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HGS Gene

protein-coding   GIFtS: 64

GC17P075097
hepatocyte growth factor-regulated tyrosine kinase substrate
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for HGS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
hepatocyte growth factor-regulated tyrosine kinase substrate1 2     Vps271
HRS2 3 5     FLJ398782
Hrs1 3     human growth factor-regulated tyrosine kinase substrate2
Protein pp1102 3     FLJ114212
ZFYVE81     

External Ids:    HGNC: 48971   Entrez Gene: 91462   Ensembl: ENSG000001853597   UniProtKB: O149643   

Export aliases for HGS gene to outside databases

Previous GC identifers: GC17U990142 GC17P080211 GC17P080346 GC17P077261 GC17P079651


Summaries
for HGS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HGS:
The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation
of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body,
targeting these proteins for lysosome-dependent degradation. (provided by RefSeq)

UniProtKB/Swiss-Prot: HGS_HUMAN, O14964
Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with
STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in
vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin.
May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor
tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds
ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further
sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the
activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein
complex required for efficient transferrin receptor recycling but not for EGFR degradation

Gene Wiki entry for HGS

Genomic Views
for HGS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HGS gene promoter:
         Arnt   Max   c-Myc   USF1   Max1   Meis-1   XBP-1   RFX1   POU3F2   POU3F2 (N-Oct-5b)   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for HGS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HGS 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25

HGS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HGS gene location

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P075097:  view genomic region     (about GC identifiers)

Start:
 75,097,190 bp from pter
End:
 75,115,047 bp from pter
Size:
 17,858 bases
Orientation:
 plus strand

1 alternative location:
Chr17+ 79,651,020-79,669,149     
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  

Proteins
for HGS gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: HGS_HUMAN, O14964 (See protein sequence)
Recommended Name: Hepatocyte growth factor-regulated tyrosine kinase substrate  
Size: 777 amino acids; 86192 Da
Subunit: Interacts with TRAK1. Interacts with TRAK2 (By similarity). Interacts with TRAK1. Component of the ESCRT-0
complex composed of STAM or STAM2 and HGS. Part of a complex at least composed of HSG, STAM2 (or probably STAM) and
EPS15. Interacts with STAM. Interacts with STAM2. Interacts with EPS15; the interaction is direct, calcium-dependent
and inhibited by SNAP25. Interacts with NF2; the interaction is direct. Interacts with ubiquitin; the interaction is
direct. Interacts with VPS37C. Interacts with SMAD1, SMAD2 and SMAD3. Interacts with TSG101; the interaction mediates
the association with the ESCRT-I complex. Interacts with SNAP25; the interaction is direct and decreases with addition
of increasing concentrations of free calcium. Interacts with SNX1; the interaction is direct. Component of a 550 kDa
membrane complex at least composed of HGS and SNX1 but excluding EGFR. Component of the CART complex, at least
composed of ACTN4, HGS/HRS, MYO5B and TRIM3
Subcellular location: Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome,
multivesicular body membrane; Peripheral membrane protein (By similarity)
PDB structure from and Proteopedia :
2D3G (3D)    3F1I (3D)    
Secondary accessions: Q9NR36
Alternative splicing: 2 isoforms:  O14964-1   O14964-2   

Explore the universe of human proteins at neXtProt for HGS: NX_O14964 

Post-translational modifications:

  • Phosphorylated on Tyr-334. A minor site of phosphorylation on Tyr-329 is detected (By similarity). Phosphorylation
    • occurs in response to EGF, IL-2, GM-CSF and HGF1
  • Ubiquitinated by ITCH1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_004703.1  

    ENSEMBL proteins: 
    ENSP00000331201 ENSP00000395686 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HGS
    GenScript Custom Purified and Recombinant Proteins Services for HGS 
    Novus Biologicals Proteins for HGS
    Novus Biologicals Lysate for HGS
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/9 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 9):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IDA18029348
    GO:0005768 endosome IDA15611048
    GO:0005769 early endosome IDA10861283
    GO:0005829 cytosol TAS--
    GO:0016020 membrane IEA--
    About this table

    HGS for ontologies           About GeneDecksing



    Antibodies for HGS: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for HGS
    Browse R&D Systems for Antibodies
    OriGene Antibodies: HGS
    GenScript Custom Superior Antibodies Services for HGS 
    Novus Biologicals Antibodies for HGS
    Epitomics antibodies for HGS

    Assays for HGS: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HGS 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HGS 

    Protein Domains/
    Families
    for HGS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGS for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR002014 VHS
     IPR018205 VHS_subgroup
     IPR000306 Znf_FYVE
     IPR013083 Znf_RING/FYVE/PHD
     IPR003903 Ubiquitin-int_motif

