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HLA-G Gene

protein-coding   GIFtS: 62

GC06P029598
major histocompatibility complex, class I, G
(Previous names: HLA-G histocompatibility antigen, class I, G )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
major histocompatibility complex, class I, G1 2     b2 microglobulin2
HLA-G histocompatibility antigen, class I, G1 2     MHC-G2
HLA G antigen2 3     HLA class I molecule2
MHC class I antigen G2 3     HLAG3
OTTHUMP000000292202     HLA-6.03
HLA class I histocompatibility antigen, alpha chain G2     

External Ids:    HGNC: 49641   Entrez Gene: 31352   Ensembl: ENSG000002046327   UniProtKB: P176933   

Export aliases for HLA-G gene to outside databases

Previous GC identifers: GC06P029852 GC06P029565 GC06P029904 GC06P029906 GC06P029907 GC06P029913


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HLA-G:
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy
chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on
fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes
the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the
alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. (provided by RefSeq)

UniProtKB/Swiss-Prot: HLAG_HUMAN, P17693
Function: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of
the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T lymphocytes,
macrophages and mononuclear cells

Gene Wiki entry for HLA-G

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HLA-G gene promoter:
         AP-1   CREB   deltaCREB   p53   c-Jun   c-Fos   IRF-1   p300   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for HLA-G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HLA-G 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.3

HLA-G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-G gene location

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P029598:  view genomic region     (about GC identifiers)

Start:
29,598,096 bp from pter
End:
29,602,239 bp from pter
Size:
4,144 bases
Orientation:
plus strand

6 alternative locations:
Chr6+,ALT_REF_LOCI_6 29,791,932-29,831,682      Chr6+,ALT_REF_LOCI_7 29,721,773-29,725,930      Chr6+,ALT_REF_LOCI_2 29,788,431-29,831,788     
Chr6+,ALT_REF_LOCI_3 29,791,968-29,807,161      Chr6+,ALT_REF_LOCI_4 29,714,745-29,718,887      Chr6+,ALT_REF_LOCI_5 29,706,458-29,710,601     
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  NT_167249.1  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: HLAG_HUMAN, P17693 (See protein sequence)
Recommended Name: HLA class I histocompatibility antigen, alpha chain G precursor  
Size: 338 amino acids; 38224 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Homodimer; disulfide-linked. Binds to
LILRB1 and LILRB2
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structures from and Proteopedia :
1YDP (3D)    2D31 (3D)    2DYP (3D)    3BZE (3D)    3CDG (3D)    3CII (3D)    3KYN (3D)    3KYO (3D)    

Explore the universe of human proteins at neXtProt for HLA-G: NX_P17693 

REFSEQ proteins: NP_002118.1  

ENSEMBL proteins: 
ENSP00000413985 ENSP00000353472 ENSP00000366016 ENSP00000366014 ENSP00000366024 ENSP00000366011 
ENSP00000412927 


Human Recombinant Proteins 
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein: HLA-G
OriGene Protein Over-expression Lysate: HLA-G
GenScript Custom Purified and Recombinant Proteins Services for HLA-G 
Novus Biologicals Lysate for HLA-G
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane TAS--
GO:0016020 membrane ----
GO:0016021 integral to membrane IEA--
GO:0042612 MHC class I protein complex IEA--
About this table

HLA-G for ontologies           About GeneDecksing



Antibodies for HLA-G: 
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
GenScript Custom Superior Antibodies Services for HLA-G 
Novus Biologicals Antibodies for HLA-G
Epitomics antibodies for HLA-G

Assays for HLA-G: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for HLA-G 
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HLA-G for domains           About GeneDecksing

5/7 InterPro domains/families (see all 7):
 IPR011162 MHC_I/II-like_Ag-recog
 IPR013783 Ig-like_fold
 IPR003597 Ig_C1-set
 IPR007110 Ig-like
 IPR003006 Ig/MHC_CS

Graphical View of Domain Structure for InterPro Entry P17693

ProtoNet protein and cluster: P17693

2 Blocks protein families:
IPB001039 MHC class I signature
IPB003597 Immunoglobulin C-type


UniProtKB/Swiss-Prot: HLAG_HUMAN, P17693
Similarity: Belongs to the MHC class I family
Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: HLAG_HUMAN, P17693
Function: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of
the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T lymphocytes,
macrophages and mononuclear cells

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for HLA-G
Sigma-Aldrich shRNA for HLA-G
OriGene 29mer shRNA kits in GFP-retroviral vector: HLA-G
OriGene shRNA RFP: HLA-G
OriGene basic RS shRNA: HLA-G
OriGene siRNA: HLA-G
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HLA-G 
miRNA:Sigma-Aldrich microRNA Mimics for HLA-G
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HLA-G 
Search SABiosciences for Assays for microRNAs that regulate HLA-G

