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GRK4 Gene

protein-coding GIFtS: 58

GC04P003002

G protein-coupled receptor kinase 4
(Previous name: G protein-coupled receptor kinase 2-like (Drosophila) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GPRK2L)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
G protein-coupled receptor kinase 4¹ ²		G protein-coupled receptor kinase 2-like²
GPRK4¹ ² ³ ⁵		GRK4a²
GPRK2L² ³ ⁵		IT11²
G protein-coupled receptor kinase GRK4² ³		OTTHUMP00000216993²
ITI1² ³		G-protein coupled receptor kinase 4²
G protein-coupled receptor kinase 2-like (Drosophila)¹		EC 2.7.11.16³

External Ids:	HGNC: 4543¹	Entrez Gene: 2868²	Ensembl: ENSG00000125388⁷	UniProtKB: P32298³

Export aliases for GRK4 gene to outside databases

Previous GC identifers: GC04P002997 GC04P002996

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRK4:

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of

the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus

initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. (provided by RefSeq)

UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298

Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate

rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do

not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2

Gene Wiki entry for GRK4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GRK4 gene promoter:
         RP58   Nkx2-2   MEF-2A   POU2F1   CUTL1   FAC1   CHOP-10   C/EBPalpha   Pax-5   Nkx3-1 v3
         Other transcription factors

Search SABiosciences Chromatin IP Primers for GRK4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3

GRK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRK4 gene location

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P003002: view genomic region (about GC identifiers)

Start:	2,903,673 bp from pter
End:	3,042,474 bp from pter
Size:	138,802 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.11 NT_006051.18

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298 (See protein sequence)

Recommended Name: G protein-coupled receptor kinase 4

Size: 578 amino acids; 66583 Da

Subunit: Interacts with DRD3

Subcellular location: Cytoplasm. Cytoplasm, cell cortex. Note=Both at the cell surface and dispersed in the cytoplasm

under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where

co-localization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 co-localize in lipid rafts of renal

proximal tubule cells

Secondary accessions: O00641 O00642 Q13293 Q13294 Q13295 Q14453 Q14725 Q15313 Q15314 Q15315 Q15316

Q17RH6 Q53EQ8

Alternative splicing: 4 isoforms: P32298-1 P32298-2 P32298-3 P32298-4

Explore the universe of human proteins at neXtProt for GRK4: NX_P32298

Post-translational modifications:

Palmitoylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001004056.1 NP_001004057.1 NP_892027.2

ENSEMBL proteins:

ENSP00000421650 ENSP00000396463 ENSP00000381125 ENSP00000427445 ENSP00000381128 ENSP00000392297

ENSP00000381129 ENSP00000264764

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: GRK4
	GenScript Custom Purified and Recombinant Proteins Services for GRK4
	Novus Biologicals Protein for GRK4
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	IEA	--
GO:0005938	cell cortex	IEA	--
GO:0030425	dendrite	IEA	--
GO:0043025	neuronal cell body	IEA	--

About this table

GRK4 for ontologies About GeneDecksing

Antibodies for GRK4:

	Millipore Mono- and Polyclonal Antibodies for the study of GRK4
	Sigma-Aldrich Antibodies for GRK4
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for GRK4
	Novus Biologicals Antibodies for GRK4
	Browse antibodies at Epitomics

Assays for GRK4:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GRK4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for GRK4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GRK4 for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR017441 Protein_kinase_ATP_BS

IPR000239 GPCR_kinase

IPR002290 Ser/Thr_prot_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_prot_kinase_AS

Graphical View of Domain Structure for InterPro Entry P32298

ProtoNet protein and cluster: P32298

3 Blocks protein families:

IPB000239 GPCR kinase signature

IPB000342 Regulator of G-protein signalling (RGS) protein signature

IPB000961 Protein kinase C-terminal domain

UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298

Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily

Similarity: Contains 1 AGC-kinase C-terminal domain

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 RGS domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298

Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate

rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do

not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2

Catalytic activity: ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate

Enzyme regulation: Inhibited by heparine

Enzyme Number (IUBMB): EC 2.7.11.16

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Sigma-Aldrich Nano Scale siRNA for GRK4 Sigma-Aldrich siRNA Panels and esiRNA and siRNA for GRK4 Sigma-Aldrich shRNA Panels and shRNA for GRK4
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): GRK4 OriGene shRNA RFP (see all 4): GRK4 OriGene basic RS shRNA (see all 4): GRK4 OriGene siRNA (see all 4): GRK4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GRK4

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GRK4
		Search SABiosciences for Assays for microRNAs that regulate GRK4

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): GRK4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): GRK4 OriGene untagged cDNA clones in CMV expression vector (see all 4): GRK4 OriGene 3'-UTR clone (see all 3): GRK4 Browse MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): GRK4
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for GRK4

5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004672	protein kinase activity	--	--
GO:0004674	protein serine/threonine kinase activity	--	--
GO:0004703	G-protein coupled receptor kinase activity	IEA	--
GO:0004871	signal transducer activity	IEA	--

About this table

GRK4 for ontologies About GeneDecksing

Animal Models: 1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Grk4):

normal

GRK4 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

GRK4 for pathways About GeneDecksing

4 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for GRK4

	G-Protein Coupled Receptor Signaling
	Inositol Phosphate Metabolism
	Nicotinate and Nicotinamide Metabolism
	cAMP-mediated Signaling

2 Kegg Pathways (Kegg details for GRK4):

	hsa04062 Chemokine signaling pathway
	hsa04144 Endocytosis

SABiosciences Custom Pathway-Focused PCR Arrays for GRK4

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GRK4

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GRK4

4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway	--	--
GO:0002031	G-protein coupled receptor internalization	IEA	--
GO:0006468	protein phosphorylation	IEA	--
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	TAS	1338872

About this table

GRK4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

GRK4 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GRK4
6 Novoseek chemical compound relationships for GRK4 gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sodium	56.4	13	16439609 (2), 15133310 (1), 16636192 (1), 16441255 (1) (see all 8)
dopamine	50.8	9	16439609 (1), 16461192 (1), 16441255 (1), 19520868 (1)
baclofen	32	2	17013811 (1)
serine	21.6	1	15521360 (1)
glutamate	10.1	6	12519791 (2), 11099476 (2), 11431139 (1)
cysteine	0	1	9341194 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Sigma-Aldrich Nano Scale siRNA for GRK4 Sigma-Aldrich siRNA Panels and esiRNA and siRNA for GRK4 Sigma-Aldrich shRNA Panels and shRNA for GRK4
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): GRK4 OriGene shRNA RFP (see all 4): GRK4 OriGene basic RS shRNA (see all 4): GRK4 OriGene siRNA (see all 4): GRK4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GRK4

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GRK4
		Search SABiosciences for Assays for microRNAs that regulate GRK4

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): GRK4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): GRK4 OriGene untagged cDNA clones in CMV expression vector (see all 4): GRK4 OriGene 3'-UTR Clone (see all 3): GRK4 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): GRK4

Primers:		OriGene genome-wide validated SYBR primer pairs: GRK4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for GRK4: PPH02621A

REFSEQ mRNAs for GRK4 gene (3 alternative transcripts):

NM_001004056.1 NM_001004057.1 NM_182982.2

Additional cDNA sequence:

AK055721.1 AK223581.1 AK292390.1 AK293569.1 BC027597.1 BC039732.1 BC063678.1 BC117320.1

U33054.1 U33055.1 U33056.1 X75897.1 X97879.1 X97880.1 X97881.1 X98118.1

10 DOTS entries:

DT.101981328 DT.40220101 DT.413731 DT.86853791 DT.101979674 DT.413730 DT.40111448 DT.413729

DT.75172625 DT.97821341

24/56 AceView cDNA sequences (see all 56):

