Home
GeneCards Guide
Suite
- GeneALaCart
- GeneDecks
- GeneIP
- GeneNote
- GeneAnnot
- GeneLoc
- GeneTide
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

GTF2E1 Gene

protein-coding GIFtS: 58

GC03P117835

general transcription factor IIE, polypeptide 1, alpha 56kDa
(Previous names: general transcription factor IIE, polypeptide 1 (alpha subunit, 56kD) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
general transcription factor IIE, polypeptide 1, alpha 56kDa¹ ²		TFIIE-alpha² ³
FE¹ ²		TF2E1² ³
TFIIE-A¹ ²		general transcription factor IIE, polypeptide 1 (alpha subunit, 56kD)¹
Transcription initiation factor IIE subunit alpha² ³		general transcription factor IIE subunit 1²
General transcription factor IIE 56 kDa subunit² ³

External Ids:	HGNC: 4650¹	Entrez Gene: 2960²	Ensembl: ENSG00000153767⁷	UniProtKB: P29083³

Export aliases for GTF2E1 gene to outside databases

Previous GC identifers: GC03P117106 GC03P120110 GC03P121742 GC03P121790 GC03P121952 GC03P120461

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: T2EA_HUMAN, P29083

Function: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and

DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GTF2E1 gene promoter:
         C/EBPbeta   E4BP4   AREB6   CREB   deltaCREB   Nkx3-1 v1   Nkx3-1 v2   Nkx3-1   Nkx3-1 v3   Nkx3-1 v4
         Other transcription factors

Search SABiosciences Chromatin IP Primers for GTF2E1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21-q24 Ensembl cytogenetic band: 3q13.33 HGNC cytogenetic band: 3q21-q24

GTF2E1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF2E1 gene location

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P117835: view genomic region (about GC identifiers)

Start:	117,835,641 bp from pter
End:	117,875,998 bp from pter
Size:	40,358 bases
Orientation:	plus strand

1 alternative location:

Chr3+ 120,461,484-120,501,916

RefSeq DNA sequence:

NC_000003.11 NT_005612.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: T2EA_HUMAN, P29083 (See protein sequence)

Recommended Name: General transcription factor IIE subunit 1

Size: 439 amino acids; 49452 Da

Subunit: Tetramer of two alpha and two beta chains. Interacts with TAF6/TAFII80. Interacts with varicella-zoster virus

IE63 protein

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1VD4 (3D)

2JTX (3D)

2RNQ (3D)

2RNR (3D)

Secondary accessions: Q16103

Explore the universe of human proteins at neXtProt for GTF2E1: NX_P29083

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005504.2

ENSEMBL proteins:

ENSP00000417077 ENSP00000283875 ENSP00000418808 ENSP00000417342

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: GTF2E1
	GenScript Custom Purified and Recombinant Proteins Services for GTF2E1
	Novus Biologicals Proteins for GTF2E1
	Novus Biologicals Lysate for GTF2E1
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	TAS	--

About this table

GTF2E1 for ontologies About GeneDecksing

Antibodies for GTF2E1:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for GTF2E1
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for GTF2E1
	Novus Biologicals Antibodies for GTF2E1
	Browse antibodies at Epitomics

Assays for GTF2E1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GTF2E1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for GTF2E1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GTF2E1 for domains About GeneDecksing

5 InterPro domains/families:

IPR013083 Znf_RING/FYVE/PHD

IPR002853 TFIIE_asu

IPR021600 TFIIE_asu_C_met

IPR017919 TFIIE/TFIIEa_HTH

IPR013137 Znf_TFIIB

Graphical View of Domain Structure for InterPro Entry P29083

ProtoNet protein and cluster: P29083

1 Blocks protein family: IPB002853 Transcription factor TFIIE

UniProtKB/Swiss-Prot: T2EA_HUMAN, P29083

Similarity: Belongs to the TFIIE alpha subunit family

Similarity: Contains 1 HTH TFE/IIEalpha-type domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: T2EA_HUMAN, P29083

Function: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and

DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for GTF2E1 Sigma-Aldrich shRNA for GTF2E1
		OriGene 29mer shRNA kits in GFP-retroviral vector: GTF2E1 OriGene shRNA RFP: GTF2E1 OriGene basic RS shRNA: GTF2E1 OriGene siRNA: GTF2E1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GTF2E1

miRNA:		Sigma-Aldrich microRNA Mimics for GTF2E1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GTF2E1
		8 SABiosciences Assays for microRNAs that regulate GTF2E1:
		hsa-miR-200c hsa-miR-124 hsa-miR-300 hsa-miR-429 hsa-miR-381 hsa-miR-506 hsa-miR-222 hsa-miR-221

