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HLA-DRB4 Gene

protein-coding   GIFtS: 49

GC06Ml32465
major histocompatibility complex, class II, DR beta 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: HLA-DR4B)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
major histocompatibility complex, class II, DR beta 41 2     leucocyte antigen DRB12
MHC class II antigen DRB42 3     MHC class II antigen DRB1*132
major histocompatibility complex, class II, DR beta 12     DRB1 transplantation antigen2
MHC class II antigen HLA-DR-beta2     MHC class II HLA-DR-beta-72
leukocyte antigen2     DR42
MHC class I antigen DRB1*122     HLA class II histocompatibility antigen, DR beta 4 chain2
DR-142     human leucocyte antigen DRB42
DRB42     MHC class II antigen DRB1*122
MHC class2 antigen2     DR-132
DR122     HLA-DR4B2
class II histocompatibility antigen HLA DR alpha, beta1-03072     DR142
DR-42     DR-122
MHC class I antigen DRB1*42     MHC class II antigen HLA-DRB12
HLA class II histocompatibility antigen, DRB1-12 beta chain2     MHC class II antigen DRB1*142
DR132     HLA class II histocompatibility antigen, DRB1-4 beta chain2
MHC HLA DR-beta chain2     MHC class II antigen DRB1*42

External Ids:    HGNC: 49521   Entrez Gene: 31262   Ensembl: ENSG000002273577   UniProtKB: P137623   

Export aliases for HLA-DRB4 gene to outside databases

Previous GC identifers: GC06U990051 GC06P9R0072 GC06M032556 GC06M032076 GC06M032507 GC06Me32508 GC06M032657 GC06Pe32515 GC06Mf32600 GC06Mf32601 GC06Mm32579 GC06Mo32509


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HLA-DRB4:
HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an
alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by
presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells
(APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6
exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the
transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the
polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone
marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and
DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related
pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. (provided by RefSeq)

UniProtKB/Swiss-Prot: DRB4_HUMAN, P13762
Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and
presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accomodates peptides
of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins
that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous
antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and
for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their
way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal
compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a
source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition
to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74
and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an
antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the
ER to form an heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen
processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a
small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM
via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules
until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported
to the cell membrane surface. In B cells, the interaction between HLA-DM and MHC class II molecules is regulated by
HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the
regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
efficient peptide loading

Gene Wiki entry for HLA-DRB4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for HLA-DRB4
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for HLA-DRB4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Chromosome:6   

Entrez Gene cytogenetic band: 6p21.3   HGNC cytogenetic band: 6p21.3

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06Ml32465:  view genomic region     (about GC identifiers)

Start:
32,465,706 bp from pter
End:
32,480,674 bp from pter
Size:
14,969 bases
Orientation:
minus strand

2 alternative locations:
Chr6-,ALT_REF_LOCI_7 32,439,895-32,454,867      Chr6-,ALT_REF_LOCI_5 32,493,744-32,508,715     
RefSeq DNA sequence:
NT_167246.1  NT_167247.1  NT_167249.1  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: DRB4_HUMAN, P13762 (See protein sequence)
Recommended Name: HLA class II histocompatibility antigen, DR beta 4 chain precursor  
Size: 266 amino acids; 29941 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms an heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
Caution: HLA-DRB3, HLA-DRB4 and HLA-DRB5 may represent a unique gene
Secondary accessions: B0S863 O78042 P79664 Q29889 Q30163 Q6TLK6 Q860N4 Q861F3 Q8WLT9 Q9BS54

Explore the universe of human proteins at neXtProt for HLA-DRB4: NX_P13762 

Post-translational modifications:

  • Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC
  • class II. When associated with ubiquitination of the alpha subunit of HLA-DR: HLA-DRA 'Lys-244', the down-regulation
    of MHC class II may be highly effective1


