Aliases &
Descriptions
for GUCA1C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| guanylate cyclase activator 1C1 2 3 | | MGC1201592 | | GCAP31 2 3 5 | | OTTHUMP000002143392 | | GCAP 32 3 | | guanylyl cyclase-activating protein 32 | | MGC1201582 | | |
Export aliases for GUCA1C gene to outside databasesPrevious GC identifers: GC03M105420 GC03M108154 GC03M109907 GC03M109948 GC03M109949 GC03M110109 GC03M108626 |
Summaries
for GUCA1C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: GUC1C_HUMAN, O95843Function: Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylylcyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC)is a key event in recovery of the dark state of rod photoreceptors following light exposure
|
Genomic Views
for GUCA1C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GUCA1C gene promoter:
IRF-7A STAT5A Pax-6 STAT5B RP58 AhR Arnt Cart-1 POU2F1 POU3F2
Other transcription factors
Search SABiosciences Chromatin IP Primers for GUCA1C
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q13.1 Ensembl cytogenetic band: 3q13.13 HGNC cytogenetic band: 3q13.1GUCA1C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M106000: view genomic region
(about GC identifiers)
Start:
|
106,000,289 bp from pter |
End:
|
106,046,248 bp from pter |
Size:
|
45,960 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr3- 108,626,639-108,672,742 |
RefSeq DNA sequence:- NC_000003.11 NT_005612.16
|
Proteins
for GUCA1C gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: GUC1C_HUMAN, O95843 (See
protein sequence)Recommended Name: Guanylyl cyclase-activating protein 3 Size: 209 amino acids; 23822 Da
Miscellaneous: Binds three calcium ions (By similarity)
PDB structures from  and Proteopedia  :2GGZ (3D)
Secondary accessions: O95844 Q9UNM0Alternative splicing: 2 isoforms: O95843-1 O95843-2 Explore the universe of human proteins at neXtProt for GUCA1C: NX_O95843
REFSEQ proteins: NP_005450.3
ENSEMBL proteins: ENSP00000261047 ENSP00000417761 ENSP00000377535
Human Recombinant Proteins
Antibodies for GUCA1C:
Assays for GUCA1C: |
Protein
Domains/
Families
for GUCA1C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GUCA1C for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry O95843ProtoNet protein and cluster: O95843 UniProtKB/Swiss-Prot: GUC1C_HUMAN, O95843Similarity: Contains 4 EF-hand domains |
Gene Function
for GUCA1C gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: GUC1C_HUMAN, O95843Function: Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylylcyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC)is a key event in recovery of the dark state of rod photoreceptors following light exposure
Genatlas biochemistry entry for GUCA1C:guanylate cyclase activating protein 1C,specifically expressed in phosphoreceptors2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- | | GO:0008048 | calcium sensitive guanylate cyclase activator activity |
TAS | 10037746 |
About this table
GUCA1C for ontologies About GeneDecksing
|
Pathways & Interactions
for GUCA1C gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
GUCA1C for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for GUCA1C
2  Kegg Pathways (Kegg details for GUCA1C):
SABiosciences Custom Pathway-Focused PCR Arrays for GUCA1C
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GUCA1C
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GUCA1C
5/7 Interacting proteins for GUCA1C (ENSP000002610473) via UniProtKB, MINT, and/or STRING (see all 7)About this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
GUCA1C for ontologies About GeneDecksing
|
Drugs & Compounds
for GUCA1C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
GUCA1C for compounds About GeneDecksing
 Browse Tocris compounds for GUCA1C
1  Novoseek chemical compound relationship for GUCA1C gene
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| guanylate |
58.7 |
2 |
15486694 (1), 11860507 (1) |
About this table
|
Transcripts
for GUCA1C gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for GUCA1C gene: NM_005459.3 Additional cDNA sequence: AF110002.1 AF110003.1 BC103993.1 BC103994.1 3 DOTS entries: DT.95362461 DT.432360 DT.100748097 24/26 AceView cDNA sequences (see all 26): AI917103 C20850 BM695917 BU726199 AW963468 AA365180 BM663382 BX282721 AF110003 BM704487 AW337860 NM_005459 AA364464 BU736658 AI969019 AA364442 BM666986 AF110002 BU160027 AA365179 AW594508 AV732101 BM685830 BG217579
 highest scoring ESTs for GUCA1C:AA364442 AF110002 AF110003 AI917103 AV732101 BM695917 BX282721 AA364464 AA365179 AA365180 Unigene Cluster for GUCA1C: Guanylate cyclase activator 1C Hs.233363 [show with all ESTs]Unigene Representative Sequence: NM_005459
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for GUCA1C
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b |
|---|
|
| SP1: | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for GUCA1C
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000261047(uc003dxj.2 uc003dxk.2) ENST00000471108 ENST00000393963
|
Expression
for GUCA1C gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| GUCA1C expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching GUCA1C gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 87700_at2, 3
|
U95-E |
1 |
0.62 |
1.00 |
1.00 |
1.00 |
AI917103 |
0.80 |
1.00 |
0.91 |
1 |
| 223928_s_at2, 3
|
U133-B |
1 |
0.91 |
1.00 |
-- |
-- |
AF110002 |
0.80 |
1.00 |
0.91 |
1 |
| 223928_s_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
GUCA1C for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.233363
UniProtKB/Swiss-Prot: GUC1C_HUMAN, O95843Tissue specificity: Retina
SABiosciences Custom PCR Arrays for GUCA1C
|
Orthologs
for GUCA1C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GUCA1C gene from 3 species
About this table Species with no ortholog for GUCA1C
ENSEMBL Gene Tree for GUCA1C (if available) |
Paralogs
for GUCA1C gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for GUCA1C gene
- EFCAB12 GUCA1B2 GUCA1A2
GUCA1C for paralogs About GeneDecksing
|
Genomic Variants
for GUCA1C gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 3 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for GUCA1C (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for GUCA1C
2 CNVs: 50899 98399 | | QIAGEN SeqTarget long-range PCR primers for resequencing GUCA1C |
|
Disorders & Mutations
for GUCA1C gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GUCA1C for disorders About GeneDecksing
OMIM: 605128
Export disorders and mutations for GUCA1C gene to outside databases
|
Medical News
for GUCA1C gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for GUCA1C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
6 PubMed articles for GUCA1C gene integrated from 7 sources:
(articles sorted by number of sources associating them with GUCA1C)- Molecular characterization of a third member of the guanylyl cyclase- activating protein subfamily. (PubMed id 10037746)1, 2, 3, 7 Haeseleer F.... Palczewski K. (1999)
- Characterization of retinal guanylate cyclase-activat ing protein 3 (GCAP3) from zebrafish to man. (PubMed id 11860507)1, 3, 7 Imanishi Y....Palczewski K. (2002)
- The crystal structure of GCAP3 suggests molecular mechanism of GCAP- linked cone dystrophies. (PubMed id 16626734)1, 2 Stephen R.... Sousa M.C. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes). (PubMed id 15486694)7 Imanishi Y....Baehr W. (2004)
- GCAPs: Ca2+-sensitive regulators of retGC. (PubMed id 12596930)7 Gorczyca W.A. and Sokal I. (2002)
|
External Searches for GUCA1C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GUCA1C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GUCA1C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GUCA1C gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for GUCA1C gene:
Search GeneIP for patents involving GUCA1C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GUCA1C gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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