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HIST1H4K Gene

protein-coding   GIFtS: 48

GC06M027606
histone cluster 1, H4k
(Previous names: H4 histone family, member D, histone 1, H4k )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: H4FD)
Products    

Aliases &
Descriptions
for HIST1H4K gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
histone cluster 1, H4k1 2     H4FA3
H4FD2 3 5     H4FH3
dJ160A22.11 2     H4F23
H4/d1 2     H4/A3
H4 histone family, member D1 2     H4FM3
histone 1, H4k1 2     H4FK3
H4F2iii1 2     H4FG3
HIST1H4F2     H4FB3
HIST1H4L2     HIST2H43
histone H42     H4/K3
HIST1H4H2     H4/N3
HIST2H4B2     H4FE3
HIST1H4I2     H4/M3
HIST1H4B2     H4FC3
HIST1H4A2     H4FI3
HIST1H4E2     H4/H3
HIST2H4A2     H4/G3
HIST4H42     H4FJ3
HIST1H4C2     H4/I3
HIST1H4J2     H4FO3
HIST1H4D2     H4/B3
H4/J3     H4/D3
H4/O3     H4/C3
H4FN3     H4/E3

External Ids:    HGNC: 47841   Entrez Gene: 83622   Ensembl: ENSG000001979147   UniProtKB: P628053   

Export aliases for HIST1H4K gene to outside databases

Previous GC identifers: GC06M027856 GC06M027906 GC06M027798


Summaries
for HIST1H4K gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST1H4K:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with
linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is
intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead
contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome
6p22-p21.3. (provided by RefSeq)

UniProtKB/Swiss-Prot: H4_HUMAN, P62805
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H4K

Genomic Views
for HIST1H4K gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H4K gene promoter:
         AhR   Arnt   MEF-2A   Pax-6   FOXO4   GATA-2   MZF-1   STAT5A   E2F-2   E2F-5   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for HIST1H4K

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HIST1H4K 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

HIST1H4K Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H4K gene location

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M027606:  view genomic region     (about GC identifiers)

Start:
 27,606,606 bp from pter
End:
 27,606,959 bp from pter
Size:
 354 bases
Orientation:
 minus strand

1 alternative location:
Chr6- 27,798,994-27,799,305     
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  

Proteins
for HIST1H4K gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: H4_HUMAN, P62805 (See protein sequence)
Recommended Name: Histone H4  
Size: 103 amino acids; 11367 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Sequence caution: Sequence=AAI28106.1; Type=Frameshift; Positions=3;
PDB structures from and Proteopedia :
2BQZ (3D)    2CV5 (3D)    2RNY (3D)    3A6N (3D)    3AFA (3D)    3CFS (3D)    3CFV (3D)    3F9W (3D)    
3F9X (3D)    3F9Y (3D)    3F9Z (3D)    3NQJ (3D)    3NQU (3D)    
Secondary accessions: A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7

Explore the universe of human proteins at neXtProt for HIST1H4K: NX_P62805 

Post-translational modifications:

  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the
    • genome but not in heterochromatin1
  • Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation1
  • Monomethylation at Arg-4 (H4R3me1) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is
    • performed by JMJD61
  • Symmetric dimethylation on Arg-4 (H4R3me2a) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage1
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by
    • SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing1
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
    • between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone
    H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may
    function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21
    methylation (H4K20me)1
  • Sumoylated, which is associated with transcriptional repression1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_003532.1  

    ENSEMBL proteins: 
    ENSP00000350159 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant HIST1H4K Protein
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HIST1H4K
    GenScript Custom Purified and Recombinant Proteins Services for HIST1H4K 
    Novus Biologicals Protein for HIST1H4K
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786 nucleosome ----
    GO:0005634 nucleus ----
    GO:0005654 nucleoplasm ----
    GO:0005694 chromosome ----
    About this table

    HIST1H4K for ontologies           About GeneDecksing



    Antibodies for HIST1H4K: 
    Millipore Mono- and Polyclonal Antibodies for the study of HIST1H4K
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for HIST1H4K 
    Epitomics antibodies for HIST1H4K

    Assays for HIST1H4K: 
    Millipore Kits and Assays for the Analysis of HIST1H4K
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIST1H4K 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HIST1H4K 

    Protein Domains/
    Families
    for HIST1H4K gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIST1H4K for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR009072 Histone-fold
     IPR019809 Histone_H4_CS
     IPR007125 Histone_core_D
     IPR001951 Histone_H4