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: GTF2E1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GTF2E1 OriGene untagged cDNA clones in CMV expression vector: GTF2E1 OriGene 3'-UTR clone: GTF2E1 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for GTF2E1
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for GTF2E1

Genatlas biochemistry entry for GTF2E1:

general transcription factor IIE,alpha polypeptide (56kDa)

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003702	RNA polymerase II transcription factor activity	IEA	--
GO:0005515	protein binding	IPI	7926747
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

GTF2E1 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

GTF2E1 for pathways About GeneDecksing

3 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for GTF2E1

	Glucocorticoid Receptor Signaling
	Androgen Signaling
	Estrogen Receptor Signaling

1 Kegg Pathway (Kegg details for GTF2E1):

hsa03022 Basal transcription factors

SABiosciences Custom Pathway-Focused PCR Arrays for GTF2E1

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GTF2E1

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GTF2E1

5/74 Interacting proteins for GTF2E1 (P29083² ENSP00000283875³) via UniProtKB, MINT, and/or STRING (see all 74)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GTF2H1	P32780², ENSP00000265963³	MINT-6543860 MINT-6544144 MINT-6543809 MINT-6543875 MINT-6544058 MINT-6544043 MINT-6544016 MINT-6543846 MINT-6544109 MINT-6543950 MINT-6543970 MINT-6544074 MINT-6544091 MINT-6543893 MINT-6543913 MINT-6543931 MINT-6543998 MINT-6543827 MINT-6544126 STRING: ENSP00000265963
GTF2E2	P29084², ENSP00000348168³	MINT-1894096 MINT-1894113 STRING: ENSP00000348168
TBP	ENSP00000230354³	STRING: ENSP00000230354
CDK7	ENSP00000256443³	STRING: ENSP00000256443
ERCC2	ENSP00000221481³	STRING: ENSP00000221481

About this table

5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	TAS	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	--
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS	--
GO:0006368	RNA elongation from RNA polymerase II promoter	EXP	9405375
GO:0010467	gene expression	TAS	--

About this table

GTF2E1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GTF2E1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for GTF2E1 Sigma-Aldrich shRNA for GTF2E1
		OriGene 29mer shRNA kits in GFP-retroviral vector: GTF2E1 OriGene shRNA RFP: GTF2E1 OriGene basic RS shRNA: GTF2E1 OriGene siRNA: GTF2E1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GTF2E1

miRNA:		Sigma-Aldrich microRNA Mimics for GTF2E1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GTF2E1
		8 SABiosciences Assays for microRNAs that regulate GTF2E1:
		hsa-miR-200c hsa-miR-124 hsa-miR-300 hsa-miR-429 hsa-miR-381 hsa-miR-506 hsa-miR-222 hsa-miR-221

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: GTF2E1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GTF2E1 OriGene untagged cDNA clones in CMV expression vector: GTF2E1 OriGene 3'-UTR Clone: GTF2E1 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for GTF2E1

Primers:		OriGene genome-wide validated SYBR primer pairs: GTF2E1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for GTF2E1: PPH12554A

REFSEQ mRNAs for GTF2E1 gene:

NM_005513.2

Additional cDNA sequence:

AK223401.1 BC005917.1 S67859.1 X63468.1

4 DOTS entries:

DT.120868996 DT.95261900 DT.95261902 DT.412523

24/39 AceView cDNA sequences (see all 39):

AA424864 BX102240 AA455964 AA243767 AW291752 BP343126 AW148448 AI800655

AL135122 BG571275 BE844117 AI039366 BE786346 AA455437 AI038742 AI167580

BF349423 BU954321 BF591217 AA453363 AA778149 BC005917 NM_005513 X63468

highest scoring ESTs for GTF2E1:

X63468 AA243782 AA309888 AA424864 AA453363 AA455437 AA732517 BE786346 BF573188 BG571275

Unigene Cluster for GTF2E1:

General transcription factor IIE, polypeptide 1, alpha 56kDa

Hs.445272 [show with all ESTs]

Unigene Representative Sequence: NM_005513

GeneLoc Exon Structure

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000492959 ENST00000283875(uc003edz.3) ENST00000497393(uc003edy.2)

ENST00000469772 ENST00000484715

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

GTF2E1 expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching GTF2E1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37882_at²^{, 3}	U95-A	1	0.75	1.00	1.00	1.00	X63468	1.00	1.00	1.00	1
205930_at²^{, 3}	U133-A	1	0.64	1.00	--	--	NM_005513	0.60	1.00	0.82	1
205930_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--

