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GTF2F2 Gene

protein-coding GIFtS: 59

GC13P026496

general transcription factor IIF, polypeptide 2, 30kDa
(Previous names: general transcription factor IIF, polypeptide 1 (74kD subunit) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
general transcription factor IIF, polypeptide 2, 30kDa¹ ²		TFIIF-beta² ³
RAP30¹ ² ³		ATP-dependent helicase GTF2F2² ³
BTF4¹ ²		general transcription factor IIF, polypeptide 1 (74kD subunit)¹
TFIIF¹ ²		general transcription factor IIF subunit 2²
General transcription factor IIF 30 kDa subunit² ³		TF2F2²
Transcription initiation factor RAP30² ³		EC 3.6.4.12³
Transcription initiation factor IIF subunit beta² ³

External Ids:	HGNC: 4653¹	Entrez Gene: 2963²	Ensembl: ENSG00000188342⁷	UniProtKB: P13984³

Export aliases for GTF2F2 gene to outside databases

Previous GC identifers: GC13P043694 GC13P039681 GC13P044631 GC13P043492 GC13P044592 GC13P045694

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: T2FB_HUMAN, P13984

Function: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to

the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows

ATP-dependent DNA-helicase activity

Gene Wiki entry for GTF2F2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GTF2F2 gene promoter:
         E2F-3a   E2F-5   E2F-4   E2F-2   E2F-1   E2F   Nkx6-1   Cdc5   RFX1   HOXA9B
         Other transcription factors

Search SABiosciences Chromatin IP Primers for GTF2F2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14 Ensembl cytogenetic band: 13q14.12 HGNC cytogenetic band: 13q14

GTF2F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF2F2 gene location

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P026496: view genomic region (about GC identifiers)

Start:	26,496,415 bp from pter
End:	26,659,718 bp from pter
Size:	163,304 bases
Orientation:	plus strand

1 alternative location:

Chr13+ 45,694,650-45,858,237

RefSeq DNA sequence:

NC_000013.10 NT_024524.14

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: T2FB_HUMAN, P13984 (See protein sequence)

Recommended Name: General transcription factor IIF subunit 2

Size: 249 amino acids; 28380 Da

Subunit: Heterodimer of an alpha and a beta subunit. Interacts with HTATSF1 and GPBP1 (By similarity)

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1BBY (3D)

1F3U (3D)

2BBY (3D)

Secondary accessions: A6NNS5 Q5W0H3

Explore the universe of human proteins at neXtProt for GTF2F2: NX_P13984

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004119.1

ENSEMBL proteins:

ENSP00000340823

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: GTF2F2 OriGene Protein Over-expression Lysate: GTF2F2
	GenScript Custom Purified and Recombinant Proteins Services for GTF2F2
	Novus Biologicals Protein for GTF2F2
	Novus Biologicals Lysates for GTF2F2
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348
GO:0005654	nucleoplasm	TAS	--
GO:0005674	transcription factor TFIIF complex	IEA	--
GO:0015630	microtubule cytoskeleton	IDA	18029348

About this table

GTF2F2 for ontologies About GeneDecksing

Antibodies for GTF2F2:

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	Novus Biologicals Antibody for GTF2F2
	Browse antibodies at Epitomics

Assays for GTF2F2:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GTF2F2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for GTF2F2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GTF2F2 for domains About GeneDecksing

4 InterPro domains/families:

IPR011991 WHTH_trsnscrt_rep_DNA-bd

IPR003196 TFIIF_beta

IPR016640 TFIIF-beta_sub

IPR011039 TFIIF_interaction

Graphical View of Domain Structure for InterPro Entry P13984

ProtoNet protein and cluster: P13984

1 Blocks protein family: IPB003196 Transcription initiation factor IIF

UniProtKB/Swiss-Prot: T2FB_HUMAN, P13984

Similarity: Belongs to the TFIIF beta subunit family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: T2FB_HUMAN, P13984

Function: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to

the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows

ATP-dependent DNA-helicase activity

Catalytic activity: ATP + H(2)O = ADP + phosphate

Enzyme Number (IUBMB): EC 3.6.4.12

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for GTF2F2 Sigma-Aldrich shRNA Panels and shRNA for GTF2F2
		OriGene 29mer shRNA kits in GFP-retroviral vector: GTF2F2 OriGene shRNA RFP: GTF2F2 OriGene basic RS shRNA: GTF2F2 OriGene siRNA: GTF2F2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GTF2F2

miRNA:		Sigma-Aldrich microRNA Mimics for GTF2F2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GTF2F2
		Search SABiosciences for Assays for microRNAs that regulate GTF2F2

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: GTF2F2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GTF2F2 OriGene untagged cDNA clones in CMV expression vector: GTF2F2 OriGene 3'-UTR clone: GTF2F2 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for GTF2F2
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for GTF2F2

Genatlas biochemistry entry for GTF2F2:

general transcription factor IIF,polypeptide 2(30kDa),increasing the average rate of RNA chain elongation across DNA

templates

5/10 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 10):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003677	DNA binding	IEA	--
GO:0003702	RNA polymerase II transcription factor activity	--	--
GO:0003824	catalytic activity	--	--
GO:0004386	helicase activity	IEA	--

