Aliases &
Descriptions
for GRM6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| glutamate receptor, metabotropic 61 2 | | CSNB1B2 5 | | MGLUR61 2 3 5 | | DKFZp686H19932 | | GPRC1F1 2 3 | | metabotropic glutamate receptor 62 | | mGlu61 2 | | mGluR63 |
Export aliases for GRM6 gene to outside databasesPrevious GC identifers: GC05M178429 GC05M179301 GC05M178505 GC05M178324 GC05M178392 |
Summaries
for GRM6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GRM6:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic andmetabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain functionand can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of Gprotein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signaltransduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have beenshown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8.Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonistselectivities. (provided by RefSeq)
UniProtKB/Swiss-Prot: GRM6_HUMAN, O15303Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylatecyclase activity
 summary
for GRM6: Metabotropic Glutamate (mGlu) group III receptors are members of the metabotropic class of glutamate
receptors, which also includes mGlu group I and mGlu group II receptors. Group III receptors are divided
into four subtypes, mGlu4, mGlu6, mGlu7 and mGlu8. The receptors are coupled to Gi/o which inhibits adenylyl
cyclase, decreasing the formation of cAMP. mGlu group III receptors are involved in spatial learning and
memory, and umami taste (mGlu4), stimulation of photoreceptors (mGlu6), long term depression (mGlu7) and
presynaptic inhibition in the perforant pathway (mGlu8). The human genes for mGlu4, mGlu6, mGlu7 and mGlu8
receptors have been localized to chromosomes 6 (6p21.3), 5 (5q35), 3 (3p26-p25) and 7 (7q31.3-q32.1)
respectively.
Gene Wiki entry for GRM6 (Metabotropic glutamate receptor 6) |
Genomic Views
for GRM6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GRM6 gene promoter:
LCR-F1 deltaCREB CREB STAT6 STAT5B STAT5A STAT4 STAT3 STAT1 STAT2
Other transcription factors
Search SABiosciences Chromatin IP Primers for GRM6
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GRM6  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35GRM6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M173132: view genomic region
(about GC identifiers)
Start:
|
173,132,574 bp from pter |
End:
|
173,149,375 bp from pter |
Size:
|
16,802 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr5- 178,392,096-178,423,207 |
RefSeq DNA sequence:- NC_000005.9 NT_023133.13
|
Proteins
for GRM6 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: GRM6_HUMAN, O15303 (See
protein sequence)Recommended Name: Metabotropic glutamate receptor 6 precursor Size: 877 amino acids; 95468 Da
Subcellular location: Cell membrane; Multi-pass membrane proteinExplore the universe of human proteins at neXtProt for GRM6: NX_O15303
REFSEQ proteins: NP_000834.2
ENSEMBL proteins: ENSP00000430767 ENSP00000325675 ENSP00000231188 ENSP00000399940
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
GRM6 for ontologies About GeneDecksing
Antibodies for GRM6:
Assays for GRM6: |
Protein
Domains/
Families
for GRM6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GRM6 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry O15303ProtoNet protein and cluster: O15303 4 Blocks protein families: IPB000112 Metabotropic glutamate receptor 6 signature IPB000162 Metabotropic glutamate receptor signature IPB000337 G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like) IPB001828 Extracellular ligand-binding receptor
UniProtKB/Swiss-Prot: GRM6_HUMAN, O15303Similarity: Belongs to the G-protein coupled receptor 3 family |
Gene Function
for GRM6 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: GRM6_HUMAN, O15303Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylatecyclase activity
Genatlas biochemistry entry for GRM6:metabotropic glutamate receptor 6,groupe III,G protein coupled receptor superfamily,restrictidly expressed in retinalbipolar cells,linked to the inhibition of cAMP cascade5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
GRM6 for ontologies About GeneDecksing
Animal Models: 3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Grm6):
GRM6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for GRM6 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
GRM6 for pathways About GeneDecksing
1  Millipore Pathway for GRM6
5/7  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for GRM6 (see all 7)
1  Kegg Pathway (Kegg details for GRM6):  | hsa04080 Neuroactive ligand-receptor interaction |
SABiosciences Pathway-Focused PCR Array including GRM6: PAHS-3009A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GRM6
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GRM6
5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0007186 | G-protein coupled receptor protein signaling pathway |
-- | -- | | GO:0007196 | inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway |
-- | -- | | GO:0007216 | metabotropic glutamate receptor signaling pathway |
TAS | 9215706 | | GO:0007268 | synaptic transmission |
-- | -- |
About this table
GRM6 for ontologies About GeneDecksing
|
Drugs & Compounds
for GRM6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
GRM6 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for GRM6 |
Compounds for GRM6 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| HomoAMPA | Potent, highly selective mGlu6 agonist | -- |
About this table
4  Novoseek chemical compound relationships for GRM6 gene
About this table
|
Transcripts
