Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



GRM1 Gene

protein-coding   GIFtS: 64

GC06P143912
glutamate receptor, metabotropic 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
glutamate receptor, metabotropic 11 2     MGLUR1A2
MGLUR11 2 3 5     OTTHUMP000000173662
GPRC1A1 2 3     metabotropic glutamate receptor 12
mGlu11 2     OTTHUMP000002221762
GRM1A2 5     OTTHUMP000000173652
OTTHUMP000002221752     mGluR13

External Ids:    HGNC: 45931   Entrez Gene: 29112   Ensembl: ENSG000001528227   UniProtKB: Q132553   

Export aliases for GRM1 gene to outside databases

Previous GC identifers: GC06P145973 GC06P146196 GC06P146330 GC06P146390


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRM1:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and
metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function
and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G
protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal
transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been
shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8.
Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist
selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked
homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system.
Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have
distinct functions. (provided by RefSeq)

UniProtKB/Swiss-Prot: GRM1_HUMAN, Q13255
Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a
phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS,
such as long-term potentiation in the hippocampus and long-term depression in the cerebellum

summary for GRM1:
Metabotropic glutamate (mGlu) group I receptors are members of the metabotropic class of glutamate
receptors, which also includes mGlu group II and mGlu group III receptors. mGlu group I receptors are
divided into two subtypes, mGlu1 and mGlu5. The receptors are coupled to Gq/11 which activates phospholipase
C and they are also associated with Na+ and K+ channels. Their action is generally excitatory, increasing
conductance, causing more glutamate to be released from the presynaptic cell. They can also increase
inhibitory postsynaptic potentials (IPSPs), inhibit glutamate release and can modulate voltage-dependent
calcium channels. Group I mGluRs, unlike other groups, are activated by 3,5-dihydroxyphenylglycine (DHPG),
allowing their function to be isolated. The human genes for mGlu1 and mGlu5 receptors have been localized to
chromosomes 6 (6q24) and 11 (11q14.3) respectively.

Gene Wiki entry for GRM1 (Metabotropic glutamate receptor 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRM1 gene promoter:
         NRSF form 1   NRSF form 2   SREBP-1a   SREBP-1c   SREBP-1b   E47   MEF-2A   RFX1   CREB   FOXL1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for GRM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24   Ensembl cytogenetic band:  6q24.3   HGNC cytogenetic band: 6q24

GRM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRM1 gene location

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P143912:  view genomic region     (about GC identifiers)

Start:
143,912,005 bp from pter
End:
144,322,102 bp from pter
Size:
410,098 bases
Orientation:
plus strand

1 alternative location:
Chr6+ 146,348,782-146,758,734     
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: GRM1_HUMAN, Q13255 (See protein sequence)
Recommended Name: Metabotropic glutamate receptor 1 precursor  
Size: 1194 amino acids; 132357 Da
Subunit: Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1,
RYR2, ITPR1, SHANK1, SHANK3 and GRASP (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein
PDB structures from and Proteopedia :
3KS9 (3D)    
Secondary accessions: B9EG79 Q13256 Q14757 Q14758 Q5VTF7 Q5VTF8 Q9NU10 Q9UGS9 Q9UGT0
Alternative splicing: 2 isoforms:  Q13255-1   Q13255-2   

Explore the universe of human proteins at neXtProt for GRM1: NX_Q13255 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_000829.2  NP_001107801.1  


    ENSEMBL proteins: 
    ENSP00000425599 ENSP00000347437 ENSP00000282753 ENSP00000424095 ENSP00000354896 ENSP00000376119 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: GRM1
    GenScript Custom Purified and Recombinant Proteins Services for GRM1 
    Novus Biologicals Protein for GRM1
    Novus Biologicals Lysate for GRM1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/10 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 10):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005792 microsome IEA--
    GO:0005886 plasma membrane TAS--
    GO:0005887 integral to plasma membrane TAS7476890
    GO:0014069 postsynaptic density IEA--
    About this table

    GRM1 for ontologies           About GeneDecksing



    Antibodies for GRM1: 
    Millipore Mono- and Polyclonal Antibodies for the study of GRM1
    Sigma-Aldrich Antibodies for GRM1
    R&D Systems Antibodies for GRM1 (mGluR1a)
    Cell Signaling Technology (CST) Antibodies for GRM1  (mGluR1)
    OriGene Antibodies: GRM1
    GenScript Custom Superior Antibodies Services for GRM1 
    Novus Biologicals Antibodies for GRM1
    Browse antibodies at Epitomics