    Graphical View of Domain Structure for InterPro Entry P62805

    ProtoNet protein and cluster: P62805

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
    Similarity: Belongs to the histone H4 family


    Gene Function
    for HIST1H4K gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: H4_HUMAN, P62805
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for HIST1H4K
    Sigma-Aldrich shRNA for HIST1H4K
    OriGene 29mer shRNA kits in GFP-retroviral vector: HIST1H4K
    OriGene shRNA RFP: HIST1H4K
    OriGene basic RS shRNA: HIST1H4K
    OriGene siRNA: HIST1H4K
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HIST1H4K 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HIST1H4K 
    Search SABiosciences for Assays for microRNAs that regulate HIST1H4K

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: HIST1H4K
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HIST1H4K
    OriGene untagged cDNA clones in CMV expression vector: HIST1H4K
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: HIST1H4K 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for HIST1H4K 

    3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding ----
    GO:0005515 protein binding ----
    GO:0016986 transcription initiation factor activity ----
    About this table

    HIST1H4K for ontologies           About GeneDecksing


    Pathways & Interactions
    for HIST1H4K gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    HIST1H4K for pathways           About GeneDecksing

    5 Millipore Pathways for HIST1H4K
        Development Notch Signaling Pathway
    Transcription Sin3 and NuRD in transcription regulation
    Histone modification
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Signal transduction Activin A signaling regulation

    1 Kegg Pathway  (Kegg details for HIST1H4K):
        hsa05322 Systemic lupus erythematosus

        SABiosciences Custom Pathway-Focused PCR Arrays for HIST1H4K 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H4K

    5/138 Interacting proteins for HIST1H4K (P628051, 2) via UniProtKB, MINT, and/or STRING (see all 138)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HAT1O149291, 2EBI-302023,EBI-2339359 MINT-7220359
    L3MBTLQ9Y4681, 2EBI-302023,EBI-1265089 MINT-2830429
    L3MBTL1Q9Y4681, 2
    HDAC1Q135471EBI-302023,EBI-301834
    HDAC4P565241EBI-302023,EBI-308629
    About this table

    5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325 chromatin organization ----
    GO:0006334 nucleosome assembly ----
    GO:0006352 transcription initiation ----
    GO:0045653 negative regulation of megakaryocyte differentiation ----
    GO:0048015 phosphoinositide-mediated signaling ----
    About this table

    HIST1H4K for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST1H4K gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H4K


    Transcripts
    for HIST1H4K gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for HIST1H4K
    Sigma-Aldrich shRNA for HIST1H4K
    OriGene 29mer shRNA kits in GFP-retroviral vector: HIST1H4K
    OriGene shRNA RFP: HIST1H4K
    OriGene basic RS shRNA: HIST1H4K
    OriGene siRNA: HIST1H4K
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HIST1H4K 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HIST1H4K 
    Search SABiosciences for Assays for microRNAs that regulate HIST1H4K
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: HIST1H4K
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HIST1H4K
    OriGene untagged cDNA clones in CMV expression vector: HIST1H4K
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: HIST1H4K 
    Primers: OriGene genome-wide validated SYBR primer pairs: HIST1H4K
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for HIST1H4K

    REFSEQ mRNAs for HIST1H4K gene: 

    NM_003541.2  

    Additional cDNA sequence: 

    BC111093.1 BC111434.1 

    3 DOTS entries:

    DT.99935921  DT.121375393  DT.101973526 

    16 AceView cDNA sequences:

    NM_021968 AW451698 BC062345 AF086564 BC017361 BU849117 AI653010 BU533398 
    NM_003541 BE669804 AA702915 AI420192 CD175217 CD175201 AA010078 BE973853 

    highest scoring ESTs for HIST1H4K:

    T98257 BC111093 BC111434 DA286485 DA436104 DA438592 DA439641 DA453996 DA946389 CK032871 

    Unigene Cluster for HIST1H4K:

    Histone cluster 1, H4k
    Hs.528055  [show with all ESTs]
    Unigene Representative Sequence: DA438592


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000357549(uc003njr.2)

    Expression
    for HIST1H4K gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    HIST1H4K expression in normal and diseased human tissues

    1  / 3 Data from Genenote  (Publications) and GNF BioGPS
        About these images

    HIST1H4K gene expression
    HIST1H4K gene electronic northern expression
    HIST1H4K gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.528055
    Primers: OriGene genome-wide validated SYBR primer pairs: HIST1H4K
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for HIST1H4K
        SABiosciences Custom PCR Arrays for HIST1H4K 