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: HLA-G
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HLA-G
OriGene untagged cDNA clones in CMV expression vector: HLA-G
OriGene 3'-UTR clone: HLA-G 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for HLA-G 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for HLA-G 

Genatlas biochemistry entry for HLA-G:
HLA class Ib ,6.0kb Hind III fragment,expressed in trophoblast (see MHC1),including a 5' locus control region (see LCR-
HLA-G)

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005515 protein binding IEA--
GO:0032393 MHC class I receptor activity TAS9539768
About this table

HLA-G for ontologies           About GeneDecksing

Animal Models: 3 MGI mutant phenotypes (inferred from 1 allele(MGI details for H2-M3):

hematopoietic systemhomeostasis/metabolismimmune system

HLA-G for phenotypes           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


HLA-G for pathways           About GeneDecksing

1 Millipore Pathway for HLA-G
    Immune response Role of DAP12 receptors in NK cells

5/12 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  HLA-G (see all 12)
    OX40 Signaling Pathway
Cdc42 Signaling
Communication between Innate and Adaptive Immune Cells
Neuroprotective Role of THOP1 in Alzheimer's Disease
Allograft Rejection Signaling

5/10 Kegg Pathways  (Kegg details for HLA-G) (see all 10):
    hsa04144 Endocytosis
hsa04145 Phagosome
hsa04514 Cell adhesion molecules (CAMs)
hsa04612 Antigen processing and presentation
hsa04650 Natural killer cell mediated cytotoxicity

    SABiosciences Pathway-Focused PCR Array including HLA-G: PAHS-016A 

    Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for HLA-G
    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HLA-G

1 Interacting protein for HLA-G (P176932) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
LILRB1Q8NHL62MINT-7144982
About this table

5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I IEA--
GO:0006955 immune response ----
GO:0006968 cellular defense response TAS9539768
GO:0019882 antigen processing and presentation IEA--
GO:0050776 regulation of immune response TAS--
About this table

HLA-G for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

HLA-G for compounds           About GeneDecksing

Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HLA-G
10/27 Novoseek chemical compound relationships for HLA-G gene (see all 27)
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
1-methyltryptophan 46.5 1 16236119 (1)
indoleamine 35 6 15878889 (2), 18289708 (2), 19143868 (1), 16129951 (1)
5-aza-2'deoxycytidine 32.3 32 16045815 (4), 18823661 (3), 18498645 (2), 12552087 (1)
neopterin 12.7 5 2129033 (2), 2117484 (1), 1878399 (1)
matrigel 12.5 2 10684818 (2)
ifn-alpha 12.5 1 12183445 (1)
progesterone 7.59 23 19527229 (4), 16210391 (4), 20052552 (2), 18824770 (2) (see all 9)
sodium 4.47 1 12545635 (1)
oxygen 2.05 4 18325889 (1), 16807282 (1)
cholesterol 0.747 1 8079411 (1)
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for HLA-G
Sigma-Aldrich shRNA for HLA-G
OriGene 29mer shRNA kits in GFP-retroviral vector: HLA-G
OriGene shRNA RFP: HLA-G
OriGene basic RS shRNA: HLA-G
OriGene siRNA: HLA-G
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HLA-G 
miRNA: Sigma-Aldrich microRNA Mimics for HLA-G
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HLA-G 
Search SABiosciences for Assays for microRNAs that regulate HLA-G
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: HLA-G
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HLA-G
OriGene untagged cDNA clones in CMV expression vector: HLA-G
OriGene 3'-UTR Clone: HLA-G 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for HLA-G 
Primers: OriGene genome-wide validated SYBR primer pairs: HLA-G
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for HLA-G: PPH23053A

REFSEQ mRNAs for HLA-G gene: 

NM_002127.5  

Additional cDNA sequence: 

AF071017.1 AF071018.1 AF071019.1 AF071020.1 AF071021.1 AF071022.1 AF196177.1 AF196178.1 
AF226990.2 AF436089.1 AK093478.1 AK302054.1 AY359818.1 BC021708.2 CR606159.1 CR608458.1 
CR613246.1 CR623340.1 M32800.1 M90683.1 M90684.1 M90685.1 M90686.1 U58024.1 
U58025.1 U58026.1 U58027.1 U58028.1 U58029.1 U58094.1 U88244.1 X17273.1 

17 DOTS entries:

DT.100753459  DT.100825997  DT.455506  DT.95158992  DT.100645441  DT.100753462  DT.100809966  DT.100046040 
DT.100733427  DT.100733440  DT.100855576  DT.100733391  DT.100859573  DT.121345649  DT.315161  DT.91722926 
DT.91783937 

24/25 AceView cDNA sequences (see all 25):

