Home
GeneCards Guide
Suite
- GeneALaCart
- GeneDecks
- GeneIP
- GeneNote
- GeneAnnot
- GeneLoc
- GeneTide
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

GTF2H4 Gene

protein-coding GIFtS: 56

GC06P030676

general transcription factor IIH, polypeptide 4, 52kDa
(Previous names: general transcription factor IIH, polypeptide 4 (52kD subunit) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
general transcription factor IIH, polypeptide 4, 52kDa¹ ²		TFIIH basal transcription factor complex p52 subunit² ³
TFB2¹ ²		general transcription factor IIH, polypeptide 4 (52kD subunit)¹
General transcription factor IIH polypeptide 4² ³		TFIIH²
Basic transcription factor 2 52 kDa subunit² ³		general transcription factor IIH subunit 4²
BTF2 p52² ³

External Ids:	HGNC: 4658¹	Entrez Gene: 2968²	Ensembl: ENSG00000213780⁷	UniProtKB: Q92759³

Export aliases for GTF2H4 gene to outside databases

Previous GC identifers: GC06U990042 GC06P030932 GC06P030646 GC06P030982 GC06P030984 GC06P030875

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TF2H4_HUMAN, Q92759

Function: Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA

and, when complexed to CAK, in RNA transcription by RNA polymerase II

Gene Wiki entry for GTF2H4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GTF2H4 gene promoter:
         NF-kappaB1   STAT1beta   STAT1   STAT1alpha   GR-alpha   NF-kappaB   CUTL1   p53   c-Myb   ZID
         Other transcription factors

Search SABiosciences Chromatin IP Primers for GTF2H4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GTF2H4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.3

GTF2H4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTF2H4 gene location

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P030676: view genomic region (about GC identifiers)

Start:	30,676,064 bp from pter
End:	30,681,967 bp from pter
Size:	5,904 bases
Orientation:	plus strand

5 alternative locations:

Chr6+,ALT_REF_LOCI_6 30,865,549-30,907,049	Chr6+,ALT_REF_LOCI_2 30,865,832-30,910,939	Chr6+,ALT_REF_LOCI_3 30,866,676-30,883,633
Chr6+,ALT_REF_LOCI_4 30,843,715-30,849,618	Chr6+,ALT_REF_LOCI_5 30,869,355-30,875,258

RefSeq DNA sequence:

NC_000006.11 NT_007592.15 NT_113891.2 NT_167245.1 NT_167246.1 NT_167247.1 NT_167248.1

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TF2H4_HUMAN, Q92759 (See protein sequence)

Recommended Name: General transcription factor IIH subunit 4

Size: 462 amino acids; 52186 Da

Subunit: One of the 6 subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex

composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor

Subcellular location: Nucleus

Explore the universe of human proteins at neXtProt for GTF2H4: NX_Q92759

REFSEQ proteins: NP_001508.1

ENSEMBL proteins:

ENSP00000422401 ENSP00000259895 ENSP00000365493 ENSP00000410160

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: GTF2H4
	GenScript Custom Purified and Recombinant Proteins Services for GTF2H4
	Novus Biologicals Proteins for GTF2H4
	Novus Biologicals Lysates for GTF2H4
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005675	holo TFIIH complex	IDA	9852112

About this table

GTF2H4 for ontologies About GeneDecksing

Antibodies for GTF2H4:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for GTF2H4
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for GTF2H4
	Novus Biologicals Antibodies for GTF2H4
	Browse antibodies at Epitomics

Assays for GTF2H4:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GTF2H4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for GTF2H4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GTF2H4 for domains About GeneDecksing

1 InterPro domain/family:

IPR004598 Tfb2

Graphical View of Domain Structure for InterPro Entry Q92759

ProtoNet protein and cluster: Q92759

1 Blocks protein family: IPB004598 Transcription factor Tfb2

UniProtKB/Swiss-Prot: TF2H4_HUMAN, Q92759

Similarity: Belongs to the TFB2 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: TF2H4_HUMAN, Q92759

Function: Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA

and, when complexed to CAK, in RNA transcription by RNA polymerase II

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for GTF2H4 Sigma-Aldrich shRNA for GTF2H4
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): GTF2H4 OriGene shRNA RFP (see all 2): GTF2H4 OriGene basic RS shRNA (see all 2): GTF2H4 OriGene siRNA: GTF2H4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GTF2H4

miRNA:		Sigma-Aldrich microRNA Mimics for GTF2H4 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GTF2H4
		Search SABiosciences for Assays for microRNAs that regulate GTF2H4

