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HMGB1 Gene

protein-coding   GIFtS: 63

GC13M011850
high-mobility group box 1
(Previous name: high-mobility group (nonhistone chromosomal) protein 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: HMG1)
Products    

Aliases &
Descriptions
for HMGB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
high-mobility group box 11 2     Amphoterin2
HMG12 3 5     OTTHUMP000000181972
DKFZp686A042361 2     OTTHUMP000000181982
HMG31 2     Sulfoglucuronyl carbohydrate binding protein2
high-mobility group (nonhistone chromosomal) protein 11 2     high mobility group box 12
SBP-11 2     high mobility group protein B12
High mobility group protein 12 3     OTTHUMP000001908592
HMG-12 3     

External Ids:    HGNC: 49831   Entrez Gene: 31462   Ensembl: ENSG000001894037   UniProtKB: P094293   

Export aliases for HMGB1 gene to outside databases

Previous GC identifers: GC13M029013 GC13M025012 GC13M029963 GC13M028831 GC13M029930 GC13M031032


Summaries
for HMGB1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: HMGB1_HUMAN, P09429
Function: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially
single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating
cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS).
Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By
similarity)

Gene Wiki entry for HMGB1

Genomic Views
for HMGB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HMGB1 gene promoter:
         NF-kappaB1   GATA-1   GATA-3   GATA-2   NF-kappaB   HNF-4alpha2   TBP   SRY   STAT3   TFIID   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for HMGB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HMGB1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12   Ensembl cytogenetic band:  13q12.3   HGNC cytogenetic band: 13q12

HMGB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMGB1 gene location

GeneLoc gene densities for chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M011850:  view genomic region     (about GC identifiers)

Start:
 11,850,667 bp from pter
End:
 11,857,904 bp from pter
Size:
 7,238 bases
Orientation:
 minus strand

1 alternative location:
Chr13- 31,032,884-31,191,734     
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  

Proteins
for HMGB1 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: HMGB1_HUMAN, P09429 (See protein sequence)
Recommended Name: High mobility group protein B1  
Size: 215 amino acids; 24894 Da
Subunit: Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or
HMGB2 (By similarity)
Subcellular location: Nucleus. Chromosome
PDB structures from and Proteopedia :
2YRQ (3D)    
Secondary accessions: A5D8W9 Q14321 Q5T7C3 Q6IBE1

Explore the universe of human proteins at neXtProt for HMGB1: NX_P09429 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_002119.1  

    ENSEMBL proteins: 
    ENSP00000410465 ENSP00000343040 ENSP00000369904 ENSP00000406375 ENSP00000382410 ENSP00000411269 
    ENSP00000384678 ENSP00000382412 ENSP00000345347 ENSP00000382417 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for HMGB1
    R&D Systems Recombinant & Natural Proteins for HMGB1 (HMGB1/HMG-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: HMGB1
    OriGene Protein Over-expression Lysate: HMGB1
    GenScript Custom Purified and Recombinant Proteins Services for HMGB1 
    Novus Biologicals Proteins for HMGB1
    Novus Biologicals Lysates for HMGB1
    Sino Biological Recombinant Protein for HMGB1
    ProSpec Recombinant Protein for HMGB1

    5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000793 condensed chromosome IDA12925773
    GO:0005615 extracellular space IDA19841752
    GO:0005634 nucleus IDA19223331
    GO:0005654 nucleoplasm EXP18239742
    GO:0005730 nucleolus IDA18029348
    About this table

    HMGB1 for ontologies           About GeneDecksing



    Antibodies for HMGB1: 
    Millipore Mono- and Polyclonal Antibodies for the study of HMGB1
    Sigma-Aldrich Antibody Arrays and Antibodies for HMGB1
    R&D Systems Antibodies for HMGB1 (HMGB1/HMG-1)
    Cell Signaling Technology (CST) Antibodies for HMGB1  (HMG-1)
    OriGene Antibodies (see all 3): HMGB1
    GenScript Custom Superior Antibodies Services for HMGB1 
    Novus Biologicals Antibodies for HMGB1
    Epitomics antibodies for HMGB1

    Assays for HMGB1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HMGB1 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 