CK725053 X97881 BX279959 W23870 BM928228 X97880 BC063678 NM_001004056

X75897 BE502168 AI243951 NM_182982 AA412224 BM725978 NM_001004057 BC039732

AW269179 CD672889 U33055 AA938959 AI150462 BU626334 U33054 AI217808

highest scoring ESTs for GRK4:

U33055 AW173257 BC027597 N23898 U33054 U33056 X97879 X97880 X97881 X98118

Unigene Cluster for GRK4:

G protein-coupled receptor kinase 4

Hs.32959 [show with all ESTs]

Unigene Representative Sequence: AK292390

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for GRK4 (see all 8)

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18a	·	18b
SP1:															-						-																						-
SP2:									-		-				-						-																						-
SP3:															-						-																				-		-
SP4:									-		-				-						-																				-		-
SP5:									-		-		-		-						-

About this scheme

ECgene alternative splicing isoforms for GRK4
14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000503518(uc003ggm.2) ENST00000446963 ENST00000398047 ENST00000504933

ENST00000398051(uc003ggq.1) ENST00000507230 ENST00000511827 ENST00000442472

ENST00000398052(uc003ggn.1 uc003ggo.1 uc003ggp.1) ENST00000505271

ENST00000504308 ENST00000509545 ENST00000505183 ENST00000345167

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

GRK4 expression in normal and diseased human tissues

¹ / ² / ³

10 probe-sets matching GRK4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39662_s_at²^{, 3}	U95-A	1	1.00	1.00	0.55	1.10	U33055	1.00	1.00	1.00	1
79543_at*²^{, 3}	U95-D	1	0.88	1.00	0.56	0.61	AA399241	0.40	1.00	0.76	1
42632_f_at*²	U95-B	1	--	--	0.42	1.35	--	--	--	--	--
210600_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U33054	0.80	1.00	0.91	1
208365_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005307	0.40	1.00	0.76	1
241989_at*²^{, 3}	U133-B	1	0.91	1.00	--	--	AW269179	0.40	1.00	0.76	1
210600_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208365_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
241989_at*²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--
1560543_at*²	U133Plus2	1	0.36	1.00	--	--	--	--	--	--	--

About this table

GRK4 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

GRK4 gene electronic northern expression

About these images

CGAP SAGE TAG: CCTTGGGAGT

SOURCE GeneReport for Unigene cluster: Hs.32959

Expression variation in blood from EXPOLDB for GRK4

UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298

Tissue specificity: Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in

myometrium

Primers:		OriGene genome-wide validated SYBR primer pairs: GRK4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for GRK4: PPH02621A

SABiosciences Custom PCR Arrays for GRK4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GRK4 gene from 5/8 species (see all 8)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GRK4¹	--	G protein-coupled receptor kinase 4	83.45(n) 79.32(a)	479075 XM_536222.2 XP_536222.2
chimpanzee (Pan troglodytes)	GRK4¹	--	G protein-coupled receptor kinase 4	99.37(n) 99.13(a)	461082 XM_001152424.1 XP_001152424.1
cow (Bos taurus)	GRK4¹	--	G protein-coupled receptor kinase 4	77.35(n) 77.96(a)	512489 XM_590012.3 XP_590012.3
rat (Rattus norvegicus)	Grk4¹	--	G protein-coupled receptor kinase 4	81.07(n) 75.96(a)	59077 NM_022928.1 NP_075217.1
mouse (Mus musculus)	Grk4^{1 , 5}	5 (17.91 cM)⁵	G protein-coupled receptor kinase 4^{1, 5}	80.94(n)¹ 75.7(a)¹	14772¹ NM_019497.2¹ NP_062370.2¹ AA110341⁵ AF040745⁵ (see all 10)

About this table Species with no ortholog for GRK4

ENSEMBL Gene Tree for GRK4 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GRK4 gene