    Orthologs
    for HIST1H4K gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for HIST1H4K gene from 5/20 species (see all 20)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 LOC6112311   -- similar to germinal histone H4 gene 90.94(n)
    100(a)    		 611231  XM_848870.1  XP_853963.1 
    chimpanzee
    (Pan troglodytes)    		 LOC7367071   -- similar to histone H4 99.35(n)
    100(a)    		 736707  XM_001138202.1  XP_001138202.1 
    cow
    (Bos taurus)    		 LOC6190941   -- similar to histone H4 85.11(n)
    99.03(a)    		 619094  XM_871414.2  XP_876507.2 
    rat
    (Rattus norvegicus)    		 LOC6798401   -- similar to germinal histone H4 gene 89(n)
    100(a)    		 679840  XM_001054684.1  XP_001054684.1 
    mouse
    (Mus musculus)    		 Hist1h4k5 13 (7.95 cM) histone cluster 1, H4k   -- BC119612 
    About this table        Species with no ortholog for HIST1H4K

    ENSEMBL Gene Tree for HIST1H4K (if available)

    Paralogs
    for HIST1H4K gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for HIST1H4K gene
    HIST1H4J  HIST1H4I1 2  HIST1H4A  HIST1H4L1 2  HIST2H4A  HIST1H4E  HIST2H4B  HIST1H4B  
    HIST1H4F  HIST1H4D  HIST1H4H1 2  HIST4H4  HIST1H4C  HIST1H4G2  

    HIST1H4K for paralogs           About GeneDecksing



    Genomic Variants
    for HIST1H4K gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/33 NCBI SNPs in HIST1H4K are shown (see all 33)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs2004881,2
    		C,F,A27799045(-) GATGTG/AGTCTA 2 /V syn1 ref1 ese33Minor allele frequency- A:0.09MN EA NA 1734
    rs4253351,2
    		C,F,27799527(-) TAACAA/GAATAC 1 -- ng519Minor allele frequency- G:0.16EA NA MN NS 556
    rs27470521,2
    		--27800612(+) ATTTTC/TTTTCT 1 -- ng51 trp30--------
    rs27470531,2
    		--27800616(+) TCTTTC/TTTATT 1 -- ng51 trp30--------
    rs47131251,2
    		A27800671(+) ttttgG/Tggaga 1 -- ng510--------
    rs47131261,2
    		--27800820(+) cccggC/Gtaatt 1 -- ng510--------
    rs93667071,2
    		C,27800502(+) gtgagG/Ccgctt 1 -- ng511Minor allele frequency- C:0.50NA 2
    rs93667081,2
    		C,27800686(+) gtctcG/Accctt 1 -- ng511Minor allele frequency- A:0.50NA 2
    rs93800201,2
    		C27798897(+) GCGAAC/TAAATG 1 -- ng310--------
    rs114551841,2
    		--27800669(+) TTTTT-/TGTGGA 1 -- ng510--------
    About this table

    HapMap Linkage Disequilibrium images for HIST1H4K (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HIST1H4K: --

    QIAGEN SeqTarget long-range PCR primers for resequencing HIST1H4K 

    Disorders & Mutations
    for HIST1H4K gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIST1H4K for disorders           About GeneDecksing

    OMIM: 602825


    Export disorders and mutations for HIST1H4K gene to outside databases

    Medical News
    for HIST1H4K gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for HIST1H4K gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/40 PubMed articles for HIST1H4K gene, integrated from 7 sources (see all 40):
    (articles sorted by number of sources associating them with HIST1H4K)
    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2, 3 Albig W. and Doenecke D. (1997)
    3. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    4. BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. (PubMed id 19818714)2 Yan Q....Shipp M.A. (2009)
    5. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    7. Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis. (PubMed id 19007248)2 Wang B.... Korner R. (2008)
    8. Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle. (PubMed id 17967882)2 Pesavento J.J.... Mizzen C.A. (2008)
    9. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. (PubMed id 18083107)2 Rikova K....Comb M.J. (2007)
    10. Characterization of histones H2A and H2B variants and their post- translational modifications by mass spectrometry. (PubMed id 16319397)2 Bonenfant D.... van Oostrum J. (2006)

    External Searches for HIST1H4K gene

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    Genome Databases showing HIST1H4K gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8362 HGNC: 4784 AceView: HIST1H4J Ensembl:ENSG00000197914 euGenes: HUgn8362
    ECgene: HIST1H4K Kegg: 8362 H-InvDB: HIST1H4K

    Other Databases showing HIST1H4K gene

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    Specialized Databases showing HIST1H4K gene

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    Intellectual Property
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