    REFSEQ proteins: NP_068818.4  

    ENSEMBL proteins: 
    ENSP00000410857 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: HLA-DRB4
    OriGene Protein Over-expression Lysate: HLA-DRB4
    GenScript Custom Purified and Recombinant Proteins Services for HLA-DRB4 
    Novus Biologicals Protein for HLA-DRB4
    Novus Biologicals Lysate for HLA-DRB4
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/11 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 11):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765 lysosomal membrane IDA18305173
    GO:0005768 endosome IEA--
    GO:0005783 endoplasmic reticulum IEA--
    GO:0005789 endoplasmic reticulum membrane IEA--
    GO:0005794 Golgi apparatus IEA--
    About this table

    HLA-DRB4 for ontologies           About GeneDecksing



    Antibodies for HLA-DRB4: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for HLA-DRB4
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for HLA-DRB4 
    Novus Biologicals Antibodies for HLA-DRB4
    Epitomics antibodies for HLA-DRB4

    Assays for HLA-DRB4: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HLA-DRB4 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HLA-DRB4 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR000353 MHC_II_b_N
     IPR013783 Ig-like_fold
     IPR014745 MHC_II_a/b_N
     IPR003597 Ig_C1-set

    Graphical View of Domain Structure for InterPro Entry P13762

    ProtoNet protein and cluster: P13762

    3 Blocks protein families:
    IPB000353 Class II histocompatibility antigen
    IPB001003 MHC Class II alpha chain
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: DRB4_HUMAN, P13762
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: DRB4_HUMAN, P13762
    Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and
    presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accomodates peptides
    of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins
    that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous
    antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and
    for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their
    way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal
    compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a
    source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition
    to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74
    and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an
    antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the
    ER to form an heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen
    processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a
    small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM
    via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules
    until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported
    to the cell membrane surface. In B cells, the interaction between HLA-DM and MHC class II molecules is regulated by
    HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the
    regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
    efficient peptide loading

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for HLA-DRB4
    Sigma-Aldrich shRNA for HLA-DRB4
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): HLA-DRB4
    OriGene shRNA RFP (see all 2): HLA-DRB4
    OriGene basic RS shRNA (see all 2): HLA-DRB4
    OriGene siRNA (see all 2): HLA-DRB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HLA-DRB4 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HLA-DRB4 
    Search SABiosciences for Assays for microRNAs that regulate HLA-DRB4

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: HLA-DRB4
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HLA-DRB4
    OriGene untagged cDNA clones in CMV expression vector: HLA-DRB4
    OriGene 3'-UTR clone: HLA-DRB4 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: HLA-DRB4 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for HLA-DRB4 

    Genatlas biochemistry entry for HLA-DRB4:
    HLA-DR,beta 4 chain,determining DRW53

    2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IEA--
    GO:0032395 MHC class II receptor activity TAS10425186
    About this table

    HLA-DRB4 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    HLA-DRB4 for pathways           About GeneDecksing

    5/6 Millipore Pathways for HLA-DRB4 (see all 6)
        Immune response Antigen presentation by MHC class II
    G-protein signaling N-RAS regulation pathway
    Immune response IL-22 signaling pathway
    Immune response NFAT in immune response
    Immune response ICOS pathway in T-helper cell

    5/8 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  HLA-DRB4 (see all 8)
        Crosstalk between Dendritic Cells and Natural Killer Cells
    Dendritic Cell Maturation
    Allograft Rejection Signaling
    Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
    Communication between Innate and Adaptive Immune Cells

    5/15 Kegg Pathways  (Kegg details for HLA-DRB4) (see all 15):
        hsa04145 Phagosome
    hsa04514 Cell adhesion molecules (CAMs)
    hsa04612 Antigen processing and presentation
    hsa04640 Hematopoietic cell lineage
    hsa04672 Intestinal immune network for IgA production

        SABiosciences Custom Pathway-Focused PCR Arrays for HLA-DRB4 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for HLA-DRB4
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HLA-DRB4

    5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA--
    GO:0006955 immune response IEA--
    GO:0007165 signal transduction NAS8775462
    GO:0019882 antigen processing and presentation ----
    GO:0031295 T cell costimulation TAS--
    About this table

