Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



GTF2F1 Gene

protein-coding   GIFtS: 59

GC19M006139
general transcription factor IIF, polypeptide 1, 74kDa
(Previous names: general transcription factor IIF, polypeptide 1 (74kD subunit) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
general transcription factor IIF, polypeptide 1, 74kDa1 2     Transcription initiation factor RAP742 3
RAP741 2 3 5     Transcription initiation factor IIF subunit alpha2 3
BTF41 2     TFIIF-alpha2 3
TF2F11 2     general transcription factor IIF, polypeptide 1 (74kD subunit)1
TFIIF1 2     general transcription factor IIF subunit 12
General transcription factor IIF 74 kDa subunit2 3     

External Ids:    HGNC: 46521   Entrez Gene: 29622   Ensembl: ENSG000001256517   UniProtKB: P352693   

Export aliases for GTF2F1 gene to outside databases

Previous GC identifers: GC19M006474 GC19M006319 GC19M006330 GC19M006235


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: T2FA_HUMAN, P35269
Function: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to
the initiation complex in collaboration with TFIIB. It promotes transcription elongation

Gene Wiki entry for GTF2F1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GTF2F1 gene promoter:
         Sp1   RFX1   ATF-2   CUTL1   c-Jun   CREB   deltaCREB   GCNF-2   GCNF-1   Nkx2-2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for GTF2F1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GTF2F1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

GTF2F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF2F1 gene location

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M006139:  view genomic region     (about GC identifiers)

Start:
6,139,725 bp from pter
End:
6,153,437 bp from pter
Size:
13,713 bases
Orientation:
minus strand

1 alternative location:
Chr19- 6,379,580-6,393,291     
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: T2FA_HUMAN, P35269 (See protein sequence)
Recommended Name: General transcription factor IIF subunit 1  
Size: 517 amino acids; 58240 Da
Subunit: Heterodimer of an alpha and a beta subunit. Interacts with GTF2F2 and CTDP1. Interacts with TAF6/TAFII80
Subcellular location: Nucleus
Caution: Was reported (PubMed:10428810) to have a protein kinase activity and to autophosphorylates on Ser-385 and
Thr-389
PDB structures from and Proteopedia :
1F3U (3D)    1I27 (3D)    1J2X (3D)    1NHA (3D)    1ONV (3D)    2K7L (3D)    
Secondary accessions: B2RCS0 Q9BWN0

Explore the universe of human proteins at neXtProt for GTF2F1: NX_P35269 

Post-translational modifications:

  • Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_002087.2  

    ENSEMBL proteins: 
    ENSP00000392107 ENSP00000377969 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: GTF2F1
    OriGene Protein Over-expression Lysate: GTF2F1
    GenScript Custom Purified and Recombinant Proteins Services for GTF2F1 
    Novus Biologicals Proteins for GTF2F1
    Novus Biologicals Lysates for GTF2F1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA18029348
    GO:0005654 nucleoplasm TAS--
    GO:0005674 transcription factor TFIIF complex TAS1734283
    GO:0030054 cell junction IDA18029348
    About this table

    GTF2F1 for ontologies           About GeneDecksing



    Antibodies for GTF2F1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for GTF2F1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for GTF2F1 
    Novus Biologicals Antibodies for GTF2F1
    Browse antibodies at Epitomics

    Assays for GTF2F1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GTF2F1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for GTF2F1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GTF2F1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR008851 TFIIF-alpha
     IPR011991 WHTH_trsnscrt_rep_DNA-bd
     IPR011039 TFIIF_interaction

    Graphical View of Domain Structure for InterPro Entry P35269

    ProtoNet protein and cluster: P35269

    1 Blocks protein family: IPB008851 Transcription initiation factor IIF

    UniProtKB/Swiss-Prot: T2FA_HUMAN, P35269
    Similarity: Belongs to the TFIIF alpha subunit family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: T2FA_HUMAN, P35269
    Function: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to
    the initiation complex in collaboration with TFIIB. It promotes transcription elongation
    Induction: Up-regulated in response to enterovirus 71 (EV71) infection