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: GTF2H4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GTF2H4 OriGene untagged cDNA clones in CMV expression vector: GTF2H4 OriGene 3'-UTR clone: GTF2H4 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: GTF2H4
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for GTF2H4

Genatlas biochemistry entry for GTF2H4:

general transcription factor HH,polypeptide 4,52kDa,recruiting the RNA polymerase II to the DB complex,involved in both

transcription and DNA repair

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	9118947
GO:0003702	RNA polymerase II transcription factor activity	IEA	--
GO:0004672	contributes to protein kinase activity	IDA	9852112
GO:0005515	protein binding	IPI	17466626
GO:0008094	contributes to DNA-dependent ATPase activity	IDA	9852112

About this table

GTF2H4 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

GTF2H4 for pathways About GeneDecksing

2 Millipore Pathways for GTF2H4

	Transcription Ligand-Dependent Transcription of Retinoid-Target genes
	Transcription P53 signaling pathway

5 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for GTF2H4

	Estrogen Receptor Signaling
	RAR Activation
	Nucleotide Excision Repair Pathway
	Glucocorticoid Receptor Signaling
	Androgen Signaling

2 Kegg Pathways (Kegg details for GTF2H4):

	hsa03022 Basal transcription factors
	hsa03420 Nucleotide excision repair

SABiosciences Custom Pathway-Focused PCR Arrays for GTF2H4

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GTF2H4

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GTF2H4

5/17 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 17):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000718	nucleotide-excision repair, DNA damage removal	EXP	10583946
GO:0006281	DNA repair	TAS	--
GO:0006283	transcription-coupled nucleotide-excision repair	TAS	--
GO:0006289	nucleotide-excision repair	TAS	--
GO:0006350	transcription	TAS	--

About this table

GTF2H4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

GTF2H4 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GTF2H4
2 Novoseek chemical compound relationships for GTF2H4 gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
amp-pnp	62.6	4	8313884 (1), 8007973 (1)
atp	25.6	9	8007973 (1), 12590132 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for GTF2H4 Sigma-Aldrich shRNA for GTF2H4
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): GTF2H4 OriGene shRNA RFP (see all 2): GTF2H4 OriGene basic RS shRNA (see all 2): GTF2H4 OriGene siRNA: GTF2H4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GTF2H4

miRNA:		Sigma-Aldrich microRNA Mimics for GTF2H4 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GTF2H4
		Search SABiosciences for Assays for microRNAs that regulate GTF2H4

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: GTF2H4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GTF2H4 OriGene untagged cDNA clones in CMV expression vector: GTF2H4 OriGene 3'-UTR Clone: GTF2H4 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: GTF2H4

Primers:		OriGene genome-wide validated SYBR primer pairs: GTF2H4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for GTF2H4: PPH02655A

REFSEQ mRNAs for GTF2H4 gene:

NM_001517.4

Additional cDNA sequence:

AK222607.1 AK298058.1 AK300239.1 AK309869.1 BC004935.1 BC016302.2 BT007321.1 CR593757.1

CR597850.1 CR598798.1 CR606017.1 CR606652.1 CR609671.1 CR610075.1 CR619568.1 CR622991.1

Y07595.1

9 DOTS entries:

DT.442849 DT.92440383 DT.99956622 DT.100787773 DT.100029918 DT.102827221 DT.92440381 DT.95147943

DT.99968525

24/258 AceView cDNA sequences (see all 258):

BX370729 BQ212016 AL559731 BU740782 BE395901 BI912530 AA761609 BQ776843

CB130836 BC016302 CR619568 CR598798 BQ055545 AI083838 CB528330 N92835

BM713660 AI744011 BF515363 BU183016 AW574540 CD611909 BE389829 BU179030

highest scoring ESTs for GTF2H4:

Y07595 AA001980 AA099183 AA113209 AA251093 AA447625 AA761609 AA810058 AA913583 AI016433

Unigene Cluster for GTF2H4:

General transcription factor IIH, polypeptide 4, 52kDa

Hs.485070 [show with all ESTs]

Unigene Representative Sequence: NM_001517

GeneLoc Exon Structure

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000506145 ENST00000259895(uc010jsf.2 uc011dmw.1) ENST00000376316

ENST00000487746(uc011dmv.1) ENST00000475845 ENST00000453897 ENST00000483318

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

GTF2H4 expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching GTF2H4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41371_at²^{, 3}	U95-A	5	1.00	0.70	1.00	1.00	Y07595	1.00	0.80	0.91	1
203577_at²^{, 3}	U133-A	5	1.00	0.78	--	--	NM_001517	0.60	0.83	0.73	1
203577_at²	U133Plus2	5	1.00	0.78	--	--	--	--	--	--	--