    Assays for GRM1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GRM1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for GRM1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GRM1 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR011500 GPCR_3_9-Cys_dom
     IPR000337 GPCR_3
     IPR017979 GPCR_3_CS
     IPR019588 Metabotropic_Glu_rcpt_Homer-bd
     IPR001256 GPCR_3_mtglu_rcpt_1

    Graphical View of Domain Structure for InterPro Entry Q13255

    ProtoNet protein and cluster: Q13255

    4 Blocks protein families:
    IPB000162 Metabotropic glutamate receptor signature
    IPB000337 G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like)
    IPB001256 Metabotropic glutamate receptor 1 signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRM1_HUMAN, Q13255
    Similarity: Belongs to the G-protein coupled receptor 3 family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: GRM1_HUMAN, Q13255
    Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a
    phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS,
    such as long-term potentiation in the hippocampus and long-term depression in the cerebellum

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for GRM1
    Sigma-Aldrich shRNA Panels and shRNA for GRM1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): GRM1
    OriGene shRNA RFP (see all 2): GRM1
    OriGene basic RS shRNA (see all 2): GRM1
    OriGene siRNA (see all 2): GRM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GRM1 
    miRNA:Sigma-Aldrich microRNA Mimics for GRM1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GRM1 
    7 SABiosciences Assays for microRNAs that regulate GRM1:
    hsa-miR-633 hsa-miR-539 hsa-miR-300 hsa-miR-514 hsa-miR-1252 hsa-miR-381 hsa-miR-218

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: GRM1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): GRM1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): GRM1
    OriGene 3'-UTR clone (see all 2): GRM1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for GRM1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for GRM1 

    Genatlas biochemistry entry for GRM1:
    metabotropic glutamate receptor 1,expressed in the brain,G protein coupled receptor superfamily,binding to HOMER
    proteins and linked to inositol phosphate receptors,activating PI turnover and triggering intracellular calcium
    release,

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity IEA--
    GO:0004930 G-protein coupled receptor activity TAS7476890
    GO:0005515 protein binding IEA--
    GO:0008066 glutamate receptor activity TAS7476890
    About this table

    GRM1 for ontologies           About GeneDecksing

    Animal Models: 9 MGI mutant phenotypes (inferred from 11 alleles(MGI details for Grm1):

    adipose tissuebehavior/neurologicalgrowth/sizelife span-post-weaning/agingmuscle
    nervous systemreproductive systemskeletonvision/eye

    GRM1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    GRM1 for pathways           About GeneDecksing

    2 Millipore Pathways for GRM1
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Glutamic acid signaling

    5/7 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  GRM1 (see all 7)
        Synaptic Long Term Potentiation
    Glutamate Receptor Signaling
    Neuropathic Pain Signaling In Dorsal Horn Neurons
    CREB Signaling in Neurons
    G-Protein Coupled Receptor Signaling

    5/6 Kegg Pathways  (Kegg details for GRM1) (see all 6):
        hsa04020 Calcium signaling pathway
    hsa04080 Neuroactive ligand-receptor interaction
    hsa04540 Gap junction
    hsa04720 Long-term potentiation
    hsa04730 Long-term depression

        SABiosciences Pathway-Focused PCR Arrays including GRM1: PAHS-071A PAHS-3009A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GRM1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRM1

    5/24 Interacting proteins for GRM1 (ENSP000002827533 Q132552) via UniProtKB, MINT, and/or STRING (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KPNA1P522942MINT-6803357 MINT-6803320
    KPNA3O005052MINT-6803333
    CAMK2BENSP000002586823STRING: ENSP00000258682
    CAMK2DENSP000003397403STRING: ENSP00000339740
    CAMK2GENSP000003190603STRING: ENSP00000319060
    About this table

    5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186 activation of MAPKK activity IEA--
    GO:0000187 activation of MAPK activity IEA--
    GO:0007186 G-protein coupled receptor protein signaling pathway TAS7476890
    GO:0007268 synaptic transmission IEA--
    GO:0007626 locomotory behavior IEA--
    About this table

    GRM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    GRM1 for compounds           About GeneDecksing

    Sigma-Aldrich Small Molecules for GRM1:
    Small Molecule - Antagonist Small Molecule - Allosteric Modulator Small Molecule - Agonist
    Enzo Life Sciences drugs & compounds for GRM1

