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HIST1H3J Gene

protein-coding   GIFtS: 45

GC06M027665
histone cluster 1, H3j
(Previous names: H3 histone family, member J, histone 1, H3j )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: H3FJ)
Products    

Aliases &
Descriptions
for HIST1H3J gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
histone cluster 1, H3j1 2     HIST1H3E2
H3FJ2 3 5     HIST1H3H2
H3 histone family, member J1 2     HIST1H3I2
H3/j1 2     HIST1H3C2
histone 1, H3j1 2     histone H3.12
Histone H3/l2 3     HIST1H3D2
Histone H3/a2 3     HIST1H3F2
Histone H3/j2 3     HIST1H3G2
Histone H3/k2 3     H3FI3
Histone H3/f2 3     H3FH3
Histone H3/d2 3     H3FF3
Histone H3/i2 3     H3FB3
Histone H3/b2 3     H3FL3
Histone H3/c2 3     H3FC3
Histone H3/h2 3     H3FA3
HIST1H3A2     H3FK3
HIST1H3B2     H3FD3

External Ids:    HGNC: 47741   Entrez Gene: 83562   Ensembl: ENSG000001971537   UniProtKB: P684313   

Export aliases for HIST1H3J gene to outside databases

Previous GC identifers: GC06M027916 GC06M027966 GC06M027862


Summaries
for HIST1H3J gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST1H3J:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with
linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is
intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead
contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome
6p22-p21.3. (provided by RefSeq)

UniProtKB/Swiss-Prot: H31_HUMAN, P68431
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H3J

Genomic Views
for HIST1H3J gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H3J gene promoter:
         Pax-6   CP1A   CP1C   NF-Y   NF-YA   NF-1   AhR   MEF-2A   GATA-2   YY1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for HIST1H3J

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

HIST1H3J Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H3J gene location

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M027665:  view genomic region     (about GC identifiers)

Start:
 27,665,758 bp from pter
End:
 27,666,235 bp from pter
Size:
 478 bases
Orientation:
 minus strand

1 alternative location:
Chr6- 27,858,160-27,860,884     
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  

Proteins
for HIST1H3J gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: H31_HUMAN, P68431 (See protein sequence)
Recommended Name: Histone H3.1  
Size: 136 amino acids; 15404 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Developmental stage: Expressed during S phase, then expression strongly decreases as cell division slows down during
the process of differentiation
Miscellaneous: This histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation of
Lys-10 (H3K9me2)
PDB structures from and Proteopedia :
1CS9 (3D)    1CT6 (3D)    1Q3L (3D)    2B2T (3D)    2B2U (3D)    2B2V (3D)    2B2W (3D)    2C1J (3D)    
2C1N (3D)    2CV5 (3D)    2RI7 (3D)    2UXN (3D)    3A1B (3D)    3AFA (3D)    
Secondary accessions: A0PJT7 A5PLR1 P02295 P02296 P16106 Q6ISV8 Q6NWP8 Q6NWP9 Q6NXU4 Q71DJ3 Q93081

Explore the universe of human proteins at neXtProt for HIST1H3J: NX_P68431 

Post-translational modifications:

  • Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9
    • (H3R8sme2). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me)1
  • Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription1
  • Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9
    • (H3R8sme2) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to
    gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the
    3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on
    active promoters1
  • Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at
    • Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA
    double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28
    (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1,
    CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation
    at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at
    Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin1
  • Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase. Phosphorylation
    • at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and
    meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because
    it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV
    irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which
    is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.
    Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from
    heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell
    transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK isoform 1, RPS6KA5 or AURKB during mitosis or upon
    ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCBB is a specific tag for epigenetic
    transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically
    phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12
    (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10
    (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from
    chromatin1
  • Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity).
    • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
    between histones and DNA and facilitate DNA accessibility to repair proteins1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_003526.1  

    ENSEMBL proteins: 
    ENSP00000352252 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for HIST1H3J 
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786 nucleosome ----
    GO:0005634 nucleus ----
    GO:0005694 chromosome ----
    About this table

    HIST1H3J for ontologies           About GeneDecksing



    Antibodies for HIST1H3J: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibody Arrays and Antibodies for HIST1H3J
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for HIST1H3J 
    Epitomics antibodies for HIST1H3J

    Assays for HIST1H3J: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIST1H3J 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HIST1H3J 

    Protein Domains/
    Families
    for HIST1H3J gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIST1H3J for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000164 Histone_H3
     IPR009072 Histone-fold
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry P68431

    ProtoNet protein and cluster: P68431

    UniProtKB/Swiss-Prot: H31_HUMAN, P68431
    Similarity: Belongs to the histone H3 family


