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GPX1 Gene

protein-coding GIFtS: 63

GC03M049369

glutathione peroxidase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
glutathione peroxidase 1¹ ²		OTTHUMP00000210766²
Cellular glutathione peroxidase² ³		MGC14399²
GSHPx-1² ³		MGC88245²
GPx-1² ³		EC 1.11.1.9³
GSHPX1²

External Ids:	HGNC: 4553¹	Entrez Gene: 2876²	Ensembl: ENSG00000233276⁷	UniProtKB: P07203³

Export aliases for GPX1 gene to outside databases

Previous GC identifers: GC03P048736 GC03P048542 GC03M049249 GC03M049353

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GPX1:

This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification

of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a

few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione

peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein

is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with

five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly

associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been

found for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: GPX1_HUMAN, P07203

Function: Protects the hemoglobin in erythrocytes from oxidative breakdown

Gene Wiki entry for GPX1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GPX1 gene promoter:
         AP-1   c-Jun   c-Fos   NF-kappaB   NF-kappaB1   GR-alpha   GR-beta   PPAR-gamma1   PPAR-gamma2   CUTL1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for GPX1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GPX1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3

GPX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPX1 gene location

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M049369: view genomic region (about GC identifiers)

Start:	49,394,609 bp from pter
End:	49,396,033 bp from pter
Size:	1,425 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.11 NT_022517.18

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: GPX1_HUMAN, P07203 (See protein sequence)

Recommended Name: Glutathione peroxidase 1

Size: 203 amino acids; 22088 Da

Subunit: Homotetramer

Subcellular location: Cytoplasm

PDB structures from and Proteopedia :

2F8A (3D)

Secondary accessions: Q7Z5H1 Q9BW12

Explore the universe of human proteins at neXtProt for GPX1: NX_P07203

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000572.2 NP_958799.1

ENSEMBL proteins:

ENSP00000391316 ENSP00000407375

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for GPX1
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for GPX1
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: GPX1
	GenScript Custom Purified and Recombinant Proteins Services for GPX1
	Novus Biologicals Protein for GPX1
	Novus Biologicals Lysate for GPX1
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	10833429
GO:0005739	mitochondrion	IDA	10833429
GO:0005829	cytosol	EXP	8428933

About this table

GPX1 for ontologies About GeneDecksing

Antibodies for GPX1:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for GPX1
	R&D Systems Antibodies for GPX1 (Glutathione Peroxidase 1/GPX1)
	Cell Signaling Technology (CST) Antibodies for GPX1
	OriGene Antibodies (see all 3): GPX1
	GenScript Custom Superior Antibodies Services for GPX1
	Novus Biologicals Antibodies for GPX1
	Epitomics antibodies for GPX1

Assays for GPX1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GPX1
	Enzo Life Sciences assays for GPX1
	Uscn ELISAs and CLIAs for GPX1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GPX1 for domains About GeneDecksing

3 InterPro domains/families:

IPR012336 Thioredoxin-like_fold

IPR012335 Thioredoxin_fold

IPR000889 Glutathione_peroxidase

Graphical View of Domain Structure for InterPro Entry P07203

ProtoNet protein and cluster: P07203

1 Blocks protein family: IPB000889 Glutathione peroxidase

UniProtKB/Swiss-Prot: GPX1_HUMAN, P07203

Similarity: Belongs to the glutathione peroxidase family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: GPX1_HUMAN, P07203

Function: Protects the hemoglobin in erythrocytes from oxidative breakdown

Catalytic activity: 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O

Enzyme Number (IUBMB): EC 1.11.1.9

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and siRNA for GPX1 Sigma-Aldrich shRNA Panels and shRNA for GPX1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): GPX1 OriGene shRNA RFP (see all 2): GPX1 OriGene basic RS shRNA (see all 2): GPX1 OriGene siRNA (see all 2): GPX1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GPX1

miRNA:		Sigma-Aldrich microRNA Mimics for GPX1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GPX1
		Search SABiosciences for Assays for microRNAs that regulate GPX1

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): GPX1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): GPX1 OriGene untagged cDNA clones in CMV expression vector (see all 2): GPX1 OriGene 3'-UTR clone (see all 2): GPX1 Browse MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): GPX1
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for GPX1