About this table

GTF2H4 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

GTF2H4 gene electronic northern expression

About these images

CGAP SAGE TAG: GTGGTGACCC

SOURCE GeneReport for Unigene cluster: Hs.485070

Expression variation in blood from EXPOLDB for GTF2H4

Primers:		OriGene genome-wide validated SYBR primer pairs: GTF2H4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for GTF2H4: PPH02655A

SABiosciences Custom PCR Arrays for GTF2H4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GTF2H4 gene from 5/20 species (see all 20)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GTF2H4¹	--	general transcription factor IIH, polypeptide 4, 52kDa	94.01(n) 99.13(a)	606988 XM_843826.1 XP_848919.1
chimpanzee (Pan troglodytes)	GTF2H4¹	--	general transcription factor IIH, polypeptide 4, 52kDa	99.71(n) 100(a)	462549 XM_518339.2 XP_518339.2
rat (Rattus norvegicus)	Gtf2h4¹	--	general transcription factor II H, polypeptide 4	90.62(n) 99.13(a)	294236 NM_212501.1 NP_997666.1
mouse (Mus musculus)	Gtf2h4^{1 , 5}	17 (18.70 cM)⁵	general transcription factor II H, polypeptide 4^{1, 5}	91.63(n)¹ 98.92(a)¹	14885¹ NM_010364.2¹ NP_034494.1¹ AF054823⁵ AI850881⁵ (see all 17)
zebrafish (Danio rerio)	wufa04h09²	--	wufa04h09	74.23(n)	334839 BC064301.1

About this table Species with no ortholog for GTF2H4

ENSEMBL Gene Tree for GTF2H4 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs886420^1,2	C,F	30879636(-)	`TTCCTG/ACTACT`	1	--	int¹		5		NS EA NA	456
rs916920^1,2	C,F,A,H	30877202(-)	`ACAGGG/AACAGA`	1	--	int¹		10		EA NS NA WA	2088
rs1052693^1,2	C,F,A	30876152(+)	`AGACTC/TGGGGT`	1	--	ut5¹		11		NS MN NA WA	944
rs1264309^1,2	C,F,A	30875899(-)	`CTCCTT/CAGAGC`	1	--	ng5¹		16		NS EA NA	1614
rs1362122^1,2	C,F,A	30877054(-)	`CTTGCC/TCCCAG`	1	--	int¹		12		EA NS NA WA	2252
rs1362123^1,2	C,F,A	30876996(-)	`TTCCAC/GTCCGC`	1	--	int¹		12		NS EA NA WA	742
rs1419693^1,2	C,F,H	30877760(-)	`AGCTGT/GGTGTG`	2	/T	ref¹ syn¹		11		MN NS EA NA WA	842
rs2074507^1,2	C	30876995(-)	`TCCAGG/TCCGCA`	1	--	int¹		0	--	--	--	--
rs2074508^1,2	C,F,A	30876438(-)	`GTCTAC/TAAGCT`	1	--	int¹		28		EA NS MN NA WA	3116
rs2074509^1,2	C,F,A	30876238(-)	`GCCTCC/TCACTC`	1	--	int¹		6		NS MN NA WA	276

About this table

HapMap Linkage Disequilibrium images for GTF2H4 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GTF2H4: --

QIAGEN SeqTarget long-range PCR primers for resequencing GTF2H4

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GTF2H4 for disorders About GeneDecksing

OMIM: 601760

Human Genome Epidemiology (HuGE) Navigator: GTF2H4 (3 documents)

Export disorders and mutations for GTF2H4 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/77 PubMed articles for GTF2H4 gene, integrated from 7 sources (see all 77):
(articles sorted by number of sources associating them with GTF2H4)

Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH. (PubMed id 9118947)^{1, 2, 3} Marinoni J.-C.... Egly J.-M. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PubMed id 9852112)^{1, 2} Kershnar E.... Chiang C.-M. (1998)
Alleviation of PC4-mediated transcriptional repression by the ERCC3 helicase activity of general transcription factor TFIIH. (PubMed id 12590132)^{1, 7} Fukuda A....Hisatake K. (2003)
Human cyclin-dependent kinase-activating kinase exists in three distinct complexes. (PubMed id 8692842)^{1, 7} Drapkin R....Reinberg D. (1996)
Variation within DNA repair pathway genes and risk of multiple sclerosis. (PubMed id 20522537)¹ Briggs F.B....Barcellos L.F. (2010)
Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)¹ Ucisik-Akkaya E....Tevfik Dorak M. (2010)
New clinico-genetic classification of trichothiodystr ophy. (PubMed id 19681155)¹ Morice-Picard F....TaA^eb A. (2009)
High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)¹ Barcellos L.F....Criswell L.A. (2009)
TFB2 is a transient component of the catalytic site o f the human mitochondrial RNA polymerase. (PubMed id 19945377)¹ Sologub M....Temiakov D. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2968	HGNC: 4658	AceView: GTF2H4	Ensembl:ENSG00000213780	euGenes: HUgn2968
ECgene: GTF2H4	Kegg: 2968	H-InvDB: GTF2H4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GTF2H4	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/gtf2h4/