About this table

GTF2E1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

GTF2E1 gene electronic northern expression

About these images

CGAP SAGE TAG: TAAAGAATAT

SOURCE GeneReport for Unigene cluster: Hs.445272

Expression variation in blood from EXPOLDB for GTF2E1

Primers:		OriGene genome-wide validated SYBR primer pairs: GTF2E1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for GTF2E1: PPH12554A

SABiosciences Custom PCR Arrays for GTF2E1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GTF2E1 gene from 5/12 species (see all 12)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GTF2E1¹	--	general transcription factor IIE, polypeptide 1, alpha more	92.85(n) 96.35(a)	488002 XM_851885.1 XP_856978.1
chimpanzee (Pan troglodytes)	GTF2E1¹	--	general transcription factor IIE, polypeptide 1, alpha more	99.24(n) 99.09(a)	460615 XM_516676.2 XP_516676.2
rat (Rattus norvegicus)	Gtf2e1¹	--	general transcription factor IIE, polypeptide 1, alpha	88.43(n) 93.15(a)	303918 XM_221426.3 XP_221426.1
mouse (Mus musculus)	Gtf2e1^{1 , 5}	16 (26.38 cM)⁵	general transcription factor II E, polypeptide 1 (alpha more^{1, 5}	88.69(n)¹ 92.94(a)¹	74197¹ NM_028812.2¹ NP_083088.1¹ AI303800⁵ AI447566⁵ (see all 14)
chicken (Gallus gallus)	GTF2E1¹	--	general transcription factor IIE, polypeptide 1, alpha more	74.87(n) 81.55(a)	418328 XM_416551.2 XP_416551.2

About this table Species with no ortholog for GTF2E1

ENSEMBL Gene Tree for GTF2E1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs225179^1,2	C,H	120481016(-)	`ctcagC/Aaccac`	1	--	int¹		3		NA	6
rs378561^1,2	C,F,O,	120493250(-)	`TTTTCG/AAACTT`	1	--	int¹		14		EA NA NS	878
rs378759^1,2	C,F,O,A,	120485709(-)	`GGACAC/TGGAAA`	1	--	int¹		14		EA NA NS WA	974
rs439596^1,2	H	120491010(-)	`AAATAG/AGACAC`	1	--	int¹		4		NS EA	418
rs447978^1,2	C,F,H,	120491086(+)	`TGGCTA/GCAATT`	1	--	int¹		19		NS EA NA WA	1390
rs537922^1,2	C	120479207(-)	`gacatC/Gattgt`	1	--	int¹		0	--	--	--	--
rs863166^1,2	H	120487707(-)	`ATATTT/GGGTAA`	1	--	int¹		4		NS EA	420
rs1056195^1,2	--	120501085(+)	`GCTTAG/TAATTT`	1	--	ut3¹		0	--	--	--	--
rs1070298^1,2	C,H,	120479504(-)	`aaaggC/Tctttg`	1	--	int¹		1		NA	2
rs1466960^1,2	C,F,A,H,	120465622(+)	`tctggG/Acaaca`	1	--	int¹		9		NS EA NA WA	586

About this table

HapMap Linkage Disequilibrium images for GTF2E1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GTF2E1: --

QIAGEN SeqTarget long-range PCR primers for resequencing GTF2E1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GTF2E1 for disorders About GeneDecksing

OMIM: 189962

Human Gene Mutation Database (HGMD): GTF2E1
Human Genome Epidemiology (HuGE) Navigator: GTF2E1 (1 document)

Export disorders and mutations for GTF2E1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/49 PubMed articles for GTF2E1 gene, integrated from 7 sources (see all 49):
(articles sorted by number of sources associating them with GTF2E1)

Evolutionary conservation of human TATA-binding-polypeptide- associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors. (PubMed id 7667268)^{1, 2} Hisatake K.... Roeder R.G. (1995)
Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome. (PubMed id 8162052)^{1, 3} Heng H.H....Tsui L.C. (1994)
Identification of two large subdomains in TFIIE-alpha on the basis of homology between Xenopus and human sequences. (PubMed id 1454543)^{1, 3} Ohkuma Y....Horikoshi M. (1992)
Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE. (PubMed id 1956403)^{1, 2} Ohkuma Y....Roeder R.G. (1991)
Structure and functional properties of human general transcription factor IIE. (PubMed id 1956398)^{1, 2} Peterson M.G.... Tjian R. (1991)
p53 and TFIIEalpha share a common binding site on the Tfb1/p62 subunit of TFIIH. (PubMed id 18160537)^{1, 7} Di Lello P....Omichinski J.G. (2008)
An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)¹ Ravasi T....Hayashizaki Y. (2010 Mar 5)
Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)¹ Vega A....Carracedo A. (2009)
MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity. (PubMed id 19106100)¹ Liu L....Nakao M. (2009)
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)² Gauci S....Mohammed S. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2960	HGNC: 4650	AceView: GTF2E1	Ensembl:ENSG00000153767	euGenes: HUgn2960
ECgene: GTF2E1	Kegg: 2960	H-InvDB: GTF2E1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for GTF2E1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for GTF2E1 gene:
Search GeneIP for patents involving GTF2E1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GTF2E1		Antibodies for GTF2E1
	Super-pooled esiRNAs for GTF2E1		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GTF2E1		microRNA Mimics for GTF2E1
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GTF2E1
	SeqTarget long-range PCR primers for resequencing GTF2E1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GTF2E1

