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HDGFL1 Gene

protein-coding   GIFtS: 41

GC06P022569
hepatoma derived growth factor-like 1
(Previous name: PWWP domain containing 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PWWP1)
Products    

Aliases &
Descriptions
for HDGFL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
hepatoma derived growth factor-like 11 2     PWWP domain-containing protein 12 3
dJ309H15.11 2     HDGF (hepatoma-derived growth factor) like2
PWWP domain containing 11 2     hepatoma-derived growth factor-like protein 12
PWWP12 3     

External Ids:    HGNC: 210951   Entrez Gene: 1541502   Ensembl: ENSG000001122737   UniProtKB: Q5TGJ63   

Export aliases for HDGFL1 gene to outside databases

Previous GC identifer: GC06P022678


Summaries
for HDGFL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for HDGFL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HDGFL1 gene promoter:
         Bach1   GR-alpha   POU2F1   Bach2   AREB6   POU3F2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   deltaCREB   CREB   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for HDGFL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HDGFL1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22.2

HDGFL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HDGFL1 gene location

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P022569:  view genomic region     (about GC identifiers)

Start:
 22,512,779 bp from pter
End:
 22,513,851 bp from pter
Size:
 1,073 bases
Orientation:
 plus strand

1 alternative location:
Chr6+ 22,569,678-22,570,750     
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  

Proteins
for HDGFL1 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: HDGL1_HUMAN, Q5TGJ6 (See protein sequence)
Recommended Name: Hepatoma-derived growth factor-like protein 1  
Size: 251 amino acids; 27234 Da
Secondary accessions: Q96MJ6

Explore the universe of human proteins at neXtProt for HDGFL1: NX_Q5TGJ6 

REFSEQ proteins: NP_612641.2  

ENSEMBL proteins: 
ENSP00000230012 


Human Recombinant Proteins 
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Antibodies for HDGFL1: 
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Assays for HDGFL1: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
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GenScript Custom Assay Services for HDGFL1 
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for HDGFL1 

Protein Domains/
Families
for HDGFL1 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HDGFL1 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR000313 PWWP

Graphical View of Domain Structure for InterPro Entry Q5TGJ6

ProtoNet protein and cluster: Q5TGJ6

1 Blocks protein family: IPB000313 PWWP domain

UniProtKB/Swiss-Prot: HDGL1_HUMAN, Q5TGJ6
Similarity: Belongs to the HDGF family
Similarity: Contains 1 PWWP domain


Gene Function
for HDGFL1 gene

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section
Inhib.
RNA:    		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for HDGFL1
Sigma-Aldrich shRNA for HDGFL1
OriGene 29mer shRNA kits in GFP-retroviral vector: HDGFL1
OriGene shRNA RFP: HDGFL1
OriGene basic RS shRNA: HDGFL1
OriGene siRNA: HDGFL1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HDGFL1 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HDGFL1 
Search SABiosciences for Assays for microRNAs that regulate HDGFL1

Gene
Editing:		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: HDGFL1
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HDGFL1
OriGene untagged cDNA clones in CMV expression vector: HDGFL1
Browse 3'-UTR reporter clones for miRNA target validation 
Browse MicroRNA Expression Plasmids 
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Browse Sino Biological Human cDNA Clones

Cell
Lines:  		GenScript Custom overexpressing Cell Line Services for HDGFL1 


Pathways & Interactions
for HDGFL1 gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for HDGFL1 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HDGFL1

Drugs & Compounds
for HDGFL1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HDGFL1


Transcripts
for HDGFL1 gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section
Inhib.
RNA:     		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for HDGFL1
Sigma-Aldrich shRNA for HDGFL1
OriGene 29mer shRNA kits in GFP-retroviral vector: HDGFL1
OriGene shRNA RFP: HDGFL1
OriGene basic RS shRNA: HDGFL1
OriGene siRNA: HDGFL1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HDGFL1 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HDGFL1 
Search SABiosciences for Assays for microRNAs that regulate HDGFL1
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: HDGFL1
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HDGFL1
OriGene untagged cDNA clones in CMV expression vector: HDGFL1
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for HDGFL1 
Primers: OriGene genome-wide validated SYBR primer pairs: HDGFL1
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for HDGFL1: PPH10614A

REFSEQ mRNAs for HDGFL1 gene: 

NM_138574.2  

Additional cDNA sequence: 

AK056824.1 AK302110.1 

1 DOTS entry:

DT.306060 

1 AceView cDNA sequence:

CD359616 

highest scoring ESTs for HDGFL1:

AI026687 AA382229 AA382230 AA382940 AA382941 AA824334 AI352424 AI797285 AI936611 AK056824 

Unigene Cluster for HDGFL1:

Hepatoma derived growth factor-like 1
Hs.629246  [show with all ESTs]
Unigene Representative Sequence: AK056824


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000230012(uc003nds.2)

Expression
for HDGFL1 gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

HDGFL1 expression in normal and diseased human tissues

1  / 2  / 3

3 probe-sets matching HDGFL1 gene

Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
55508_at2, 3 U95-B 1 0.62 1.00 1.00 1.00 AI026687 1.00 1.00 1.00 1
232680_at2, 3 U133-B 1 0.27 1.00 -- -- AI352424 0.80 1.00 0.91 1
232680_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
About this table

