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GRM6 Gene

protein-coding   GIFtS: 58

GC05M173132
glutamate receptor, metabotropic 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
glutamate receptor, metabotropic 61 2     CSNB1B2 5
MGLUR61 2 3 5     DKFZp686H19932
GPRC1F1 2 3     metabotropic glutamate receptor 62
mGlu61 2     mGluR63

External Ids:    HGNC: 45981   Entrez Gene: 29162   Ensembl: ENSG000001132627   UniProtKB: O153033   

Export aliases for GRM6 gene to outside databases

Previous GC identifers: GC05M178429 GC05M179301 GC05M178505 GC05M178324 GC05M178392


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRM6:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and
metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function
and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G
protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal
transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been
shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8.
Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist
selectivities. (provided by RefSeq)

UniProtKB/Swiss-Prot: GRM6_HUMAN, O15303
Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate
cyclase activity

summary for GRM6:
Metabotropic Glutamate (mGlu) group III receptors are members of the metabotropic class of glutamate
receptors, which also includes mGlu group I and mGlu group II receptors. Group III receptors are divided
into four subtypes, mGlu4, mGlu6, mGlu7 and mGlu8. The receptors are coupled to Gi/o which inhibits adenylyl
cyclase, decreasing the formation of cAMP. mGlu group III receptors are involved in spatial learning and
memory, and umami taste (mGlu4), stimulation of photoreceptors (mGlu6), long term depression (mGlu7) and
presynaptic inhibition in the perforant pathway (mGlu8). The human genes for mGlu4, mGlu6, mGlu7 and mGlu8
receptors have been localized to chromosomes 6 (6p21.3), 5 (5q35), 3 (3p26-p25) and 7 (7q31.3-q32.1)
respectively.

Gene Wiki entry for GRM6 (Metabotropic glutamate receptor 6)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRM6 gene promoter:
         LCR-F1   deltaCREB   CREB   STAT6   STAT5B   STAT5A   STAT4   STAT3   STAT1   STAT2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for GRM6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GRM6 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35

GRM6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRM6 gene location

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M173132:  view genomic region     (about GC identifiers)

Start:
173,132,574 bp from pter
End:
173,149,375 bp from pter
Size:
16,802 bases
Orientation:
minus strand

1 alternative location:
Chr5- 178,392,096-178,423,207     
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: GRM6_HUMAN, O15303 (See protein sequence)
Recommended Name: Metabotropic glutamate receptor 6 precursor  
Size: 877 amino acids; 95468 Da
Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for GRM6: NX_O15303 

REFSEQ proteins: NP_000834.2  

ENSEMBL proteins: 
ENSP00000430767 ENSP00000325675 ENSP00000231188 ENSP00000399940 


Human Recombinant Proteins 
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
Browse OriGene Protein Over-expression Lysates
GenScript Custom Purified and Recombinant Proteins Services for GRM6 
Novus Biologicals Proteins for GRM6
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular ----
GO:0005886 plasma membrane TAS--
GO:0005887 integral to plasma membrane TAS9215706
GO:0016021 integral to membrane ----
About this table

GRM6 for ontologies           About GeneDecksing



Antibodies for GRM6: 
Millipore Mono- and Polyclonal Antibodies for the study of GRM6
Sigma-Aldrich Antibodies for GRM6
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
GenScript Custom Superior Antibodies Services for GRM6 
Novus Biologicals Antibodies for GRM6
Epitomics antibodies for GRM6

Assays for GRM6: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for GRM6 
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for GRM6 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GRM6 for domains           About GeneDecksing

5/7 InterPro domains/families (see all 7):
 IPR011500 GPCR_3_9-Cys_dom
 IPR000337 GPCR_3
 IPR017979 GPCR_3_CS
 IPR000112 GPCR_3_mtglu_rcpt_6
 IPR017978 GPCR_3_C

Graphical View of Domain Structure for InterPro Entry O15303

ProtoNet protein and cluster: O15303

4 Blocks protein families:
IPB000112 Metabotropic glutamate receptor 6 signature
IPB000162 Metabotropic glutamate receptor signature
IPB000337 G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like)
IPB001828 Extracellular ligand-binding receptor


UniProtKB/Swiss-Prot: GRM6_HUMAN, O15303
Similarity: Belongs to the G-protein coupled receptor 3 family


