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GRK4 Gene

protein-coding   GIFtS: 58

GC04P003002
G protein-coupled receptor kinase 4
(Previous name: G protein-coupled receptor kinase 2-like (Drosophila) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GPRK2L)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
G protein-coupled receptor kinase 41 2     G protein-coupled receptor kinase 2-like2
GPRK41 2 3 5     GRK4a2
GPRK2L2 3 5     IT112
G protein-coupled receptor kinase GRK42 3     OTTHUMP000002169932
ITI12 3     G-protein coupled receptor kinase 42
G protein-coupled receptor kinase 2-like (Drosophila)1     EC 2.7.11.163

External Ids:    HGNC: 45431   Entrez Gene: 28682   Ensembl: ENSG000001253887   UniProtKB: P322983   

Export aliases for GRK4 gene to outside databases

Previous GC identifers: GC04P002997 GC04P002996


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRK4:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of
the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus
initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. (provided by RefSeq)

UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298
Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate
rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do
not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2

Gene Wiki entry for GRK4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRK4 gene promoter:
         RP58   Nkx2-2   MEF-2A   POU2F1   CUTL1   FAC1   CHOP-10   C/EBPalpha   Pax-5   Nkx3-1 v3   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for GRK4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

GRK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRK4 gene location

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P003002:  view genomic region     (about GC identifiers)

Start:
2,903,673 bp from pter
End:
3,042,474 bp from pter
Size:
138,802 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000004.11  NT_006051.18  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298 (See protein sequence)
Recommended Name: G protein-coupled receptor kinase 4  
Size: 578 amino acids; 66583 Da
Subunit: Interacts with DRD3
Subcellular location: Cytoplasm. Cytoplasm, cell cortex. Note=Both at the cell surface and dispersed in the cytoplasm
under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where
co-localization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 co-localize in lipid rafts of renal
proximal tubule cells
Secondary accessions: O00641 O00642 Q13293 Q13294 Q13295 Q14453 Q14725 Q15313 Q15314 Q15315 Q15316
Q17RH6 Q53EQ8
Alternative splicing: 4 isoforms:  P32298-1   P32298-2   P32298-3   P32298-4   

Explore the universe of human proteins at neXtProt for GRK4: NX_P32298 

Post-translational modifications:

  • Palmitoylated1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_001004056.1  NP_001004057.1  NP_892027.2  


    ENSEMBL proteins: 
    ENSP00000421650 ENSP00000396463 ENSP00000381125 ENSP00000427445 ENSP00000381128 ENSP00000392297 
    ENSP00000381129 ENSP00000264764 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: GRK4
    GenScript Custom Purified and Recombinant Proteins Services for GRK4 
    Novus Biologicals Protein for GRK4
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0005829 cytosol IEA--
    GO:0005938 cell cortex IEA--
    GO:0030425 dendrite IEA--
    GO:0043025 neuronal cell body IEA--
    About this table

    GRK4 for ontologies           About GeneDecksing



    Antibodies for GRK4: 
    Millipore Mono- and Polyclonal Antibodies for the study of GRK4
    Sigma-Aldrich Antibodies for GRK4
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for GRK4 
    Novus Biologicals Antibodies for GRK4
    Browse antibodies at Epitomics

    Assays for GRK4: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GRK4 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for GRK4 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GRK4 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR017441 Protein_kinase_ATP_BS
     IPR000239 GPCR_kinase
     IPR002290 Ser/Thr_prot_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_prot_kinase_AS

    Graphical View of Domain Structure for InterPro Entry P32298

    ProtoNet protein and cluster: P32298

    3 Blocks protein families:
    IPB000239 GPCR kinase signature
    IPB000342 Regulator of G-protein signalling (RGS) protein signature
    IPB000961 Protein kinase C-terminal domain


    UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 RGS domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298
    Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate
    rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do
    not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2
    Catalytic activity: ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate
    Enzyme regulation: Inhibited by heparine
    Enzyme Number (IUBMB): EC 2.7.11.16 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for GRK4
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for GRK4
    Sigma-Aldrich shRNA Panels and shRNA for GRK4
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): GRK4
    OriGene shRNA RFP (see all 4): GRK4
    OriGene basic RS shRNA (see all 4): GRK4
    OriGene siRNA (see all 4): GRK4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GRK4 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GRK4 
    Search SABiosciences for Assays for microRNAs that regulate GRK4

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): GRK4
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): GRK4
    OriGene untagged cDNA clones in CMV expression vector (see all 4): GRK4
    OriGene 3'-UTR clone (see all 3): GRK4 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): GRK4 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for GRK4 

    5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004672 protein kinase activity ----
    GO:0004674 protein serine/threonine kinase activity ----
    GO:0004703 G-protein coupled receptor kinase activity IEA--
    GO:0004871 signal transducer activity IEA--
    About this table

    GRK4 for ontologies           About GeneDecksing

    Animal Models: 1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Grk4):

    normal

    GRK4 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    GRK4 for pathways           About GeneDecksing

    4 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  GRK4
        G-Protein Coupled Receptor Signaling
    Inositol Phosphate Metabolism
    Nicotinate and Nicotinamide Metabolism
    cAMP-mediated Signaling

    2 Kegg Pathways  (Kegg details for GRK4):
        hsa04062 Chemokine signaling pathway
    hsa04144 Endocytosis

        SABiosciences Custom Pathway-Focused PCR Arrays for GRK4 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GRK4
        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GRK4

    4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway ----
    GO:0002031 G-protein coupled receptor internalization IEA--
    GO:0006468 protein phosphorylation IEA--
    GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS1338872
    About this table

    GRK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    GRK4 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GRK4
    6 Novoseek chemical compound relationships for GRK4 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sodium 56.4 13 16439609 (2), 15133310 (1), 16636192 (1), 16441255 (1) (see all 8)
    dopamine 50.8 9 16439609 (1), 16461192 (1), 16441255 (1), 19520868 (1)
    baclofen 32 2 17013811 (1)
    serine 21.6 1 15521360 (1)
    glutamate 10.1 6 12519791 (2), 11099476 (2), 11431139 (1)
    cysteine 0 1 9341194 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for GRK4
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for GRK4
    Sigma-Aldrich shRNA Panels and shRNA for GRK4
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): GRK4
    OriGene shRNA RFP (see all 4): GRK4
    OriGene basic RS shRNA (see all 4): GRK4
    OriGene siRNA (see all 4): GRK4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GRK4 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GRK4 
    Search SABiosciences for Assays for microRNAs that regulate GRK4
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): GRK4
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): GRK4
    OriGene untagged cDNA clones in CMV expression vector (see all 4): GRK4
    OriGene 3'-UTR Clone (see all 3): GRK4 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): GRK4 
    Primers: OriGene genome-wide validated SYBR primer pairs: GRK4
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for GRK4: PPH02621A

    REFSEQ mRNAs for GRK4 gene (3 alternative transcripts): 

    NM_001004056.1  NM_001004057.1  NM_182982.2  

    Additional cDNA sequence: 

    AK055721.1 AK223581.1 AK292390.1 AK293569.1 BC027597.1 BC039732.1 BC063678.1 BC117320.1 
    U33054.1 U33055.1 U33056.1 X75897.1 X97879.1 X97880.1 X97881.1 X98118.1 

    10 DOTS entries:

    DT.101981328  DT.40220101  DT.413731  DT.86853791  DT.101979674  DT.413730  DT.40111448  DT.413729 
    DT.75172625  DT.97821341 

    24/56 AceView cDNA sequences (see all 56):

    CK725053 X97881 BX279959 W23870 BM928228 X97880 BC063678 NM_001004056 
    X75897 BE502168 AI243951 NM_182982 AA412224 BM725978 NM_001004057 BC039732 
    AW269179 CD672889 U33055 AA938959 AI150462 BU626334 U33054 AI217808 

    highest scoring ESTs for GRK4:

    U33055 AW173257 BC027597 N23898 U33054 U33056 X97879 X97880 X97881 X98118 

    Unigene Cluster for GRK4:

    G protein-coupled receptor kinase 4
    Hs.32959  [show with all ESTs]
    Unigene Representative Sequence: AK292390


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for GRK4 (see all 8)

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:                                            -                 -                                                                 -               
    SP2:                          -     -           -                 -                                                                 -               
    SP3:                                            -                 -                                                           -     -               
    SP4:                          -     -           -                 -                                                           -     -               
    SP5:                          -     -     -     -                 -                                                                                 

    About this scheme

    ECgene alternative splicing isoforms for GRK4
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503518(uc003ggm.2) ENST00000446963 ENST00000398047 ENST00000504933
    ENST00000398051(uc003ggq.1) ENST00000507230 ENST00000511827 ENST00000442472
    ENST00000398052(uc003ggn.1 uc003ggo.1 uc003ggp.1) ENST00000505271
    ENST00000504308 ENST00000509545 ENST00000505183 ENST00000345167

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    GRK4 expression in normal and diseased human tissues

    1  / 2  / 3

    10 probe-sets matching GRK4 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    39662_s_at2, 3 U95-A 1 1.00 1.00 0.55 1.10 U33055 1.00 1.00 1.00 1
    79543_at*2, 3 U95-D 1 0.88 1.00 0.56 0.61 AA399241 0.40 1.00 0.76 1
    42632_f_at*2 U95-B 1 -- -- 0.42 1.35 -- -- -- -- --
    210600_s_at2, 3 U133-A 1 1.00 1.00 -- -- U33054 0.80 1.00 0.91 1
    208365_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005307 0.40 1.00 0.76 1
    241989_at*2, 3 U133-B 1 0.91 1.00 -- -- AW269179 0.40 1.00 0.76 1
    210600_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    208365_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    241989_at*2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    1560543_at*2 U133Plus2 1 0.36 1.00 -- -- -- -- -- -- --
    About this table

    GRK4 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    GRK4 gene expression
    GRK4 gene electronic northern expression
    GRK4 gene sage expression
    About these images

    CGAP SAGE TAG: CCTTGGGAGT

    SOURCE GeneReport for Unigene cluster: Hs.32959

    Expression variation in blood from EXPOLDB for GRK4

    UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298
    Tissue specificity: Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in
    myometrium

    Primers: OriGene genome-wide validated SYBR primer pairs: GRK4
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for GRK4: PPH02621A
        SABiosciences Custom PCR Arrays for GRK4 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for GRK4 gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    GRK41   -- G protein-coupled receptor kinase 4 83.45(n)
    79.32(a)
    479075  XM_536222.2  XP_536222.2 
    chimpanzee
    (Pan troglodytes)
    GRK41   -- G protein-coupled receptor kinase 4 99.37(n)
    99.13(a)
    461082  XM_001152424.1  XP_001152424.1 
    cow
    (Bos taurus)
    GRK41   -- G protein-coupled receptor kinase 4 77.35(n)
    77.96(a)
    512489  XM_590012.3  XP_590012.3 
    rat
    (Rattus norvegicus)
    Grk41   -- G protein-coupled receptor kinase 4 81.07(n)
    75.96(a)
    59077  NM_022928.1  NP_075217.1 
    mouse
    (Mus musculus)
    Grk41 , 5 5 (17.91 cM)5
    G protein-coupled receptor kinase 41, 5 80.94(n)1
    75.7(a)1
    147721  NM_019497.21  NP_062370.21 
     AA1103415  AF0407455  (see all 10)
    About this table        Species with no ortholog for GRK4

    ENSEMBL Gene Tree for GRK4 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for GRK4 gene
    GRK72  ADRBK22  GRK12  GRK52  ADRBK12  GRK62  