    Compounds for GRM1 available from Tocris Bioscience
    CompoundAction CAS number
    YM 298198 hydrochloride Highly potent, selective non-competitive mGlu1 antagonist [748758-45-4]
    CPCCOEtSelective non-competitive mGlu1 receptor antagonist[179067-99-3]
    JNJ 16259685 Extremely potent, mGlu1-selective non-competitive antagonist [409345-29-5]
    LY 367385Selective mGlu1a antagonist[198419-91-9]
    A 841720Selective mGlu1 antagonist[869802-58-4]
    About this table


    10/35 Novoseek chemical compound relationships for GRM1 gene (see all 35)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ly367385 90 13 15140199 (4), 15182196 (2), 11414795 (1), 19474170 (1) (see all 7)
    glutamate 89.1 381 9692717 (7), 15182196 (6), 11961129 (5), 9639261 (4) (see all 99)
    cpccoet 87.5 12 17292864 (2), 10051528 (1), 10835431 (1), 11414795 (1) (see all 8)
    2-methyl-6-(phenylethynyl)pyridine 82.1 2 12815014 (1), 11880516 (1)
    quisqualate 77.5 15 8093260 (3), 15184361 (2), 8103516 (2), 8528465 (1) (see all 8)
    nmda 69.1 49 16699816 (3), 19403613 (3), 16489129 (2), 11487629 (2) (see all 26)
    ganciclovir 64.8 8 18094230 (1), 19474170 (1), 16023154 (1), 11387401 (1) (see all 8)
    chpg 57.3 1 10428410 (1)
    inositol 1,4,5 trisphosphate 56.9 7 11461909 (1), 12586823 (1), 16234485 (1), 10798399 (1) (see all 7)
    gaba 52.3 6 19415487 (2), 10923987 (1), 16982110 (1), 9065826 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for GRM1
    Sigma-Aldrich shRNA Panels and shRNA for GRM1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): GRM1
    OriGene shRNA RFP (see all 2): GRM1
    OriGene basic RS shRNA (see all 2): GRM1
    OriGene siRNA (see all 2): GRM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GRM1 
    miRNA: Sigma-Aldrich microRNA Mimics for GRM1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GRM1 
    7 SABiosciences Assays for microRNAs that regulate GRM1:
    hsa-miR-633 hsa-miR-539 hsa-miR-300 hsa-miR-514 hsa-miR-1252 hsa-miR-381 hsa-miR-218
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: GRM1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): GRM1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): GRM1
    OriGene 3'-UTR Clone (see all 2): GRM1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for GRM1 
    Primers: OriGene genome-wide validated SYBR primer pairs: GRM1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for GRM1: PPH01866A

    REFSEQ mRNAs for GRM1 gene (2 alternative transcripts): 

    NM_000838.3  NM_001114329.1  

    Additional cDNA sequence: 

    AB208837.1 AK308550.1 BC136280.1 BC143777.1 BC143779.1 L76627.1 L76631.1 U31215.1 
    U31216.1 

    2 DOTS entries:

    DT.102836021  DT.87046965 

    19 AceView cDNA sequences:

    L76631 AA322702 AL118996 NM_000838 U31215 U31216 L76627 BV183579 
    BX477925 BX954545 CD609632 AV730666 CD609630 CD609625 CB990979 CD609627 
    CD609622 CD609619 CD609624 

    highest scoring ESTs for GRM1:

    L76627 U31216 AA322702 AL118996 AV730666 BX477925 CB990979 M79013 M79016 CD609619 

    Unigene Cluster for GRM1:

    Glutamate receptor, metabotropic 1
    Hs.32945  [show with all ESTs]
    Unigene Representative Sequence: NM_001114329


    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for GRM1

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                                                        
    SP2:                                                        -               

    About this scheme

    ECgene alternative splicing isoforms for GRM1
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000507005(uc010khu.1) ENST00000507907 ENST00000355289 ENST00000282753
    ENST00000492807(uc003qll.2) ENST00000502405 ENST00000361719 ENST00000392299(uc011edz.1 uc011eea.1 uc010khv.1 uc010khw.1)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    GRM1 expression in normal and diseased human tissues

