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GTPBP4 Gene

protein-coding   GIFtS: 55

GC10P000973
GTP binding protein 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
GTP binding protein 41 2     Chronic renal failure gene protein2 3
NOG11 2 3     GTP-binding protein NGB2 3
CRFG1 2 3     FLJ397742
NGB1 2     G protein-binding protein CRFG2
FLJ106861 2     nucleolar GTP-binding protein 12
FLJ106901 2     

External Ids:    HGNC: 215351   Entrez Gene: 235602   Ensembl: ENSG000001079377   UniProtKB: Q9BZE43   

Export aliases for GTPBP4 gene to outside databases

Previous GC identifers: GC10P001024 GC10P000988


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GTPBP4:
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP
is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal
to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor
changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their
GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it
back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and
deliver its message for a prolonged period to its downstream target. (provided by RefSeq)

UniProtKB/Swiss-Prot: NOG1_HUMAN, Q9BZE4
Function: Involved in the biogenesis of the 60S ribosomal subunit (By similarity)

Gene Wiki entry for GTPBP4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GTPBP4 gene promoter:
         POU2F1   RORalpha2   Nkx6-1   Meis-1   HOXA9B   ISGF-3   FOXL1   C/EBPalpha   CUTL1   STAT3   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for GTPBP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for GTPBP4 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15-p14   Ensembl cytogenetic band:  10p15.3   HGNC cytogenetic band: 10p15-p14

GTPBP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GTPBP4 gene location

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P000973:  view genomic region     (about GC identifiers)

Start:
973,776 bp from pter
End:
1,003,177 bp from pter
Size:
29,402 bases
Orientation:
plus strand

1 alternative location:
Chr10+ 1,034,338-1,065,876     
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: NOG1_HUMAN, Q9BZE4 (See protein sequence)
Recommended Name: Nucleolar GTP-binding protein 1  
Size: 634 amino acids; 73964 Da
Subcellular location: Nucleus, nucleolus
Secondary accessions: O95446 Q5T3R8 Q9NVJ8

Explore the universe of human proteins at neXtProt for GTPBP4: NX_Q9BZE4 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_036473.2  

    ENSEMBL proteins: 
    ENSP00000354040 ENSP00000353168 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: GTPBP4
    GenScript Custom Purified and Recombinant Proteins Services for GTPBP4 
    Novus Biologicals Protein for GTPBP4
    Novus Biologicals Lysates for GTPBP4
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular ----
    GO:0005634 nucleus IDA17210637
    GO:0005730 nucleolus IEA--
    GO:0005737 cytoplasm IDA17210637
    GO:0048471 perinuclear region of cytoplasm IDA17210637
    About this table

    GTPBP4 for ontologies           About GeneDecksing



    Antibodies for GTPBP4: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for GTPBP4
    Browse R&D Systems for Antibodies
    OriGene Antibodies: GTPBP4
    GenScript Custom Superior Antibodies Services for GTPBP4 
    Novus Biologicals Antibodies for GTPBP4
    Epitomics antibodies for GTPBP4

    Assays for GTPBP4: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GTPBP4 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for GTPBP4 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GTPBP4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR005225 Small_GTP-bd
     IPR010674 NOG1_GTP-bd
     IPR006073 GTP1_OBG
     IPR012973 NOG_C

    Graphical View of Domain Structure for InterPro Entry Q9BZE4

    ProtoNet protein and cluster: Q9BZE4

    3 Blocks protein families:
    IPB002917 GTP-binding protein
    IPB006073 GTP1/OBG GTP-binding protein family signature
    IPB010674 Nucleolar GTP-binding 1


    UniProtKB/Swiss-Prot: NOG1_HUMAN, Q9BZE4
    Similarity: Belongs to the GTP1/OBG family. NOG subfamily


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: NOG1_HUMAN, Q9BZE4
    Function: Involved in the biogenesis of the 60S ribosomal subunit (By similarity)

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for GTPBP4
    Sigma-Aldrich shRNA for GTPBP4
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): GTPBP4
    OriGene shRNA RFP (see all 2): GTPBP4
    OriGene basic RS shRNA (see all 2): GTPBP4
    OriGene siRNA: GTPBP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GTPBP4 
    miRNA:Sigma-Aldrich microRNA Mimics for GTPBP4
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GTPBP4 
    1 SABiosciences Assays for microRNA that regulate GTPBP4:
    hsa-miR-545

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: GTPBP4
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GTPBP4
    OriGene untagged cDNA clones in CMV expression vector (see all 2): GTPBP4
    OriGene 3'-UTR clone: GTPBP4 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: GTPBP4 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for GTPBP4 