    Gene Function
    for HIST1H3J gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: H31_HUMAN, P68431
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for HIST1H3J
    Sigma-Aldrich shRNA for HIST1H3J
    OriGene 29mer shRNA kits in GFP-retroviral vector: HIST1H3J
    OriGene shRNA RFP: HIST1H3J
    OriGene basic RS shRNA: HIST1H3J
    OriGene siRNA: HIST1H3J
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HIST1H3J 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HIST1H3J 
    1 SABiosciences Assays for microRNA that regulate HIST1H3J:
    hsa-miR-760

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: HIST1H3J
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HIST1H3J
    OriGene untagged cDNA clones in CMV expression vector: HIST1H3J
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: HIST1H3J 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for HIST1H3J 

    2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding ----
    GO:0005515 protein binding ----
    About this table

    HIST1H3J for ontologies           About GeneDecksing


    Pathways & Interactions
    for HIST1H3J gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    HIST1H3J for pathways           About GeneDecksing

    1 Kegg Pathway  (Kegg details for HIST1H3J):
        hsa05322 Systemic lupus erythematosus

        SABiosciences Custom Pathway-Focused PCR Arrays for HIST1H3J 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H3J

    5/57 Interacting proteins for HIST1H3J (P684311, 2 ENSP000003522523) via UniProtKB, MINT, and/or STRING (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBX1P839161, 2, ENSP000002256033EBI-79722,EBI-78129 MINT-2830869 MINT-2829009 MINT-2830731 MINT-2830755 MINT-2829033 MINT-2828976 MINT-2829858 STRING: ENSP00000225603
    ASF1BQ9NVP21, 2, ENSP000002633823EBI-79722,EBI-1055650 MINT-7221095 MINT-7220359 STRING: ENSP00000263382
    KDM4AO751642, ENSP000003614733MINT-2830454 MINT-2830478 MINT-2829063 MINT-2830611 MINT-2829672 MINT-2829698 MINT-2829722 STRING: ENSP00000361473
    CHAF1AQ131112, ENSP000003012803MINT-7221095 MINT-7221140 MINT-7220359 STRING: ENSP00000301280
    CHAF1BQ131122, ENSP000003157003MINT-7221095 MINT-7221140 MINT-7220359 STRING: ENSP00000315700
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334 nucleosome assembly ----
    About this table

    HIST1H3J for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST1H3J gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H3J


    Transcripts
    for HIST1H3J gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for HIST1H3J
    Sigma-Aldrich shRNA for HIST1H3J
    OriGene 29mer shRNA kits in GFP-retroviral vector: HIST1H3J
    OriGene shRNA RFP: HIST1H3J
    OriGene basic RS shRNA: HIST1H3J
    OriGene siRNA: HIST1H3J
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HIST1H3J 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HIST1H3J 
    1 SABiosciences Assays for microRNA that regulate HIST1H3J:
    hsa-miR-760
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: HIST1H3J
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HIST1H3J
    OriGene untagged cDNA clones in CMV expression vector: HIST1H3J
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: HIST1H3J 
    Primers: OriGene genome-wide validated SYBR primer pairs: HIST1H3J
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for HIST1H3J: PPH22514A

    REFSEQ mRNAs for HIST1H3J gene: 

    NM_003535.2  

    Additional cDNA sequence: CR612219.1 

    1 DOTS entry:

    DT.91669233 

    8 AceView cDNA sequences:

    CR612219 NM_003535 BX371361 BX368993 AL522145 AI970475 BF511773 AL522144 

    highest scoring ESTs for HIST1H3J:

    AL522145 CR612219 NM_003535 AI970475 AL522144 BF511773 BX368993 BX371361 DW430291 

    Unigene Cluster for HIST1H3J:

    Histone cluster 1, H3j
    Hs.484990  [show with all ESTs]
    Unigene Representative Sequence: CR612219


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479986 ENST00000359303(uc003nka.2)

    Expression
    for HIST1H3J gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    HIST1H3J expression in normal and diseased human tissues

    1  / 3 Data from Genenote  (Publications) and GNF BioGPS
        About these images

    HIST1H3J gene expression
    HIST1H3J gene electronic northern expression
    HIST1H3J gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.484990
    Primers: OriGene genome-wide validated SYBR primer pairs: HIST1H3J
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for HIST1H3J: PPH22514A
        SABiosciences Custom PCR Arrays for HIST1H3J 


    Orthologs
    for HIST1H3J gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for HIST1H3J gene from 5/16 species (see all 16)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 LOC4831671   -- similar to H3 histone, family 2 isoform 2 84.31(n)
    99.26(a)    		 483167  XM_540285.1  XP_540285.1 
    chimpanzee
    (Pan troglodytes)    		 H3F3B1   -- H3 histone, family 3B (H3.3B) 78.92(n)
    96.32(a)    		 738262  XM_001146144.1  XP_001146144.1 
    cow
    (Bos taurus)    		 LOC5045991   -- histone H3.2 84.07(n)
    99.26(a)    		 504599  XM_580747.2  XP_580747.1 
    rat
    (Rattus norvegicus)    		 Hist2h3c21   -- histone cluster 2, H3c2 85.05(n)
    99.26(a)    		 310678  XM_227460.3  XP_227460.3 
    mouse
    (Mus musculus)    		 Hist2h3c11   -- histone cluster 2, H3c1 85.05(n)
    99.26(a)    		 15077  NM_178216.1  NP_835734.1 
    About this table        Species with no ortholog for HIST1H3J

