2 23 12810669 (4), 16945136 (4), 7850813 (3), 14744747 (3) (see all 10)
    About this table

    1 PharmGKB disease relationship for GPX1 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Breast NeoplasmsFA  14514655
    About this table

    Genatlas disease: GPX1
    hemolytic anemia

    Human Gene Mutation Database (HGMD): GPX1
    Genetic Association Database (GAD): GPX1
    Human Genome Epidemiology (HuGE) Navigator: GPX1 (113 documents)

    Export disorders and mutations for GPX1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/381 PubMed articles for GPX1 gene, integrated from 7 sources (see all 381):
    (articles sorted by number of sources associating them with GPX1)
    1. Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients. (PubMed id 15331559)1, 2, 4, 7 Hamanishi T.... Nanjo K. (2004)
    2. Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant. (PubMed id 15247771)1, 2, 4, 7 Ichimura Y.... Kato T. (2004)
    3. Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer. (PubMed id 12496980)1, 2, 4, 7 Kote-Jarai Z.... Eeles R. (2002)
    4. Association between polymorphisms of the GPX1 gene and second primary tumours after index squamous cell cancer of the head and neck. (PubMed id 15878749)1, 4, 7 Jefferies S.... . (2005)
    5. Functional polymorphism of the glutathione peroxidase 1 gene is associated with personality traits in healthy subjects. (PubMed id 15990458)1, 4, 7 Matsuzawa D....Iyo M. (2005)
    6. Genetic variants of GPX1 and SOD2 and breast cancer risk at the Ontario site of the Breast Cancer Family Registry. (PubMed id 14744747)1, 4, 7 Knight J.A....Ozcelik H. (2004)
    7. Glutathione pathway genes and lung cancer risk in young and old populations. (PubMed id 15192016)1, 4, 7 Yang P....de Andrade M. (2004)
    8. Phenotype determination of a common Pro-Leu polymorphism in human glutathione peroxidase 1. (PubMed id 11112379)1, 4, 7 Forsberg L....Morgenstern R. (2000)
    9. Associations between GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, alcohol consumption and breast cancer risk in a prospective cohort study. (PubMed id 16287877)1, 4, 7 Ravn-Haren G....Vogel U. (2006)
    10. Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway. (PubMed id 15829318)1, 4, 7 Skuladottir H....Olsen J.H. (2005)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2876 HGNC: 4553 AceView: RHOA Ensembl:ENSG00000233276 euGenes: HUgn2876
    ECgene: GPX1 Kegg: 2876 H-InvDB: GPX1

    (According to HUGE)
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    ATLAS Chromosomes in Cancer entry for GPX1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gpx1/
    Wikipedia http://en.wikipedia.org/wiki/Glutathione_peroxidase

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    Patent Information for GPX1 gene:
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