Aliases &
Descriptions
for GPX6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| glutathione peroxidase 6 (olfactory)1 2 | | glutathione peroxidase 62 | | glutathione peroxidase pseudogene 31 2 | | GPX5p2 | | GPx-62 3 | | dJ1186N242 | | GSHPx-62 3 | | dJ1186N24.12 | | GPXP32 | | EC 1.11.1.93 |
Export aliases for GPX6 gene to outside databasesPrevious GC identifers: GC00U990129 GC06M028541 GC06P028601 GC06M028579 GC06M028471 |
Summaries
for GPX6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GPX6:
This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogenperoxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGAcodon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loopstructure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon ratherthan as a stop signal. Expression of this gene is restricted to embryos and adult olfactory epithelium. (provided byRefSeq)
|
Genomic Views
for GPX6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GPX6 gene promoter:
C/EBPbeta SRF c-Rel ARP-1 MRF-2 FOXO4 PPAR-gamma1 PPAR-gamma2 HSF2 RelA
Other transcription factors
Search SABiosciences Chromatin IP Primers for GPX6
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p22.1 Ensembl cytogenetic band: 6p22.1 HGNC cytogenetic band: 6p22.1GPX6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M028277: view genomic region
(about GC identifiers)
Start:
|
28,277,455 bp from pter |
End:
|
28,289,954 bp from pter |
Size:
|
12,500 bases |
Orientation:
|
minus strand |
2 alternative locations:
| Chr6-,ALT_REF_LOCI_2 28,517,716-28,522,758 | Chr6- 28,471,073-28,503,695 |
RefSeq DNA sequence:- NC_000006.11 NT_007592.15 NT_113891.2
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Proteins
for GPX6 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: GPX6_HUMAN, P59796 (See
protein sequence)Recommended Name: Glutathione peroxidase 6 precursor Size: 221 amino acids; 24971 Da
Subcellular location: Secreted (By similarity)
Secondary accessions: Q4PJ17Explore the universe of human proteins at neXtProt for GPX6: NX_P59796
REFSEQ proteins: NP_874360.1
ENSEMBL proteins: ENSP00000354581 ENSP00000417364 ENSP00000382223
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
About this table
GPX6 for ontologies About GeneDecksing
Antibodies for GPX6:
Assays for GPX6: |
Protein
Domains/
Families
for GPX6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GPX6 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P59796ProtoNet protein and cluster: P59796 1 Blocks protein family: IPB000889 Glutathione peroxidase
UniProtKB/Swiss-Prot: GPX6_HUMAN, P59796Similarity: Belongs to the glutathione peroxidase family |
Gene Function
for GPX6 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: GPX6_HUMAN, P59796Catalytic activity: 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)OEnzyme Number (IUBMB): EC 1.11.1.9
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004602 | glutathione peroxidase activity |
IEA | -- | | GO:0016491 | oxidoreductase activity |
IEA | -- |
About this table
GPX6 for ontologies About GeneDecksing
|
Pathways & Interactions
for GPX6 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
GPX6 for pathways About GeneDecksing
1  Millipore Pathway for GPX6
2  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for GPX6
2  Kegg Pathways (Kegg details for GPX6):
SABiosciences Pathway-Focused PCR Arrays including GPX6 (see all 3): PAHS-062A PAHS-065A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GPX6
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPX6
5/36 Interacting proteins for GPX6 (ENSP000003545813) via UniProtKB, MINT, and/or STRING (see all 36)About this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006979 | response to oxidative stress |
IEA | -- | | GO:0055114 | oxidation-reduction process |
IEA | -- |
About this table
GPX6 for ontologies About GeneDecksing
|
Drugs & Compounds
for GPX6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for GPX6
|
Transcripts
for GPX6 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for GPX6 gene: NM_182701.1 Additional cDNA sequence: AY324826.1 BC133691.1 BC148315.2 1 DOTS entry: DT.101977842 2 AceView cDNA sequences: NM_182701 AY324826
 highest scoring ESTs for GPX6:AY324826 NM_182701 DB034136 DB337290 Unigene Cluster for GPX6: Glutathione peroxidase 6 (olfactory) Hs.448570 Unigene Representative Sequence: AY324826
GeneLoc Exon Structure
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361902(uc011dlj.1 uc010jrg.1) ENST00000474923 ENST00000483058
ENST00000399282
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Expression
for GPX6 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| GPX6 expression in normal and diseased human tissues
1 Data from GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GCACCTGGGC
SOURCE GeneReport for Unigene cluster: Hs.448570
UniProtKB/Swiss-Prot: GPX6_HUMAN, P59796Tissue specificity: Expressed in olfactory epithelium and embryos
SABiosciences Expression via Pathway-Focused PCR Arrays including GPX6 (see all 3): PAHS-062A PAHS-065A
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Orthologs
for GPX6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GPX6 gene from 3 species
About this table Species with no ortholog for GPX6
ENSEMBL Gene Tree for GPX6 (if available) |
Paralogs
for GPX6 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for GPX6 gene
- GPX52 GPX22 GPX42 GPX72 GPX12 GPX82 GPX32
GPX6 for paralogs About GeneDecksing
|
Genomic Variants
for GPX6 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 6 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for GPX6 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GPX6
1 CNV: 81297 | | QIAGEN SeqTarget long-range PCR primers for resequencing GPX6 |
|
Disorders & Mutations
for GPX6 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GPX6 for disorders About GeneDecksing
OMIM: 607913
Human Genome Epidemiology (HuGE) Navigator: GPX6 (4 documents)
Export disorders and mutations for GPX6 gene to outside databases
|
Medical News
for GPX6 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for GPX6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10 PubMed articles for GPX6 gene integrated from 7 sources:
(articles sorted by number of sources associating them with GPX6)- Characterization of mammalian selenoproteomes. (PubMed id 12775843)1, 2 Kryukov G.V.... Gladyshev V.N. (2003)
- Glutathione pathway genetic polymorphisms and lung ca ncer survival after platinum-based chemotherapy. (PubMed id 20200426)1 Moyer A.M....Weinshilboum R.M. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells. (PubMed id 15910762)1 Price T.O....Banks W.A. (2005)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation. (PubMed id 11368344)1 Richard M.J....Favier A. (2001)
- Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice. (PubMed id 10652368)1 Choi J....Forman H.J. (2000)
- Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor. (PubMed id 9501919)1 Opalenik S.R....Thompson J.A. (1998)
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External Searches for GPX6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing GPX6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GPX6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GPX6 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| NIEHS-SNPs | http://egp.gs.washington.edu/data/gpx6/ |
|
| | |
About This Section
| Patent Information for GPX6 gene:
Search GeneIP for patents involving GPX6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GPX6 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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 | | | ELISAs and CLIAs for GPX6 |
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