Intellectual Property for GTF2H4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for GTF2H4 gene:
Search GeneIP for patents involving GTF2H4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GTF2H4		Antibodies for GTF2H4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GTF2H4		microRNA Mimics for GTF2H4
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GTF2H4
	SeqTarget long-range PCR primers for resequencing GTF2H4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GTF2H4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GTF2H4

	GenScript Custom Purified and Recombinant Proteins Services for GTF2H4		GenScript cDNA clones with any tag delivered in your preferred vector for GTF2H4
	GenScript Custom Assay Services for GTF2H4		GenScript Custom Superior Antibodies Services for GTF2H4
	GenScript Custom overexpressing Cell Line Services for GTF2H4		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in GTF2H4 promoter
	Search Chromatin IP Primers for GTF2H4
	RT² qPCR Primer Assay for GTF2H4
	GNC Network for GTF2H4
	Search for Assays for microRNAs that regulate GTF2H4
	SABiosciences Custom PCR Arrays for GTF2H4

Search Tocris compounds for GTF2H4

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for GTF2H4
	Proteins for GTF2H4
	Lysates for GTF2H4

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for GTF2H4

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

View Random Gene

Category
GIFtS Group

The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

GTF2H4 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

Advanced Search

Export list of displayed genes

GTF2H4 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for GTF2H4 gene

Summaries
for GTF2H4 gene

Genomic Views
for GTF2H4 gene

Proteins
for GTF2H4 gene

Protein Domains/
Families
for GTF2H4 gene

Gene Function
for GTF2H4 gene

Pathways & Interactions
for GTF2H4 gene

Drugs & Compounds
for GTF2H4 gene

Transcripts
for GTF2H4 gene

Expression
for GTF2H4 gene

Orthologs
for GTF2H4 gene

Paralogs
for GTF2H4 gene

Genomic Variants
for GTF2H4 gene

Disorders & Mutations
for GTF2H4 gene

Medical News
for GTF2H4 gene

Publications
for GTF2H4 gene

External Searches for GTF2H4 gene

Genome Databases showing GTF2H4 gene

Other Databases showing GTF2H4 gene

Specialized Databases showing GTF2H4 gene

Intellectual Property
for GTF2H4 gene

Products
for GTF2H4 gene

View Random Gene

Advanced Search

Export list of displayed genes

GTF2H4 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor GTF2H4 gene

Summariesfor GTF2H4 gene

Genomic Viewsfor GTF2H4 gene

Proteinsfor GTF2H4 gene

Protein Domains/Familiesfor GTF2H4 gene

Gene Functionfor GTF2H4 gene

Pathways & Interactionsfor GTF2H4 gene

Drugs & Compoundsfor GTF2H4 gene

Transcriptsfor GTF2H4 gene

Expression for GTF2H4 gene

Orthologsfor GTF2H4 gene

Paralogsfor GTF2H4 gene

Genomic Variantsfor GTF2H4 gene

Disorders & Mutationsfor GTF2H4 gene

Medical Newsfor GTF2H4 gene

Publicationsfor GTF2H4 gene

External Searches for GTF2H4 gene

Genome Databases showing GTF2H4 gene

Other Databases showing GTF2H4 gene

Specialized Databases showing GTF2H4 gene

Intellectual Propertyfor GTF2H4 gene

Productsfor GTF2H4 gene

View Random Gene

Aliases &
Descriptions
for GTF2H4 gene

Summaries
for GTF2H4 gene

Genomic Views
for GTF2H4 gene

Proteins
for GTF2H4 gene

Protein Domains/
Families
for GTF2H4 gene

Gene Function
for GTF2H4 gene

Pathways & Interactions
for GTF2H4 gene

Drugs & Compounds
for GTF2H4 gene

Transcripts
for GTF2H4 gene

Expression
for GTF2H4 gene

Orthologs
for GTF2H4 gene

Paralogs
for GTF2H4 gene

Genomic Variants
for GTF2H4 gene

Disorders & Mutations
for GTF2H4 gene

Medical News
for GTF2H4 gene

Publications
for GTF2H4 gene

Intellectual Property
for GTF2H4 gene

Products
for GTF2H4 gene