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003924 GTPase activity IDA17210637
    GO:0005515 protein binding IPI17210637
    GO:0005525 GTP binding IDA17210637
    About this table

    GTPBP4 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for GTPBP4 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GTPBP4

    5/574 Interacting proteins for GTPBP4 (ENSP000003531683 Q9BZE41, 2) via UniProtKB, MINT, and/or STRING (see all 574)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF6P565371STRING: ENSP00000363574 EBI-1056249,EBI-372243
    LYARQ9NX581EBI-1056249,EBI-713507
    NF2P352401EBI-1056249,EBI-1014472
    PINX1Q96BK51EBI-1056249,EBI-721782
    ABCF1Q8NE712MINT-7945693
    About this table

    5/11 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 11):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079 regulation of cyclin-dependent protein kinase activity IDA17210637
    GO:0007264 small GTPase mediated signal transduction ----
    GO:0008156 negative regulation of DNA replication IMP17210637
    GO:0008285 negative regulation of cell proliferation IMP17210637
    GO:0015031 protein transport ----
    About this table

    GTPBP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GTPBP4


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for GTPBP4
    Sigma-Aldrich shRNA for GTPBP4
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): GTPBP4
    OriGene shRNA RFP (see all 2): GTPBP4
    OriGene basic RS shRNA (see all 2): GTPBP4
    OriGene siRNA: GTPBP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GTPBP4 
    miRNA: Sigma-Aldrich microRNA Mimics for GTPBP4
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GTPBP4 
    1 SABiosciences Assays for microRNA that regulate GTPBP4:
    hsa-miR-545
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: GTPBP4
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GTPBP4
    OriGene untagged cDNA clones in CMV expression vector (see all 2): GTPBP4
    OriGene 3'-UTR Clone: GTPBP4 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: GTPBP4 
    Primers: OriGene genome-wide validated SYBR primer pairs: GTPBP4
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for GTPBP4: PPH14539A

    REFSEQ mRNAs for GTPBP4 gene: 

    NM_012341.2  

    Additional cDNA sequence: 

    AF120334.1 AF325353.1 AK001548.1 AK001552.1 AK097093.1 AK126769.1 AK222861.1 AK295231.1 
    AK301721.1 AK302219.1 BC008683.1 BC021243.2 BC033784.1 BC038975.2 CR613289.1 

    10 DOTS entries:

    DT.446676  DT.100793039  DT.121275758  DT.95272319  DT.121275655  DT.100702798  DT.121275763  DT.448603 
    DT.121275725  DT.75197811 

    24/306 AceView cDNA sequences (see all 306):

    BM978586 BM683894 AU130103 AW576508 BM782273 AI540513 CR613289 AA598422 
    CN484082 BM746603 AI762903 CB110624 CB137547 BI756794 BU186693 AW274978 
    T51116 BG251553 T51024 BU633657 CB140332 BC021243 BM471989 AV709054 

    highest scoring ESTs for GTPBP4:

    AW008363 AA091109 AA173591 AA419438 AA419439 AA699430 AA736763 AA765257 AA767083 AA769068 

    Unigene Cluster for GTPBP4:

    GTP binding protein 4
    Hs.215766  [show with all ESTs]
    Unigene Representative Sequence: AK126769


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GTPBP4 (see all 6)

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b
    SP1:              -                       -                                         -                 -           -                                 
    SP2:              -           -                                                     -                 -                                             
    SP3:                                                                                                                                                
    SP4:              -                                                                                                                                 
    SP5:                                                                                                                                                

    About this scheme

    ECgene alternative splicing isoforms for GTPBP4
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483839 ENST00000360803(uc001ift.2 uc001ifu.2 uc010qad.1 uc010qae.1)
    ENST00000491635(uc010qac.1) ENST00000360059 ENST00000491261

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    GTPBP4 expression in normal and diseased human tissues

    1  / 2  / 3

    10 probe-sets matching GTPBP4 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    49472_at2, 3 U95-B 1 0.94 1.00 0.86 1.25 AW008363 1.00 0.90 0.95 1
    47538_at2, 3 U95-B 2 0.38 0.50 0.27 0.76 AI923217 0.60 0.50 0.55 1
    218239_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_012341 0.60 0.83 0.73 1
    218238_at2, 3 U133-A 1 0.82 1.00 -- -- NM_012341 0.60 0.83 0.73 1
    217631_at2, 3 U133-A 1 0.46 1.00 -- -- AI081107 0.40 0.38 0.39 2
    228002_at2, 3 U133-B 2 0.27 0.50 -- -- AI814569 0.40 0.50 0.45 1
    218239_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    218238_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    217631_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    228002_at2 U133Plus2 2 0.27 0.50 -- -- -- -- -- -- --
    About this table