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: GRM6_HUMAN, O15303
Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate
cyclase activity

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for GRM6
Sigma-Aldrich shRNA Panels and shRNA for GRM6
OriGene 29mer shRNA kits in GFP-retroviral vector: GRM6
OriGene shRNA RFP: GRM6
OriGene basic RS shRNA: GRM6
OriGene siRNA: GRM6
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GRM6 
miRNA:Sigma-Aldrich microRNA Mimics for GRM6
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GRM6 
Search SABiosciences for Assays for microRNAs that regulate GRM6

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Millipore Clones for the Expression of GRM6
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: GRM6
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GRM6
OriGene untagged cDNA clones in CMV expression vector: GRM6
Browse 3'-UTR reporter clones for miRNA target validation 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for GRM6 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for GRM6 

Genatlas biochemistry entry for GRM6:
metabotropic glutamate receptor 6,groupe III,G protein coupled receptor superfamily,restrictidly expressed in retinal
bipolar cells,linked to the inhibition of cAMP cascade

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0001640 adenylate cyclase inhibiting metabotropic glutamate receptor activity ----
GO:0003676 nucleic acid binding ----
GO:0004872 receptor activity IEA--
GO:0004930 G-protein coupled receptor activity TAS9215706
GO:0008066 glutamate receptor activity TAS9215706
About this table

GRM6 for ontologies           About GeneDecksing

Animal Models: 3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Grm6):

behavior/neurologicalnervous systemvision/eye

GRM6 for phenotypes           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


GRM6 for pathways           About GeneDecksing

1 Millipore Pathway for GRM6
    Glutamic acid signaling

5/7 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  GRM6 (see all 7)
    Glutamate Receptor Signaling
Synaptic Long Term Depression
G-Protein Coupled Receptor Signaling
cAMP-mediated Signaling
CREB Signaling in Neurons

1 Kegg Pathway  (Kegg details for GRM6):
    hsa04080 Neuroactive ligand-receptor interaction

    SABiosciences Pathway-Focused PCR Array including GRM6: PAHS-3009A 

    Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GRM6
    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GRM6

5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10):

GO IDQualified GO termEvidencePubMed IDs
GO:0006355 regulation of transcription, DNA-dependent ----
GO:0007186 G-protein coupled receptor protein signaling pathway ----
GO:0007196 inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway ----
GO:0007216 metabotropic glutamate receptor signaling pathway TAS9215706
GO:0007268 synaptic transmission ----
About this table

GRM6 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

GRM6 for compounds           About GeneDecksing

Sigma-Aldrich Small Molecules for GRM6:
Small Molecule - Antagonist Small Molecule - Allosteric Modulator Small Molecule - Agonist
Enzo Life Sciences drugs & compounds for GRM6

Compounds for GRM6 available from Tocris Bioscience
CompoundAction CAS number
HomoAMPA Potent, highly selective mGlu6 agonist --
About this table


4 Novoseek chemical compound relationships for GRM6 gene
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
glutamate 73.9 45 11292414 (4), 17430614 (2), 11179672 (2), 9357538 (2) (see all 23)
kainate 51.1 3 18653656 (1), 10515165 (1)
nmda 38.2 2 10515165 (1)
aspartate 9.78 1 8759641 (1)
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for GRM6
Sigma-Aldrich shRNA Panels and shRNA for GRM6
OriGene 29mer shRNA kits in GFP-retroviral vector: GRM6
OriGene shRNA RFP: GRM6
OriGene basic RS shRNA: GRM6
OriGene siRNA: GRM6
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GRM6 
miRNA: Sigma-Aldrich microRNA Mimics for GRM6
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GRM6 
Search SABiosciences for Assays for microRNAs that regulate GRM6
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: GRM6
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GRM6
OriGene untagged cDNA clones in CMV expression vector: GRM6
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for GRM6 
Primers: OriGene genome-wide validated SYBR primer pairs: GRM6
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for GRM6: PPH02353A

REFSEQ mRNAs for GRM6 gene: 

NM_000843.3  

Additional cDNA sequence: 

AJ245871.1 AJ245872.1 BX647168.1 

1 DOTS entry:

DT.91701632 

8 AceView cDNA sequences:

BM681239 AJ245871 BM665594 BX647168 AJ245872 NM_000843 BM726590 W25882 

highest scoring ESTs for GRM6:

AJ245871 AJ245872 NM_000843 BM665594 BM681239 BM726590 BX647168 BY796285 BY797310 W25882 

Unigene Cluster for GRM6:

Glutamate receptor, metabotropic 6
Hs.248131  [show with all ESTs]
Unigene Representative Sequence: NM_000843


GeneLoc Exon Structure

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000517717 ENST00000519003 ENST00000518082 ENST00000519175 ENST00000319065(uc003mjs.1)
ENST00000231188(uc003mjq.2 uc003mjr.2 uc010jla.1) ENST00000458391


(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

GRM6 expression in normal and diseased human tissues

1  / 2  / 3

2 probe-sets matching GRM6 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
208035_at2, 3 U133-A 1 0.46 1.00 -- -- NM_000843 0.60 1.00 0.82 1
208035_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
About this table
Data from Genenote  (Publications) and GNF BioGPS
    About these images
GRM6 gene expression
GRM6 gene electronic northern expression
GRM6 gene sage expression
About these images

CGAP SAGE TAG: TTTACACAAT

SOURCE GeneReport for Unigene cluster: Hs.248131
Primers: OriGene genome-wide validated SYBR primer pairs: GRM6
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for GRM6: PPH02353A
    SABiosciences Expression via Pathway-Focused PCR Array including GRM6: PAHS-3009A 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GRM6 gene from 5/7 species (see all 7)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
GRM61   -- glutamate receptor, metabotropic 6 90.35(n)
94.75(a)
481452  XM_538573.2  XP_538573.2 
chimpanzee
(Pan troglodytes)
GRM61   -- glutamate receptor, metabotropic 6 98.94(n)
98.97(a)
462323  XM_001149247.1  XP_001149247.1 
cow
(Bos taurus)
GRM61   -- glutamate receptor, metabotropic 6 90.44(n)
96.28(a)
529656  XM_608110.2  XP_608110.2 
rat
(Rattus norvegicus)
Grm61   -- glutamate receptor, metabotropic 6 87.89(n)
94.23(a)
24419  NM_022920.1  NP_075209.1 
mouse
(Mus musculus)
Grm65 11 (30.93 cM) glutamate receptor, metabotropic 6   -- BC152480 
About this table        Species with no ortholog for GRM6

ENSEMBL Gene Tree for GRM6 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for GRM6 gene
GRM72  GRM42  GRM82  GRM22  GRM32  ENSG000002050352  GRM52  GRM12  

GRM6 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/360 NCBI SNPs in GRM6 are shown (see all 360)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 5 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs9039821,2
C,A,H,178422829(-) CTCTTG/CCTTAG 1 -- ng51 trp39Minor allele frequency- C:0.20MN NA EA WA 334
rs9039831,2
C,A,H,178422826(-) TTCCTC/TAGGCC 1 -- ng51 trp39Minor allele frequency- T:0.36MN NA EA WA 334
rs9039841,2
H178418794(-) AAGCAG/CAAAGA 1 -- int15Minor allele frequency- C:0.00NA NS EA 474
rs9039851,2
C,F,A,H,178417288(-) GAGGGC/TGGGAG 1 -- int113Minor allele frequency- T:0.05EA NA NS WA 420
rs9039881,2
C,F,H,178410738(+) GAGTAT/CTGGAG 1 -- int119Minor allele frequency- C:0.01EA NA MN NS WA 1102
rs10768761,2
A178421859(+) CCCGCC/GGCGCG 2 A syn1 ref1 ese30--------
rs10768771,2
A178421835(+) AGGCCG/TCCCGC 2 G syn1 ref1 ese30--------
rs10789781,2
C,A,178422083(+) CACTTC/TGGCTC 1 -- ut51 ese32Minor allele frequency- T:0.50WA NA 4
rs14723881,2
--178409351(+) aggcaA/Gatggg 1 -- int10--------
rs14759491,2
C,F,178410668(-) TGTGGC/TGTGCC 1 -- int16Minor allele frequency- T:0.05NA PA EA WA 392
About this table

HapMap Linkage Disequilibrium images for GRM6 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for GRM6
     2 CNVs: 51651 51652

QIAGEN SeqTarget long-range PCR primers for resequencing GRM6 

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GRM6 for disorders           About GeneDecksing