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for GTF2F1
    Sigma-Aldrich shRNA for GTF2F1
    OriGene 29mer shRNA kits in GFP-retroviral vector: GTF2F1
    OriGene shRNA RFP: GTF2F1
    OriGene basic RS shRNA: GTF2F1
    OriGene siRNA: GTF2F1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GTF2F1 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GTF2F1 
    Search SABiosciences for Assays for microRNAs that regulate GTF2F1

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: GTF2F1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GTF2F1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): GTF2F1
    OriGene 3'-UTR clone: GTF2F1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for GTF2F1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for GTF2F1 

    Genatlas biochemistry entry for GTF2F1:
    general transcription factor IIF,polypeptide 1 (74kDa),increasing the average rate of RNA chain elongation across DNA
    templates

    5/9 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 9):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IEA--
    GO:0003702 RNA polymerase II transcription factor activity ----
    GO:0003713 transcription coactivator activity TAS7854423
    GO:0003824 catalytic activity IEA--
    GO:0005515 protein binding IPI7590250
    About this table

    GTF2F1 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    GTF2F1 for pathways           About GeneDecksing

    1 Millipore Pathway for GTF2F1
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    3 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  GTF2F1
        Glucocorticoid Receptor Signaling
    Estrogen Receptor Signaling
    Androgen Signaling

    1 Kegg Pathway  (Kegg details for GTF2F1):
        hsa03022 Basal transcription factors

        SABiosciences Pathway-Focused PCR Array including GTF2F1: PAHS-075A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GTF2F1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GTF2F1

    5/6 Interacting proteins for GTF2F1 (P352691, 2) via UniProtKB, MINT, and/or STRING (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102751EBI-457886,EBI-608057
    TAF1P216751EBI-457886,EBI-491289
    FEZ1Q996892MINT-63690
    GTF2BQ004032MINT-2983013
    PTNP212462MINT-63689
    About this table

    5/12 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 12):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398 nuclear mRNA splicing, via spliceosome TAS--
    GO:0006350 transcription TAS--
    GO:0006366 transcription from RNA polymerase II promoter TAS--
    GO:0006367 transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368 RNA elongation from RNA polymerase II promoter TAS--
    About this table

    GTF2F1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    GTF2F1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GTF2F1
    2 Novoseek chemical compound relationships for GTF2F1 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testosterone 16.3 1 18284209 (1)
    zinc 0 2 15385556 (1), 8504927 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for GTF2F1
    Sigma-Aldrich shRNA for GTF2F1
    OriGene 29mer shRNA kits in GFP-retroviral vector: GTF2F1
    OriGene shRNA RFP: GTF2F1
    OriGene basic RS shRNA: GTF2F1
    OriGene siRNA: GTF2F1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GTF2F1 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GTF2F1 
    Search SABiosciences for Assays for microRNAs that regulate GTF2F1
    Clones: Sigma-Aldrich FLAG tag genes for GTF2F1
    OriGene GFP tagged cDNA clones in CMV expression vector: GTF2F1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GTF2F1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): GTF2F1
    OriGene 3'-UTR Clone: GTF2F1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for GTF2F1 
    Primers: OriGene genome-wide validated SYBR primer pairs: GTF2F1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for GTF2F1: PPH09789A

    REFSEQ mRNAs for GTF2F1 gene: 

    NM_002096.2  

    Additional cDNA sequence: 

    AK293124.1 AK302178.1 AK315240.1 BC000120.1 BC013007.2 BT007097.1 CR456798.1 X64002.1 
    X64037.1 

    10 DOTS entries:

    DT.315980  DT.92445174  DT.121499285  DT.100001515  DT.100819253  DT.92445167  DT.97847120  DT.40114942 
    DT.91654735  DT.91968175 

    24/302 AceView cDNA sequences (see all 302):

    AW404784 BU609071 BM818653 CK903018 AL120157 AA300338 BQ925302 BM975394 
    AI357142 BM709655 CA438420 BQ071344 CF264843 BU617787 CA843785 AA381284 
    AI394578 BM728178 BX488964 H41752 BQ962892 BM561030 NM_004158 CD367758 

    highest scoring ESTs for GTF2F1:

    X64037 AA075871 AA282092 AA306505 AA326407 AA724591 AA741571 AA813597 AI304441 AI680603 

    Unigene Cluster for GTF2F1:

    General transcription factor IIF, polypeptide 1, 74kDa
    Hs.68257  [show with all ESTs]
    Unigene Representative Sequence: NM_002096


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for GTF2F1 (see all 8)

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a ·
    SP1:                          -           -                                   -     -                                                                           
    SP2:                                                                                                                                                        -   
    SP3:        -                 -           -                                                                                                                     
    SP4:                          -           -                 -                 -     -                                                                           
    SP5:                                      -                                   -     -                                                                           

    ExUns: 18b · 18c · 18d
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  

    About this scheme

    ECgene alternative splicing isoforms for GTF2F1
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429701(uc010xjc.1) ENST00000394456(uc010xjb.1 uc002meq.2)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    GTF2F1 expression in normal and diseased human tissues

    1  / 2  / 3

    7 probe-sets matching GTF2F1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    36826_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 X64037 1.00 0.90 0.95 1
    202354_s_at2, 3 U133-A 1 1.00 1.00 -- -- AW190445 0.60 0.83 0.73 1
    202355_s_at2, 3 U133-A 1 1.00 1.00 -- -- BC000120 0.80 0.88 0.84 1
    202356_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002096 0.60 0.83 0.73 1
    202354_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    202355_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    202356_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    GTF2F1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    GTF2F1 gene expression
    GTF2F1 gene electronic northern expression
    GTF2F1 gene sage expression
    About these images

    CGAP SAGE TAG: GTGGCGGGAG

    SOURCE GeneReport for Unigene cluster: Hs.68257

    Expression variation in blood from EXPOLDB for GTF2F1

    Primers: OriGene genome-wide validated SYBR primer pairs: GTF2F1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for GTF2F1: PPH09789A
        SABiosciences Expression via Pathway-Focused PCR Array including GTF2F1: PAHS-075A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for GTF2F1 gene from 5/13 species (see all 13)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    GTF2F11   -- general transcription factor IIF, polypeptide 1, 74kDa 87.86(n)
    93.6(a)
    476731  XM_533935.2  XP_533935.2 
    chimpanzee
    (Pan troglodytes)
    GTF2F11   -- general transcription factor IIF, polypeptide 1, 74kDa 98.71(n)
    99.42(a)
    455639  XM_512314.2  XP_512314.2 
    cow
    (Bos taurus)
    GTF2F11   -- general transcription factor IIF, polypeptide 1, 74kDa 86.91(n)
    95.16(a)
    505702  NM_001015527.1  NP_001015527.1 
    rat
    (Rattus norvegicus)
    Gtf2f11   -- general transcription factor IIF, polypeptide 1 86.35(n)
    93.11(a)
    316123  NM_001007711.1  NP_001007712.1 
    mouse
    (Mus musculus)
    Gtf2f11 , 5 17 (29.62 cM)5
    general transcription factor IIF, polypeptide 11, 5 86.02(n)1
    93.11(a)1
    980531  NM_133801.21  NP_598562.11 
     AA7645575  AI8533405  (see all 18)
    About this table        Species with no ortholog for GTF2F1

    ENSEMBL Gene Tree for GTF2F1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/198 NCBI SNPs in GTF2F1 are shown (see all 198)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs11301941,2
    6379647(-) CACCAC/TGCCAC 1 -- ut310--------
    rs22417231,2
    C,F,O,6393620(+) CGGGTC/GGAACC 1 -- ng519Minor allele frequency- G:0.35EA NS NA WA 2034
    rs22477851,2
    C,F,A,6392078(+) AATCAA/GCCACC 1 -- int111Minor allele frequency- G:0.35EA NS NA WA 2848
    rs23041961,2
    C,F,6392006(+) AGAGGT/CAGTGT 1 -- int111Minor allele frequency- C:0.36EA NS NA WA 2338
    rs23041991,2
    C,F,6381296(+) CTGCAG/AGGGAG 1 -- int1 trp36Minor allele frequency- A:0.06EA NS 1620
    rs30880231,2
    C,F,6393152(+) CTGGCG/ACTGGG 1 -- ut5113Minor allele frequency- A:0.40MN NS EA NA WA 1172
    rs37455731,2
    C,6383537(+) ATGCCG/AGGCCT 1 -- int15Minor allele frequency- A:0.27EA NA WA 2416
    rs65108951,2
    C,F,A,6391847(+) CACAAC/TCACCA 1 -- int117Minor allele frequency- N:0.00NS EA NA WA 1256
    rs72472871,2
    C,F,6381675(+) CTGCAT/CGGGGT 1 -- int11Minor allele frequency- C:0.20WA 50
    rs72551281,2
    F,H6384380(+) cgggcG/Atggtg 1 -- int14Minor allele frequency- A:0.02NS EA 418
    About this table

