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HIST1H2AB Gene

protein-coding   GIFtS: 51

GC06M025976
histone cluster 1, H2ab
(Previous names: H2A histone family, member M, histone 1, H2ab )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: H2AFM)
Products    

Aliases &
Descriptions
for HIST1H2AB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
histone cluster 1, H2ab1 2     Histone H2A/a2 3
H2AFM2 3 5     Histone H2A.22 3
H2A/m1 2     HIST1H2AE2
H2A histone family, member M1 2     histone H2A type 1-B/E2
histone 1, H2ab1 2     H2AFA3
Histone H2A/m2 3     

External Ids:    HGNC: 47341   Entrez Gene: 83352   Ensembl: ENSG000001372597   UniProtKB: P049083   

Export aliases for HIST1H2AB gene to outside databases

Previous GC identifers: GC06M026090 GC06M026141


Summaries
for HIST1H2AB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST1H2AB:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of
pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.
This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails;
instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on
chromosome 6p22-p21.3. (provided by RefSeq)

UniProtKB/Swiss-Prot: H2A1B_HUMAN, P04908
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H2AB

Genomic Views
for HIST1H2AB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H2AB gene promoter:
         oct-B3   Oct-B1   POU2F2C   POU2F2B   POU2F2 (Oct-2.1)   POU2F2   POU2F1   oct-B2   NRSF form 2   NRSF form 1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for HIST1H2AB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H2AB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2AB gene location

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M025976:  view genomic region     (about GC identifiers)

Start:
 25,976,385 bp from pter
End:
 25,976,861 bp from pter
Size:
 477 bases
Orientation:
 minus strand

1 alternative location:
Chr6- 26,033,320-26,033,796     
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  

Proteins
for HIST1H2AB gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: H2A1B_HUMAN, P04908 (See protein sequence)
Recommended Name: Histone H2A type 1-B/E  
Size: 130 amino acids; 14135 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Mass spectrometry: Mass=14037.9; Method=Electrospray; Range=2-130; Note=Monoisotopic with N-acetylserine;
Source=PubMed:16457589;
PDB structures from and Proteopedia :
2CV5 (3D)    3A6N (3D)    3AFA (3D)    
Secondary accessions: P28001 Q76P63

Explore the universe of human proteins at neXtProt for HIST1H2AB: NX_P04908 

Post-translational modifications:

  • The chromatin-associated form is phosphorylated on Thr-121 during mitosis (Probable)1
  • Deiminated on Arg-4 in granulocytes upon calcium entry1
  • Monoubiquitination of Lys-120 by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional
    • repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both
    imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination
    of H2A functions downstream of methylation of 'Lys-27' of histone H3. Monoubiquitination of Lys-120 by RNF2/RING2 can
    also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is
    ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and
    RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Monoubiquitination and ionizing
    radiation-induced 'Lys-63'-linked ubiquitination are distinct events1
  • Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses
    • transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK11
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By
    • similarity)1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_003504.2  

    ENSEMBL proteins: 
    ENSP00000259791 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HIST1H2AB
    GenScript Custom Purified and Recombinant Proteins Services for HIST1H2AB 
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786 nucleosome NAS--
    GO:0005634 nucleus IEA--
    GO:0005694 chromosome IEA--
    About this table

    HIST1H2AB for ontologies           About GeneDecksing



    Antibodies for HIST1H2AB: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for HIST1H2AB 
    Browse antibodies at Epitomics

    Assays for HIST1H2AB: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIST1H2AB 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HIST1H2AB 

    Protein Domains/
    Families
    for HIST1H2AB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIST1H2AB for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry P04908

    ProtoNet protein and cluster: P04908

    1 Blocks protein family: IPB002119 Histone H2A

    UniProtKB/Swiss-Prot: H2A1B_HUMAN, P04908
    Similarity: Belongs to the histone H2A family


    Gene Function
    for HIST1H2AB gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: H2A1B_HUMAN, P04908
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for HIST1H2AB
    Sigma-Aldrich shRNA for HIST1H2AB
    OriGene 29mer shRNA kits in GFP-retroviral vector: HIST1H2AB
    OriGene shRNA RFP: HIST1H2AB
    OriGene basic RS shRNA: HIST1H2AB
    OriGene siRNA: HIST1H2AB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HIST1H2AB 
    miRNA:Sigma-Aldrich microRNA Mimics for HIST1H2AB
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HIST1H2AB 
    1 SABiosciences Assays for microRNA that regulate HIST1H2AB:
    hsa-miR-760

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: HIST1H2AB
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HIST1H2AB
    OriGene untagged cDNA clones in CMV expression vector: HIST1H2AB
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: HIST1H2AB 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for HIST1H2AB 