    Graphical View of Domain Structure for InterPro Entry O14964

    ProtoNet protein and cluster: O14964

    2 Blocks protein families:
    IPB000306 Zn-finger
    IPB002014 VHS


    UniProtKB/Swiss-Prot: HGS_HUMAN, O14964
    Domain: Has a double-sided UIM that can bind 2 ubiquitin molecules, one on each side of the helix
    Domain: The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of
    early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially
    increased in acidic conditions
    Similarity: Contains 1 FYVE-type zinc finger
    Similarity: Contains 1 UIM (ubiquitin-interacting motif) repeat
    Similarity: Contains 1 VHS domain


    Gene Function
    for HGS gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: HGS_HUMAN, O14964
    Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with
    STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in
    vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin.
    May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor
    tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds
    ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further
    sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the
    activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein
    complex required for efficient transferrin receptor recycling but not for EGFR degradation

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for HGS
    Sigma-Aldrich shRNA Panels and shRNA for HGS
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): HGS
    OriGene shRNA RFP (see all 2): HGS
    OriGene basic RS shRNA (see all 2): HGS
    OriGene siRNA: HGS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HGS 
    miRNA:Sigma-Aldrich microRNA Mimics for HGS
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HGS 
    1 SABiosciences Assays for microRNA that regulate HGS:
    hsa-miR-142-3p

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: HGS
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HGS
    OriGene untagged cDNA clones in CMV expression vector (see all 2): HGS
    OriGene 3'-UTR clone: HGS 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: HGS 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for HGS 

    Genatlas biochemistry entry for HGS:
    hepatocyte growth factor-regulated tyrosine kinase substrate,inhibiting the cytokine cell growth function induced by
    STAM

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI15113837
    GO:0008270 zinc ion binding IEA--
    GO:0019904 protein domain specific binding IPI11984006
    GO:0046872 metal ion binding IEA--
    About this table

    HGS for ontologies           About GeneDecksing

    Animal Models: 9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Hgs):

    behavior/neurologicalcardiovascular systemcellulardigestive/alimentaryembryogenesis
    growth/sizelethality-prenatal/perinatalnervous systemreproductive system

    HGS for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HGS gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    HGS for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  HGS
        Clathrin-mediated Endocytosis Signaling

    2 Kegg Pathways  (Kegg details for HGS):
        hsa04144 Endocytosis
    hsa04145 Phagosome

        SABiosciences Pathway-Focused PCR Array including HGS: PAHS-084A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for HGS
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HGS

    5/56 Interacting proteins for HGS (O149641, 2 ENSP000003312013) via UniProtKB, MINT, and/or STRING (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSG101Q998162, ENSP000002519683MINT-50310 MINT-50311 MINT-50312 MINT-50313 MINT-68474 STRING: ENSP00000251968
    STAMQ927832, ENSP000003667463MINT-68442 STRING: ENSP00000366746
    GGA2Q9UJY42, ENSP000003119623MINT-58568 STRING: ENSP00000311962
    STAM2O758862, ENSP000002639043MINT-67925 STRING: ENSP00000263904
    CEP55Q53EZ42MINT-6173401 MINT-6173438
    About this table

    5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886 intracellular protein transport IEA--
    GO:0007165 signal transduction TAS9407053
    GO:0007173 epidermal growth factor receptor signaling pathway TAS--
    GO:0008285 negative regulation of cell proliferation TAS9407053
    GO:0016197 endosome transport NAS10861283
    About this table

    HGS for ontologies           About GeneDecksing



    Drugs & Compounds
    for HGS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    HGS for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HGS
    10/13 Novoseek chemical compound relationships for HGS gene (see all 13)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    propanil 94 51 15113837 (8), 20422006 (6), 9407053 (5), 12551915 (3) (see all 19)
    phosphatidylinositol 3-phosphate 80 7 11493665 (3), 10889197 (1), 14618335 (1), 11456498 (1)
    tyrosine 74.9 139 17101784 (4), 9630564 (2), 11003664 (2), 12180964 (2) (see all 81)
    gefitinib 55.5 4 16869787 (1), 16204931 (1), 18379356 (1)
    erlotinib 52.1 1 16869787 (1)
    mannose 6-phosphate 50 1 18031739 (1)
    wortmannin 40.2 2 11003664 (1), 11532964 (1)
    phosphotyrosine 29.7 1 7819083 (1)
    proline 28.4 3 10889197 (1), 17182674 (1)
    phosphoinositide 27.8 1 11456498 (1)
    About this table