    Protein Domains/
    Families
    for HMGB1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HMGB1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011989 ARM-like
     IPR009071 HMG_superfamily
     IPR000910 HMG_HMG1/HMG2
     IPR017967 HMG_boxA_CS
     IPR000135 HMG_HMG1/HMG2_subgr

    Graphical View of Domain Structure for InterPro Entry P09429

    ProtoNet protein and cluster: P09429

    1 Blocks protein family: IPB000135 High mobility group proteins HMG1 and HMG2

    UniProtKB/Swiss-Prot: HMGB1_HUMAN, P09429
    Similarity: Belongs to the HMGB family
    Similarity: Contains 2 HMG box DNA-binding domains


    Gene Function
    for HMGB1 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: HMGB1_HUMAN, P09429
    Function: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially
    single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating
    cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS).
    Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By
    similarity)

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for HMGB1
    Sigma-Aldrich shRNA Panels and shRNA for HMGB1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): HMGB1
    OriGene shRNA RFP (see all 2): HMGB1
    OriGene basic RS shRNA (see all 2): HMGB1
    OriGene siRNA: HMGB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HMGB1 
    miRNA:Sigma-Aldrich microRNA Mimics for HMGB1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HMGB1 
    8/13 SABiosciences Assays for microRNAs that regulate HMGB1 (see all 13):
    hsa-miR-505 hsa-miR-495 hsa-miR-513a-3p hsa-miR-557 hsa-miR-944 hsa-miR-410 hsa-miR-1284 hsa-miR-582-5p

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: HMGB1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HMGB1
    OriGene untagged cDNA clones in CMV expression vector (see all 3): HMGB1
    OriGene 3'-UTR clone: HMGB1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for HMGB1 
    Sino Biological Human cDNA Clone for HMGB1

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for HMGB1 

    5/12 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 12):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding ----
    GO:0003684 damaged DNA binding ISS--
    GO:0003690 double-stranded DNA binding ISS--
    GO:0003697 single-stranded DNA binding ISS--
    GO:0003700 sequence-specific DNA binding transcription factor activity IDA19223331
    About this table

    HMGB1 for ontologies           About GeneDecksing

    Animal Models: 8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hmgb1):

    behavior/neurologicalcellulargrowth/sizehomeostasis/metabolismlethality-prenatal/perinatal
    life span-post-weaning/agingrespiratory systemvision/eye

    HMGB1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HMGB1 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    HMGB1 for pathways           About GeneDecksing

    1 Millipore Pathway for HMGB1
        Selected targets of Oct-3/4

    2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  HMGB1
        Glucocorticoid Receptor Signaling
    HMGB1 Signaling

    1 Kegg Pathway  (Kegg details for HMGB1):
        hsa03410 Base excision repair

        SABiosciences Pathway-Focused PCR Arrays including HMGB1 (see all 3): PAHS-005A PAHS-018A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for HMGB1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HMGB1

    5/12 Interacting proteins for HMGB1 (ENSP000003453473 P094291, 2) via UniProtKB, MINT, and/or STRING (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046371STRING: ENSP00000269305 EBI-389432,EBI-366083
    TP73O153501EBI-389432,EBI-389606
    CSNK1A1P487292MINT-14881 MINT-16364
    TXNP105992MINT-6795963
    HMGB2ENSP000002965033STRING: ENSP00000296503
    About this table

    5/19 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 19):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP19158276
    GO:0001773 myeloid dendritic cell activation ISS--
    GO:0002407 dendritic cell chemotaxis ISS--
    GO:0002437 inflammatory response to antigenic stimulus IEP19841752
    GO:0006265 DNA topological change ISS--
    About this table

    HMGB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HMGB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    HMGB1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HMGB1
    10/53 Novoseek chemical compound relationships for HMGB1 gene (see all 53)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hmga 61.7 3 10598102 (1), 12590928 (1)
    endotoxin 56.4 53 10398600 (4), 17339485 (4), 16424112 (3), 19450686 (3) (see all 27)
    cisplatin 51.8 85 9427537 (6), 11245470 (5), 12614161 (5), 17922863 (3) (see all 29)
    glycyrrhizin 49.1 23 16935945 (2), 17462578 (2), 19906009 (1), 20419158 (1) (see all 8)
    neurocan 37.6 5 9507007 (4), 11766883 (1)
    platinum 36.5 7 10460158 (2), 11733188 (1), 10747955 (1), 18777181 (1) (see all 6)
    cholesterol-sulfate 35.3 9 11243881 (4), 14993789 (1)
    anaphylatoxin 32 1 17464119 (1)
    perchloric acid 27.2 1 18682735 (1)
    sb 203580 20.6 5 19726280 (2), 17135572 (1), 18949384 (1), 18402807 (1)
    About this table