Genatlas biochemistry entry for GPX1:

glutathione peroxidase 1,selenium dependent,cellular,catabolic pathway of activated oxygen species,free radical

detoxification

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004602	glutathione peroxidase activity	IDA	12829378
GO:0004866	endopeptidase inhibitor activity	IDA	12751788
GO:0016491	oxidoreductase activity	IEA	--
GO:0017124	SH3 domain binding	IPI	12893824

About this table

GPX1 for ontologies About GeneDecksing

Animal Models: 12 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Gpx1):

cellular	digestive/alimentary	endocrine/exocrine gland	growth/size	hearing/vestibular/ear
hematopoietic system	homeostasis/metabolism	immune system	life span-post-weaning/aging	nervous system
no phenotypic analysis	vision/eye

GPX1 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

GPX1 for pathways About GeneDecksing

2 Millipore Pathways for GPX1

	HETE and HPETE biosynthesis and metabolism
	Glutathione metabolism

3 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for GPX1

	Glutathione Metabolism
	Arachidonic Acid Metabolism
	Amyotrophic Lateral Sclerosis Signaling

4 Kegg Pathways (Kegg details for GPX1):

	hsa00480 Glutathione metabolism
	hsa00590 Arachidonic acid metabolism
	hsa05014 Amyotrophic lateral sclerosis (ALS)
	hsa05016 Huntington's disease

SABiosciences Pathway-Focused PCR Arrays including GPX1 (see all 7): PAHS-002A PAHS-003A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GPX1

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GPX1

5/48 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 48):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000302	response to reactive oxygen species	--	--
GO:0001659	temperature homeostasis	IEA	--
GO:0001836	release of cytochrome c from mitochondria	IMP	12221075
GO:0001885	endothelial cell development	IEA	--
GO:0002862	negative regulation of inflammatory response to antigenic stimulus	IEA	--

About this table

GPX1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

GPX1 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GPX1
10/50 Novoseek chemical compound relationships for GPX1 gene (see all 50)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
selenium	82.2	102	18940188 (8), 19415410 (7), 17625244 (4), 17052796 (3) (see all 36)
selenocysteine	80.9	20	9488664 (2), 10970865 (2), 16354666 (2), 16764674 (1) (see all 10)
selenite	73.7	8	19033020 (3), 17150329 (2), 12896980 (1), 17115890 (1) (see all 5)
manganese superoxide	71.3	16	16538174 (1), 15496407 (1), 16945136 (1), 18379781 (1) (see all 12)
h2o2	60.4	42	8824885 (3), 17886026 (2), 8597083 (1), 18853169 (1) (see all 18)
superoxide	58.2	55	14633623 (2), 14573732 (2), 14962293 (2), 20083859 (2) (see all 34)
oxygen	57.6	17	12398936 (2), 14633623 (1), 15082714 (1), 19415410 (1) (see all 13)
12-hpete	54.1	3	17608719 (1), 11115402 (1)
gsts	48	3	12140174 (1), 18449862 (1), 18664505 (1)
8-oxo-dg	44.3	3	16615267 (1), 16448453 (1), 10657953 (1)

About this table

2 PharmGKB drug compound relationships for GPX1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
estradiol	FA	14514655
tamoxifen	FA	14514655

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and siRNA for GPX1 Sigma-Aldrich shRNA Panels and shRNA for GPX1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): GPX1 OriGene shRNA RFP (see all 2): GPX1 OriGene basic RS shRNA (see all 2): GPX1 OriGene siRNA (see all 2): GPX1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GPX1

miRNA:		Sigma-Aldrich microRNA Mimics for GPX1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GPX1
		Search SABiosciences for Assays for microRNAs that regulate GPX1

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): GPX1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): GPX1 OriGene untagged cDNA clones in CMV expression vector (see all 2): GPX1 OriGene 3'-UTR Clone (see all 2): GPX1 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): GPX1

Primers:		OriGene genome-wide validated SYBR primer pairs: GPX1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for GPX1: PPH00154A

REFSEQ mRNAs for GPX1 gene (2 alternative transcripts):

NM_000581.2 NM_201397.1

Additional cDNA sequence:

AK130160.1 AK225835.1 BC000742.2 BC007865.2 BC070258.1 CR595371.1 CR601795.1 CR614747.1

CR620255.1 CR626479.1 M21304.1 X13709.1 X13710.1 Y00433.1

24/26 DOTS entries (see all 26):