    1  / 2  / 3

    9 probe-sets matching GRM1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    31468_f_at2, 3 U95-A 1 1.00 1.00 0.60 0.69 W26104 0.40 1.00 0.76 1
    33510_s_at2, 3 U95-A 1 1.00 1.00 -0.10 1.67 U31216 1.00 0.87 0.94 1
    33509_at2, 3 U95-A 1 0.88 1.00 0.87 0.80 L76627 1.00 0.87 0.94 1
    210939_s_at2, 3 U133-A 1 1.00 1.00 -- -- L76631 0.80 0.83 0.82 1
    210940_s_at2, 3 U133-A 1 1.00 1.00 -- -- U31216 1.00 0.87 0.94 1
    207299_s_at2, 3 U133-A 1 0.73 1.00 -- -- NM_000838 0.60 1.00 0.82 1
    210939_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    210940_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    207299_s_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    About this table

    GRM1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    GRM1 gene expression
    GRM1 gene electronic northern expression
    GRM1 gene sage expression
    About these images

    CGAP SAGE TAG: CTTATTTTTT

    SOURCE GeneReport for Unigene cluster: Hs.32945

    Expression variation in blood from EXPOLDB for GRM1

    Primers: OriGene genome-wide validated SYBR primer pairs: GRM1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for GRM1: PPH01866A
        SABiosciences Expression via Pathway-Focused PCR Arrays including GRM1: PAHS-071A PAHS-3009A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for GRM1 gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    GRM11   -- glutamate receptor, metabotropic 1 92.45(n)
    96.13(a)
    484024  XM_845272.1  XP_850365.1 
    chimpanzee
    (Pan troglodytes)
    GRM11   -- glutamate receptor, metabotropic 1 99.61(n)
    99.92(a)
    463049  XM_518785.2  XP_518785.2 
    cow
    (Bos taurus)
    GRM11   -- glutamate receptor, metabotropic 1 90.66(n)
    94.44(a)
    540485  XM_611688.3  XP_611688.3 
    rat
    (Rattus norvegicus)
    Grm11   -- glutamate receptor, metabotropic 1 88.83(n)
    95.13(a)
    24414  NM_017011.1  NP_058707.1 
    mouse
    (Mus musculus)
    Grm11 , 5 10 (3.44 cM)5
    glutamate receptor, metabotropic 11, 5 88.22(n)1
    94.96(a)1
    148161  NM_016976.11  NP_058672.11 
     AF3201265  AI8352465  (see all 11)
    About this table        Species with no ortholog for GRM1

    ENSEMBL Gene Tree for GRM1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for GRM1 gene
    GRM72  GRM42  GRM62  GRM82  GRM52  GRM22  ENSG000002050352  GRM32  

    GRM1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/3261 NCBI SNPs in GRM1 are shown (see all 3261)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs29411,2
    C,F,146755132(+) CAGCCG/ATCATC 1 -- ut31 ese38Minor allele frequency- A:0.05MN EA NS 1048
    rs29421,2
    C,F,A,146755140(+) ATCAAA/GCCCCT 1 -- ut31 ese315Minor allele frequency- G:0.46MN NA NS EA 906
    rs565661,2
    C,F,O,A,H,146669045(+) GTTTAT/CAGCCC 1 -- int132Minor allele frequency- C:0.22NA NS EA WA 3499
    rs619141,2
    C,F,A,H,146676265(-) CATTAA/TTACAG 1 -- int1109Minor allele frequency- N:0.00NS EA PA EU CA WA NA 6974
    rs3628151,2
    C,F,A,H,146753282(+) GTAAGG/ACATAT 1 -- int112Minor allele frequency- A:0.49EA NS NA WA 502
    rs3628161,2
    C,F,A,H,146754029(+) GGCTGG/CTTTTC 1 -- int113Minor allele frequency- C:0.33NS EA NA WA 770
    rs3628171,2
    C,F,O,A,H,146754127(+) GTTTTT/CGTCTC 1 -- int117Minor allele frequency- C:0.44NA NS EA WA 956
    rs3628181,2
    C,F,A,H,146754317(+) GTGAAT/CTGTGA 1 -- int124Minor allele frequency- C:0.48NA NS EA WA 1622
    rs3628191,2
    C,F,A,H,146756569(+) TCCACC/TGCAAC 1 -- ut31 ese313Minor allele frequency- T:0.42EA MN NS NA WA 2264
    rs3628201,2
    C,F,A,146757302(+) GTTTTA/GTACAT 1 -- ut31 ese315Minor allele frequency- G:0.43EA MN NS NA WA 2254
    About this table