About this table

GTF2F2 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

GTF2F2 for pathways About GeneDecksing

1 Millipore Pathway for GTF2F2

Transcription Ligand-Dependent Transcription of Retinoid-Target genes

2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for GTF2F2

	Estrogen Receptor Signaling
	Glucocorticoid Receptor Signaling

1 Kegg Pathway (Kegg details for GTF2F2):

hsa03022 Basal transcription factors

SABiosciences Custom Pathway-Focused PCR Arrays for GTF2F2

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GTF2F2

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GTF2F2

3 Interacting proteins for GTF2F2 (P13984^{1, 2}) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPL27A	P46776¹	EBI-1030560,EBI-350581
TCTEX1D2	Q8WW35¹	EBI-1030560,EBI-2692044
GTF2B	Q00403²	MINT-2982956

About this table

5/12 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 12):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000398	nuclear mRNA splicing, via spliceosome	TAS	--
GO:0006350	transcription	TAS	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	--
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS	--
GO:0006368	RNA elongation from RNA polymerase II promoter	TAS	--

About this table

GTF2F2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

GTF2F2 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GTF2F2
3 Novoseek chemical compound relationships for GTF2F2 gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphodiester	53.5	2	10872452 (1), 8631733 (1)
alanine	16.2	1	16169872 (1)
atp	11.9	2	7982911 (1), 8631733 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for GTF2F2 Sigma-Aldrich shRNA Panels and shRNA for GTF2F2
		OriGene 29mer shRNA kits in GFP-retroviral vector: GTF2F2 OriGene shRNA RFP: GTF2F2 OriGene basic RS shRNA: GTF2F2 OriGene siRNA: GTF2F2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GTF2F2

miRNA:		Sigma-Aldrich microRNA Mimics for GTF2F2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GTF2F2
		Search SABiosciences for Assays for microRNAs that regulate GTF2F2

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: GTF2F2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GTF2F2 OriGene untagged cDNA clones in CMV expression vector: GTF2F2 OriGene 3'-UTR Clone: GTF2F2 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for GTF2F2

Primers:		OriGene genome-wide validated SYBR primer pairs: GTF2F2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for GTF2F2: PPH09605A

REFSEQ mRNAs for GTF2F2 gene:

NM_004128.2

Additional cDNA sequence:

AK291545.1 BC001771.1 BT019525.1 CR598374.1 CR609785.1 X16901.1 X59745.1

7 DOTS entries:

DT.114042 DT.100796480 DT.100834650 DT.40130785 DT.99997299 DT.120789664 DT.120789671

24/152 AceView cDNA sequences (see all 152):

CF272406 BU184889 CR598374 BG678009 CA444768 CD368832 CB125610 AW004843

BQ416647 AA831833 BE906625 CA443379 N73082 BQ422614 BX089414 CB134833

BQ001106 BX281310 CB126197 AA831445 CB125216 BU686020 BI755137 BM457007

highest scoring ESTs for GTF2F2:

X16901 AA478656 AA479196 AA831445 AA831833 AA831834 AA868805 AI126584 AI394702 AI400144

Unigene Cluster for GTF2F2:

General transcription factor IIF, polypeptide 2, 30kDa

Hs.654582 [show with all ESTs]

Unigene Representative Sequence: NM_004128

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for GTF2F2

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b
SP1:							-		-				-		-
SP2:							-		-				-		-
SP3:									-				-		-
SP4:
SP5:													-		-

About this scheme

ECgene alternative splicing isoforms for GTF2F2
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000340473(uc001uzv.2 uc001uzw.2) ENST00000494087 ENST00000461904

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

GTF2F2 expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching GTF2F2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36510_at²^{, 3}	U95-A	1	0.75	1.00	1.00	1.00	X16901	1.00	0.90	0.95	1
209595_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC001771	0.80	0.88	0.84	1
209595_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

GTF2F2 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

GTF2F2 gene electronic northern expression

About these images

CGAP SAGE TAG: CTAGTGAAAC

SOURCE GeneReport for Unigene cluster: Hs.654582

Expression variation in blood from EXPOLDB for GTF2F2

Primers:		OriGene genome-wide validated SYBR primer pairs: GTF2F2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for GTF2F2: PPH09605A

SABiosciences Custom PCR Arrays for GTF2F2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GTF2F2 gene from 5/14 species (see all 14)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GTF2F2¹	--	general transcription factor IIF, polypeptide 2, 30kDa less	93.57(n) 97.99(a)	609164 XM_846373.1 XP_851466.1
chimpanzee (Pan troglodytes)	GTF2F2¹	--	general transcription factor IIF, polypeptide 2, 30kDa less	99.6(n) 100(a)	741868 XM_001154142.1 XP_001154142.1
cow (Bos taurus)	GTF2F2¹	--	general transcription factor IIF, polypeptide 2, 30kDa less	92.24(n) 97.59(a)	509259 NM_001038064.1 NP_001033153.1
rat (Rattus norvegicus)	Gtf2f2¹	--	general transcription factor IIF, polypeptide 2	90.36(n) 97.59(a)	81674 NM_031042.3 NP_112304.2
mouse (Mus musculus)	Gtf2f2^{1 , 5}	14 (40.29 cM)⁵	general transcription factor IIF, polypeptide 2^{1, 5}	89.96(n)¹ 97.99(a)¹	68705¹ NM_026816.3¹ NP_081092.1¹ AI326315⁵ AI841186⁵ (see all 12)

