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HLA-DPA1 Gene

protein-coding   GIFtS: 56

GC06M032775
major histocompatibility complex, class II, DP alpha 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: HLA-DP1A)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
major histocompatibility complex, class II, DP alpha 11 2     HLA class II histocompatibility antigen, DP alpha chain2
DP(W4)2 3     MHC class II HLA-DPA1 antigen2
MHC class II DPA12 3     OTTHUMP000000290662
HLA-SB alpha chain2 3     HLA class II histocompatibility antigen, DP alpha 1 chain2
DP(W3)2 3     OTTHUMP000001787702
HLA-DP1A2 3     MHC class II antigen2
MHC class II DP3-alpha2 3     OTTHUMP000000290672
HLASB2 3     PLT12
HLADP2 5     Primed lymphocyte test-12

External Ids:    HGNC: 49381   Entrez Gene: 31132   Ensembl: ENSG000002313897   UniProtKB: P200363   

Export aliases for HLA-DPA1 gene to outside databases

Previous GC identifers: GC06U990043 GC06M033029 GC06M033079 GC06M033140 GC06M033032


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HLA-DPA1:
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an
alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by
presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells
(APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5
exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the
transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain
the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. (provided by
RefSeq)

UniProtKB/Swiss-Prot: DPA1_HUMAN, P20036
Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and
presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accomodates peptides
of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins
that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous
antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and
for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their
way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal
compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a
source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition
to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74
and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an
antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the
ER to form an heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen
processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a
small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM
via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules
until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported
to the cell membrane surface. In B cells, the interaction between HLA-DM and MHC class II molecules is regulated by
HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the
regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
efficient peptide loading


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HLA-DPA1 gene promoter:
         MEF-2A   Bach1   USF1   COUP-TF1   HNF-4alpha2   c-Jun   Fra-1   AP-1   JunB   JunD   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for HLA-DPA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

HLA-DPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-DPA1 gene location

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032775:  view genomic region     (about GC identifiers)

Start:
32,775,234 bp from pter
End:
32,783,818 bp from pter
Size:
8,585 bases
Orientation:
minus strand

6/7 alternative locations (see all 7):
Chr6-,ALT_REF_LOCI_7 33,102,763-33,111,347      Chr6-,ALT_REF_LOCI_4 33,109,993-33,118,577      Chr6-,ALT_REF_LOCI_5 32,981,090-32,989,656     
Chr6-,ALT_REF_LOCI_6 32,961,400-33,006,013      Chr6-,ALT_REF_LOCI_1 33,015,768-33,033,082      Chr6-,ALT_REF_LOCI_2 32,954,322-33,002,542     
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: DPA1_HUMAN, P20036 (See protein sequence)
Recommended Name: HLA class II histocompatibility antigen, DP alpha 1 chain precursor  
Size: 260 amino acids; 29381 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms an heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC
class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the
cell membrane for antigen presentation
Sequence caution: Sequence=AAC64233.1; Type=Erroneous gene model prediction; Sequence=AAD42927.1; Type=Erroneous gene
model prediction;
PDB structures from and Proteopedia :
3LQZ (3D)    
Secondary accessions: A9YWH7 B9UKH4 O19722 O46883 P01905 P79554 Q2Q060 Q2Q061 Q5EY03 Q6DQK4 Q9BCQ1
Q9TPX3 Q9XS10

Explore the universe of human proteins at neXtProt for HLA-DPA1: NX_P20036 

REFSEQ proteins: NP_291032.2  

ENSEMBL proteins: 
ENSP00000390929 ENSP00000405500 ENSP00000402872 ENSP00000412313 ENSP00000398134 ENSP00000393566 


Human Recombinant Proteins 
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate: HLA-DPA1
GenScript Custom Purified and Recombinant Proteins Services for HLA-DPA1 
Novus Biologicals Protein for HLA-DPA1
Novus Biologicals Lysates for HLA-DPA1
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

5/10 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 10):

GO IDQualified GO termEvidencePubMed IDs
GO:0005765 lysosomal membrane IEA--
GO:0005768 endosome IEA--
GO:0005783 endoplasmic reticulum IEA--
GO:0005789 endoplasmic reticulum membrane IEA--
GO:0005794 Golgi apparatus IEA--
About this table

HLA-DPA1 for ontologies           About GeneDecksing



Antibodies for HLA-DPA1: 
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for HLA-DPA1
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
GenScript Custom Superior Antibodies Services for HLA-DPA1 
Novus Biologicals Antibodies for HLA-DPA1
Browse antibodies at Epitomics

Assays for HLA-DPA1: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for HLA-DPA1 
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HLA-DPA1 for domains           About GeneDecksing

