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GZMB Gene

protein-coding GIFtS: 64

GC14M005214

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: CTLA1, CSPB)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)¹ ²		T-cell serine protease 1-3E² ³
CGL1¹ ² ³		C11² ³
CTSGL1¹ ² ³		CTLA-1² ³
SECT¹ ² ³		granzyme B²
HLP¹ ² ³		OTTHUMP00000028189²
CTLA1² ³ ⁵		fragmentin 2²
CSPB² ³ ⁵		fragmentin-2²
CCPI¹ ²		granzyme-2²
CGL-1¹ ²		cytotoxic serine protease B²
CSP-B¹ ²		Granzyme-2³
Lymphocyte protease² ³		Fragmentin-2³
Cytotoxic T-lymphocyte proteinase 2² ³		GRB³
Cathepsin G-like 1² ³		EC 3.4.21.79³
Human lymphocyte protein² ³

External Ids:	HGNC: 4709¹	Entrez Gene: 3002²	Ensembl: ENSG00000100453⁷	UniProtKB: P10144³

Export aliases for GZMB gene to outside databases

Previous GC identifers: GC14M022472 GC14M018887 GC14M023090 GC14M024170 GC14M025100

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GZMB:

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse

specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself'

antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by

this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

(provided by RefSeq)

UniProtKB/Swiss-Prot: GRAB_HUMAN, P10144

Function: This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems

to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis

execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis

summary for GZMB:

Caspases (short for 'cysteinyl aspartate proteases') are involved in the signal transduction pathways of

apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and

effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with,

upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector

caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the

executioner caspases. More than 400 caspase substrates have so far been identified (see The Caspase

Substrate Database). Initiator caspases, such as caspase 8, may be directly activated by death receptors

such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For

example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form

part of the inflammasome, a key part of cytokine processing during inflammation. Caspases are regulated by

inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of

many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory

disease.

Gene Wiki entry for GZMB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GZMB gene promoter:
         CREB   deltaCREB   IRF-7A   STAT5A   c-Rel   MRF-2   AREB6   SRF   RREB-1   c-Jun
         Other transcription factors

Search SABiosciences Chromatin IP Primers for GZMB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q12 HGNC cytogenetic band: 14q11.2

GZMB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GZMB gene location

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M005214: view genomic region (about GC identifiers)

Start:	5,214,872 bp from pter
End:	5,218,144 bp from pter
Size:	3,273 bases
Orientation:	minus strand

1 alternative location:

Chr14- 25,100,161-25,103,473

RefSeq DNA sequence:

NC_000014.8 NT_026437.12

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: GRAB_HUMAN, P10144 (See protein sequence)

Recommended Name: Granzyme B precursor

Size: 247 amino acids; 27688 Da

Subcellular location: Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer

cells

PDB structure from and Proteopedia :

1FQ3 (3D)

1IAU (3D)

Secondary accessions: Q8N1D2 Q9UCC1

Explore the universe of human proteins at neXtProt for GZMB: NX_P10144

REFSEQ proteins: NP_004122.2

ENSEMBL proteins:

ENSP00000216341 ENSP00000387385 ENSP00000371979 ENSP00000371980 ENSP00000371982

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for GZMB (Granzyme B)
	Enzo Life Sciences proteins for GZMB
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: GZMB
	GenScript Custom Purified and Recombinant Proteins Services for GZMB
	Novus Biologicals Proteins for GZMB
	Novus Biologicals Lysates for GZMB
	Sino Biological Recombinant Protein for GZMB
	Browse ProSpec Recombinant Proteins

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001772	immunological synapse	TAS	12524539
GO:0005634	nucleus	TAS	11909973
GO:0005737	cytoplasm	IDA	18029348
GO:0005829	cytosol	EXP	11114298
GO:0043231	intracellular membrane-bounded organelle	IDA	18029348

About this table

GZMB for ontologies About GeneDecksing

Antibodies for GZMB:

	Millipore Mono- and Polyclonal Antibodies for the study of GZMB
	Sigma-Aldrich Antibody Arrays and Antibodies for GZMB
	R&D Systems Antibodies for GZMB (Granzyme B)
	Cell Signaling Technology (CST) Antibodies for GZMB (Granzyme B)
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for GZMB
	Novus Biologicals Antibodies for GZMB
	Browse antibodies at Epitomics