CR608458 CR613246 CR623340 AF196177 AF071018 AF226990 M90684 M90686 
M90683 AF071020 AF196178 AF071021 CR606159 X17273 AY359818 NM_002127 
M90685 AF071017 M32800 AK093478 AX748153 AF071022 BC021708 AF071019 

highest scoring ESTs for HLA-G:

X17273 M90683 AF071017 AF071018 AF071019 AF071020 BX464534 AA622642 AL542094 AL577012 

Unigene Cluster for HLA-G:

Major histocompatibility complex, class I, G
Hs.512152  [show with all ESTs]
Unigene Representative Sequence: AK093478


GeneLoc Exon Structure

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000442051 ENST00000360323 ENST00000478355 ENST00000376820 ENST00000376818
ENST00000376828(uc003ran.1 uc003raj.3 uc003nnz.3 uc010jrn.2 uc011dmb.1)
ENST00000376815 ENST00000478519(uc003nny.3) ENST00000428701(uc003nnw.2)


(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

HLA-G expression in normal and diseased human tissues

1  / 2  / 3

10 probe-sets matching HLA-G gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
40370_f_at2, 3 U95-A 41 1.00 0.77 1.00 0.97 M90683 1.00 0.71 0.87 1
40369_f_at2, 3 U95-A 45 1.00 0.51 0.99 1.03 X17273 1.00 0.80 0.91 1
211530_x_at2, 3 U133-A 23 1.00 0.83 -- -- M90686 0.80 0.75 0.78 1
210514_x_at2, 3 U133-A 25 1.00 0.75 -- -- AF226990 0.80 0.75 0.78 1
211528_x_at2, 3 U133-A 28 1.00 0.75 -- -- M90685 0.80 0.64 0.73 1
211529_x_at2, 3 U133-A 14 0.73 0.79 -- -- M90684 0.80 0.75 0.78 1
211530_x_at2 U133Plus2 23 1.00 0.83 -- -- -- -- -- -- --
210514_x_at2 U133Plus2 25 1.00 0.75 -- -- -- -- -- -- --
211528_x_at2 U133Plus2 28 1.00 0.75 -- -- -- -- -- -- --
211529_x_at2 U133Plus2 14 0.73 0.79 -- -- -- -- -- -- --
About this table

HLA-G for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
HLA-G gene expression
HLA-G gene electronic northern expression
HLA-G gene sage expression
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.512152

Expression variation in blood from EXPOLDB for HLA-G

UniProtKB/Swiss-Prot: HLAG_HUMAN, P17693
Tissue specificity: Expressed in trophoblasts

Primers: OriGene genome-wide validated SYBR primer pairs: HLA-G
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for HLA-G: PPH23053A
    SABiosciences Expression via Pathway-Focused PCR Array including HLA-G: PAHS-016A 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HLA-G gene from 2 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
rat
(Rattus norvegicus)
H2-M31   -- histocompatibility 2, M region locus 3 69.94(n)
58.93(a)
24747  NM_022921.1  NP_075210.1 
mouse
(Mus musculus)
H2-M31 , 5 17 (19.16 cM)5
histocompatibility 2, M region locus 31, 5 71.5(n)1
63.72(a)1
149911  NM_013819.21  NP_038847.11 
 AA1634745  AB2670965  (see all 13)
About this table        Species with no ortholog for HLA-G

ENSEMBL Gene Tree for HLA-G (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for HLA-G gene
HLA-F2  HLA-B2  HLA-E2  HLA-C2  HLA-A2  

HLA-G for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/337 NCBI SNPs in HLA-G are shown (see all 337)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 6 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs17041,2
C,F29798581(+) GCAAGC/TTCCCT 2 -- ut314Minor allele frequency- ATTTGTTCATGCCT:0.28EU NA EA 342
rs17071,2
C,F,H29798610(+) TGACTT/CCTCTT 2 -- ut31 ese310Minor allele frequency- C:0.23MN NS EA NA 718
rs17101,2
C,F,H29798617(+) TCTTTC/GTGCAG 2 -- ut313Minor allele frequency- G:0.40MN NA 278
rs3941461,2
C,A,H,29799235(-) GTGAGA/GCTCCA 1 -- ng310--------
rs9156671,2
C,F29798140(-) GAAAAC/TGTCCT 1 -- int18Minor allele frequency- T:0.35EA MN NA WA 1736
rs9156681,2
C,F,A,H29798459(-) ACATTC/GAAGTC 1 -- int123Minor allele frequency- G:0.43MN NA NS EA WA 1838
rs9156691,2
C,F,A,H29798425(-) TGTCCA/C/GCTGTT 1 -- int1 ese310MN NS EA NA WA 516
rs9156701,2
C,F29798419(-) CTGTTC/G/TCCCTC 1 -- int15MN NA WA 94
rs10490331,2
C,F,A29797639(-) ACCAGG/ACCAGC 4 /G ref1 syn1 ese311Minor allele frequency- A:0.21EA NS NA WA 2104
rs10633201,2
C,F,A,H29798749(-) CAGTGC/GACCAC 2 -- ut31 ese327Minor allele frequency- G:0.43MN NS EA NA WA 2244
About this table

