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HIST2H3A Gene

protein-coding   GIFtS: 38

GC01M121194
histone cluster 2, H3a
(Previous names: histone 2, H3a )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
histone cluster 2, H3a1 2     HIST2H3D2
H3/o1 2     histone H3.22
H3/n1 2     HIST2H3C2
histone 2, H3a1 2     H3F23
Histone H3/m2 3     H3FM3
Histone H3/o2 3     

External Ids:    HGNC: 205051   Entrez Gene: 3339322   Ensembl: ENSG000002038527   UniProtKB: Q71DI33   

Export aliases for HIST2H3A gene to outside databases

Previous GC identifers: GC01U900020 GC01M147029 GC01M147031 GC01M146625 GC01P148090 GC01P149824


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST2H3A:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of
pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.
This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails;
instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This
gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.
(provided by RefSeq)

UniProtKB/Swiss-Prot: H32_HUMAN, Q71DI3
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST2H3A gene promoter:
         CUTL1   YY1   IRF-1   Pax-5   Arnt   AhR   ATF-2   TFIID   TBP   IRF-7A   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for HIST2H3A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HIST2H3A 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

HIST2H3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST2H3A gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M121194:  view genomic region     (about GC identifiers)

Start:
121,194,969 bp from pter
End:
121,195,475 bp from pter
Size:
507 bases
Orientation:
minus strand

1 alternative location:
Chr1+ 149,824,181-149,825,836     
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: H32_HUMAN, Q71DI3 (See protein sequence)
Recommended Name: Histone H3.2  
Size: 136 amino acids; 15388 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome
assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer
Subcellular location: Nucleus. Chromosome
Developmental stage: Expressed during S phase, then expression strongly decreases as cell division slows down during
the process of differentiation
PDB structures from and Proteopedia :
2IIJ (3D)    2X4W (3D)    2X4X (3D)    2X4Y (3D)    3DB3 (3D)    3MO8 (3D)    
Secondary accessions: A2BDF6 A6NFS4 Q6B053

Explore the universe of human proteins at neXtProt for HIST2H3A: NX_Q71DI3 

Post-translational modifications:

  • Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9
  • (H3R8sme2). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me)1
  • Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription1
  • Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9
  • (H3R8sme2) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to
    gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the
    3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on
    active promoters1
  • Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at
  • Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA
    double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28
    (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1,
    CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation
    at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at
    Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin1
  • Phosphorylated at Thr-4 (H3T3ph) by GSG2/haspin during prophase and dephosphorylated during anaphase. Phosphorylation
  • at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and
    meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because
    it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV
    irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which
    is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.
    Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from
    heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell
    transformation. Phosphorylated at Ser-29 (H3S28ph) by MLTK isoform 1, RPS6KA5 or AURKB during mitosis or upon
    ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCBB is a specific tag for epigenetic
    transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically
    phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12
    (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10
    (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from
    chromatin1
  • Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity).
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction
    between histones and DNA and facilitate DNA accessibility to repair proteins1


    REFSEQ proteins: NP_001005464.1  

    ENSEMBL proteins: 
    ENSP00000385479 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HIST2H3A
    GenScript Custom Purified and Recombinant Proteins Services for HIST2H3A 
    Novus Biologicals Protein for HIST2H3A
    Novus Biologicals Lysate for HIST2H3A
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786 nucleosome ----
    GO:0005634 nucleus ----
    GO:0005694 chromosome ----
    About this table

    HIST2H3A for ontologies           About GeneDecksing



    Antibodies for HIST2H3A: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibody Arrays and Antibodies for HIST2H3A
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for HIST2H3A 
    Browse antibodies at Epitomics

    Assays for HIST2H3A: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIST2H3A 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HIST2H3A 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HIST2H3A for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000164 Histone_H3
     IPR009072 Histone-fold
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry Q71DI3

    ProtoNet protein and cluster: Q71DI3

    1 Blocks protein family: IPB000164 Histone H3

    UniProtKB/Swiss-Prot: H32_HUMAN, Q71DI3
    Similarity: Belongs to the histone H3 family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: H32_HUMAN, Q71DI3
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for HIST2H3A
    Sigma-Aldrich shRNA for HIST2H3A
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): HIST2H3A
    OriGene shRNA RFP (see all 2): HIST2H3A
    OriGene basic RS shRNA (see all 2): HIST2H3A
    OriGene siRNA (see all 2): HIST2H3A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HIST2H3A 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HIST2H3A 
    1 SABiosciences Assays for microRNA that regulate HIST2H3A:
    hsa-miR-760

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: HIST2H3A
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HIST2H3A
    OriGene untagged cDNA clones in CMV expression vector: HIST2H3A
    OriGene 3'-UTR clone: HIST2H3A 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for HIST2H3A 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for HIST2H3A 

    2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding ----
    GO:0005515 protein binding ----
    About this table

    HIST2H3A for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    HIST2H3A for pathways           About GeneDecksing

    1 Kegg Pathway  (Kegg details for HIST2H3A):
        hsa05322 Systemic lupus erythematosus

        SABiosciences Custom Pathway-Focused PCR Arrays for HIST2H3A 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST2H3A