    HLA-DRB4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HLA-DRB4


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for HLA-DRB4
    Sigma-Aldrich shRNA for HLA-DRB4
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): HLA-DRB4
    OriGene shRNA RFP (see all 2): HLA-DRB4
    OriGene basic RS shRNA (see all 2): HLA-DRB4
    OriGene siRNA (see all 2): HLA-DRB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HLA-DRB4 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HLA-DRB4 
    Search SABiosciences for Assays for microRNAs that regulate HLA-DRB4
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: HLA-DRB4
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HLA-DRB4
    OriGene untagged cDNA clones in CMV expression vector: HLA-DRB4
    OriGene 3'-UTR Clone: HLA-DRB4 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: HLA-DRB4 
    Primers: OriGene genome-wide validated SYBR primer pairs: HLA-DRB4
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for HLA-DRB4

    REFSEQ mRNAs for HLA-DRB4 gene: 

    NM_021983.4  

    Additional cDNA sequence: 

    M14190.1 M15071.1 M16732.1 M17388.1 S48645.1 U29342.1 U47028.1 

    9 DOTS entries:

    DT.92410344  DT.100776434  DT.121314547  DT.87013458  DT.87079048  DT.95227533  DT.92047682  DT.121314545 
    DT.95236254 

    highest scoring ESTs for HLA-DRB4:

    M14190 M15071 M16732 M17388 AW394274 BE827532 BF342032 BF797132 BF855724 BF975444 

    Unigene Cluster for HLA-DRB4:

    Major histocompatibility complex, class II, DR beta 4
    Hs.716081  [show with all ESTs]
    Unigene Representative Sequence: BF342032


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000411565(uc011jsg.1)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    HLA-DRB4 expression in normal and diseased human tissues

    1  / 2  / 3

    13 probe-sets matching HLA-DRB4 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    41723_s_at2, 3 U95-A 19 1.00 0.10 0.96 1.47 M32578 0.20 0.03 0.14 3
    32035_at2, 3 U95-A 7 0.62 0.49 0.96 1.26 U70543 0.40 0.50 0.45 1
    54906_r_at*2 U95-C 1 -- -- 0.88 0.32 -- -- -- -- --
    209312_x_at2 U133-A 15 1.00 0.16 -- -- -- -- -- -- --
    215193_x_at2 U133-A 23 1.00 0.13 -- -- -- -- -- -- --
    209728_at2, 3 U133-A 4 0.91 0.73 -- -- BC005312 0.20 0.50 0.38 1
    208306_x_at2, 3 U133-A 11 0.64 0.14 -- -- NM_021983 0.20 0.50 0.38 1
    215666_at2, 3 U133-A 1 0.55 1.00 -- -- U70544 0.20 0.50 0.38 1
    209312_x_at2 U133Plus2 15 1.00 0.16 -- -- -- -- -- -- --
    215193_x_at2 U133Plus2 23 1.00 0.13 -- -- -- -- -- -- --
    209728_at2 U133Plus2 4 0.91 0.73 -- -- -- -- -- -- --
    208306_x_at2 U133Plus2 11 0.64 0.14 -- -- -- -- -- -- --
    215666_at2 U133Plus2 1 0.55 1.00 -- -- -- -- -- -- --
    About this table

    HLA-DRB4 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    HLA-DRB4 gene expression
    HLA-DRB4 gene electronic northern expression
    HLA-DRB4 gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.716081
    Primers: OriGene genome-wide validated SYBR primer pairs: HLA-DRB4
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for HLA-DRB4
        SABiosciences Custom PCR Arrays for HLA-DRB4 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    ENSEMBL Gene Tree for HLA-DRB4 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    UniProtKB/Swiss-Prot: DRB4_HUMAN, P13762
    Polymorphism: The following alleles of DRB4 are known: DRB4*01:01, DRB4*01:02, DRB4*01:03, DRB4*01:04, DRB4*01:05,
    DRB4*01:06 and DRB4*01:07. The sequence shown is that of DRB4*01:03