About this table Species with no ortholog for GTF2F2

ENSEMBL Gene Tree for GTF2F2 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

2 related pseudogenes

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs766530^1,2	C,F,	45752313(-)	`AACTGT/CTGGCC`	1	--	int¹		8		NA NS EA	544
rs766531^1,2	C,F,A,	45752206(-)	`tgaagG/Caagac`	1	--	int¹		14		NS EA NA WA	1032
rs912414^1,2	H	45699413(+)	`AGAAAT/ATTTTT`	1	--	int¹ trp³		4		NS EA	420
rs951853^1,2	C,F,	45810507(-)	`TATTTC/TCATAA`	1	--	int¹		80		NS EA PA EU CA WA	4152
rs957035^1,2	C,F,O,A,	45800647(-)	`AAATAG/ATATGT`	1	--	int¹		16		NA NS EA WA	1100
rs1473741^1,2	C,A,	45715795(-)	`ACACAC/TACACA`	1	--	int¹		5		NA WA	128
rs1610999^1,2	F	45752475(-)	`agaag-/AAGAAG cataa`	1	--	int¹		4		EU NA EA	342
rs1886192^1,2	C,F,H,	45707733(+)	`aaaccG/Atctga`	1	--	int¹		11		NS EA NA WA	432
rs1964876^1,2	--	45833941(-)	`gtggcA/Gggcgc`	1	--	int¹		0	--	--	--	--
rs1980759^1,2	C,F,O,A,H,	45805760(+)	`CCACAA/GCTGGT`	1	--	int¹		18		NS EA NA WA	1132

About this table

HapMap Linkage Disequilibrium images for GTF2F2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GTF2F2: --

QIAGEN SeqTarget long-range PCR primers for resequencing GTF2F2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GTF2F2 for disorders About GeneDecksing

OMIM: 189969

Export disorders and mutations for GTF2F2 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/115 PubMed articles for GTF2F2 gene, integrated from 7 sources (see all 115):
(articles sorted by number of sources associating them with GTF2F2)

Tat-SF1 protein associates with RAP30 and human SPT5 proteins. (PubMed id 10454543)^{1, 2, 7} Kim J.B.... Sharp P.A. (1999)
Global phosphoproteome of HT-29 human colon adenocarcinoma cells. (PubMed id 16083285)^{1, 2} Kim J.-E.... White F.M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Structural homology between the Rap30 DNA-binding domain and linker histone H5: implications for preinitiation complex assembly. (PubMed id 9689043)^{1, 2} Groft C.M.... Werner M.H. (1998)
Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome. (PubMed id 8162052)^{1, 3} Heng H.H....Tsui L.C. (1994)
Nucleotide and amino acid sequence of RAP30. (PubMed id 1840667)^{1, 2} Horikoshi M.... Roeder R.G. (1991)
Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase II. (PubMed id 2477704)^{1, 2} Sopta M.... Greenblatt J. (1989)
Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP). (PubMed id 12737519)^{1, 7} Wei W....Murakami S. (2003)
Mutational analysis of human RNA polymerase II subunit 5 (RPB5): the residues critical for interactions with TFIIF subunit RAP30 and hepatitis B virus X protein. (PubMed id 16169872)^{1, 7} Le T.T....Murakami S. (2005)
Distinct domains of hTAFII100 are required for functional interaction with transcription factor TFIIF beta (RAP30) and incorporation into the TFIID complex. (PubMed id 8758937)^{1, 7} Dubrovskaya V....Tora L. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2963	HGNC: 4653	AceView: GTF2F2	Ensembl:ENSG00000188342	euGenes: HUgn2963
ECgene: GTF2F2	Kegg: 2963	H-InvDB: GTF2F2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for GTF2F2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for GTF2F2 gene:
Search GeneIP for patents involving GTF2F2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
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	Predesigned and custom siRNAs for GTF2F2		Antibodies for GTF2F2
	Super-pooled esiRNAs for GTF2F2		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GTF2F2		microRNA Mimics for GTF2F2
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GTF2F2
	SeqTarget long-range PCR primers for resequencing GTF2F2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GTF2F2

	GenScript Custom Purified and Recombinant Proteins Services for GTF2F2		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for GTF2F2
	GenScript Custom Assay Services for GTF2F2		GenScript Custom Superior Antibodies Services for GTF2F2
	GenScript Custom overexpressing Cell Line Services for GTF2F2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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ELISAs and CLIAs for GTF2F2

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

GTF2F2 gene at Home site.

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GTF2F2 Gene

protein-coding GIFtS: 59

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GTF2F2 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor GTF2F2 gene

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Expression
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