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HIST2H2BF Gene

protein-coding   GIFtS: 44

GC01M149758
histone cluster 2, H2bf
(Previous names: histone 2, H2bf )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
histone cluster 2, H2bf1 2     histone H2B type 2-F2
histone 2, H2bf1 2     FLJ567872
FLJ567802     MGC1316392
FLJ350992     

External Ids:    HGNC: 247001   Entrez Gene: 4406892   Ensembl: ENSG000002038147   UniProtKB: Q5QNW63   

Export aliases for HIST2H2BF gene to outside databases

Previous GC identifers: GC01M146591 GC01M148048 GC01M149765


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: H2B2F_HUMAN, Q5QNW6
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST2H2BF

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST2H2BF gene promoter:
         POU2F1   Oct-B1   oct-B2   oct-B3   POU2F2   POU2F2 (Oct-2.1)   POU2F2B   POU2F2C   Cdc5   CUTL1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for HIST2H2BF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

HIST2H2BF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST2H2BF gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M149758:  view genomic region     (about GC identifiers)

Start:
149,754,245 bp from pter
End:
149,783,928 bp from pter
Size:
29,684 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: H2B2F_HUMAN, Q5QNW6 (See protein sequence)
Recommended Name: Histone H2B type 2-F  
Size: 126 amino acids; 13920 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Secondary accessions: A8K0U9

Explore the universe of human proteins at neXtProt for HIST2H2BF: NX_Q5QNW6 

Post-translational modifications:

  • Monoubiquitination of Lys-121 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation
  • and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the
    FACT dimer to stimulate elongation by RNA polymerase II1
  • Phosphorylated on Ser-15 by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also
  • phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation
    and immunoglobulin class-switch recombination1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001019770.1  NP_001154806.1  


    ENSEMBL proteins: 
    ENSP00000358164 ENSP00000407461 


    Human Recombinant Proteins 
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    OriGene Protein Over-expression Lysate: HIST2H2BF
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    Browse ProSpec Recombinant Proteins

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786 nucleosome IEA--
    GO:0005634 nucleus IEA--
    GO:0005694 chromosome IEA--
    About this table

    HIST2H2BF for ontologies           About GeneDecksing



    Antibodies for HIST2H2BF: 
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    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HIST2H2BF for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009072 Histone-fold
     IPR000558 Histone_H2B
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry Q5QNW6

    ProtoNet protein and cluster: Q5QNW6

    UniProtKB/Swiss-Prot: H2B2F_HUMAN, Q5QNW6
    Similarity: Belongs to the histone H2B family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: H2B2F_HUMAN, Q5QNW6
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
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    OriGene basic RS shRNA (see all 3): HIST2H2BF
    OriGene siRNA (see all 2): HIST2H2BF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HIST2H2BF 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HIST2H2BF 
    1 SABiosciences Assays for microRNA that regulate HIST2H2BF:
    hsa-miR-760

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): HIST2H2BF
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): HIST2H2BF
    OriGene untagged cDNA clones in CMV expression vector: HIST2H2BF
    OriGene 3'-UTR clone (see all 2): HIST2H2BF 
    Browse MicroRNA Expression Plasmids 
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    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for HIST2H2BF 

    1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IEA--
    About this table

    HIST2H2BF for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    HIST2H2BF for pathways           About GeneDecksing

    1 Kegg Pathway  (Kegg details for HIST2H2BF):
        hsa05322 Systemic lupus erythematosus

        SABiosciences Custom Pathway-Focused PCR Arrays for HIST2H2BF 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST2H2BF

    1 Interacting protein for HIST2H2BF (Q5QNW62) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042MINT-3296671
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334 nucleosome assembly IEA--
    About this table

    HIST2H2BF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST2H2BF


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for HIST2H2BF
    Sigma-Aldrich shRNA for HIST2H2BF
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): HIST2H2BF
    OriGene shRNA RFP (see all 3): HIST2H2BF
    OriGene basic RS shRNA (see all 3): HIST2H2BF
    OriGene siRNA (see all 2): HIST2H2BF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HIST2H2BF 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HIST2H2BF 
    1 SABiosciences Assays for microRNA that regulate HIST2H2BF:
    hsa-miR-760
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): HIST2H2BF
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): HIST2H2BF
    OriGene untagged cDNA clones in CMV expression vector: HIST2H2BF
    OriGene 3'-UTR Clone (see all 2): HIST2H2BF 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for HIST2H2BF 
    Primers: OriGene genome-wide validated SYBR primer pairs: HIST2H2BF
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for HIST2H2BF: PPH63479A

    REFSEQ mRNAs for HIST2H2BF gene (2 alternative transcripts): 

    NM_001024599.3  NM_001161334.1  

    Additional cDNA sequence: 

    AK092418.1 AK289664.1 AK296916.1 AK299108.1 BC110793.1 

    4 DOTS entries:

    DT.40219799  DT.92010992  DT.114591  DT.121372893 

    7 AceView cDNA sequences:

    BX282515 BI835621 BE742212 BI836145 CD698245 AI147174 AI660196 

    highest scoring ESTs for HIST2H2BF:

    BE742212 BI835621 BI836145 BX282515 AI147174 BF765751 CD109968 DA042901 DA137545 DA178178 

    Unigene Cluster for HIST2H2BF:

    Histone cluster 2, H2bf
    Hs.726907  [show with all ESTs]
    Unigene Representative Sequence: AK092418


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369167(uc010pbj.1 uc001esr.2) ENST00000427880(uc010pbk.1)
    ENST00000469483

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    HIST2H2BF expression in normal and diseased human tissues

    1  / 2  / 3

    2 probe-sets matching HIST2H2BF gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    69102_at2, 3 U95-D 1 0.75 1.00 0.97 1.15 AI950819 0.40 0.75 0.60 1
    71712_at2, 3 U95-D 3 0.56 0.78 0.98 0.86 AI660196 0.60 0.56 0.58 1
    About this table

    HIST2H2BF for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    HIST2H2BF gene expression
    HIST2H2BF gene electronic northern expression
    HIST2H2BF gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.726907
    Primers: OriGene genome-wide validated SYBR primer pairs: HIST2H2BF
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for HIST2H2BF: PPH63479A
        SABiosciences Custom PCR Arrays for HIST2H2BF 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for HIST2H2BF gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC4831641   -- similar to Histone H2B 291B 94.97(n)
    100(a)
    483164  XM_540282.2  XP_540282.1 
    chimpanzee
    (Pan troglodytes)
    LOC4572601   -- similar to histone H2b-616 99.74(n)
    100(a)
    457260  XM_513763.2  XP_513763.2 
    cow
    (Bos taurus)
    LOC6150911   -- similar to histone cluster 1, H2bd 90.21(n)
    100(a)
    615091  XM_866798.2  XP_871891.1 
    rat
    (Rattus norvegicus)
    Hist2h2bb1   -- histone cluster 2, H2bb 88.36(n)
    100(a)
    295278  XM_227463.2  XP_227463.1 
    mouse
    (Mus musculus)
    Hist2h2bb1   -- histone cluster 2, H2bb 88.36(n)
    100(a)
    319189  NM_175666.2  NP_783597.2 
    About this table        Species with no ortholog for HIST2H2BF

    ENSEMBL Gene Tree for HIST2H2BF (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for HIST2H2BF gene
    HIST1H2BO2  HIST3H2BB2  HIST1H2BK2  HIST1H2BJ2  HIST2H2BE2  HIST1H2BH2  

    HIST2H2BF for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/168 NCBI SNPs in HIST2H2BF are shown (see all 168)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs5834731,2
    C,A,H149764594(+) agctcC/Tcgggc 1 -- int10--------
    rs5929981,2
    C,A,H149769356(+) gccatG/Attgtc 1 -- int11Minor allele frequency- A:0.50NA 2
    rs6007621,2
    H149781965(+) ATACCG/ACATTT 2 -- int1 ng314Minor allele frequency- A:0.00NS EA 418
    rs6093101,2
    --149771442(-) ggagaA/Cccccc 1 -- int10--------
    rs6093121,2
    C,A149771437(-) accccC/Gctccg 1 -- int10--------
    rs6097171,2
    C,A149771356(-) TCATGA/GTGATC 1 -- int10--------
    rs6109051,2
    C,F,A,H149777480(-) gctctG/Attagc 1 -- int11Minor allele frequency- A:0.39MN 184
    rs6191111,2
    C,A,H149777196(+) CAATCC/GCATTT 1 -- int10--------
    rs6195901,2
    C,A,H149777295(+) TAATAG/AGGATA 1 -- int14Minor allele frequency- A:0.00NS EA 392
    rs6226861,2
    C,A149771364(+) TGAGGA/CCggag 1 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for HIST2H2BF (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 19 variations for HIST2H2BF
         15/18 CNVs (see all 18): 8924 6785 48120 2326 48129 22942 64903 4255 8329 64896 64904 3313 30433 48130 48128
         1 Inversion: 37080

    QIAGEN SeqTarget long-range PCR primers for resequencing HIST2H2BF 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/12 PubMed articles for HIST2H2BF gene, integrated from 7 sources (see all 12):
    (articles sorted by number of sources associating them with HIST2H2BF)
    1. Characterization of histones H2A and H2B variants and their post- translational modifications by mass spectrometry. (PubMed id 16319397)1, 2 Bonenfant D.... van Oostrum J. (2006)
    2. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563)1, 2 Pavri R....Reinberg D. (2006)
    3. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)1, 2 Kim S.C.... Zhao Y. (2006)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2 Zhu B.... Reinberg D. (2005)
    6. Inhibition of core histones acetylation by carcinogenic nickel(II). (PubMed id 16283522)1, 2 Golebiowski F. and Kasprzak K.S. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PubMed id 12757711)1, 2 Cheung W.L.... Allis C.D. (2003)
    10. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 440689 HGNC: 24700 AceView: LOC440689 Ensembl:ENSG00000203814 euGenes: HUgn440689
    ECgene: HIST2H2BF Kegg: 440689 H-InvDB: HIST2H2BF

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for HIST2H2BF gene:
    Search GeneIP for patents involving HIST2H2BF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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