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HAO1 Gene

protein-coding GIFtS: 56

GC20M007863

hydroxyacid oxidase (glycolate oxidase) 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GOX1)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
hydroxyacid oxidase (glycolate oxidase) 1¹ ²		(S)-2-hydroxy-acid oxidase²
GOX¹ ² ³		MGC142225²
GOX1² ³ ⁵		hydroxyacid oxidase 1²
Glycolate oxidase² ³		MGC142227²
HAOX1² ³		EC 1.1.3.15³

External Ids:	HGNC: 4809¹	Entrez Gene: 54363²	Ensembl: ENSG00000101323⁷	UniProtKB: Q9UJM8³

Export aliases for HAO1 gene to outside databases

Previous GC identifers: GC20M007851 GC20M007858 GC20M007811

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HAO1:

This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino

acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the

peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most

active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript

detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple

near-consensus upstream polyadenylation site. (provided by RefSeq)

UniProtKB/Swiss-Prot: HAOX1_HUMAN, Q9UJM8

Function: Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on

2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HAO1 gene promoter:
         Sp1   POU2F1   CUTL1   MIF-1   LCR-F1   GATA-1   Sox9   Bach1   STAT5A   RFX1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for HAO1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12 Ensembl cytogenetic band: 20p12.3 HGNC cytogenetic band: 20p12

HAO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HAO1 gene location

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M007863: view genomic region (about GC identifiers)

Start:	7,814,621 bp from pter
End:	7,921,121 bp from pter
Size:	106,501 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000020.10 NT_011387.8

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: HAOX1_HUMAN, Q9UJM8 (See protein sequence)

Recommended Name: Hydroxyacid oxidase 1

Size: 370 amino acids; 40924 Da

Cofactor: FMN

Subcellular location: Peroxisome

PDB structures from and Proteopedia :

2NZL (3D)

2RDT (3D)

2RDU (3D)

2RDW (3D)

2W0U (3D)

Secondary accessions: Q14CQ0 Q9UPZ0 Q9Y3I7

Explore the universe of human proteins at neXtProt for HAO1: NX_Q9UJM8

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_060015.1

ENSEMBL proteins:

ENSP00000368066

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for HAO1 (Hydroxyacid Oxidase-1/HAO-1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: HAO1 OriGene Protein Over-expression Lysate: HAO1
	GenScript Custom Purified and Recombinant Proteins Services for HAO1
	Novus Biologicals Proteins for HAO1
	Novus Biologicals Lysate for HAO1
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005777	peroxisome	TAS	10777549
GO:0005782	peroxisomal matrix	TAS	--

About this table

HAO1 for ontologies About GeneDecksing

Antibodies for HAO1:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for HAO1
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for HAO1
	Novus Biologicals Antibody for HAO1
	Browse antibodies at Epitomics

Assays for HAO1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HAO1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HAO1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HAO1 for domains About GeneDecksing

4 InterPro domains/families:

IPR013785 Aldolase_TIM

IPR012133 Alpha-hydoxy_acid_DH_FMN

IPR000262 FMN-dep_DH

IPR008259 FMN_hydac_DH_AS

Graphical View of Domain Structure for InterPro Entry Q9UJM8

ProtoNet protein and cluster: Q9UJM8

1 Blocks protein family: IPB000262 FMN-dependent alpha-hydroxy acid dehydrogenase

UniProtKB/Swiss-Prot: HAOX1_HUMAN, Q9UJM8

Similarity: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: HAOX1_HUMAN, Q9UJM8

Function: Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on

2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate

Catalytic activity: (S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2)

Biophysicochemical properties: Kinetic parameters: KM=141 uM for glycolate; KM=40 uM for 2-hydroxy octanoate; KM=2200

uM for glyoxylate;

Enzyme Number (IUBMB): EC 1.1.3.15

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for HAO1 Sigma-Aldrich shRNA for HAO1
		OriGene 29mer shRNA kits in GFP-retroviral vector: HAO1 OriGene shRNA RFP: HAO1 OriGene basic RS shRNA: HAO1 OriGene siRNA: HAO1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HAO1

miRNA:		Sigma-Aldrich microRNA Mimics for HAO1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HAO1
		2 SABiosciences Assays for microRNAs that regulate HAO1:
		hsa-miR-1197 hsa-miR-660