    10/60 NCBI SNPs in HLA-DRB4 are shown (see all 60)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs11350851,2
    --32522477(-) CTCACA/GGTGCA 2 T syn1 ref10--------
    rs38288281,2
    --32521243(-) CTGGGA/GCATTG 1 -- int10--------
    rs38288291,2
    --32521233(-) GTGTTA/GGAAGA 1 -- int10--------
    rs38288311,2
    C32521117(-) GATTCG/AGTTTC 1 -- int11Minor allele frequency- A:0.00NA 2
    rs38288321,2
    C,H,32521083(-) AAGGCA/GTGAGA 1 -- int10--------
    rs38288331,2
    C,32521062(-) AGGAAG/AGACTT 1 -- int12Minor allele frequency- A:0.25NA 4
    rs355744901,2
    C,F32521210(-) CATAWC/ATTTTA 1 -- int11Minor allele frequency- A:0.50MN 10
    rs584951481,2
    C32520816(+) GTCATC/GTGCAC 1 -- ut311Minor allele frequency- G:0.00NA 2
    rs588487281,2
    C,H,32521340(+) TGAAGC/TGTGAA 1 -- int10--------
    rs606947401,2
    C,H,32521326(+) GACCAC/TGTGAC 1 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for HLA-DRB4 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HLA-DRB4: --

    Search QIAGEN SeqTarget long-range PCR primers for resequencing for HLA-DRB4 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HLA-DRB4 for disorders           About GeneDecksing

    3 Novoseek disease relationships for HLA-DRB4 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hashimotos thyroiditis 39.9 2 7744616 (1), 15055474 (1)
    mimicry 37.2 2 7536796 (1), 10397736 (1)
    autoimmune diseases 3.01 1 7536796 (1)
    About this table

    Locus Specific Mutation Databases (LSDB): HLA-DRB4
    Human Gene Mutation Database (HGMD): HLA-DRB4
    Genetic Association Database (GAD): HLA-DRB4
    Human Genome Epidemiology (HuGE) Navigator: HLA-DRB4 (42 documents)

    Export disorders and mutations for HLA-DRB4 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/191 PubMed articles for HLA-DRB4 gene, integrated from 7 sources (see all 191):
    (articles sorted by number of sources associating them with HLA-DRB4)
    1. Specific amplification of the HLA-DRB4 gene from c-DNA. Complete coding sequence of the HLA alleles DRB4*0103101 and DRB4*01033. (PubMed id 11972878)1, 2, 7 De Pablo R.... Vilches C. (2002)
    2. Interactions of HLA-DRB4 and CTLA-4 genes influence thyroid function in Hashimoto's thyroiditis in Japanese population. (PubMed id 15055474)1, 4, 7 Terauchi M....Saruta T. (2003)
    3. HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma. (PubMed id 15902698)1, 4, 7 Dorak M.T....Kaslow R.A. (2005)
    4. HLA-DR and DQB1 gene polymorphism in the North-western Colombian population. (PubMed id 12144632)1, 4, 7 Correa P.A....Anaya J.M. (2002)
    5. MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. (PubMed id 18305173)1, 2 De Gassart A....Gatti E. (2008)
    6. Association between psoriasis vulgaris and MHC-DRB, -DQB genes as a contribution to disease diagnosis. (PubMed id 15908298)1, 4 Cardoso C.B....Kraemer M.H. (2005)
    7. HLA class II alleles in systemic sclerosis patients with anti-RNA polymerase I/III antibody: associations with subunit reactivities. (PubMed id 14677183)1, 4 Kuwana M....Kaburaki J. (2003)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    9. HLA class II DNA typing in a large series of European patients with systemic lupus erythematosus: correlations with clinical and autoantibody subsets. (PubMed id 11997714)1, 4 Galeazzi M....Marcolongo R. (2002)
    10. A male-specific increase in the HLA-DRB4 (DR53) frequency in high-risk and relapsed childhood ALL. (PubMed id 12008082)1, 4 Dorak M.T....Carin M. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3126 HGNC: 4952 Ensembl:ENSG00000227357 euGenes: HUgn3126 ECgene: HLA-DRB4 Kegg: 3126
    H-InvDB: HLA-DRB4

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for HLA-DRB4 gene:
    Search GeneIP for patents involving HLA-DRB4

    GeneCards and IP:
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