    1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding NAS6647026
    About this table

    HIST1H2AB for ontologies           About GeneDecksing


    Pathways & Interactions
    for HIST1H2AB gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    HIST1H2AB for pathways           About GeneDecksing

    1 Kegg Pathway  (Kegg details for HIST1H2AB):
        hsa05322 Systemic lupus erythematosus

        SABiosciences Custom Pathway-Focused PCR Arrays for HIST1H2AB 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H2AB

    5/77 Interacting proteins for HIST1H2AB (ENSP000002597913 P049082) via UniProtKB, MINT, and/or STRING (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRMT5O147442MINT-56508 MINT-6489539
    DHX30Q7L2E32MINT-6489539
    DHX9Q082112MINT-6489539
    DICER1Q9UPY32MINT-6489539
    EBNA1BP2Q998482MINT-6489539
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334 nucleosome assembly NAS--
    About this table

    HIST1H2AB for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST1H2AB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H2AB


    Transcripts
    for HIST1H2AB gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for HIST1H2AB
    Sigma-Aldrich shRNA for HIST1H2AB
    OriGene 29mer shRNA kits in GFP-retroviral vector: HIST1H2AB
    OriGene shRNA RFP: HIST1H2AB
    OriGene basic RS shRNA: HIST1H2AB
    OriGene siRNA: HIST1H2AB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HIST1H2AB 
    miRNA: Sigma-Aldrich microRNA Mimics for HIST1H2AB
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HIST1H2AB 
    1 SABiosciences Assays for microRNA that regulate HIST1H2AB:
    hsa-miR-760
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: HIST1H2AB
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HIST1H2AB
    OriGene untagged cDNA clones in CMV expression vector: HIST1H2AB
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: HIST1H2AB 
    Primers: OriGene genome-wide validated SYBR primer pairs: HIST1H2AB
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for HIST1H2AB: PPH15008A

    REFSEQ mRNAs for HIST1H2AB gene: 

    NM_003513.2  

    Additional cDNA sequence: 

    AK311785.1 BC125140.1 

    1 DOTS entry:

    DT.91859377 

    9 AceView cDNA sequences:

    NM_003513 CK130258 CK130259 CF272106 CK130257 CK130255 CK130278 CK130256 
    CK130253 

    highest scoring ESTs for HIST1H2AB:

    CF272106 CK130253 CK130255 CK130256 CK130257 CK130258 CK130259 CK130261 CK130278 CF272107 

    Unigene Cluster for HIST1H2AB:

    Histone cluster 1, H2ab
    Hs.248174  [show with all ESTs]
    Unigene Representative Sequence: CK130254


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000259791(uc003nft.1)

    Expression
    for HIST1H2AB gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    HIST1H2AB expression in normal and diseased human tissues

    1  / 2  / 3

    2 probe-sets matching HIST1H2AB gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    208569_at2, 3 U133-A 2 0.73 0.94 -- -- NM_003513 0.60 1.00 0.82 1
    208569_at2 U133Plus2 2 0.73 0.94 -- -- -- -- -- -- --
    About this table
    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    HIST1H2AB gene expression
    HIST1H2AB gene electronic northern expression
    HIST1H2AB gene sage expression
    About these images

    CGAP SAGE TAG: CACTGCTGTT

    SOURCE GeneReport for Unigene cluster: Hs.248174
    Primers: OriGene genome-wide validated SYBR primer pairs: HIST1H2AB
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for HIST1H2AB: PPH15008A
        SABiosciences Custom PCR Arrays for HIST1H2AB 


    Orthologs
    for HIST1H2AB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for HIST1H2AB gene from 5 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 LOC6110821   -- similar to Histone H2A.1 86.15(n)
    100(a)    		 611082  XM_848716.1  XP_853809.1 
    chimpanzee
    (Pan troglodytes)    		 LOC7484951   -- similar to Chain K, 2.9 Angstrom X-Ray Structure Of Hybrid Macroh2a Nucleosomes less 98.72(n)
    100(a)    		 748495  XM_001172704.1  XP_001172704.1 
    cow
    (Bos taurus)    		 LOC6181471   -- similar to histone, H2A 84.87(n)
    100(a)    		 618147  XM_870473.2  XP_875566.1 
    rat
    (Rattus norvegicus)    		 LOC3069621   -- similar to histone 2a 85.64(n)
    100(a)    		 306962  XM_225372.3  XP_225372.3 
    mouse
    (Mus musculus)    		 Hist1h2ab5
    Hist1h2ai1    		 13 (9.91 cM)5
    		 histone cluster 1, H2ab5
    histone cluster 1, H2ai1    		 86.41(n)1
    100(a)1    		 3191911  NM_178182.11  NP_835489.11 
     AL5903885  AY1589205  (see all 9)
    About this table        Species with no ortholog for HIST1H2AB