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: HAO1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HAO1 OriGene untagged cDNA clones in CMV expression vector: HAO1 OriGene 3'-UTR clone: HAO1 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: HAO1
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for HAO1

Genatlas biochemistry entry for HAO1:

hydroxyacid oxidase 1,glycolate oxidase

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003973	(S)-2-hydroxy-acid oxidase activity	TAS	10777549
GO:0008891	glycolate oxidase activity	TAS	--
GO:0010181	FMN binding	IDA	18215067
GO:0016491	oxidoreductase activity	IEA	--
GO:0047969	glyoxylate oxidase activity	TAS	--

About this table

HAO1 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

HAO1 for pathways About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for HAO1

Glyoxylate and Dicarboxylate Metabolism

3 Kegg Pathways (Kegg details for HAO1):

	hsa00630 Glyoxylate and dicarboxylate metabolism
	hsa01100 Metabolic pathways
	hsa04146 Peroxisome

UniProtKB/Swiss-Prot: HAOX1_HUMAN, Q9UJM8

Pathway: Organic acid metabolism; glycolate degradation; 3-phospho-D-glycerate from glycolate: step 1/4

    SABiosciences Custom Pathway-Focused PCR Arrays for HAO1

  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for HAO1
  Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HAO1

4 Interacting proteins for HAO1 (ENSP00000368066³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AGXT	ENSP00000302620³	STRING: ENSP00000302620
DAO	ENSP00000228476³	STRING: ENSP00000228476
AGXT2	ENSP00000231420³	STRING: ENSP00000231420
HAO2	ENSP00000358428³	STRING: ENSP00000358428

About this table

5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001561	fatty acid alpha-oxidation	TAS	10777549
GO:0006979	response to oxidative stress	IEA	--
GO:0046296	glycolate catabolic process	IDA	18215067
GO:0046487	glyoxylate metabolic process	EXP	15956068
GO:0055114	oxidation-reduction process	IEA	--

About this table

HAO1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

HAO1 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HAO1
10/52 Novoseek chemical compound relationships for HAO1 gene (see all 52)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glucose	82.3	475	17365439 (5), 16870421 (3), 19505077 (3), 19269439 (3) (see all 99)
nafion	82.2	9	16275055 (1), 15967398 (1), 19071561 (1), 16219381 (1) (see all 7)
agcl	78.1	1	15649080 (1)
fadh2	77.4	8	15461503 (2), 12622383 (1), 15970532 (1), 15649080 (1)
poly(dimethyl diallyl ammonium chloride)	77.1	7	18180205 (2), 16430853 (1), 16207046 (1), 17314038 (1)
poly(1-vinylimidazole)	75.5	2	14516076 (1), 15794489 (1)
ferrocenemethanol	73.6	1	16471810 (1)
platinum	71.1	20	9491756 (1), 19112013 (1), 20388977 (1), 15284922 (1) (see all 13)
ethylene glycol diglycidyl ether	70.9	2	7733469 (1)
ferrocene	70	19	19505077 (2), 8797376 (2), 12298004 (2), 11411531 (2) (see all 10)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for HAO1 Sigma-Aldrich shRNA for HAO1
		OriGene 29mer shRNA kits in GFP-retroviral vector: HAO1 OriGene shRNA RFP: HAO1 OriGene basic RS shRNA: HAO1 OriGene siRNA: HAO1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HAO1

miRNA:		Sigma-Aldrich microRNA Mimics for HAO1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HAO1
		2 SABiosciences Assays for microRNAs that regulate HAO1:
		hsa-miR-1197 hsa-miR-660

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: HAO1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HAO1 OriGene untagged cDNA clones in CMV expression vector: HAO1 OriGene 3'-UTR Clone: HAO1 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: HAO1

Primers:		OriGene genome-wide validated SYBR primer pairs: HAO1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for HAO1: PPH14086A

REFSEQ mRNAs for HAO1 gene:

NM_017545.2

Additional cDNA sequence:

AB024079.1 AF231916.1 AF244134.1 AK289423.1 AK308963.1 AK313839.1 AL121739.1 BC113665.1

BC113667.1

2 DOTS entries:

DT.105299 DT.99965022

24/28 AceView cDNA sequences (see all 28):