    Transcripts
    for HGS gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for HGS
    Sigma-Aldrich shRNA Panels and shRNA for HGS
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): HGS
    OriGene shRNA RFP (see all 2): HGS
    OriGene basic RS shRNA (see all 2): HGS
    OriGene siRNA: HGS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HGS 
    miRNA: Sigma-Aldrich microRNA Mimics for HGS
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HGS 
    1 SABiosciences Assays for microRNA that regulate HGS:
    hsa-miR-142-3p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: HGS
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HGS
    OriGene untagged cDNA clones in CMV expression vector (see all 2): HGS
    OriGene 3'-UTR Clone: HGS 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: HGS 
    Primers: OriGene genome-wide validated SYBR primer pairs: HGS
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for HGS: PPH19788A

    REFSEQ mRNAs for HGS gene: 

    NM_004712.4  

    Additional cDNA sequence: 

    AF260566.1 AK097197.1 AK294190.1 AK303800.1 BC003565.1 BT009754.1 D84064.1 U43895.1 

    24/32 DOTS entries (see all 32):

    DT.215617  DT.99958034  DT.100804007  DT.120892426  DT.116243  DT.97821159  DT.100029956  DT.65288039 
    DT.120892488  DT.91801095  DT.97786986  DT.100009326  DT.120892515  DT.91768738  DT.95165972  DT.97860828 
    DT.100029957  DT.100785819  DT.40110140  DT.91768724  DT.100785821  DT.120892411  DT.120892534  DT.120892559 

    24/715 AceView cDNA sequences (see all 715):

    BM763843 BM794188 BM555175 AW137926 AW009230 CD672786 BI222755 CF995726 
    AW629684 CA489484 BM911608 BQ686580 BU855778 CD675019 AI199487 BM463921 
    AW249230 AI968961 AI688672 BQ425577 BM810168 BQ957698 BM823438 BM556222 

    highest scoring ESTs for HGS:

    D84064 AA158251 AA158271 AA526268 AA563979 AA576289 AA612806 AA613007 AA724589 AA732815 

    Unigene Cluster for HGS:

    Hepatocyte growth factor-regulated tyrosine kinase substrate
    Hs.514590  [show with all ESTs]
    Unigene Representative Sequence: AK097197


    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for HGS (see all 11)

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a ·
    SP1:                          -                                   -           -                                   -                                         -   
    SP2:                          -                                   -           -                                   -                                         -   
    SP3:                                                                                                              -                       -     -           -   
    SP4:                                                                                                              -                                             
    SP5:        -     -           -                                                                                                                                 

    ExUns: 18b · 18c ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b · 24c · 24d
    SP1:                                                                                    
    SP2:        -     -     -                                                               
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    

    About this scheme

    ECgene alternative splicing isoforms for HGS
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329138(uc010wus.1 uc002kbg.2) ENST00000442335

    Expression
    for HGS gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    HGS expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching HGS gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    33887_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 D84064 1.00 1.00 1.00 1
    210428_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF260566 0.60 1.00 0.82 1
    232627_at*2, 3 U133-B 1 0.46 1.00 -- -- AA161299 0.60 0.83 0.73 1
    210428_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    232627_at*2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    About this table

    HGS for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    HGS gene expression
    HGS gene electronic northern expression
    HGS gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.514590

    Expression variation in blood from EXPOLDB for HGS

    UniProtKB/Swiss-Prot: HGS_HUMAN, O14964
    Tissue specificity: Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral
    blood leukocytes

    Primers: OriGene genome-wide validated SYBR primer pairs: HGS
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for HGS: PPH19788A
        SABiosciences Expression via Pathway-Focused PCR Array including HGS: PAHS-084A 


    Orthologs
    for HGS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for HGS gene from 5/18 species (see all 18)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 HGS1   -- hepatocyte growth factor-regulated tyrosine kinase more 87.75(n)
    93.1(a)    		 483367  XM_850826.1  XP_855919.1 
    chimpanzee
    (Pan troglodytes)    		 HGS1   -- hepatocyte growth factor-regulated tyrosine kinase more 96.01(n)
    95.62(a)    		 454966  XM_511742.2  XP_511742.2 
    cow
    (Bos taurus)    		 HGS1   -- hepatocyte growth factor-regulated tyrosine kinase more 87.77(n)
    93.28(a)    		 511582  NM_001046089.1  NP_001039554.1 
    rat
    (Rattus norvegicus)    		 Hgs1   -- hepatocyte growth factor-regulated tyrosine kinase more 86.81(n)
    93.51(a)    		 56084  NM_019387.2  NP_062260.2 
    mouse
    (Mus musculus)    		 Hgs1 , 5 11 (84.16 cM)5
    		 HGF-regulated tyrosine kinase substrate1, 5 86.97(n)1
    93.42(a)1    		 152391  NM_008244.21  NP_032270.21 
     AK0462995  AK1450315  (see all 25)
    About this table        Species with no ortholog for HGS