Assays for GZMB:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development OriGene Fluorogenic Cell Assay Kit: GZMB
	R&D Systems ELISpot Kits & Development Modules for GZMB (Granzyme B)
	GenScript Custom Assay Services for GZMB
	Enzo Life Sciences assays for GZMB
	Uscn ELISAs and CLIAs for GZMB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GZMB for domains About GeneDecksing

4 InterPro domains/families:

IPR001314 Peptidase_S1A

IPR001254 Peptidase_S1_S6

IPR018114 Peptidase_S1/S6_AS

IPR009003 Ser/Cys_Pept_Trypsin-like

Graphical View of Domain Structure for InterPro Entry P10144

ProtoNet protein and cluster: P10144

2 Blocks protein families:

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

UniProtKB/Swiss-Prot: GRAB_HUMAN, P10144

Similarity: Belongs to the peptidase S1 family. Granzyme subfamily

Similarity: Contains 1 peptidase S1 domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: GRAB_HUMAN, P10144

Function: This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems

to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis

execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis

Catalytic activity: Preferential cleavage: -Asp- -Xaa- >> -Asn- -Xaa- > -Met- -Xaa-, -Ser- -Xaa-

Enzyme regulation: Inactivated by the serine protease inhibitor diisopropylfluorophosphate

Induction: By staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes

Enzyme Number (IUBMB): EC 3.4.21.79

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for GZMB Sigma-Aldrich shRNA Panels and shRNA for GZMB
		OriGene 29mer shRNA kits in GFP-retroviral vector: GZMB OriGene shRNA RFP: GZMB OriGene basic RS shRNA: GZMB OriGene siRNA: GZMB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GZMB

miRNA:		Sigma-Aldrich microRNA Mimics for GZMB Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GZMB
		Search SABiosciences for Assays for microRNAs that regulate GZMB

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: GZMB OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GZMB OriGene untagged cDNA clones in CMV expression vector: GZMB OriGene 3'-UTR clone: GZMB Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for GZMB
		Sino Biological Human cDNA Clone for GZMB

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for GZMB

Genatlas biochemistry entry for GZMB:

cytotoxic T-lymphocyte-associated granule serine protease 1,also expressed in lymphokine activated killer (LAK) and

natural killer (NK) cells (cathepsin G-like 1) (see SPAS@)

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0004252	serine-type endopeptidase activity	TAS	12524539
GO:0005515	protein binding	IPI	11911826
GO:0008233	peptidase activity	IEA	--
GO:0008236	serine-type peptidase activity	TAS	2402757

About this table

GZMB for ontologies About GeneDecksing

Animal Models: 5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Gzmb):

hematopoietic system

homeostasis/metabolism

immune system

life span-post-weaning/aging

tumorigenesis

GZMB for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

GZMB for pathways About GeneDecksing

5/8 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for GZMB (see all 8)

	Granzyme B Signaling
	Graft-versus-Host Disease Signaling
	Lysine Degradation
	Allograft Rejection Signaling
	Type I Diabetes Mellitus Signaling

5 Kegg Pathways (Kegg details for GZMB):

	hsa04650 Natural killer cell mediated cytotoxicity
	hsa04940 Type I diabetes mellitus
	hsa05320 Autoimmune thyroid disease
	hsa05330 Allograft rejection
	hsa05332 Graft-versus-host disease

SABiosciences Pathway-Focused PCR Arrays including GZMB: PAHS-068A PAHS-074A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for GZMB

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GZMB

5/20 Interacting proteins for GZMB (ENSP00000371982³ P10144^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRF1	P14222¹	STRING: ENSP00000362305 EBI-2505785,EBI-724466
SRGN	P10124¹	STRING: ENSP00000242465 EBI-2505785,EBI-744915
ELANE	P08246²	MINT-6803398
CASP10	ENSP00000286186³	STRING: ENSP00000286186
IL12A	ENSP00000303231³	STRING: ENSP00000303231

About this table

5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0006915	apoptosis	TAS	--
GO:0006922	cleavage of lamin	IDA	11331782
GO:0008629	induction of apoptosis by intracellular signals	TAS	--
GO:0008633	activation of pro-apoptotic gene products	TAS	--