    ENSEMBL Gene Tree for HIST1H2AB (if available)

    Paralogs
    for HIST1H2AB gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for HIST1H2AB gene
    HIST1H2AE1 2  HIST3H2A2  HIST2H2AA42  HIST1H2AA2  HIST1H2AD2  HIST2H2AC2  HIST2H2AA32  HIST1H2AC2  
    H2AFJ2  

    HIST1H2AB for paralogs           About GeneDecksing


    Pseudogenes
    1 related pseudogene



    Genomic Variants
    for HIST1H2AB gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/12 NCBI SNPs in HIST1H2AB are shown (see all 12)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs44016501,2
    		C,F,A,26035208(+) taaaaA/Gtatta 1 -- ng5114Minor allele frequency- G:0.15NS EA NA WA 812
    rs121944211,2
    		H26035740(+) GGTATC/TTACTA 1 -- ng514Minor allele frequency- T:0.00NS EA 402
    rs284322101,2
    		--26035731(+) AATTTA/CTGAGG 1 -- ng510--------
    rs737365231,2
    		C,26035216(+) TTACTC/GTAACC 1 -- ng511Minor allele frequency- G:0.02WA 50
    rs754354211,2
    		--26034372(+) AAAAAG/ACCGGG 1 -- ng511Minor allele frequency- A:0.50NA 2
    rs759817001,2
    		--26034619(+) ATAAGG/TGAGAA 1 -- ng511Minor allele frequency- T:0.50NA 2
    rs770101031,2
    		C,F,26035588(+) TTATTA/CCAGCC 1 -- ng511Minor allele frequency- C:0.21NA 72
    rs771189761,2
    		C,F,26034541(+) GGAGGG/AGGAGT 1 -- ng511Minor allele frequency- A:0.07EA 88
    rs794511601,2
    		--26034370(+) AAAAA-/AAGCCG 1 -- ng510--------
    rs795984931,2
    		--26034371(+) AAAAAG/AGCCGG 1 -- ng511Minor allele frequency- A:0.00NA 2
    About this table

    HapMap Linkage Disequilibrium images for HIST1H2AB (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HIST1H2AB: --

    QIAGEN SeqTarget long-range PCR primers for resequencing HIST1H2AB 

    Disorders & Mutations
    for HIST1H2AB gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIST1H2AB for disorders           About GeneDecksing

    OMIM: 602795

    Human Genome Epidemiology (HuGE) Navigator: HIST1H2AB (1 document)

    Export disorders and mutations for HIST1H2AB gene to outside databases

    Medical News
    for HIST1H2AB gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for HIST1H2AB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/30 PubMed articles for HIST1H2AB gene, integrated from 7 sources (see all 30):
    (articles sorted by number of sources associating them with HIST1H2AB)
    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2, 3 Albig W. and Doenecke D. (1997)
    3. DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (PubMed id 16702407)1, 2 Bergink S.... Dantuma N.P. (2006)
    4. Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. (PubMed id 15823041)1, 2 Hagiwara T.... Yamada M. (2005)
    5. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PubMed id 16359901)1, 2 Cao R.... Zhang Y. (2005)
    6. Role of histone H2A ubiquitination in Polycomb silencing. (PubMed id 15386022)1, 2 Wang H.... Zhang Y. (2004)
    7. Phosphorylation of histone H2A inhibits transcription on chromatin templates. (PubMed id 15010469)1, 2 Zhang Y.... Parvin J.D. (2004)
    8. Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. (PubMed id 15078818)1, 2 Aihara H.... Ito T. (2004)
    9. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 3 Albig W.... Doenecke D. (1997)
    10. The primary structure and expression of four cloned human histone genes. (PubMed id 6647026)1, 2 Zhong R.... Heintz N. (1983)

    External Searches for HIST1H2AB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIST1H2AB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8335 HGNC: 4734 AceView: HIST1H2AB Ensembl:ENSG00000137259 euGenes: HUgn8335
    ECgene: HIST1H2AB Kegg: 8335 H-InvDB: HIST1H2AB

    Other Databases showing HIST1H2AB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST1H2AB gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for HIST1H2AB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for HIST1H2AB gene:
    Search GeneIP for patents involving HIST1H2AB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HIST1H2AB gene

    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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     Regulatory tfbs in HIST1H2AB promoter
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     ELISAs and CLIAs for HIST1H2AB
           

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