    Transcripts
    for HMGB1 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for HMGB1
    Sigma-Aldrich shRNA Panels and shRNA for HMGB1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): HMGB1
    OriGene shRNA RFP (see all 2): HMGB1
    OriGene basic RS shRNA (see all 2): HMGB1
    OriGene siRNA: HMGB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HMGB1 
    miRNA: Sigma-Aldrich microRNA Mimics for HMGB1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HMGB1 
    8/13 SABiosciences Assays for microRNAs that regulate HMGB1 (see all 13):
    hsa-miR-505 hsa-miR-495 hsa-miR-513a-3p hsa-miR-557 hsa-miR-944 hsa-miR-410 hsa-miR-1284 hsa-miR-582-5p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: HMGB1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HMGB1
    OriGene untagged cDNA clones in CMV expression vector (see all 3): HMGB1
    OriGene 3'-UTR Clone: HMGB1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for HMGB1 
    Primers: OriGene genome-wide validated SYBR primer pairs: HMGB1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for HMGB1: PPH00999A

    REFSEQ mRNAs for HMGB1 gene: 

    NM_002128.4  

    Additional cDNA sequence: 

    AB208998.1 AF283771.2 AF401215.1 AK057120.1 AK122825.1 AK291494.1 AK304506.1 AK310975.1 
    AL110194.1 BC030981.1 BC141844.1 BX647267.1 CR591935.1 CR600442.1 CR601960.1 CR608517.1 
    CR625918.1 CR749614.1 

    24/92 DOTS entries (see all 92):

    DT.100052897  DT.92071638  DT.100680078  DT.92071310  DT.92049316  DT.95377774  DT.100697450  DT.100697442 
    DT.100697434  DT.100697445  DT.414948  DT.100697446  DT.95253133  DT.100697429  DT.438329  DT.120795160 
    DT.120905298  DT.100712011  DT.121044751  DT.40252816  DT.92071298  DT.100697454  DT.100857814  DT.120795196 

    24/1611 AceView cDNA sequences (see all 1611):

    AA315398 AA206166 BU678237 AA331597 BM662712 CA418167 AA903448 CB137935 
    CR625251 BG034466 AI318055 BF435533 CR607900 AW512749 AW467749 AI342253 
    BX387085 BU656300 CR625918 BQ025193 CB108564 AI278561 AA360132 BF692448 

    highest scoring ESTs for HMGB1:

    D63874 AA026548 AA045605 AA083770 AA132393 AA150678 AA152381 AA169369 AA204770 AA206991 

    Unigene Clusters for HMGB1:

    High-mobility group box 1
    Hs.593339  [show with all ESTs], Hs.596078  [show with all ESTs], Hs.725141  [show with all ESTs]
    Unigene Representative Sequences: BG421380, CR616734, AK122825


    GeneLoc Exon Structure

    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398908 ENST00000339872 ENST00000326004 ENST00000432889 ENST00000399487
    ENST00000426225 ENST00000405805(uc001usv.2 uc001usw.2 uc001usx.2 uc001usy.2 uc001usz.2)
    ENST00000399489 ENST00000341423(uc001uta.1) ENST00000468384 ENST00000490788
    ENST00000399494

    Expression
    for HMGB1 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    HMGB1 expression in normal and diseased human tissues