C20914 NM_017545 AB024079 CB161531 AI913732 AF244134 AL121739 BG656034

AW772047 AV682372 AV646933 AL449681 CB163751 BG568066 BX094967 AV647445

H70488 AF231916 H69642 BG656337 T72614 AL449669 T74667 T97636

highest scoring ESTs for HAO1:

AB024079 AF231916 AF244134 AI913732 AL121739 AL449668 AL449669 AL449681 T58830 T64673

Unigene Cluster for HAO1:

Hydroxyacid oxidase (glycolate oxidase) 1

Hs.193640 [show with all ESTs]

Unigene Representative Sequence: AL121739

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000378789(uc002wmw.1 uc010gbu.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

HAO1 expression in normal and diseased human tissues

¹ / ² / ³

4 probe-sets matching HAO1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35891_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.03	AB024079	1.00	1.00	1.00	1
60957_at²^{, 3}	U95-C	1	0.69	1.00	0.99	1.03	AI913732	0.80	1.00	0.91	1
220224_at²^{, 3}	U133-A	1	0.91	1.00	--	--	NM_017545	0.60	1.00	0.82	1
220224_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

HAO1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

HAO1 gene electronic northern expression

About these images

CGAP SAGE TAG: TCTTTAAAAC

SOURCE GeneReport for Unigene cluster: Hs.193640

UniProtKB/Swiss-Prot: HAOX1_HUMAN, Q9UJM8

Tissue specificity: Liver

Primers:		OriGene genome-wide validated SYBR primer pairs: HAO1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for HAO1: PPH14086A

SABiosciences Custom PCR Arrays for HAO1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HAO1 gene from 5/20 species (see all 20)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HAO1¹	--	hydroxyacid oxidase (glycolate oxidase) 1	87.39(n) 88.11(a)	485774 XM_854694.1 XP_859787.1
chimpanzee (Pan troglodytes)	HAO1¹	--	hydroxyacid oxidase (glycolate oxidase) 1	99.46(n) 100(a)	747888 XM_001167611.1 XP_001167611.1
cow (Bos taurus)	HAO1¹	--	hydroxyacid oxidase (glycolate oxidase) 1	89.01(n) 92.16(a)	533957 XM_613535.3 XP_613535.2
rat (Rattus norvegicus)	Hao1¹	--	hydroxyacid oxidase 1, liver	85.86(n) 89.46(a)	311446 XM_230613.4 XP_230613.2
mouse (Mus musculus)	Hao1^{1 , 5}	2 (65.65 cM)⁵	hydroxyacid oxidase 1, liver^{1, 5}	87.12(n)¹ 89.46(a)¹	15112¹ NM_010403.2¹ NP_034533.1¹ AF104312⁵ AI195865⁵ (see all 9)

About this table Species with no ortholog for HAO1

ENSEMBL Gene Tree for HAO1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HAO1 gene

HAO2²

HAO1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs941425^1,2	C,F,O,A,	7905283(-)	`TTCTGC/TTTGAA`	1	--	int¹		107	NS EA PA EU CA WA NA	8244
rs941426^1,2	C,F,A,	7905050(-)	`TGGATT/CTGACA`	1	--	int¹		106	NS MN EA NA PA EU CA WA	8236
rs1028310^1,2	C,F,A,H,	7897326(-)	`TTATTA/TCATTT`	1	--	int¹		18	NA PA NS EA WA	944
rs1540901^1,2	C,F,O,A,	7894274(-)	`AAAACA/CATATA`	1	--	int¹		15	MN NS EA NA WA	962
rs1569453^1,2	C,F,A,H,	7899591(-)	`ATGAGT/ACAGTG`	1	--	int¹		20	MN NS EA NA WA	1340
rs1569454^1,2	C,F,O,A,H,	7877416(-)	`GAACTT/GGATAA`	1	--	int¹		15	NS EA NA WA	2036
rs1883209^1,2	C,F,O,A,	7919396(-)	`attccC/Actgga`	1	--	int¹		9	NA EA WA	358
rs1883210^1,2	C,F,A,	7919085(-)	`CAGTGC/TCACCT`	1	--	int¹		11	EA MN NA WA	2020
rs1883211^1,2	C,F,A,	7905138(-)	`ATTATA/GATTCC`	1	--	int¹		8	MN NS EA NA WA	710
rs1983559^1,2	C,F,A,H,	7892334(-)	`GGTCCC/TGTCTC`	1	--	int¹		18	MN NS EA NA WA	1160