HapMap Linkage Disequilibrium images for HLA-G (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for HLA-G
     3 CNVs: 64462 64460 3599

QIAGEN SeqTarget long-range PCR primers for resequencing HLA-G 

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HLA-G for disorders           About GeneDecksing

OMIM: 142871   disorders: 600807  

10/89 Novoseek disease relationships for HLA-G gene (see all 89)

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
choriocarcinoma 75.1 39 16202295 (5), 17949227 (2), 19145204 (2), 15209386 (2) (see all 23)
miscarriage 67.1 46 20228379 (3), 9333005 (3), 16426245 (2), 12392506 (2) (see all 24)
tumor escape 66.5 10 15814900 (2), 12552087 (1), 16911982 (1), 17072500 (1) (see all 8)
miscarriage recurrent 65.4 16 16514201 (4), 11925408 (2), 18480096 (2), 10102087 (2) (see all 9)
preeclampsia 63.7 91 14985477 (6), 12797524 (5), 7547760 (4), 11766889 (4) (see all 35)
pregnancy disorder 54.1 3 16867913 (1), 17026466 (1)
pediatric soft tissue sarcoma 49.2 3 19693535 (2), 20033427 (1)
pregnancy loss 44.3 8 17629722 (1), 19127811 (1), 12900514 (1), 19527228 (1)
lymphocytic leukemia chronic b-cell 43.2 9 18241213 (2), 19298722 (2), 18499249 (1), 15466928 (1) (see all 6)
severe pre-eclampsia 40.3 4 19811467 (2), 10611266 (1), 20070604 (1)
About this table

1 PharmGKB disease relationship for HLA-G gene
Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
Immunologic DiseasesGN  11975984
About this table

Locus Specific Mutation Databases (LSDB): HLA-G
Human Gene Mutation Database (HGMD): HLA-G
Genetic Association Database (GAD): HLA-G
Human Genome Epidemiology (HuGE) Navigator: HLA-G (2670 documents)

Export disorders and mutations for HLA-G gene to outside databases

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
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10/699 PubMed articles for HLA-G gene, integrated from 7 sources (see all 699):
(articles sorted by number of sources associating them with HLA-G)
  1. HLA-G and IL-10 in serum in relation to HLA-G genotype and polymorphisms. (PubMed id 15133645)1, 4, 7 Hviid T.V....Baricordi O.R. (2004)
  2. HLA-G polymorphisms in couples with recurrent spontaneous abortions. (PubMed id 12392506)1, 4, 7 Hviid T.V....Christiansen O.B. (2002)
  3. Disulfide bond-mediated dimerization of HLA-G on the cell surface. (PubMed id 12454284)1, 2, 7 Boyson J.E.... Strominger J.L. (2002)
  4. Association of soluble HLA-G plasma levels with HLA-G alleles. (PubMed id 11169254)1, 4, 7 Rebmann V....Grosse-Wilde H. (2001)
  5. Altered HLA-G transcription in pre-eclampsia is associated with allele specific inheritance: possible role of the HLA-G gene in susceptibility to the disease. (PubMed id 11766889)1, 4, 7 O'Brien M....Moreau P. (2001)
  6. HLA-G and HLA-E polymorphisms in an indigenous African population. The ZVITAMBO Study Group. (PubMed id 11137220)1, 4, 7 Matte C....Roger M. (2000)
  7. Genetic variants in nonclassical major histocompatibility complex class I human leukocyte antigen (HLA)-E and HLA-G molecules are associated with susceptibility to heterosexual acquisition of HIV-1. (PubMed id 16362895)1, 4, 7 Lajoie J....Roger M. (2006)
  8. Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer. (PubMed id 16455647)1, 2, 7 Shiroishi M.... Maenaka K. (2006)
  9. Association between human leukocyte antigen-G genotype and success of in vitro fertilization and pregnancy outcome. (PubMed id 15191524)1, 4, 7 Hviid T.V....Christiansen O.B. (2004)
  10. Analysis of human leukocyte antigen (HLA)-G polymorphism in normal women and in women with recurrent spontaneous abortions. (PubMed id 15548266)1, 4, 7 Abbas A....Agrawal S. (2004)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3135 HGNC: 4964 AceView: HLA-G Ensembl:ENSG00000204632 euGenes: HUgn3135
ECgene: HLA-G Kegg: 3135 H-InvDB: HLA-G

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
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Patent Information for HLA-G gene:
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