HDGFL1 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
HDGFL1 gene expression
HDGFL1 gene electronic northern expression
HDGFL1 gene sage expression
About these images

CGAP SAGE TAG: TGGGGAATGC

SOURCE GeneReport for Unigene cluster: Hs.629246
Primers: OriGene genome-wide validated SYBR primer pairs: HDGFL1
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for HDGFL1: PPH10614A
    SABiosciences Custom PCR Arrays for HDGFL1 


Orthologs
for HDGFL1 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for HDGFL1 gene from 3 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
chimpanzee
(Pan troglodytes)		 HDGFL11   -- hepatoma derived growth factor-like 1 98.25(n)
95.95(a)		 471867  XM_527245.2  XP_527245.2 
cow
(Bos taurus)		 HDGFL11   -- hepatoma derived growth factor-like 1 75.94(n)
63.48(a)		 407143  NM_001001136.2  NP_001001136.2 
mouse
(Mus musculus)		 Hdgfl15 13 (12.09 cM) hepatoma derived growth factor-like 1   -- D63663 
About this table        Species with no ortholog for HDGFL1

ENSEMBL Gene Tree for HDGFL1 (if available)

Paralogs
for HDGFL1 gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for HDGFL1 gene
PSIP12  HDGF2  HDGFRP32  HDGFRP22  

HDGFL1 for paralogs           About GeneDecksing



Genomic Variants
for HDGFL1 gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/38 NCBI SNPs in HDGFL1 are shown (see all 38)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 6 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
----------
rs13616971,2
C,F,A,H,22568534(-) CAGTAA/CAACTC 1 -- ng51102Minor allele frequency- T:0.00NS EA PA EU CA WA NA 6430
rs20730301,2
C,F,A,22569634(+) TGCACA/TCTTCG 1 -- ng5117Minor allele frequency- T:0.25EA NA NS WA 2568
rs20765061,2
C,F,22570064(+) CCCCAC/TGGTCC 2 T M ref1 mis1 ese315Minor allele frequency- T:0.19NA NS EA 1494
rs23287341,2
--22568931(+) AAACAC/TGTGTC 1 -- ng510--------
rs30650421,2
--22568929(+) GAAAA-/CATGTGT 1 -- ng510--------
rs58748751,2
C22568930(+) AAAAC-/ATGTGTC 1 -- ng510--------
rs69006271,2
C,F,A,22570245(+) AAGAGG/AAGCGC 2 /R syn1 ref1 ese37Minor allele frequency- A:0.16NS EA NA WA 418
rs69229601,2
C,F,A,22570189(+) ACGAAT/CTGGGG 2 /L syn1 ref19Minor allele frequency- C:0.26NS EA NA 562
rs69381141,2
C,22569500(+) GTAGAG/AATTGA 1 -- ng511Minor allele frequency- A:0.50WA 2
rs77659551,2
--22567948(+) AGAACC/TGGTCC 1 -- ng510--------
About this table

HapMap Linkage Disequilibrium images for HDGFL1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for HDGFL1: --

QIAGEN SeqTarget long-range PCR primers for resequencing HDGFL1 

Disorders & Mutations
for HDGFL1 gene

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Medical News
for HDGFL1 gene

(Possibly Related Articles in Doctor's Guide)
About This Section
   --

Publications
for HDGFL1 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

5 PubMed articles for HDGFL1 gene integrated from 7 sources:
(articles sorted by number of sources associating them with HDGFL1)
  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  2. Mild intellectual disability associated with a progen y of father-daughter incest: genetic and environmental considerations. (PubMed id 20509080)1 Ansermet F....Paoloni-Giacobino A. (2010)
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
  5. The monomer-dimer equilibrium of stromal cell-derived factor-1 (CXCL 12) is altered by pH, phosphate, sulfate, and heparin. (PubMed id 15741341)7 Veldkamp C.T....Volkman B.F. (2005)

External Searches for HDGFL1 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing HDGFL1 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 154150 HGNC: 21095 AceView: PWWP1 Ensembl:ENSG00000112273 euGenes: HUgn154150
ECgene: HDGFL1 H-InvDB: HDGFL1

Other Databases showing HDGFL1 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing HDGFL1 gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
   --

Intellectual Property
for HDGFL1 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for HDGFL1 gene:
Search GeneIP for patents involving HDGFL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for HDGFL1 gene

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services

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 "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
 Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
 Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
 Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
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 miRNA Expression Plasmids

 		 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HDGFL1
 SeqTarget long-range PCR primers for resequencing HDGFL1
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HDGFL1
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HDGFL1
 GenScript Custom Purified and Recombinant Proteins Services for HDGFL1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for HDGFL1
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 Regulatory tfbs in HDGFL1 promoter
 Search Chromatin IP Primers for HDGFL1
 RT2 qPCR Primer Assay for HDGFL1
 Search GNC Networks for HDGFL1
 Search for Assays for microRNAs that regulate HDGFL1
 SABiosciences Custom PCR Arrays for HDGFL1
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 Novus Tissue Slides
 Proteins for HDGFL1
 Browse antibodies at Epitomics
 Browse ProSpec Recombinant Proteins

 ELISAs and CLIAs for HDGFL1
       

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