Aliases &
Descriptions
for GPX8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| glutathione peroxidase 8 (putative)1 2 | | GSHPx-82 3 | | EPLA8471 2 | | OTTHUMP000002223862 | | UNQ8471 2 | | probable glutathione peroxidase 82 | | GPx-82 3 | | EC 1.11.1.93 |
Export aliases for GPX8 gene to outside databasesPrevious GC identifer: GC05P054493 |
Summaries
for GPX8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for GPX8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for GPX8
Other transcription factors
Search SABiosciences Chromatin IP Primers for GPX8
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q11.2 Ensembl cytogenetic band: 5q11.2 HGNC cytogenetic band: 5q11.2GPX8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P051429: view genomic region
(about GC identifiers)
Start:
|
51,429,158 bp from pter |
End:
|
51,436,302 bp from pter |
Size:
|
7,145 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr5+ 54,455,946-54,462,899 |
RefSeq DNA sequence:- NC_000005.9 NT_006713.15
|
Proteins
for GPX8 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: GPX8_HUMAN, Q8TED1 (See
protein sequence)Recommended Name: Probable glutathione peroxidase 8 Size: 209 amino acids; 23881 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
PDB structures from  and Proteopedia  :3CYN (3D)
Explore the universe of human proteins at neXtProt for GPX8: NX_Q8TED1
REFSEQ proteins: NP_001008398.2
ENSEMBL proteins: ENSP00000423822 ENSP00000427466 ENSP00000296734 ENSP00000430956
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
About this table
GPX8 for ontologies About GeneDecksing
Antibodies for GPX8:
Assays for GPX8: |
Protein
Domains/
Families
for GPX8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GPX8 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TED1ProtoNet protein and cluster: Q8TED1 1 Blocks protein family: IPB000889 Glutathione peroxidase
UniProtKB/Swiss-Prot: GPX8_HUMAN, Q8TED1Similarity: Belongs to the glutathione peroxidase family |
Gene Function
for GPX8 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: GPX8_HUMAN, Q8TED1Catalytic activity: 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)OEnzyme Number (IUBMB): EC 1.11.1.9
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004602 | glutathione peroxidase activity |
IEA | -- | | GO:0016491 | oxidoreductase activity |
IEA | -- |
About this table
GPX8 for ontologies About GeneDecksing
|
Pathways & Interactions
for GPX8 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
GPX8 for pathways About GeneDecksing
2  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for GPX8
SABiosciences Pathway-Focused PCR Array including GPX8: PAHS-094A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GPX8
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GPX8
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006979 | response to oxidative stress |
IEA | -- | | GO:0055114 | oxidation-reduction process |
IEA | -- |
About this table
GPX8 for ontologies About GeneDecksing
|
Drugs & Compounds
for GPX8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for GPX8
|
Transcripts
for GPX8 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for GPX8 gene: NM_001008397.2 Additional cDNA sequence: AF086192.1 AK022110.1 AK074216.1 AK298545.1 AK307365.1 AY358715.1 BC029424.1 BX537894.1 BX647770.1 CR620005.1 CR623605.1 8 DOTS entries: DT.212649 DT.92423608 DT.92423609 DT.100801024 DT.95266794 DT.110213 DT.97759851 DT.100024994 Unigene Cluster for GPX8: Glutathione peroxidase 8 (putative) Hs.289044 [show with all ESTs]Unigene Representative Sequence: NM_001008397
GeneLoc Exon Structure
9 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000511617 ENST00000505096 ENST00000503787 ENST00000515370 ENST00000506123(uc003jps.2 uc003jpt.2)
ENST00000514317 ENST00000296734(uc003jpq.2 uc003jpr.2) ENST00000521115
ENST00000502733
|
Expression
for GPX8 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| GPX8 expression in normal and diseased human tissues
1 / 2 5 probe-sets matching GPX8 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 52123_at2
|
U95-B |
1 |
0.69 |
1.00 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
| 227628_at2
|
U133-B |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 228141_at2
|
U133-B |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 227628_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 228141_at2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
GPX8 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AAAGAGTATT
SOURCE GeneReport for Unigene cluster: Hs.289044
SABiosciences Expression via Pathway-Focused PCR Array including GPX8: PAHS-094A
|
Orthologs
for GPX8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GPX8 gene from 5/8 species (see all 8)
About this table Species with no ortholog for GPX8
ENSEMBL Gene Tree for GPX8 (if available) |
Paralogs
for GPX8 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for GPX8 gene
- GPX62 GPX52 GPX22 GPX42 GPX72 GPX12 GPX32
GPX8 for paralogs About GeneDecksing
|
Genomic Variants
for GPX8 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
| | | QIAGEN SeqTarget long-range PCR primers for resequencing GPX8 |
|
Disorders & Mutations
for GPX8 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for GPX8 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for GPX8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
7 PubMed articles for GPX8 gene integrated from 7 sources:
(articles sorted by number of sources associating them with GPX8)- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Evolutionary and structural insights into the multifaceted glutathione peroxidase (Gpx) superfamily. (PubMed id 18498225)1 Toppo S....Tosatto S.C. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for GPX8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GPX8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GPX8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GPX8 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for GPX8 gene:
Search GeneIP for patents involving GPX8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GPX8 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for GPX8 |
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