DT.100695209 DT.95377672 DT.120904358 DT.453375 DT.120904697 DT.120904391 DT.95377397 DT.100660428

DT.419998 DT.100660424 DT.120904690 DT.100853695 DT.100878930 DT.40133618 DT.120904525 DT.120904753

DT.100660420 DT.100660421 DT.120904378 DT.120904805 DT.95376893 DT.100660426 DT.101986123 DT.120904496

24/2393 AceView cDNA sequences (see all 2393):

BF968073 BM457182 BQ431815 BQ670305 BM799554 BE906974 BU075925 BM751450

BQ423912 AL548314 BI258857 AA195163 BM849484 BM556509 CR601531 AU125345

W94542 BU151682 F02985 AU143571 BX091260 AA315468 BG249486 BM770359

highest scoring ESTs for GPX1:

AA147790 AA157154 AA157493 AA187407 AA224081 AA300266 AA310925 AA312505 AA313224 AA314246

Unigene Cluster for GPX1:

Glutathione peroxidase 1

Hs.76686 [show with all ESTs]

Unigene Representative Sequence: BM478682

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000419349(uc011bcm.1) ENST00000419783(uc011bcl.1) ENST00000496791

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

GPX1 expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching GPX1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37033_s_at²^{, 3}	U95-A	2	1.00	0.91	1.00	1.00	X13710	0.80	0.75	0.78	1
200736_s_at²^{, 3}	U133-A	3	1.00	0.71	--	--	NM_000581	0.60	1.00	0.82	1
200736_s_at²	U133Plus2	3	1.00	0.71	--	--	--	--	--	--	--

About this table

GPX1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

GPX1 gene electronic northern expression

About these images

CGAP SAGE TAG: CTCTTCGAGA

SOURCE GeneReport for Unigene cluster: Hs.76686

Expression variation in blood from EXPOLDB for GPX1

Primers:		OriGene genome-wide validated SYBR primer pairs: GPX1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for GPX1: PPH00154A

SABiosciences Expression via Pathway-Focused PCR Arrays including GPX1 (see all 7): PAHS-002A PAHS-003A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GPX1 gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GPX1¹	--	glutathione peroxidase 1	88.57(n) 94.29(a)	442961 XM_533828.2 XP_533828.2
cow (Bos taurus)	GPX1¹	--	glutathione peroxidase 1	85.07(n) 89.55(a)	281209 NM_174076.2 NP_776501.1
rat (Rattus norvegicus)	Gpx1¹	--	glutathione peroxidase 1	82.75(n) 84.92(a)	24404 NM_030826.2 NP_110453.2
mouse (Mus musculus)	Gpx1^{1 , 5}	9 (59.24 cM)⁵	glutathione peroxidase 1^{1, 5}	85.71(n)¹ 88.27(a)¹	14775¹ NM_008160.5¹ NP_032186.2¹ AI195024⁵ AK002245⁵ (see all 24)
zebrafish (Danio rerio)	wufd42f12²	--	Transcribed sequence with weak similarity to protein more	77.57(n)	57057448

About this table Species with no ortholog for GPX1

ENSEMBL Gene Tree for GPX1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GPX1 gene

GPX6² GPX5² GPX2² GPX4² GPX7² GPX8² GPX3²

GPX1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1800668^1,2	C,F,	49395757(-)	`CCTTAC/TAGTGC`	2	--	ut5¹		25		MN NS NA EA	3132
rs4991448^1,2	--	49395695(-)	`TCGGCC/TAgcgg`	4	P L	mis¹ ref¹		0	--	--	--	--
rs8179167^1,2	F,H	49395816(-)	`ACTGCC/GTGTGC`	2	--	ng5¹		5		NS EA	592
rs8179168^1,2	--	49395724(-)	`TTCTTG/AGACAA`	2	--	ut5¹		1		NS	172
rs8179169^1,2	C,F	49395698(-)	`TGCTCG/CGCTAg`	4	/P /R	mis¹ ref¹		1		NS	180
rs17838762^1,2	C,F	49395674(-)	`GCGGC-/GGCCCAGT`	6	A AA AAA	fra¹ ref¹		2		EA NA	202
rs28362588^1,2	--	49395686(+)	`CCGCC-/GCCGCTAG`	6	A AA AAA	fra¹ ref¹		0	--	--	--	--
rs35810966^1,2	--	49395837(+)	`TGAGG-/GTCCCG`	2	--	ng5¹		0	--	--	--	--
rs41276539^1,2	--	49395752(+)	`AACAAG/TCACTG`	2	--	ut5¹		0	--	--	--	--
rs56041243^1,2	--	49395688(+)	`GCCGC-/CGCCGC TAGCC`	4	A AAA	fra¹ ref¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for GPX1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GPX1: --