OMIM: 604096   disorders: 257270  

UniProtKB/Swiss-Prot: GRM6_HUMAN, O15303

  • Defects in GRM6 are the cause of congenital stationary night blindness type 1B (CSNB1B) [MIM:257270]. This
  • disorder consits of a previously unrecognized, autosomal recessive form of congenital night blindness associated with
    a negative electroretinogram waveform. Patients are night blind from an early age, and when maximally dark-adapted,
    they could perceive lights only with an intensity equal to or slightly dimmer than that normally detected by the cone
    system. ERGs in response to single brief flashes of light have clearly detectable a-waves, which are derived from
    photoreceptors, and greatly reduced b-waves, which are derived from the second-order inner retinal neurons. ERGs in
    response to sawtooth flickering light indicate a markedly reduced ON response and a nearly normal OFF response. There
    is no subjective delay in the perception of suddenly appearing white vs black objects on a gray background

    1 Novoseek disease relationship for GRM6 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    night blindness, congenital stationary 93.3 8 16622103 (1), 19666700 (1), 19862333 (1), 17405131 (1)
    About this table

    Human Gene Mutation Database (HGMD): GRM6
    Human Genome Epidemiology (HuGE) Navigator: GRM6 (7 documents)

    Export disorders and mutations for GRM6 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/48 PubMed articles for GRM6 gene, integrated from 7 sources (see all 48):
    (articles sorted by number of sources associating them with GRM6)
    1. The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6. (PubMed id 9215706)1, 2, 3, 7 Hashimoto T....Nakanishi S. (1997)
    2. Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6. (PubMed id 15781871)1, 2, 7 Dryja T.P.... Rajagopalan A.S. (2005)
    3. Night blindness-associated mutations in the ligand-binding, cysteine-rich, and intracellular domains of the metabotropic glutamate receptor 6 abolish protein trafficking. (PubMed id 17405131)1, 7 Zeitz C....Berger W. (2007)
    4. Altered G-protein coupling in an mGluR6 point mutant associated with congenital stationary night blindness. (PubMed id 19666700)1, 7 Beqollari D....Kammermeier P.J. (2009)
    5. Identification of novel alternatively-spliced mRNA isoforms of metabotropic glutamate receptor 6 gene in rat and human retina. (PubMed id 11179672)1, 7 Valerio A.... Barlati S. (2001)
    6. Sequence variations of GRM6 in patients with high myo pia. (PubMed id 19862333)1, 7 Xu X....Zhang Q. (2009)
    7. Mutations in GRM6 cause autosomal recessive congenital stationary night blindness with a distinctive scotopic 15-Hz flicker electroretinogram. (PubMed id 16249515)1, 7 Zeitz C....Berger W. (2005)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. Response to methadone maintenance treatment is associ ated with the MYOCD and GRM6 genes. (PubMed id 20560679)1 Fonseca F....Torrens M. (2010 Jun 1)
    10. Simultaneous Mutation Detection in 90 Retinal Disease Genes in Multiple Patients Using a Custom-designed 300-kb Retinal Resequencing Chip. (PubMed id 20801516)1 Booij J.C....Florijn R.J. (2010 Aug 27)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2916 HGNC: 4598 AceView: GRM6 Ensembl:ENSG00000113262 euGenes: HUgn2916
    ECgene: GRM6 Kegg: 2916 H-InvDB: GRM6

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for GRM6 gene:
    Search GeneIP for patents involving GRM6

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    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for GRM6 Antibodies for GRM6
     Super-pooled esiRNAs for GRM6 Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for GRM6 microRNA Mimics for GRM6
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Small molecules for GRM6
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
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     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GRM6
     SeqTarget long-range PCR primers for resequencing GRM6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GRM6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GRM6
     GenScript Custom Purified and Recombinant Proteins Services for GRM6 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for GRM6
     GenScript Custom Assay Services for GRM6 GenScript Custom Superior Antibodies Services for GRM6
     GenScript Custom overexpressing Cell Line Services for GRM6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GRM6 promoter
     Search Chromatin IP Primers for GRM6
     RT2 qPCR Primer Assay for GRM6
     Search GNC Networks for GRM6
     Search for Assays for microRNAs that regulate GRM6
     SABiosciences PCR Arrays including GRM6
     Tocris compounds for GRM6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Drugs for GRM6
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for GRM6
     Proteins for GRM6
     Antibodies for GRM6
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for GRM6
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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