GRK7² ADRBK2² GRK1² GRK5² ADRBK1² GRK6²

GRK4 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs729826^1,2	C,A,H,	3016790(-)	`GGTGGT/GATTTG`	3	--	int¹		12		NA EA WA	474
rs732859^1,2	C,O,A,H,	3033643(-)	`GCCACG/TGCCAG`	3	--	int¹		13		EA NA WA	1872
rs1008210^1,2	C,F,O,A,H,	3038112(-)	`TTCATC/ACCCTC`	3	--	int¹		19		MN NS EA NA WA	2454
rs1010290^1,2	C,F,A,H,	3033182(-)	`CCTGCG/ACCGTC`	3	--	int¹		11		MN NS EA NA WA	574
rs1024322^1,2	C,A,	3006515(-)	`ccaacC/Tcctcc`	3	--	int¹ trp³		1		NA	2
rs1024323^1,2	C,F,A,	3006043(-)	`CAAAGG/ACTTTT`	6	/A /V	ref¹ mis¹		21		MN NS EA NA WA	1466
rs1056094^1,2	C,F,O,A,H,	2967598(+)	`TCCCTG/CACTGT`	3	--	int¹		20		MN NA NS EA WA	1322
rs1129292^1,2	--	3042300(+)	`TGAGGA/GCTGCC`	6	D G	mis¹ ref¹		0	--	--	--	--
rs1140085^1,2	C,F,	3015553(+)	`GATTCG/ATAGTA`	6	/I /V	mis¹ ref¹		5		NS EA NA	492
rs1263310^1,2	C,H,	3023178(-)	`ATAGGG/AAGAAA`	3	--	int¹		12		MN NS EA NA WA	576

About this table

HapMap Linkage Disequilibrium images for GRK4 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GRK4: --

Search QIAGEN SeqTarget long-range PCR primers for resequencing for GRK4

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GRK4 for disorders About GeneDecksing

OMIM: 137026

2 Novoseek disease relationships for GRK4 gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
genetic hypertension	79.4	2	16636192 (2)
essential hypertension	61.6	17	17044852 (2), 15097232 (1), 11904438 (1), 16339846 (1) (see all 9)

About this table

Human Gene Mutation Database (HGMD): GRK4
Genetic Association Database (GAD): GRK4
Human Genome Epidemiology (HuGE) Navigator: GRK4 (16 documents)

Export disorders and mutations for GRK4 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/79 PubMed articles for GRK4 gene, integrated from 7 sources (see all 79):
(articles sorted by number of sources associating them with GRK4)

A novel G protein-coupled receptor kinase gene cloned from 4p16.3. (PubMed id 1338872)^{1, 2, 3} Ambrose C.... McDonald M.E. (1992)
G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor. (PubMed id 19520868)^{1, 2, 7} Villar V.A.M....Jose P.A. (2009)
Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. (PubMed id 8626439)^{1, 2, 7} Premont R.T.... Lefkowitz R.J. (1996)
G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells. (PubMed id 9092566)^{1, 2, 7} Sallese M.... de Blasi A. (1997)
Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning. (PubMed id 8135832)^{1, 2, 7} Sallese M.... de Blasi A. (1994)
Genotyping of essential hypertension single-nucleotide polymorphisms by a homogeneous PCR method with universal energy transfer primers. (PubMed id 12446468)^{1, 4, 7} Bengra C....Felder R.A. (2002)
Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension. (PubMed id 15097232)^{1, 4, 7} Speirs H.J....Morris B.J. (2004)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression. (PubMed id 16636192)^{2, 7} Sanada H....Jose P.A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2868	HGNC: 4543	AceView: GRK4	Ensembl:ENSG00000125388	euGenes: HUgn2868
ECgene: GRK4	Kegg: 2868	H-InvDB: GRK4

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property for GRK4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for GRK4 gene:
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