	GenScript Custom Purified and Recombinant Proteins Services for GTF2E1		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for GTF2E1
	GenScript Custom Assay Services for GTF2E1		GenScript Custom Superior Antibodies Services for GTF2E1
	GenScript Custom overexpressing Cell Line Services for GTF2E1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in GTF2E1 promoter
	Search Chromatin IP Primers for GTF2E1
	RT² qPCR Primer Assay for GTF2E1
	Search GNC Networks for GTF2E1
	Assays for microRNAs that regulate GTF2E1
	SABiosciences Custom PCR Arrays for GTF2E1

Search Tocris compounds for GTF2E1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for GTF2E1
	Proteins for GTF2E1
	Lysates for GTF2E1

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for GTF2E1

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

View Random Gene

Category
GIFtS Group

The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

GTF2E1 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

Advanced Search

Export list of displayed genes

GTF2E1 Gene

protein-coding GIFtS: 58

Aliases &
Descriptions
for GTF2E1 gene

Summaries
for GTF2E1 gene

Genomic Views
for GTF2E1 gene

Proteins
for GTF2E1 gene

Protein Domains/
Families
for GTF2E1 gene

Gene Function
for GTF2E1 gene

Pathways & Interactions
for GTF2E1 gene

Drugs & Compounds
for GTF2E1 gene

Transcripts
for GTF2E1 gene

Expression
for GTF2E1 gene

Orthologs
for GTF2E1 gene

Paralogs
for GTF2E1 gene

Genomic Variants
for GTF2E1 gene

Disorders & Mutations
for GTF2E1 gene

Medical News
for GTF2E1 gene

Publications
for GTF2E1 gene

External Searches for GTF2E1 gene

Genome Databases showing GTF2E1 gene

Other Databases showing GTF2E1 gene

Specialized Databases showing GTF2E1 gene

Intellectual Property
for GTF2E1 gene

Products
for GTF2E1 gene

View Random Gene

Advanced Search

Export list of displayed genes

GTF2E1 Gene

protein-coding GIFtS: 58

Aliases & Descriptionsfor GTF2E1 gene

Summariesfor GTF2E1 gene

Genomic Viewsfor GTF2E1 gene

Proteinsfor GTF2E1 gene

Protein Domains/Familiesfor GTF2E1 gene

Gene Functionfor GTF2E1 gene

Pathways & Interactionsfor GTF2E1 gene

Drugs & Compoundsfor GTF2E1 gene

Transcriptsfor GTF2E1 gene

Expression for GTF2E1 gene

Orthologsfor GTF2E1 gene

Paralogsfor GTF2E1 gene

Genomic Variantsfor GTF2E1 gene

Disorders & Mutationsfor GTF2E1 gene

Medical Newsfor GTF2E1 gene

Publicationsfor GTF2E1 gene

External Searches for GTF2E1 gene

Genome Databases showing GTF2E1 gene

Other Databases showing GTF2E1 gene

Specialized Databases showing GTF2E1 gene

Intellectual Propertyfor GTF2E1 gene

Productsfor GTF2E1 gene

View Random Gene

Aliases &
Descriptions
for GTF2E1 gene

Summaries
for GTF2E1 gene

Genomic Views
for GTF2E1 gene

Proteins
for GTF2E1 gene

Protein Domains/
Families
for GTF2E1 gene

Gene Function
for GTF2E1 gene

Pathways & Interactions
for GTF2E1 gene

Drugs & Compounds
for GTF2E1 gene

Transcripts
for GTF2E1 gene

Expression
for GTF2E1 gene

Orthologs
for GTF2E1 gene

Paralogs
for GTF2E1 gene

Genomic Variants
for GTF2E1 gene

Disorders & Mutations
for GTF2E1 gene

Medical News
for GTF2E1 gene

Publications
for GTF2E1 gene

Intellectual Property
for GTF2E1 gene

Products
for GTF2E1 gene