for GRM6 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for GRM6 gene: NM_000843.3 Additional cDNA sequence: AJ245871.1 AJ245872.1 BX647168.1 1 DOTS entry: DT.91701632 8 AceView cDNA sequences: BM681239 AJ245871 BM665594 BX647168 AJ245872 NM_000843 BM726590 W25882
 highest scoring ESTs for GRM6:AJ245871 AJ245872 NM_000843 BM665594 BM681239 BM726590 BX647168 BY796285 BY797310 W25882 Unigene Cluster for GRM6: Glutamate receptor, metabotropic 6 Hs.248131 [show with all ESTs]Unigene Representative Sequence: NM_000843
GeneLoc Exon Structure
7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000517717 ENST00000519003 ENST00000518082 ENST00000519175 ENST00000319065(uc003mjs.1)
ENST00000231188(uc003mjq.2 uc003mjr.2 uc010jla.1) ENST00000458391
|
Expression
for GRM6 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| GRM6 expression in normal and diseased human tissues
1 / 2 / 3 2 probe-sets matching GRM6 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 208035_at2, 3
|
U133-A |
1 |
0.46 |
1.00 |
-- |
-- |
NM_000843 |
0.60 |
1.00 |
0.82 |
1 |
| 208035_at2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTTACACAAT
SOURCE GeneReport for Unigene cluster: Hs.248131
SABiosciences Expression via Pathway-Focused PCR Array including GRM6: PAHS-3009A
|
Orthologs
for GRM6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GRM6 gene from 5/7 species (see all 7)
About this table Species with no ortholog for GRM6
ENSEMBL Gene Tree for GRM6 (if available) |
Paralogs
for GRM6 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for GRM6 gene
- GRM72 GRM42 GRM82 GRM22 GRM32 ENSG000002050352 GRM52 GRM12
GRM6 for paralogs About GeneDecksing
|
Genomic Variants
for GRM6 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 5 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for GRM6 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for GRM6
2 CNVs: 51651 51652 | | QIAGEN SeqTarget long-range PCR primers for resequencing GRM6 |
|
Disorders & Mutations
for GRM6 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GRM6 for disorders About GeneDecksing
OMIM: 604096 disorders: 257270 UniProtKB/Swiss-Prot: GRM6_HUMAN, O15303
Defects in GRM6 are the cause of congenital stationary night blindness type 1B (CSNB1B) [MIM:257270]. Thisdisorder consits of a previously unrecognized, autosomal recessive form of congenital night blindness associated witha negative electroretinogram waveform. Patients are night blind from an early age, and when maximally dark-adapted,they could perceive lights only with an intensity equal to or slightly dimmer than that normally detected by the conesystem. ERGs in response to single brief flashes of light have clearly detectable a-waves, which are derived fromphotoreceptors, and greatly reduced b-waves, which are derived from the second-order inner retinal neurons. ERGs inresponse to sawtooth flickering light indicate a markedly reduced ON response and a nearly normal OFF response. Thereis no subjective delay in the perception of suddenly appearing white vs black objects on a gray background
1 Novoseek disease relationship for GRM6 gene
About this table
Human Gene Mutation Database (HGMD): GRM6
Human Genome Epidemiology (HuGE) Navigator: GRM6 (7 documents)
Export disorders and mutations for GRM6 gene to outside databases
|
Medical News
for GRM6 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for GRM6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/48 PubMed articles for GRM6 gene, integrated from 7 sources (see all 48):
(articles sorted by number of sources associating them with GRM6)- The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6. (PubMed id 9215706)1, 2, 3, 7 Hashimoto T....Nakanishi S. (1997)
- Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6. (PubMed id 15781871)1, 2, 7 Dryja T.P.... Rajagopalan A.S. (2005)
- Night blindness-associated mutations in the ligand-binding, cysteine-rich, and intracellular domains of the metabotropic glutamate receptor 6 abolish protein trafficking. (PubMed id 17405131)1, 7 Zeitz C....Berger W. (2007)
- Altered G-protein coupling in an mGluR6 point mutant associated with congenital stationary night blindness. (PubMed id 19666700)1, 7 Beqollari D....Kammermeier P.J. (2009)
- Identification of novel alternatively-spliced mRNA isoforms of metabotropic glutamate receptor 6 gene in rat and human retina. (PubMed id 11179672)1, 7 Valerio A.... Barlati S. (2001)
- Sequence variations of GRM6 in patients with high myo pia. (PubMed id 19862333)1, 7 Xu X....Zhang Q. (2009)
- Mutations in GRM6 cause autosomal recessive congenital stationary night blindness with a distinctive scotopic 15-Hz flicker electroretinogram. (PubMed id 16249515)1, 7 Zeitz C....Berger W. (2005)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Response to methadone maintenance treatment is associ ated with the MYOCD and GRM6 genes. (PubMed id 20560679)1 Fonseca F....Torrens M. (2010 Jun 1)
- Simultaneous Mutation Detection in 90 Retinal Disease Genes in Multiple Patients Using a Custom-designed 300-kb Retinal Resequencing Chip. (PubMed id 20801516)1 Booij J.C....Florijn R.J. (2010 Aug 27)
|
External Searches for GRM6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GRM6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GRM6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GRM6 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for GRM6 gene:
Search GeneIP for patents involving GRM6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GRM6 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Tocris compounds for GRM6 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for GRM6 |
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