QIAGEN SeqTarget long-range PCR primers for resequencing GPX1

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GPX1 for disorders About GeneDecksing

OMIM: 138320

10/29 Novoseek disease relationships for GPX1 gene (see all 29)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
selenium deficiency	72.2	4	18940188 (3)
cancer	28.4	18	16317164 (2), 9792801 (2), 15203190 (2), 19826042 (2) (see all 10)
hyperhomocysteinemia	26.6	4	18237028 (1), 14656025 (1), 17822368 (1)
atherosclerosis	26.3	18	17350371 (4), 17420349 (3), 15331559 (1), 17255533 (1) (see all 6)
hepatitis acute viral	26.2	1	1803152 (1)
cardiovascular diseases	19.7	3	17822368 (1), 19327385 (1), 18541150 (1)
insulinoma	19.1	1	14962293 (1)
cancer lung	15.5	14	16615267 (5), 17052796 (2), 8001233 (1), 14744747 (1) (see all 6)
breast carcinoma	13.5	3	11502879 (1), 12398936 (1), 12810669 (1)
breast cancer	11.2	23	12810669 (4), 16945136 (4), 7850813 (3), 14744747 (3) (see all 10)

About this table

1 PharmGKB disease relationship for GPX1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Breast Neoplasms	FA	14514655

About this table

Genatlas disease: GPX1

hemolytic anemia

Human Gene Mutation Database (HGMD): GPX1
Genetic Association Database (GAD): GPX1
Human Genome Epidemiology (HuGE) Navigator: GPX1 (113 documents)

Export disorders and mutations for GPX1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/381 PubMed articles for GPX1 gene, integrated from 7 sources (see all 381):
(articles sorted by number of sources associating them with GPX1)

Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients. (PubMed id 15331559)^{1, 2, 4, 7} Hamanishi T.... Nanjo K. (2004)
Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant. (PubMed id 15247771)^{1, 2, 4, 7} Ichimura Y.... Kato T. (2004)
Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer. (PubMed id 12496980)^{1, 2, 4, 7} Kote-Jarai Z.... Eeles R. (2002)
Association between polymorphisms of the GPX1 gene and second primary tumours after index squamous cell cancer of the head and neck. (PubMed id 15878749)^{1, 4, 7} Jefferies S.... . (2005)
Functional polymorphism of the glutathione peroxidase 1 gene is associated with personality traits in healthy subjects. (PubMed id 15990458)^{1, 4, 7} Matsuzawa D....Iyo M. (2005)
Genetic variants of GPX1 and SOD2 and breast cancer risk at the Ontario site of the Breast Cancer Family Registry. (PubMed id 14744747)^{1, 4, 7} Knight J.A....Ozcelik H. (2004)
Glutathione pathway genes and lung cancer risk in young and old populations. (PubMed id 15192016)^{1, 4, 7} Yang P....de Andrade M. (2004)
Phenotype determination of a common Pro-Leu polymorphism in human glutathione peroxidase 1. (PubMed id 11112379)^{1, 4, 7} Forsberg L....Morgenstern R. (2000)
Associations between GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, alcohol consumption and breast cancer risk in a prospective cohort study. (PubMed id 16287877)^{1, 4, 7} Ravn-Haren G....Vogel U. (2006)
Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway. (PubMed id 15829318)^{1, 4, 7} Skuladottir H....Olsen J.H. (2005)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2876	HGNC: 4553	AceView: RHOA	Ensembl:ENSG00000233276	euGenes: HUgn2876
ECgene: GPX1	Kegg: 2876	H-InvDB: GPX1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for GPX1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/gpx1/
Wikipedia	http://en.wikipedia.org/wiki/Glutathione_peroxidase

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