    GRK4 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/888 NCBI SNPs in GRK4 are shown (see all 888)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 4 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs7298261,2
    C,A,H,3016790(-) GGTGGT/GATTTG 3 -- int112Minor allele frequency- G:0.46NA EA WA 474
    rs7328591,2
    C,O,A,H,3033643(-) GCCACG/TGCCAG 3 -- int113Minor allele frequency- T:0.47EA NA WA 1872
    rs10082101,2
    C,F,O,A,H,3038112(-) TTCATC/ACCCTC 3 -- int119Minor allele frequency- A:0.42MN NS EA NA WA 2454
    rs10102901,2
    C,F,A,H,3033182(-) CCTGCG/ACCGTC 3 -- int111Minor allele frequency- A:0.27MN NS EA NA WA 574
    rs10243221,2
    C,A,3006515(-) ccaacC/Tcctcc 3 -- int1 trp31Minor allele frequency- T:0.00NA 2
    rs10243231,2
    C,F,A,3006043(-) CAAAGG/ACTTTT 6 /A /V ref1 mis121Minor allele frequency- A:0.40MN NS EA NA WA 1466
    rs10560941,2
    C,F,O,A,H,2967598(+) TCCCTG/CACTGT 3 -- int120Minor allele frequency- C:0.30MN NA NS EA WA 1322
    rs11292921,2
    --3042300(+) TGAGGA/GCTGCC 6 D G mis1 ref10--------
    rs11400851,2
    C,F,3015553(+) GATTCG/ATAGTA 6 /I /V mis1 ref15Minor allele frequency- A:0.07NS EA NA 492
    rs12633101,2
    C,H,3023178(-) ATAGGG/AAGAAA 3 -- int112Minor allele frequency- A:0.00MN NS EA NA WA 576
    About this table

    HapMap Linkage Disequilibrium images for GRK4 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GRK4: --

    Search QIAGEN SeqTarget long-range PCR primers for resequencing for GRK4 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GRK4 for disorders           About GeneDecksing

    OMIM: 137026

    2 Novoseek disease relationships for GRK4 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    genetic hypertension 79.4 2 16636192 (2)
    essential hypertension 61.6 17 17044852 (2), 15097232 (1), 11904438 (1), 16339846 (1) (see all 9)
    About this table

    Human Gene Mutation Database (HGMD): GRK4
    Genetic Association Database (GAD): GRK4
    Human Genome Epidemiology (HuGE) Navigator: GRK4 (16 documents)

    Export disorders and mutations for GRK4 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/79 PubMed articles for GRK4 gene, integrated from 7 sources (see all 79):
    (articles sorted by number of sources associating them with GRK4)
    1. A novel G protein-coupled receptor kinase gene cloned from 4p16.3. (PubMed id 1338872)1, 2, 3 Ambrose C.... McDonald M.E. (1992)
    2. G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor. (PubMed id 19520868)1, 2, 7 Villar V.A.M....Jose P.A. (2009)
    3. Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. (PubMed id 8626439)1, 2, 7 Premont R.T.... Lefkowitz R.J. (1996)
    4. G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells. (PubMed id 9092566)1, 2, 7 Sallese M.... de Blasi A. (1997)
    5. Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning. (PubMed id 8135832)1, 2, 7 Sallese M.... de Blasi A. (1994)
    6. Genotyping of essential hypertension single-nucleotide polymorphisms by a homogeneous PCR method with universal energy transfer primers. (PubMed id 12446468)1, 4, 7 Bengra C....Felder R.A. (2002)
    7. Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension. (PubMed id 15097232)1, 4, 7 Speirs H.J....Morris B.J. (2004)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression. (PubMed id 16636192)2, 7 Sanada H....Jose P.A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2868 HGNC: 4543 AceView: GRK4 Ensembl:ENSG00000125388 euGenes: HUgn2868
    ECgene: GRK4 Kegg: 2868 H-InvDB: GRK4

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for GRK4 gene:
    Search GeneIP for patents involving GRK4

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