    HapMap Linkage Disequilibrium images for GRM1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for GRM1
         2 CNVs: 0092 64679
         1 Indel: 11269

    QIAGEN SeqTarget long-range PCR primers for resequencing GRM1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GRM1 for disorders           About GeneDecksing

    OMIM: 604473

    10/16 Novoseek disease relationships for GRM1 gene (see all 16)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypocalcemia, autosomal dominant 81.3 1 12890593 (1)
    neurodegenerative diseases 31.3 1 10668448 (1)
    cns diseases 30.6 3 16178731 (1)
    epilepsy temporal lobe 20.7 3 17446080 (2), 10744030 (1)
    neurodegeneration 18 2 17265692 (1), 10530809 (1)
    epilepsy 15.7 2 16563443 (2)
    parkinson disease 9.04 1 11786307 (1)
    schizophrenia 4.93 3 15945063 (2), 16699816 (1)
    necrosis 4.04 1 17168764 (1)
    tumors 1.58 2 17168764 (1), 20061814 (1)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: GRM1 (8 documents)

    Export disorders and mutations for GRM1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/304 PubMed articles for GRM1 gene, integrated from 7 sources (see all 304):
    (articles sorted by number of sources associating them with GRM1)
    1. Human metabotropic glutamate receptor 1: mRNA distribution, chromosome localization and functional expression of two splice variants. (PubMed id 9076744)1, 2, 3, 7 Stephan D.... Pruss R.M. (1996)
    2. Cys-140 is critical for metabotropic glutamate receptor-1 dimerization. (PubMed id 10945991)1, 2, 7 Ray K. and Hauschild B.C. (2000)
    3. Expression of a novel splice variant of human mGluR1 in the cerebellum. (PubMed id 9376535)1, 3, 7 Makoff A.J....Emson P. (1997)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter. (PubMed id 7476890)1, 2 Desai M.A.... Schoepp D.D. (1995)
    6. Metabotropic glutamate receptor 1 internalization induced by muscarinic acetylcholine receptor activation: differential dependency of internalization of splice variants on nonvisual arrestins. (PubMed id 11961129)1, 7 Mundell S.J....Kelly E. (2002)
    7. The metabotropic glutamate receptor 1, GRM1: evaluati on as a candidate gene for inherited forms of cerebellar ataxia. (PubMed id 19924463)1, 7 Rossi P.I....Puliti A. (2010)
    8. Phosphorylation-independent regulation of metabotropic glutamate receptor 1 signaling requires g protein-coupled receptor kinase 2 binding to the second intracellular loop. (PubMed id 15870073)1, 7 Dhami G.K....Ferguson S.S. (2005)
    9. Transcriptional activators and repressors for the neuron-specific expression of a metabotropic glutamate receptor. (PubMed id 17430891)1, 7 Crepaldi L....Ferraguti F. (2007)
    10. The human immunodeficiency virus-1 protein transactivator of transcription up-regulates N-methyl-D-aspartate receptor function by acting at metabotropic glutamate receptor 1 receptors coexisting on human and rat brain noradrenergic neurones. (PubMed id 16489129)1, 7 Longordo F....Pittaluga A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2911 HGNC: 4593 AceView: GRM1 Ensembl:ENSG00000152822 euGenes: HUgn2911
    ECgene: GRM1 Kegg: 2911 H-InvDB: GRM1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for GRM1 gene:
    Search GeneIP for patents involving GRM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for GRM1 Antibodies for GRM1
     Super-pooled esiRNAs for GRM1 Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for GRM1 microRNA Mimics for GRM1
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Small molecules for GRM1
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies for GRM1 (mGluR1a)   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GRM1
     SeqTarget long-range PCR primers for resequencing GRM1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GRM1
     GenScript Custom Purified and Recombinant Proteins Services for GRM1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for GRM1
     GenScript Custom Assay Services for GRM1 GenScript Custom Superior Antibodies Services for GRM1
     GenScript Custom overexpressing Cell Line Services for GRM1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for GRM1  (mGluR1)

     Regulatory tfbs in GRM1 promoter
     Search Chromatin IP Primers for GRM1
     RT2 qPCR Primer Assay for GRM1
     GNC Network for GRM1
     Assays for microRNAs that regulate GRM1
     SABiosciences PCR Arrays including GRM1
     Tocris compounds for GRM1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Drugs for GRM1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for GRM1
     Proteins for GRM1
     Lysates for GRM1
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for GRM1
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    GRM1 gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4