Aliases &
Descriptions
for HIPK4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| homeodomain interacting protein kinase 41 2 | | FLJ328181 2 | | homeodomain-interacting protein kinase 42 | | EC 2.7.11.13 |
Export aliases for HIPK4 gene to outside databasesPrevious GC identifers: GC19M045577 GC19M040885 |
Summaries
for HIPK4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: HIPK4_HUMAN, Q8NE63Function: Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter(By similarity). May act as a corepressor of transcription factors (Potential)
|
Genomic Views
for HIPK4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HIPK4 gene promoter:
HNF-4alpha2 p53 SRF IRF-7A LUN-1 RP58 deltaCREB CREB Lmo2 Egr-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HIPK4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2HIPK4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M037320: view genomic region
(about GC identifiers)
Start:
|
37,320,650 bp from pter |
End:
|
37,331,675 bp from pter |
Size:
|
11,026 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr19- 40,885,179-40,896,094 |
RefSeq DNA sequence:- NC_000019.9 NT_011109.16
|
Proteins
for HIPK4 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: HIPK4_HUMAN, Q8NE63 (See
protein sequence)Recommended Name: Homeodomain-interacting protein kinase 4 Size: 616 amino acids; 69425 Da
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: A8K863 Q96M54Alternative splicing: 2 isoforms: Q8NE63-1 Q8NE63-2 Explore the universe of human proteins at neXtProt for HIPK4: NX_Q8NE63
Post-translational modifications:
Autophosphorylated (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_653286.2
ENSEMBL proteins: ENSP00000291823 ENSP00000397736
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
About this table
HIPK4 for ontologies About GeneDecksing
Antibodies for HIPK4:
Assays for HIPK4: |
Protein
Domains/
Families
for HIPK4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HIPK4 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q8NE63ProtoNet protein and cluster: Q8NE63 UniProtKB/Swiss-Prot: HIPK4_HUMAN, Q8NE63Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamilySimilarity: Contains 1 protein kinase domain |
Gene Function
for HIPK4 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: HIPK4_HUMAN, Q8NE63Function: Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter(By similarity). May act as a corepressor of transcription factors (Potential)Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.1
5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
HIPK4 for ontologies About GeneDecksing
|
Pathways & Interactions
for HIPK4 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for HIPK4
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIPK4
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006468 | protein phosphorylation |
IEA | -- |
About this table
HIPK4 for ontologies About GeneDecksing
|
Drugs & Compounds
for HIPK4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for HIPK4
|
Transcripts
for HIPK4 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for HIPK4 gene: NM_144685.3 Additional cDNA sequence: AK057380.1 AK292228.1 AK301713.1 AK302301.1 BC034501.2 3 DOTS entries: DT.100016640 DT.100667090 DT.435710 18 AceView cDNA sequences: NM_144685 BC034501 AK057380 CD637132 BG772881 BM554291 AI001807 CD637133 BX099852 BU678003 CD637134 CD637135 AI806773 BI827147 BG771831 BI561789 BG720082 BF950933
 highest scoring ESTs for HIPK4:AI806773 BC034501 BG720082 BG771831 BG772881 BI561789 BI827147 AI001807 AK057380 BG105231 Unigene Cluster for HIPK4: Homeodomain interacting protein kinase 4 Hs.79363 [show with all ESTs]Unigene Representative Sequence: NM_144685
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000291823(uc002onp.2) ENST00000452139
|
Expression
for HIPK4 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| HIPK4 expression in normal and diseased human tissues
1 / 2 / 3 2 probe-sets matching HIPK4 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 70928_at2, 3
|
U95-E |
1 |
0.81 |
1.00 |
1.00 |
1.00 |
AI806773 |
0.80 |
1.00 |
0.91 |
1 |
| 1553238_a_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
HIPK4 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TCACCGGGCA
SOURCE GeneReport for Unigene cluster: Hs.79363
SABiosciences Custom PCR Arrays for HIPK4
|
Orthologs
for HIPK4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HIPK4 gene from 5/6 species (see all 6)
About this table Species with no ortholog for HIPK4
ENSEMBL Gene Tree for HIPK4 (if available) |
Paralogs
for HIPK4 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for HIPK4 gene
- DYRK1A2 HIPK12 HIPK32 HIPK22 DYRK1B2
HIPK4 for paralogs About GeneDecksing
|
Genomic Variants
for HIPK4 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
| | | QIAGEN SeqTarget long-range PCR primers for resequencing HIPK4 |
|
Disorders & Mutations
for HIPK4 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HIPK4 for disorders About GeneDecksing
OMIM: 611712
Export disorders and mutations for HIPK4 gene to outside databases
|
Medical News
for HIPK4 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for HIPK4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
5 PubMed articles for HIPK4 gene integrated from 7 sources:
(articles sorted by number of sources associating them with HIPK4)- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9. (PubMed id 18022393)1 Arai S.... Kurokawa R. (2007)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for HIPK4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HIPK4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HIPK4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HIPK4 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for HIPK4 gene:
Search GeneIP for patents involving HIPK4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HIPK4 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for HIPK4 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for HIPK4 |
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