5/7 InterPro domains/families (see all 7):
 IPR001003 MHC_II_a_N
 IPR011162 MHC_I/II-like_Ag-recog
 IPR013783 Ig-like_fold
 IPR014745 MHC_II_a/b_N
 IPR003597 Ig_C1-set

Graphical View of Domain Structure for InterPro Entry P20036

ProtoNet protein and cluster: P20036

2 Blocks protein families:
IPB001003 MHC Class II alpha chain
IPB003597 Immunoglobulin C-type


UniProtKB/Swiss-Prot: DPA1_HUMAN, P20036
Similarity: Belongs to the MHC class II family
Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: DPA1_HUMAN, P20036
Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and
presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accomodates peptides
of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins
that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous
antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and
for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their
way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal
compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a
source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition
to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74
and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an
antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the
ER to form an heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen
processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a
small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM
via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules
until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported
to the cell membrane surface. In B cells, the interaction between HLA-DM and MHC class II molecules is regulated by
HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the
regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
efficient peptide loading

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for HLA-DPA1
Sigma-Aldrich shRNA for HLA-DPA1
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): HLA-DPA1
OriGene shRNA RFP (see all 4): HLA-DPA1
OriGene basic RS shRNA (see all 4): HLA-DPA1
OriGene siRNA (see all 2): HLA-DPA1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HLA-DPA1 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HLA-DPA1 
Search SABiosciences for Assays for microRNAs that regulate HLA-DPA1

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: HLA-DPA1
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HLA-DPA1
OriGene untagged cDNA clones in CMV expression vector: HLA-DPA1
OriGene 3'-UTR clone: HLA-DPA1 
Browse MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: HLA-DPA1 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for HLA-DPA1 

Genatlas biochemistry entry for HLA-DPA1:
HLA-DP,alpha chain

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005515 protein binding IEA--
GO:0032395 MHC class II receptor activity NAS2461352
About this table

HLA-DPA1 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


HLA-DPA1 for pathways           About GeneDecksing

5/6 Millipore Pathways for HLA-DPA1 (see all 6)
    Immune response Antigen presentation by MHC class II
G-protein signaling N-RAS regulation pathway
Immune response IL-22 signaling pathway
Immune response NFAT in immune response
Immune response ICOS pathway in T-helper cell

5 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  HLA-DPA1
    Cdc42 Signaling
Allograft Rejection Signaling
Antigen Presentation Pathway
OX40 Signaling Pathway
Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells

5/14 Kegg Pathways  (Kegg details for HLA-DPA1) (see all 14):
    hsa04145 Phagosome
hsa04514 Cell adhesion molecules (CAMs)
hsa04612 Antigen processing and presentation
hsa04672 Intestinal immune network for IgA production
hsa04940 Type I diabetes mellitus

    SABiosciences Pathway-Focused PCR Array including HLA-DPA1: PAHS-406A 

    Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for HLA-DPA1
    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HLA-DPA1

1 Interacting protein for HLA-DPA1 (P200362) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
CD74P042332MINT-72790
About this table

5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA--
GO:0006955 immune response NAS2461352
GO:0019882 antigen processing and presentation ----
GO:0031295 T cell costimulation TAS--
GO:0050852 T cell receptor signaling pathway TAS--
About this table

HLA-DPA1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

HLA-DPA1 for compounds           About GeneDecksing

Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HLA-DPA1
1 Novoseek chemical compound relationship for HLA-DPA1 gene
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
dpa 1 95 5 9154456 (3), 8225437 (1)
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for HLA-DPA1
Sigma-Aldrich shRNA for HLA-DPA1
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): HLA-DPA1
OriGene shRNA RFP (see all 4): HLA-DPA1
OriGene basic RS shRNA (see all 4): HLA-DPA1
OriGene siRNA (see all 2): HLA-DPA1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HLA-DPA1 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HLA-DPA1 
Search SABiosciences for Assays for microRNAs that regulate HLA-DPA1
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: HLA-DPA1
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HLA-DPA1
OriGene untagged cDNA clones in CMV expression vector: HLA-DPA1
OriGene 3'-UTR Clone: HLA-DPA1 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: HLA-DPA1 
Primers: OriGene genome-wide validated SYBR primer pairs: HLA-DPA1
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for HLA-DPA1: PPH07026A

REFSEQ mRNAs for HLA-DPA1 gene: 

NM_033554.2  

Additional cDNA sequence: 

AB209058.1 AK292709.1 BC009956.2 CR601798.1 CR617728.1 M27487.1 X00457.1 

24/35 DOTS entries (see all 35):