About this table

GZMB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

GZMB for compounds About GeneDecksing

Sigma-Aldrich Small Molecules for GZMB:

Small Molecule - Substrate

Enzo Life Sciences drugs & compounds for GZMB

Compounds for GZMB available from Tocris Bioscience

Compound	Action	CAS number
Ac-IEPD-AFC	Fluorogenic granzyme B substrate	--

About this table

10/59 Novoseek chemical compound relationships for GZMB gene (see all 59)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
serine	70.6	111	11562487 (2), 12792516 (2), 8626751 (2), 8601703 (2) (see all 80)
concanamycin a	68.1	3	12199864 (1), 11502983 (1)
[alcl]	67.6	8	10396241 (2), 11237071 (1), 18323280 (1), 9028330 (1) (see all 7)
3,4-dichloroisocoumarin	59.7	3	8760815 (1), 9036942 (1)
itcl	58	2	9349234 (2)
mannose 6-phosphate	41.6	14	16280358 (5), 18220730 (1), 15528317 (1), 11081635 (1) (see all 6)
ponasterone a	38.3	1	15367364 (1)
clostripain	35.5	1	14697268 (1)
z-vad-fmk	34.1	1	11050075 (1)
cysteine	25.9	16	8631895 (2), 11278459 (1), 15029525 (1), 8663294 (1) (see all 13)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for GZMB Sigma-Aldrich shRNA Panels and shRNA for GZMB
		OriGene 29mer shRNA kits in GFP-retroviral vector: GZMB OriGene shRNA RFP: GZMB OriGene basic RS shRNA: GZMB OriGene siRNA: GZMB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of GZMB

miRNA:		Sigma-Aldrich microRNA Mimics for GZMB Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of GZMB
		Search SABiosciences for Assays for microRNAs that regulate GZMB

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: GZMB OriGene Myc/DDK tagged cDNA clones in CMV expression vector: GZMB OriGene untagged cDNA clones in CMV expression vector: GZMB OriGene 3'-UTR Clone: GZMB Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for GZMB

Primers:		OriGene genome-wide validated SYBR primer pairs: GZMB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for GZMB: PPH02594A

REFSEQ mRNAs for GZMB gene:

NM_004131.4

Additional cDNA sequence:

AY232655.1 AY232656.1 AY372494.1 BC030195.1 J03189.1 J04071.1

3 DOTS entries:

DT.410314 DT.97839362 DT.95233859

24/48 AceView cDNA sequences (see all 48):

BE502328 BM917944 BM923149 NM_004131 BC030195 BQ012224 AW817157 BM987823

BI909392 AY372494 BI833067 J04071 BM561748 J03189 CF528868 BE502557

CB528665 BU603175 AY232654 BI907734 M17016 AA381640 BU600317 BF589964

highest scoring ESTs for GZMB:

AA381074 AA381640 AW960218 AY232654 AY232655 BC030195 BI832941 BI833067 BI836851 BM561748

Unigene Cluster for GZMB:

Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

Hs.1051 [show with all ESTs]

Unigene Representative Sequence: BQ052893

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for GZMB

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4	^	5a	·	5b	·	5c
SP1:							-
SP2:
SP3:							-				-

About this scheme

ECgene alternative splicing isoforms for GZMB
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000216341(uc001wps.2 uc010ama.2 uc010amb.2) ENST00000415355

ENST00000382539 ENST00000382540 ENST00000382542

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

GZMB expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching GZMB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37137_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M17016	0.80	1.00	0.91	1
210164_at²^{, 3}	U133-A	1	1.00	1.00	--	--	J03189	0.80	1.00	0.91	1
210164_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

GZMB for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

GZMB gene electronic northern expression

About these images

CGAP SAGE TAG: AAACGCTACT

SOURCE GeneReport for Unigene cluster: Hs.1051

Expression variation in blood from EXPOLDB for GZMB

Primers:		OriGene genome-wide validated SYBR primer pairs: GZMB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for GZMB: PPH02594A

