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Aliases & Descriptionsfor HIST2H2BF gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions histone cluster 2, H2bf1 2 histone H2B type 2-F2 histone 2, H2bf1 2 FLJ567872 FLJ567802 MGC1316392 FLJ350992
Export aliases for HIST2H2BF gene to outside databases Previous GC identifers: GC01M146591 GC01M148048 GC01M149765
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Summariesfor HIST2H2BF gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: H2B2F_HUMAN, Q5QNW6 Function : Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility tothe cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling Gene Wiki entry for HIST2H2BF
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Genomic Viewsfor HIST2H2BF gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the HIST2H2BF gene promoter: POU2F1 Oct-B1 oct-B2 oct-B3 POU2F2 POU2F2 (Oct-2.1) POU2F2B POU2F2C Cdc5 CUTL1 Other transcription factors Search SABiosciences Chromatin IP Primers for HIST2H2BF Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q21.2 Ensembl cytogenetic band: 1q21.2 HGNC cytogenetic band: 1q21.2 HIST2H2BF Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M149758: view genomic region
(about GC identifiers )
Start:
149,754,245 bp from pter
End:
149,783,928 bp from pter
Size:
29,684 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.10 NT_004487.19
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Proteinsfor HIST2H2BF gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: H2B2F_HUMAN, Q5QNW6 (See
protein sequence )Recommended Name: Histone H2B type 2-F Size : 126 amino acids; 13920 Da
Subunit : The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in oneH3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location : Nucleus. Chromosome
Secondary accessions : A8K0U9Explore the universe of human proteins at neXtProt for HIST2H2BF: NX_Q5QNW6 Post-translational modifications:
Monoubiquitination of Lys-121 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II1
Phosphorylated on Ser-15 by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001019770.1 NP_001154806.1 ENSEMBL proteins: ENSP00000358164 ENSP00000407461 Human Recombinant Proteins 3 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
About this table
HIST2H2BF for ontologies About GeneDecksing Antibodies for HIST2H2BF: Assays for HIST2H2BF:
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Protein
Domains/ Familiesfor HIST2H2BF gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
HIST2H2BF for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q5QNW6 ProtoNet protein and cluster: Q5QNW6
UniProtKB/Swiss-Prot: H2B2F_HUMAN, Q5QNW6 Similarity : Belongs to the histone H2B family
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Gene Functionfor HIST2H2BF gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: H2B2F_HUMAN, Q5QNW6 Function : Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility tothe cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
1 Gene Ontology (GO) molecular function term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding
IEA --
About this table
HIST2H2BF for ontologies About GeneDecksing
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Pathways & Interactionsfor HIST2H2BF gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section
HIST2H2BF for pathways About GeneDecksing 1 Kegg Pathway (Kegg details for HIST2H2BF) : SABiosciences Custom Pathway-Focused PCR Arrays for HIST2H2BF Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST2H2BF 1 Interacting protein for HIST2H2BF (Q5QNW6 2 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006334 nucleosome assembly
IEA --
About this table
HIST2H2BF for ontologies About GeneDecksing
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Drugs & Compoundsfor HIST2H2BF gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for HIST2H2BF
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Transcriptsfor HIST2H2BF gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for HIST2H2BF gene (2 alternative transcripts): NM_001024599.3 NM_001161334.1
Additional cDNA sequence: AK092418.1 AK289664.1 AK296916.1 AK299108.1 BC110793.1
4 DOTS entries : DT.40219799 DT.92010992 DT.114591 DT.121372893
7 AceView cDNA sequences :
BX282515 BI835621 BE742212 BI836145 CD698245 AI147174 AI660196
highest scoring ESTs for HIST2H2BF :BE742212 BI835621 BI836145 BX282515 AI147174 BF765751 CD109968 DA042901 DA137545 DA178178 Unigene Cluster for HIST2H2BF:
Histone cluster 2, H2bf Hs.726907 [show with all ESTs ] Unigene Representative Sequence: AK092418 GeneLoc Exon Structure 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000369167 (uc010pbj.1 uc001esr.2 ) ENST00000427880 (uc010pbk.1 )ENST00000469483
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Expression for HIST2H2BF gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section HIST2H2BF expression in normal and diseased human tissues 1 / 2 / 3
2 probe-sets matching HIST2H2BF gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
69102_at2 , 3
U95-D
1
0.75
1.00
0.97
1.15
AI950819
0.40
0.75
0.60
1
71712_at2 , 3
U95-D
3
0.56
0.78
0.98
0.86
AI660196
0.60
0.56
0.58
1
About this table
HIST2H2BF for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.726907 SABiosciences Custom PCR Arrays for HIST2H2BF
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Orthologsfor HIST2H2BF gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for HIST2H2BF gene from 5 species
About this table Species with no ortholog for HIST2H2BF ENSEMBL Gene Tree for HIST2H2BF (if available)
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Paralogsfor HIST2H2BF gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for HIST2H2BF gene HIST1H2BO 2 HIST3H2BB 2 HIST1H2BK 2 HIST1H2BJ 2 HIST2H2BE 2 HIST1H2BH 2
HIST2H2BF for paralogs About GeneDecksing
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Genomic Variantsfor HIST2H2BF gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 1 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for HIST2H2BF (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 19 variations for HIST2H2BF 15/18 CNVs (see all 18 ): 8924 6785 48120 2326 48129 22942 64903 4255 8329 64896 64904 3313 30433 48130 48128 1 Inversion : 37080
QIAGEN SeqTarget long-range PCR primers for resequencing HIST2H2BF
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Disorders & Mutationsfor HIST2H2BF gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Medical Newsfor HIST2H2BF gene (Possibly Related Articles in
Doctor's Guide )
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Publicationsfor HIST2H2BF gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/12 PubMed articles for HIST2H2BF gene, integrated from 7 sources (see all 12 ): (articles sorted by number of sources associating them with HIST2H2BF) Characterization of histones H2A and H2B variants and their post- translational modifications by mass spectrometry. (PubMed id 16319397) 1 , 2 Bonenfant D.... van Oostrum J. (2006) Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563) 1 , 2 Pavri R....Reinberg D. (2006) Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647) 1 , 2 Kim S.C.... Zhao Y. (2006) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923) 1 , 2 Zhu B.... Reinberg D. (2005) Inhibition of core histones acetylation by carcinogenic nickel(II). (PubMed id 16283522) 1 , 2 Golebiowski F. and Kasprzak K.S. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PubMed id 12757711) 1 , 2 Cheung W.L.... Allis C.D. (2003) Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861) 2 Choudhary C.... Mann M. (2009)
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External Searches for HIST2H2BF gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing HIST2H2BF gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing HIST2H2BF gene
(According to HUGE )
About This Section --
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Specialized Databases showing HIST2H2BF gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for HIST2H2BF gene: Search GeneIP for patents involving HIST2H2BF GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor HIST2H2BF gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
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