DT.121402866  DT.95202456  DT.449635  DT.100838953  DT.95163812  DT.95163813  DT.100830372  DT.95163821 
DT.100838951  DT.100838955  DT.95163816  DT.100045889  DT.95163819  DT.95106210  DT.121402704  DT.91970147 
DT.100855331  DT.91764764  DT.100838956  DT.121402712  DT.121402724  DT.121402761  DT.121402790  DT.121402837 

24/699 AceView cDNA sequences (see all 699):

BM876262 CA425549 BQ061344 BQ062257 CA436269 BX363746 BQ882245 AW085969 
BQ004485 BQ446041 BU617249 BQ270512 BM710171 BU616367 BU621846 BQ955105 
BU071266 BM767805 BU626683 CA426210 BE644615 CD365987 CA308455 CA445802 

highest scoring ESTs for HLA-DPA1:

AI979193 AL048565 AW406086 BC009956 BF662838 BF663966 BF794242 BF794550 BF796372 BF797055 

Unigene Cluster for HLA-DPA1:

Major histocompatibility complex, class II, DP alpha 1
Hs.347270  [show with all ESTs]
Unigene Representative Sequence: AB209058


GeneLoc Exon Structure

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000453337(uc003oct.1) ENST00000479107(uc010juk.2) ENST00000437811
ENST00000428995 ENST00000463066 ENST00000448544 ENST00000417724 ENST00000476642
ENST00000419277(uc003ocs.1)

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

HLA-DPA1 expression in normal and diseased human tissues

1  / 2  / 3

9 probe-sets matching HLA-DPA1 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
38833_at2, 3 U95-A 1 0.75 1.00 0.96 1.16 X00457 0.80 1.00 0.91 1
54984_at2, 3 U95-C 1 0.69 1.00 0.94 0.57 AI128225 0.60 1.00 0.82 1
91041_at2, 3 U95-E 1 0.62 1.00 0.98 1.28 AI979193 0.80 1.00 0.91 1
211991_s_at2, 3 U133-A 1 0.91 1.00 -- -- M27487 0.80 1.00 0.91 1
213537_at2, 3 U133-A 1 0.64 1.00 -- -- AI128225 0.60 1.00 0.82 1
211990_at2, 3 U133-A 1 0.36 1.00 -- -- M27487 0.80 1.00 0.91 1
211991_s_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
213537_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
211990_at2 U133Plus2 1 0.36 1.00 -- -- -- -- -- -- --
About this table

HLA-DPA1 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
HLA-DPA1 gene expression
HLA-DPA1 gene electronic northern expression
HLA-DPA1 gene sage expression
About these images

CGAP SAGE TAG: TGAAAACTAC

SOURCE GeneReport for Unigene cluster: Hs.347270

Expression variation in blood from EXPOLDB for HLA-DPA1

Primers: OriGene genome-wide validated SYBR primer pairs: HLA-DPA1
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for HLA-DPA1: PPH07026A
    SABiosciences Expression via Pathway-Focused PCR Array including HLA-DPA1: PAHS-406A 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HLA-DPA1 gene from 4 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
PATR-DPA11   -- major histocompatibility complex, class II, DP alpha more 97.95(n)
95.77(a)
462598  XM_518390.2  XP_518390.2 
rat
(Rattus norvegicus)
RT1-Ha1   -- RT1 class II, locus Ha 74.41(n)
64.17(a)
24986  NM_001008848.1  NP_001008848.1 
mouse
(Mus musculus)
H2-Pa5 17 (17.98 cM) histocompatibility 2, P region alpha locus   -- D64112 
zebrafish
(Danio rerio)
si:busm1-266f07.21   -- si:busm1-266f07.2 52.68(n)
38.34(a)
368878  NM_001004521.2  NP_001004521.2 
About this table        Species with no ortholog for HLA-DPA1

ENSEMBL Gene Tree for HLA-DPA1 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for HLA-DPA1 gene
HLA-DOA2  HLA-DQA12  HLA-DRA2  B2M2  HLA-DQA22  HLA-DMA2  

HLA-DPA1 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

UniProtKB/Swiss-Prot: DPA1_HUMAN, P20036
Polymorphism: The following alleles of DPA1 are known: DPA1*01:03, DPA1*01:04, DPA1*01:05, DPA1*01:06, DPA1*01:07,
DPA1*01:08, DPA1*01:09, DPA1*01:10, DPA1*02:01, DPA1*02:02, DPA1*02:03, DPA1*02:04, DPA1*03:01, DPA1*03:02,
DPA1*03:03, DPA1*04:01 The sequence shown is that of DPA1*01:03