    GTPBP4 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    GTPBP4 gene expression
    GTPBP4 gene electronic northern expression
    GTPBP4 gene sage expression
    About these images

    CGAP SAGE TAG: AAATTGGAGC

    SOURCE GeneReport for Unigene cluster: Hs.215766
    Primers: OriGene genome-wide validated SYBR primer pairs: GTPBP4
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for GTPBP4: PPH14539A
        SABiosciences Custom PCR Arrays for GTPBP4 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for GTPBP4 gene from 5/23 species (see all 23)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    GTPBP41   -- GTP binding protein 4 86.11(n)
    93.59(a)
    478021  XM_535203.2  XP_535203.2 
    cow
    (Bos taurus)
    GTPBP41   -- GTP binding protein 4 86.01(n)
    93.85(a)
    524743  XM_603075.3  XP_603075.3 
    rat
    (Rattus norvegicus)
    Gtpbp41   -- GTP binding protein 4 85.44(n)
    90.69(a)
    114300  NM_053689.1  NP_446141.1 
    mouse
    (Mus musculus)
    Gtpbp41 , 5 13 (3.64 cM)5
    GTP binding protein 41, 5 88.96(n)1
    94.79(a)1
    692371  NM_027000.31  NP_081276.21 
     AF3253545  AF3482085  (see all 18)
    chicken
    (Gallus gallus)
    GTPBP41   -- GTP binding protein 4 78.55(n)
    86.53(a)
    420458  NM_001006354.1  NP_001006354.1 
    About this table        Species with no ortholog for GTPBP4

    ENSEMBL Gene Tree for GTPBP4 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/499 NCBI SNPs in GTPBP4 are shown (see all 499)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs145851,2
    --1063474(-) GAAAAA/TAAGGT 1 -- ut310--------
    rs12508831,2
    C,H,1034216(-) GGGCCC/TCAGGA 1 -- ng519Minor allele frequency- T:0.00EA NA MN 250
    rs12508841,2
    C1034058(-) GGAGGG/ATCCGG 1 -- ng514Minor allele frequency- A:0.05EA NA MN 246
    rs12508861,2
    C,F,A,H,1044320(-) attcaC/Tgcctg 1 -- int110Minor allele frequency- T:0.40NA WA 72
    rs12508871,2
    C,F,A,1043058(-) GGCCTG/ATGGTG 1 -- int116Minor allele frequency- A:0.01NS EA NA WA 910
    rs12508881,2
    C,H,1042502(-) CAAGTA/GTTTTT 1 -- int16Minor allele frequency- G:0.02NA WA 60
    rs12508891,2
    C,F,1042462(-) AGCCAC/GCTTAG 1 -- int14Minor allele frequency- G:0.01NS EA 418
    rs12508901,2
    --1040220(-) caaaaC/Taaaca 1 -- int10--------
    rs12508911,2
    C,A,1040159(-) AGGTAC/GTCTCT 1 -- int15Minor allele frequency- G:0.13NA WA 128
    rs15391751,2
    C,F1033880(-) CGCGCG/TTGGGA 1 -- ng515Minor allele frequency- T:0.00MN NS EA 602
    About this table

    HapMap Linkage Disequilibrium images for GTPBP4 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for GTPBP4
         1 CNV: 65561
         1 Indel: 100824

    QIAGEN SeqTarget long-range PCR primers for resequencing GTPBP4 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GTPBP4 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: GTPBP4 (1 document)

    Export disorders and mutations for GTPBP4 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/21 PubMed articles for GTPBP4 gene, integrated from 7 sources (see all 21):
    (articles sorted by number of sources associating them with GTPBP4)
    1. Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease. (PubMed id 11316846)1, 2, 3 Laping N.J.... Zhu Y. (2001)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    6. A genome-scale protein interaction profile of Drosoph ila p53 uncovers additional nodes of the human p53 network. (PubMed id 20308539)1 Lunardi A....Collavin L. (2010)
    7. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
    10. Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis. (PubMed id 19007248)2 Wang B.... Korner R. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23560 HGNC: 21535 AceView: GTPBP4 Ensembl:ENSG00000107937 euGenes: HUgn23560
    ECgene: GTPBP4 H-InvDB: GTPBP4

    (According to HUGE)
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      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for GTPBP4 gene:
    Search GeneIP for patents involving GTPBP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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     Regulatory tfbs in GTPBP4 promoter
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     ELISAs and CLIAs for GTPBP4
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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