    ENSEMBL Gene Tree for HGS (if available)

    Paralogs
    for HGS gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for HGS gene
    WDFY22  WDFY12  

    HGS for paralogs           About GeneDecksing



    Genomic Variants
    for HGS gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/186 NCBI SNPs in HGS are shown (see all 186)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs40746821,2
    		--79657793(+) GGGGGC/TTCTAC 1 -- int10--------
    rs65656201,2
    		C,F,A,79658100(+) TCTTAC/TCCTCG 1 -- int116Minor allele frequency- T:0.09NS EA NA WA 1392
    rs65656211,2
    		C,A,H,79665412(+) ggcctC/Tccaaa 1 -- int14Minor allele frequency- T:0.38NA WA 8
    rs72081441,2
    		C,F,A,H,79654808(+) GTCCCG/AACCTG 1 -- int110Minor allele frequency- A:0.47NA EA WA 226
    rs72141251,2
    		C,F,A,79659627(+) TCCCAG/ACGCCA 1 -- int15Minor allele frequency- A:0.27NA WA 80
    rs72157381,2
    		C,79659847(+) ctctaC/Tttttt 1 -- int10--------
    rs72162391,2
    		C,F,79660187(+) TTGCCC/TCTTCT 1 -- int12Minor allele frequency- T:0.12NA WA 122
    rs72180121,2
    		H79662109(+) GGGCCA/GCTCCC 1 -- int14Minor allele frequency- G:0.00NS EA 416
    rs74064401,2
    		C,A79666512(+) gtgcaA/Gtggtg 1 -- int13Minor allele frequency- G:0.33NA 6
    rs74069451,2
    		C,H,79666508(+) tggagC/Tgcagt 1 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for HGS (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for HGS
         3 CNVs: 30036 73071 30034

    QIAGEN SeqTarget long-range PCR primers for resequencing HGS 

    Disorders & Mutations
    for HGS gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HGS for disorders           About GeneDecksing

    OMIM: 604375

    9 Novoseek disease relationships for HGS gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibromatosis type 2 54.2 2 20054405 (2)
    nsclc 15.4 2 15182824 (1), 16204931 (1)
    tumors 10.3 9 18716056 (1), 14695211 (1), 12372820 (1), 20054405 (1) (see all 7)
    cancer lung 6.03 2 16869787 (1), 16361567 (1)
    leukemia 0 1 17182674 (1)
    breast cancer 0 1 7905269 (1)
    metastasis 0 2 16361567 (1), 16832584 (1)
    carcinoma 0 1 16832584 (1)
    prostate cancer 0 1 12447997 (1)
    About this table


    Export disorders and mutations for HGS gene to outside databases

    Medical News
    for HGS gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    Publications
    for HGS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/188 PubMed articles for HGS gene, integrated from 7 sources (see all 188):
    (articles sorted by number of sources associating them with HGS)
    1. Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. (PubMed id 9407053)1, 2, 3, 7 Asao H.... Sugamura K. (1997)
    2. Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17. (PubMed id 9630564)1, 2, 3, 7 Lu L....Kitamura N. (1998)
    3. STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. (PubMed id 12551915)1, 2, 7 Bache K.G.... Stenmark H. (2003)
    4. HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein. (PubMed id 12900394)1, 2, 7 Pornillos O.... Sundquist W.I. (2003)
    5. CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling. (PubMed id 15772161)1, 2, 7 Yan Q....Bean A.J. (2005)
    6. Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking. (PubMed id 18675823)1, 2 Webber E....Chin L.S. (2008)
    7. Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting. (PubMed id 16462748)1, 2 Hirano S....Wakatsuki S. (2006)
    8. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    9. Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC). (PubMed id 16212419)1, 2 Amanchy R.... Pandey A. (2005)
    10. Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. (PubMed id 15509564)1, 2 Eastman S.W.... Bieniasz P.D. (2005)

    External Searches for HGS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HGS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9146 HGNC: 4897 AceView: MRPL12andHGS Ensembl:ENSG00000185359 euGenes: HUgn9146
    ECgene: HGS Kegg: 9146 H-InvDB: HGS

    Other Databases showing HGS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HGS gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for HGS Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for HGS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for HGS gene:
    Search GeneIP for patents involving HGS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HGS gene

    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
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     Regulatory tfbs in HGS promoter
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     RT2 qPCR Primer Assay for HGS
     GNC Network for HGS
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     ELISAs and CLIAs for HGS
           

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