10/779 NCBI SNPs in HLA-DPA1 are shown (see all 779)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 6 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs30771,2
C,F33033022(-) ACTACT/CCCAGT 1 -- ut3120Minor allele frequency- C:0.48MN EA NS NA WA 1874
rs79051,2
C,F33032975(-) TATCCA/GTTACC 1 -- ut317Minor allele frequency- G:0.34MN NS EA WA 766
rs84861,2
C,F33032968(-) TACCTA/C/G/
        
AAAGC
1 -- ut313MN EA WA 252
rs88071,2
C,F,A33032851(-) GAAGAA/GCCCCT 1 -- ut314Minor allele frequency- G:0.17MN NA 424
rs3615271,2
C33032920(-) AATGA-/ATAA  
 ATGTTGA
CACTT
1 -- ut312Minor allele frequency- ATAAATGTTGA:0.00MN EA 136
rs10421741,2
C,F,A33037626(-) CAGACG/CCATAG 2 /T syn1 ref19Minor allele frequency- C:0.47NA NS EA WA 638
rs10421751,2
H33037603(-) GTTTAC/G/TGTTTG 3 T R M mis1 ref12NS 222
rs10421761,2
C,F33037560(-) CTGGAC/TAAGAA 2 D ref1 syn12Minor allele frequency- T:0.21NA WA 78
rs10421771,2
C,F33037557(-) GACAAG/AAAGGA 2 /K syn1 ref16Minor allele frequency- A:0.10NA NS EA WA 496
rs10421781,2
C,F33037522(-) TGGCCA/GAGCCT 2 Q R ref1 mis111Minor allele frequency- N:0.01EA NA MN NS WA 894
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HapMap Linkage Disequilibrium images for HLA-DPA1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for HLA-DPA1
     3 CNVs: 69474 69477 59334

QIAGEN SeqTarget long-range PCR primers for resequencing HLA-DPA1 

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
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HLA-DPA1 for disorders           About GeneDecksing

OMIM: 142880

2 Novoseek disease relationships for HLA-DPA1 gene

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
celiac disease 39.7 2 7576003 (1), 1676703 (1)
lupus erythematosus systemic 17.7 4 8154937 (2), 2323107 (1)
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Locus Specific Mutation Databases (LSDB): HLA-DPA1
Genetic Association Database (GAD): HLA-DPA1
Human Genome Epidemiology (HuGE) Navigator: HLA-DPA1 (36 documents)

Export disorders and mutations for HLA-DPA1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
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10/120 PubMed articles for HLA-DPA1 gene, integrated from 7 sources (see all 120):
(articles sorted by number of sources associating them with HLA-DPA1)
  1. Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes. (PubMed id 6584734)1, 2, 3 Auffray C....Strominger J.L. (1984)
  2. [Studies on the association of human leukocyte antigen class II alleles with advanced hepatosplenic schistosomiasis japonica] (PubMed id 16042197)1, 4 Zhang J.H....Long X.C. (2005)
  3. HLA-DPA1 promoter haplotypes are differently distributed in southern Chinese ethnic groups. (PubMed id 15713216)1, 4 Liu X....Xu A. (2005)
  4. Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69. (PubMed id 16098233)1, 4 Amicosante M....Saltini C. (2005)
  5. High-resolution sequence-based DPA1 typing identified two novel DPA1 alleles, DPA1*010303 and DPA1*0303, from a Kenyan population. (PubMed id 15663751)1, 2 Luo M.... Plummer F.A. (2005)
  6. Role of HLA class II alleles in susceptibility to and protection from localized cutaneous leishmaniasis. (PubMed id 15041165)1, 4 Olivo-Diaz A....Gorodezky C. (2004)
  7. Associations between human leukocyte antigen (HLA) alleles and very high levels of measles antibody following vaccination. (PubMed id 15121303)1, 4 Ovsyannikova I.G....Poland G.A. (2004)
  8. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. (PubMed id 15191952)1, 4 Flomenberg N....Weisdorf D. (2004)
  9. Genetic polymorphism and linkage disequilibrium of the HLA-DP region in Basques from Navarre (Spain). (PubMed id 15304007)1, 4 Perez-Miranda A.M....Pena J.A. (2004)
  10. HLA-DP polymorphism in Venezuelan Amerindians. (PubMed id 15603877)1, 4 Gendzekhadze K....Layrisse Z. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3113 HGNC: 4938 AceView: HLA-DPA1 Ensembl:ENSG00000231389 euGenes: HUgn3113
ECgene: HLA-DPA1 Kegg: 3113 H-InvDB: HLA-DPA1

(According to HUGE)
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  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
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Patent Information for HLA-DPA1 gene:
Search GeneIP for patents involving HLA-DPA1

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