SABiosciences Expression via Pathway-Focused PCR Arrays including GZMB: PAHS-068A PAHS-074A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GZMB gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GZMB¹	--	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated more	77.44(n) 71.18(a)	490630 XM_547752.2 XP_547752.2
chimpanzee (Pan troglodytes)	GZMB¹	--	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated more	98.52(n) 97.57(a)	452825 XM_509879.2 XP_509879.2
cow (Bos taurus)	GZMB¹	--	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated more	79.51(n) 72.54(a)	508646 XM_585453.3 XP_585453.2
mouse (Mus musculus)	Gzmb^{1 , 5}	14 (28.19 cM)⁵	granzyme B^{1, 5}	75.78(n)¹ 68.16(a)¹	14939¹ NM_013542.2¹ NP_038570.1¹ AI553453⁵ AK157856⁵ (see all 11)

About this table Species with no ortholog for GZMB

ENSEMBL Gene Tree for GZMB (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GZMB gene

GZMH² CMA1² CTSG²

GZMB for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs985931^1,2	C,	25105341(+)	`gaaaaA/Gtaata`	1	--	ng5¹		3	NS NA	188
rs1126639^1,2	C,F,H	25101548(-)	`TCCAAC/TGACAT`	2	N	ref¹ syn¹		8	NS EA NA WA	498
rs2236337^1,2	C,F,O,	25100247(+)	`TTCATT/CACAGC`	1	--	ut3¹		13	EA NA NS WA	2266
rs2236338^1,2	C,F,O,	25100282(+)	`TTAGTA/GGCGTT`	2	H Y	mis¹ ref¹		19	EA NA NS WA	2848
rs2273843^1,2	C,	25103409(+)	`TTTCCT/CCCTTG`	1	--	ut5¹ ese³ trp³		4	NA EA WA	212
rs2273844^1,2	C,F,A,	25103414(+)	`TCCTTG/ACTCTC`	1	--	ut5¹		18	NA NS EA WA	1184
rs6573910^1,2	C,F,A,	25100882(+)	`GCCTCC/TTGGTA`	1	--	int¹		20	NA NS EA WA	1210
rs6573911^1,2	C,F,A,	25100933(+)	`CCCCTC/TTTCTC`	1	--	int¹ trp³		19	NA NS EA WA	1198
rs7144366^1,2	C,F,A,	25103662(+)	`GTGAAC/TTGTAG`	1	--	ng5¹		106	EA NS NA PA EU CA WA	6896
rs8012846^1,2	C,F,A,	25105151(+)	`ttaacC/Tatttt`	1	--	ng5¹ tfbs³		1	WA	50

About this table

HapMap Linkage Disequilibrium images for GZMB (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GZMB: --

QIAGEN SeqTarget long-range PCR primers for resequencing GZMB

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GZMB for disorders About GeneDecksing

OMIM: 123910

10/93 Novoseek disease relationships for GZMB gene (see all 93)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma t-cell	77.2	15	17260002 (3), 9349234 (1), 12688326 (1), 9409191 (1) (see all 11)
lymphoma t-cell peripheral	71.8	1	16160469 (1)
anaplastic large cell lymphoma	67.9	1	18324919 (1)
tumors	57.6	129	11413524 (3), 16497444 (3), 15843372 (2), 16452233 (2) (see all 92)
lymphoma	57.6	51	11413524 (5), 9409191 (3), 14616965 (2), 10368677 (2) (see all 30)
toxic epidermal necrolysis	52.6	2	18409354 (1), 17008937 (1)
lymphomatoid papulosis	50.1	3	10672058 (1), 10233858 (1), 9347791 (1)
stevens-johnson syndrome	50	2	18409354 (1), 17008937 (1)
necrosis	46.9	48	9250156 (2), 17260002 (2), 17258890 (2), 15855326 (1) (see all 42)
lymphoma large cell	45.4	3	10492036 (1), 14712286 (1)

About this table

Human Gene Mutation Database (HGMD): GZMB
Human Genome Epidemiology (HuGE) Navigator: GZMB (12 documents)

Export disorders and mutations for GZMB gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/828 PubMed articles for GZMB gene, integrated from 7 sources (see all 828):
(articles sorted by number of sources associating them with GZMB)

Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14. (PubMed id 2323780)^{1, 2, 3} Dahl C.A.... Cairns J.S. (1990)
The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1. (PubMed id 11325591)^{1, 2, 7} Rotonda J.... Becker J.W. (2001)
Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue. (PubMed id 11209755)^{1, 2, 7} Estebanez-Perpina E.... Bode W. (2000)
Nucleotide sequence and genomic organization of a human T lymphocyte serine protease gene. (PubMed id 2365998)^{1, 2, 7} Caputo A.... Rowe P.B. (1990)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population. (PubMed id 12721789)^{1, 2} Saito S....Nakamura Y. (2003)
Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity. (PubMed id 1985927)^{1, 2} Poe M....Zweerink H.J. (1991)
Structural organization of the hCTLA-1 gene encoding human granzyme B. (PubMed id 2332171)^{1, 2} Haddad P.... Mathieu-Mahul D. (1990)
Genomic organization and chromosomal assignment for a serine protease gene (CSPB) expressed by human cytotoxic lymphocytes. (PubMed id 2788607)^{1, 2} Klein J.L.... Trapani J.A. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3002	HGNC: 4709	AceView: GZMB	Ensembl:ENSG00000100453	euGenes: HUgn3002
ECgene: GZMB	Kegg: 3002	H-InvDB: GZMB

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for GZMB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for GZMB gene:
Search GeneIP for patents involving GZMB

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
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Antibodies & Assays for GZMB
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GZMB Gene

protein-coding GIFtS: 64

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GZMB (Gene Symbol)
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
CGL1
CTSGL1
SECT
HLP
CTLA1
CSPB
CCPI
CGL-1
CSP-B
Lymphocyte protease
Cytotoxic T-lymphocyte proteinase 2
Cathepsin G-like 1
Human lymphocyte protein
T-cell serine protease 1-3E
C11
CTLA-1
granzyme B
OTTHUMP00000028189
fragmentin 2
fragmentin-2
granzyme-2
cytotoxic serine protease B
Granzyme-2
Fragmentin-2
GRB
EC 3.4.21.79

Lymphoma Large Cell
Microsatellite Instability
Hepatitis Chronic
Carcinoma Basal Cell
Sclerosis
Lymphoma T-Cell
Colitis Ulcerative
Allergic Reaction
COLON CARCINOMA
Liver diseases
Atherosclerosis
Breast Cancer
Sjogrens Syndrome Primary
anaplastic large cell lymphoma
NSCLC
primary tumor
Rasmussen Encephalitis
Asthma
BILIARY CIRRHOSIS PRIMARY
Mycosis Fungoides
Cancer
Alopecia Areata
Cervical Intraepithelial Neoplasia
Lymphocytosis
Urticaria
Lymphoma
Shock
Bronchoalveolar Lavage Fluid
Colorectal Cancer
Cowpox
Inflammation
Tuberculosis
Hepatitis
Neutropenia
Psoriasis
Hepatitis B
Pulmonary Disease Chronic Obstructive
Sarcoidosis
Rheumatoid Arthritis
prostate cancer
Tumors
Lymphomatoid Papulosis
Celiac Disease
Autoimmunity
Necrosis
Liver Cirrhosis
Asthma allergic
Lichen Planus
virus infection
Lymphoma T-Cell Cutaneous
Gastric Cancer
Stevens-Johnson Syndrome
Leukemia Lymphocytic Large Granular
Autoimmune Diseases
Melanoma
BREAST CARCINOMA
Toxic Epidermal Necrolysis
Dermatitis
Demyelination
atherosclerotic plaque
Leukocytosis
Carcinoma
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Myeloid Leukemia Chronic
Sjogrens Syndrome
HEPATOCELLULAR CARCINOMA
CERVICAL CARCINOMA
metastatic melanoma
Acute graft-versus-host disease
Cancer Lung
Influenza
Keratoacanthoma
cytopenia
Lymphoma B-Cell
HIV Infections
Carcinoma Medullary
Lymphoproliferative Disorders
Carcinoma Squamous Cell
Histopathology
SKIN LESION
Autoimmune Response
Atrophy
Anemia Aplastic
Graft-Versus-Host Disease
Myositis
Lymphoma Non-Hodgkins
Polymyositis
Myelodysplastic Syndromes
Lymphoma T-Cell Peripheral
LEUKAEMIA LYMPHOCYTIC
Choriocarcinoma
Arthritis

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GZMB Gene

protein-coding GIFtS: 64

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