    3 Interacting proteins for HIST2H3A (Q71DI31, 2) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP3Q9Y6F11EBI-750650,EBI-1045281
    LMNAP025452MINT-7893990 MINT-7893924 MINT-7894005 MINT-7894023 MINT-7893941 MINT-7894038
    --Q6UYC32MINT-7893974 MINT-7893957 MINT-7894055
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334 nucleosome assembly ----
    About this table

    HIST2H3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST2H3A


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for HIST2H3A
    Sigma-Aldrich shRNA for HIST2H3A
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): HIST2H3A
    OriGene shRNA RFP (see all 2): HIST2H3A
    OriGene basic RS shRNA (see all 2): HIST2H3A
    OriGene siRNA (see all 2): HIST2H3A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HIST2H3A 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HIST2H3A 
    1 SABiosciences Assays for microRNA that regulate HIST2H3A:
    hsa-miR-760
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: HIST2H3A
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HIST2H3A
    OriGene untagged cDNA clones in CMV expression vector: HIST2H3A
    OriGene 3'-UTR Clone: HIST2H3A 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for HIST2H3A 
    Primers: OriGene genome-wide validated SYBR primer pairs: HIST2H3A
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for HIST2H3A: PPH63447A

    REFSEQ mRNAs for HIST2H3A gene: 

    NM_001005464.2  

    Additional cDNA sequence: 

    BC130635.1 BC130637.1 

    2 DOTS entries:

    DT.121432808  DT.92452709 

    5 AceView cDNA sequences:

    NM_021059 BC015544 BC074969 BX356867 BE889837 

    highest scoring ESTs for HIST2H3A:

    NM_001005464 BC074969 BC015544 BG389013 BX356867 

    Unigene Cluster for HIST2H3A:

    Histone cluster 2, H3a
    Hs.706618
    Unigene Representative Sequence: NM_001005464


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000403683(uc001esy.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    HIST2H3A expression in normal and diseased human tissues

    1 Data from GNF BioGPS
        About these images

    HIST2H3A gene expression
    HIST2H3A gene electronic northern expression
    HIST2H3A gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.706618
    Primers: OriGene genome-wide validated SYBR primer pairs: HIST2H3A
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for HIST2H3A: PPH63447A
        SABiosciences Custom PCR Arrays for HIST2H3A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for HIST2H3A gene from 5/10 species (see all 10)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC6085861   -- similar to CG31613-PA 93.14(n)
    100(a)
    608586  XM_845651.1  XP_850744.1 
    chimpanzee
    (Pan troglodytes)
    LOC7464301   -- similar to Histone 2, H3c1 99.51(n)
    100(a)
    746430  XM_001166180.1  XP_001166180.1 
    cow
    (Bos taurus)
    LOC5319901   -- similar to His3:CG31613 CG31613-PA 92.4(n)
    99.26(a)
    531990  XM_610495.1  XP_610495.1 
    rat
    (Rattus norvegicus)
    LOC6804981   -- similar to CG31613-PA 86.52(n)
    99.26(a)
    680498  XM_001057443.1  XP_001057443.1 
    mouse
    (Mus musculus)
    Hist2h3b1   -- histone cluster 2, H3b 93.38(n)
    100(a)
    319154  NM_178215.1  NP_835587.1 
    About this table        Species with no ortholog for HIST2H3A

    ENSEMBL Gene Tree for HIST2H3A (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for HIST2H3A gene
    HIST2H3C1 2  HIST2H3D1 2  HIST2H3PS22  

    HIST2H3A for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for HIST2H3A
         6 CNVs: 3313 2326 48130 4255 2052 8329
         3 Inversions: 0391 37081 37080
    QIAGEN SeqTarget long-range PCR primers for resequencing HIST2H3A 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/58 PubMed articles for HIST2H3A gene, integrated from 7 sources (see all 58):
    (articles sorted by number of sources associating them with HIST2H3A)
    1. Functional characterization of a human histone gene cluster duplication. (PubMed id 15527963)1, 2, 3 Braastad C.D....Stein G.S. (2004)
    2. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    3. Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. (PubMed id 17189264)1, 2 Morris S.A.... Strahl B.D. (2007)
    4. Organismal differences in post-translational modifications in histones H3 and H4. (PubMed id 17194708)1, 2 Garcia B.A.... Hunt D.F. (2007)
    5. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)1, 2 Kim S.C.... Zhao Y. (2006)
    6. Expression patterns and post-translational modifications associated with mammalian histone H3 variants. (PubMed id 16267050)1, 2 Hake S.B.... Hunt D.F. (2006)
    7. Quantitative proteomic analysis of post-translational modifications of human histones. (PubMed id 16627869)1, 2 Beck H.C.... Jensen O.N. (2006)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    9. Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17. (PubMed id 16497732)1, 2 Miao F.... Natarajan R. (2006)
    10. Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. (PubMed id 16678110)1, 2 Wang H.... Zhang Y. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 333932 HGNC: 20505 AceView: HIST2H3A Ensembl:ENSG00000203852 euGenes: HUgn333932
    ECgene: HIST2H3A Kegg: 333932 H-InvDB: HIST2H3A

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for HIST2H3A gene:
    Search GeneIP for patents involving HIST2H3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
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     Regulatory tfbs in HIST2H3A promoter
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     ELISAs and CLIAs for HIST2H3A
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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