About this table

HapMap Linkage Disequilibrium images for HAO1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HAO1: --

QIAGEN SeqTarget long-range PCR primers for resequencing HAO1

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HAO1 for disorders About GeneDecksing

OMIM: 605023

1 Novoseek disease relationship for HAO1 gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hypoglycemia	0	1	17365439 (1)

About this table

Human Genome Epidemiology (HuGE) Navigator: HAO1 (1 document)

Export disorders and mutations for HAO1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/220 PubMed articles for HAO1 gene, integrated from 7 sources (see all 220):
(articles sorted by number of sources associating them with HAO1)

Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases. (PubMed id 10777549)^{1, 2, 7} Jones J.M.... Gould S.J. (2000)
Structure of human glycolate oxidase in complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazole. (PubMed id 20054120)^{1, 2} Bourhis J.M....Lindqvist Y. (2009)
Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design. (PubMed id 18215067)^{1, 2} Murray M.S....Lowther W.T. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Identification and expression of a cDNA for human glycolate oxidase. (PubMed id 10978532)^{1, 2} Williams E.L.... Rumsby G. (2000)
Molecular cloning of mouse glycolate oxidase. High evolutionary conservation and presence of an iron-responsive element-like sequence in the mRNA. (PubMed id 9891009)^{1, 3} Kohler S.A....Kuhn L.C. (1999)
Genome-wide association study of childhood acute lymp hoblastic leukemia in Korea. (PubMed id 20189245)¹ Han S....Kang D. (2010)
Purification and characterization of recombinant human liver glycolate oxidase. (PubMed id 17669354)¹ Vignaud C....Lederer F. (2007)
Primary hyperoxaluria: from gene defects to designer drugs? (PubMed id 15956068)¹ Danpure C.J. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54363	HGNC: 4809	AceView: HAO1	Ensembl:ENSG00000101323	euGenes: HUgn54363
ECgene: HAO1	Kegg: 54363	H-InvDB: HAO1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property for HAO1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for HAO1 gene:
Search GeneIP for patents involving HAO1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HAO1		Antibodies for HAO1
	Super-pooled esiRNAs for HAO1		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HAO1		microRNA Mimics for HAO1
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
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	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for HAO1 (Hydroxyacid Oxidase-1/HAO-1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HAO1
	SeqTarget long-range PCR primers for resequencing HAO1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HAO1

	GenScript Custom Purified and Recombinant Proteins Services for HAO1		GenScript cDNA clones with any tag delivered in your preferred vector for HAO1
	GenScript Custom Assay Services for HAO1		GenScript Custom Superior Antibodies Services for HAO1
	GenScript Custom overexpressing Cell Line Services for HAO1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in HAO1 promoter
	Search Chromatin IP Primers for HAO1
	RT² qPCR Primer Assay for HAO1
	Search GNC Networks for HAO1
	Assays for microRNAs that regulate HAO1
	SABiosciences Custom PCR Arrays for HAO1

Search Tocris compounds for HAO1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for HAO1
	Proteins for HAO1
	Lysates for HAO1

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for HAO1

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

HAO1 gene at Home site.

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HAO1 Gene

protein-coding GIFtS: 56

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HAO1 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor HAO1 gene

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Specialized Databases showing HAO1 gene

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Aliases &
Descriptions
for HAO1 gene

Summaries
for HAO1 gene

Genomic Views
for HAO1 gene

Proteins
for HAO1 gene

Protein Domains/
Families
for HAO1 gene

Gene Function
for HAO1 gene

Pathways & Interactions
for HAO1 gene

Drugs & Compounds
for HAO1 gene

Transcripts
for HAO1 gene

Expression
for HAO1 gene

Orthologs
for HAO1 gene

Paralogs
for HAO1 gene

Genomic Variants
for HAO1 gene

Disorders & Mutations
for HAO1 gene

Medical News
for HAO1 gene

Publications
for HAO1 gene

Intellectual Property
for HAO1 gene

Products
for HAO1 gene