    HapMap Linkage Disequilibrium images for GTF2F1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GTF2F1: --

    QIAGEN SeqTarget long-range PCR primers for resequencing GTF2F1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GTF2F1 for disorders           About GeneDecksing

    OMIM: 189968

    Human Genome Epidemiology (HuGE) Navigator: GTF2F1 (1 document)

    Export disorders and mutations for GTF2F1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/168 PubMed articles for GTF2F1 gene, integrated from 7 sources (see all 168):
    (articles sorted by number of sources associating them with GTF2F1)
    1. A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II. (PubMed id 1734284)1, 2, 3, 7 Finkelstein A.... Burton Z.F. (1992)
    2. Solution structure of the carboxyl-terminal domain of RAP74 and NMR characterization of the FCP1-binding sites of RAP74 and human TFIIB. (PubMed id 12578358)1, 2, 7 Nguyen B.D....Omichinski J.G. (2003)
    3. NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1. (PubMed id 12732728)1, 2, 7 Nguyen B.D.... Omichinski J.G. (2003)
    4. Evolutionary conservation of human TATA-binding-polypeptide- associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors. (PubMed id 7667268)1, 2, 7 Hisatake K.... Roeder R.G. (1995)
    5. Novel dimerization fold of RAP30/RAP74 in human TFIIF at 1.7 A resolution. (PubMed id 11183778)1, 2, 7 Gaiser F.... Richmond T.J. (2000)
    6. Molecular mechanism of recruitment of TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1) by transcription factor IIF. (PubMed id 12591941)1, 2, 7 Kamada K.... Burley S.K. (2003)
    7. Characterization of cDNA for the large subunit of the transcription initiation factor TFIIF. (PubMed id 1734283)1, 2, 7 Aso T.... Yasukochi Y. (1992)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    9. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PubMed id 16548883)1, 2 Leong W.F. and Chow V.T. (2006)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2962 HGNC: 4652 AceView: GTF2F1andPSPN Ensembl:ENSG00000125651 euGenes: HUgn2962
    ECgene: GTF2F1 Kegg: 2962 H-InvDB: GTF2F1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for GTF2F1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for GTF2F1 gene:
    Search GeneIP for patents involving GTF2F1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for GTF2F1 Antibodies for GTF2F1
     Super-pooled esiRNAs for GTF2F1 Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for GTF2F1 Browse microRNA Mimics at Sigma-Aldrich
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     FLAG tag genes for GTF2F1 Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GTF2F1
     SeqTarget long-range PCR primers for resequencing GTF2F1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GTF2F1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GTF2F1
     GenScript Custom Purified and Recombinant Proteins Services for GTF2F1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for GTF2F1
     GenScript Custom Assay Services for GTF2F1 GenScript Custom Superior Antibodies Services for GTF2F1
     GenScript Custom overexpressing Cell Line Services for GTF2F1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GTF2F1 promoter
     Search Chromatin IP Primers for GTF2F1
     RT2 qPCR Primer Assay for GTF2F1
     GNC Network for GTF2F1
     Search for Assays for microRNAs that regulate GTF2F1
     SABiosciences PCR Arrays including GTF2F1
     Search Tocris compounds for GTF2F1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for GTF2F1
     Proteins for GTF2F1
     Lysates for GTF2F1
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for GTF2F1
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    GTF2F1 gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4