Aliases &
Descriptions
for HIST2H3A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| histone cluster 2, H3a1 2 | | HIST2H3D2 | | H3/o1 2 | | histone H3.22 | | H3/n1 2 | | HIST2H3C2 | | histone 2, H3a1 2 | | H3F23 | | Histone H3/m2 3 | | H3FM3 | | Histone H3/o2 3 | | |
Export aliases for HIST2H3A gene to outside databasesPrevious GC identifers: GC01U900020 GC01M147029 GC01M147031 GC01M146625 GC01P148090 GC01P149824 |
Summaries
for HIST2H3A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HIST2H3A:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber ineukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed ofpairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through theinteraction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails;instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. Thisgene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.(provided by RefSeq)
UniProtKB/Swiss-Prot: H32_HUMAN, Q71DI3Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility tothe cellular machineries which require DNA as a template. Histones thereby play a central role in transcriptionregulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set ofpost-translational modifications of histones, also called histone code, and nucleosome remodeling
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Genomic Views
for HIST2H3A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HIST2H3A gene promoter:
CUTL1 YY1 IRF-1 Pax-5 Arnt AhR ATF-2 TFIID TBP IRF-7A
Other transcription factors
Search SABiosciences Chromatin IP Primers for HIST2H3A
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HIST2H3A  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.2 Ensembl cytogenetic band: 1q21.2 HGNC cytogenetic band: 1q21.2HIST2H3A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M121194: view genomic region
(about GC identifiers)
Start:
|
121,194,969 bp from pter |
End:
|
121,195,475 bp from pter |
Size:
|
507 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr1+ 149,824,181-149,825,836 |
RefSeq DNA sequence:- NC_000001.10 NT_004487.19
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Proteins
for HIST2H3A gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: H32_HUMAN, Q71DI3 (See
protein sequence)Recommended Name: Histone H3.2 Size: 136 amino acids; 15388 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in oneH3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosomeassembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer
Subcellular location: Nucleus. Chromosome
Developmental stage: Expressed during S phase, then expression strongly decreases as cell division slows down duringthe process of differentiation
PDB structures from  and Proteopedia  :2IIJ (3D)
2X4W (3D)
2X4X (3D)
2X4Y (3D)
3DB3 (3D)
3MO8 (3D)
Secondary accessions: A2BDF6 A6NFS4 Q6B053Explore the universe of human proteins at neXtProt for HIST2H3A: NX_Q71DI3
Post-translational modifications:
Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9(H3R8sme2). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me)1
Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription1
Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9(H3R8sme2) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked togene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent onactive promoters1
Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation atLys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNAdouble-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28(H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1,CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylationat Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation atLys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin1
Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase. Phosphorylationat Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis andmeiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase becauseit enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UVirradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), whichis linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) fromheterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic celltransformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK isoform 1, RPS6KA5 or AURKB during mitosis or uponultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCBB is a specific tag for epigenetictranscriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specificallyphosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12(H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10(H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) fromchromatin1
Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity).Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interactionbetween histones and DNA and facilitate DNA accessibility to repair proteins1
REFSEQ proteins: NP_001005464.1
ENSEMBL proteins: ENSP00000385479
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
HIST2H3A for ontologies About GeneDecksing
Antibodies for HIST2H3A:
Assays for HIST2H3A: |
Protein
Domains/
Families
for HIST2H3A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HIST2H3A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q71DI3ProtoNet protein and cluster: Q71DI3 1 Blocks protein family: IPB000164 Histone H3
UniProtKB/Swiss-Prot: H32_HUMAN, Q71DI3Similarity: Belongs to the histone H3 family |
Gene Function
for HIST2H3A gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: H32_HUMAN, Q71DI3Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility tothe cellular machineries which require DNA as a template. Histones thereby play a central role in transcriptionregulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set ofpost-translational modifications of histones, also called histone code, and nucleosome remodeling
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
HIST2H3A for ontologies About GeneDecksing
|
Pathways & Interactions
for HIST2H3A gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
HIST2H3A for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for HIST2H3A):
SABiosciences Custom Pathway-Focused PCR Arrays for HIST2H3A
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST2H3A
3 Interacting proteins for HIST2H3A (Q71DI31, 2) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006334 | nucleosome assembly |
-- | -- |
About this table
HIST2H3A for ontologies About GeneDecksing
|
Drugs & Compounds
for HIST2H3A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for HIST2H3A
|
Transcripts
for HIST2H3A gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for HIST2H3A gene: NM_001005464.2 Additional cDNA sequence: BC130635.1 BC130637.1 2 DOTS entries: DT.121432808 DT.92452709 5 AceView cDNA sequences: NM_021059 BC015544 BC074969 BX356867 BE889837
 highest scoring ESTs for HIST2H3A:NM_001005464 BC074969 BC015544 BG389013 BX356867 Unigene Cluster for HIST2H3A: Histone cluster 2, H3a Hs.706618 Unigene Representative Sequence: NM_001005464
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000403683(uc001esy.2)
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Expression
for HIST2H3A gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| HIST2H3A expression in normal and diseased human tissues
1 Data from GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.706618
SABiosciences Custom PCR Arrays for HIST2H3A
|
Orthologs
for HIST2H3A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HIST2H3A gene from 5/10 species (see all 10)
About this table Species with no ortholog for HIST2H3A
ENSEMBL Gene Tree for HIST2H3A (if available) |
Paralogs
for HIST2H3A gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for HIST2H3A gene
- HIST2H3C1 2 HIST2H3D1 2 HIST2H3PS22
HIST2H3A for paralogs About GeneDecksing
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Genomic Variants
for HIST2H3A gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for HIST2H3A
6 CNVs: 3313 2326 48130 4255 2052 8329
3 Inversions: 0391 37081 37080 | | QIAGEN SeqTarget long-range PCR primers for resequencing HIST2H3A |
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Disorders & Mutations
for HIST2H3A gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for HIST2H3A gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for HIST2H3A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/58 PubMed articles for HIST2H3A gene, integrated from 7 sources (see all 58):
(articles sorted by number of sources associating them with HIST2H3A)- Functional characterization of a human histone gene cluster duplication. (PubMed id 15527963)1, 2, 3 Braastad C.D....Stein G.S. (2004)
- The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
- Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. (PubMed id 17189264)1, 2 Morris S.A.... Strahl B.D. (2007)
- Organismal differences in post-translational modifications in histones H3 and H4. (PubMed id 17194708)1, 2 Garcia B.A.... Hunt D.F. (2007)
- Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)1, 2 Kim S.C.... Zhao Y. (2006)
- Expression patterns and post-translational modifications associated with mammalian histone H3 variants. (PubMed id 16267050)1, 2 Hake S.B.... Hunt D.F. (2006)
- Quantitative proteomic analysis of post-translational modifications of human histones. (PubMed id 16627869)1, 2 Beck H.C.... Jensen O.N. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17. (PubMed id 16497732)1, 2 Miao F.... Natarajan R. (2006)
- Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. (PubMed id 16678110)1, 2 Wang H.... Zhang Y. (2006)
|
External Searches for HIST2H3A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HIST2H3A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HIST2H3A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HIST2H3A gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for HIST2H3A gene:
Search GeneIP for patents involving HIST2H3A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HIST2H3A gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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