    ENSEMBL Gene Tree for HIST1H3J (if available)

    Paralogs
    for HIST1H3J gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for HIST1H3J gene
    HIST1H3I1 2  HIST1H3H1 2  HIST1H3F1 2  HIST1H3C1 2  HIST1H3D1 2  HIST1H3A1 2  HIST1H3E1 2  HIST1H3G1 2  
    HIST1H3B1 2  HIST3H32  

    HIST1H3J for paralogs           About GeneDecksing



    Genomic Variants
    for HIST1H3J gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/15 NCBI SNPs in HIST1H3J are shown (see all 15)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs2009711,2
    		C,A,H,27858904(-) TCTCTA/GCTAAA 1 -- ng512Minor allele frequency- G:0.25NA WA 4
    rs2009721,2
    		C,A,27858837(-) GAGGCG/AGAATC 1 -- ng512Minor allele frequency- A:0.25NA WA 4
    rs2009731,2
    		C,F,A,27858421(+) ATCTCA/GCGCAA 2 R syn1 ref1 ese36Minor allele frequency- G:0.12MN EA NS 1332
    rs617340001,2
    		--27858192(+) CGCAAA/GCTGGA 2 L F ref1 mis10--------
    rs624014121,2
    		--27857834(+) GGACAA/GCATGT 1 -- ng311Minor allele frequency- G:0.00NA 2
    rs624014131,2
    		27859072(+) TCCCCC/TAATGA 1 -- ng511Minor allele frequency- T:0.50NA 2
    rs627909601,2
    		--27858734(+) TTTTT-/TTTTT 
                TTTTT     		1 -- ng510--------
    rs637451601,2
    		--27858721(+) CCACT-/TTTTT 
                TTTTT     		1 -- ng510--------
    rs724413571,2
    		--27858729(+) TTTTT-/TTTT  
                TTTTT     		1 -- ng510--------
    rs733866511,2
    		C,F,27858040(+) TTTAAA/GGTTGA 1 -- ng312Minor allele frequency- G:0.06WA 52
    About this table

    HapMap Linkage Disequilibrium images for HIST1H3J (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HIST1H3J: --

    QIAGEN SeqTarget long-range PCR primers for resequencing HIST1H3J 

    Disorders & Mutations
    for HIST1H3J gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIST1H3J for disorders           About GeneDecksing

    OMIM: 602817


    Export disorders and mutations for HIST1H3J gene to outside databases

    Medical News
    for HIST1H3J gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for HIST1H3J gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/48 PubMed articles for HIST1H3J gene, integrated from 7 sources (see all 48):
    (articles sorted by number of sources associating them with HIST1H3J)
    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2, 3 Albig W. and Doenecke D. (1997)
    3. Phosphorylation of histone H3T6 by PKCbeta(I) control s demethylation at histone H3K4. (PubMed id 20228790)2 Metzger E....SchA1le R. (2010)
    4. JAK2 phosphorylates histone H3Y41 and excludes HP1alp ha from chromatin. (PubMed id 19783980)2 Dawson M.A....Kouzarides T. (2009)
    5. Arginine methylation of the histone H3 tail impedes effector binding. (PubMed id 18077460)2 Iberg A.N.... Bedford M.T. (2008)
    6. Phosphorylation of histone H3 at threonine 11 establi shes a novel chromatin mark for transcriptional regulation. (PubMed id 18066052)2 Metzger E....SchA1le R. (2008)
    7. Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis. (PubMed id 19007248)2 Wang B.... Korner R. (2008)
    8. Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. (PubMed id 17189264)2 Morris S.A.... Strahl B.D. (2007)
    9. Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive. (PubMed id 17898714)2 Guccione E....Amati B. (2007)
    10. Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS spectra. (PubMed id 17924679)2 Yu L.-R.... Veenstra T.D. (2007)

    External Searches for HIST1H3J gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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    Genome Databases showing HIST1H3J gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8356 HGNC: 4774 AceView: HIST1H3J Ensembl:ENSG00000197153 euGenes: HUgn8356
    ECgene: HIST1H3J Kegg: 8356 H-InvDB: HIST1H3J

    Other Databases showing HIST1H3J gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST1H3J gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for HIST1H3J gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for HIST1H3J gene:
    Search GeneIP for patents involving HIST1H3J

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    Products
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