    1  / 2  / 3

    13 probe-sets matching HMGB1 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    59135_at2, 3 U95-B 1 0.56 1.00 0.96 1.21 N92507 0.80 1.00 0.91 1
    65806_at2, 3 U95-C 1 0.50 1.00 0.88 1.05 AI690476 0.60 1.00 0.82 1
    32220_at2, 3 U95-A 3 0.44 0.62 0.69 0.74 D63874 1.00 0.87 0.94 1
    224731_at2, 3 U133-B 1 1.00 1.00 -- -- BF673940 0.20 1.00 0.72 1
    214938_x_at2, 3 U133-A 2 1.00 0.86 -- -- AF283771 0.40 1.00 0.76 1
    200680_x_at2, 3 U133-A 6 1.00 0.77 -- -- NM_002128 0.60 1.00 0.82 1
    200679_x_at2, 3 U133-A 15 1.00 0.31 -- -- BE311760 0.60 1.00 0.82 1
    224734_at2, 3 U133-B 1 0.82 1.00 -- -- N92507 0.80 1.00 0.91 1
    224731_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    214938_x_at2 U133Plus2 2 1.00 0.86 -- -- -- -- -- -- --
    200680_x_at2 U133Plus2 6 1.00 0.77 -- -- -- -- -- -- --
    200679_x_at2 U133Plus2 15 1.00 0.31 -- -- -- -- -- -- --
    224734_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    About this table

    HMGB1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    HMGB1 gene expression
    HMGB1 gene electronic northern expression
    HMGB1 gene sage expression
    About these images

    CGAP SAGE TAG: GAAATTTAAA

    SOURCE GeneReport for Unigene clusters: Hs.593339 Hs.596078 Hs.725141

    Expression variation in blood from EXPOLDB for HMGB1

    Primers: OriGene genome-wide validated SYBR primer pairs: HMGB1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for HMGB1: PPH00999A
        SABiosciences Expression via Pathway-Focused PCR Arrays including HMGB1 (see all 3): PAHS-005A PAHS-018A  


    Orthologs
    for HMGB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for HMGB1 gene from 5/12 species (see all 12)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 HMGB11   -- high-mobility group box 1 95.19(n)
    100(a)    		 403170  NM_001002937.1  NP_001002937.1 
    chimpanzee
    (Pan troglodytes)    		 HMGB11   -- high-mobility group box 1 99.69(n)
    99.53(a)    		 452518  XM_001140879.1  XP_001140879.1 
    cow
    (Bos taurus)    		 HMGB11   -- high-mobility group box 1 94.26(n)
    99.53(a)    		 282691  NM_176612.1  NP_788785.1 
    rat
    (Rattus norvegicus)    		 LOC6800541   -- similar to High mobility group protein 1 (HMG-1) (High more 91.32(n)
    98.6(a)    		 680054  XM_001055841.1  XP_001055841.1 
    mouse
    (Mus musculus)    		 Hmgb15
    Hmg1l11    		 5 (89.18 cM)5
    		 high mobility group box 15
    high-mobility group (nonhistone chromosomal) protein more1    		 90.85(n)1
    97.21(a)1    		 4341741  XM_485920.41  XP_485920.11 
     AK0345355  AK0379285  (see all 37)
    About this table        Species with no ortholog for HMGB1

    ENSEMBL Gene Tree for HMGB1 (if available)

    Paralogs
    for HMGB1 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for HMGB1 gene
    HMGB32  ENSG000002134722  HMGB22  

    HMGB1 for paralogs           About GeneDecksing


    Pseudogenes
    10 related pseudogenes



    Genomic Variants
    for HMGB1 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/107 NCBI SNPs in HMGB1 are shown (see all 107)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 13 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs125891,2
    		C,F,A,31033042(-) CAAAGG/ATTGAG 1 -- ut31 ese36Minor allele frequency- A:0.01MN NS EA WA 606
    rs9692481,2
    		C,F,O,A,31037213(-) TCATAT/CTGGTT 1 -- int19Minor allele frequency- C:0.10NS EA NA WA 612
    rs9837231,2
    		C,F,A,31037445(-) GCAAAA/GGCGGA 2 K ref1 syn1 ese32Minor allele frequency- G:0.25WA 52
    rs10454111,2
    		C,F,A,H,31033232(-) GTGCTG/ATGGGG 1 -- ut3115Minor allele frequency- A:0.19MN NA NS EA WA 1136
    rs10561301,2
    		C,F,31038651(+) CCGAGG/AAGAGA 1 -- int1 trp32Minor allele frequency- A:0.19MN NA 186
    rs10603481,2
    		C,F31036837(-) TTCTTC/TCTCTT 2 F ref1 syn12Minor allele frequency- T:0.13MN WA 46
    rs13317001,2
    		C,F,31041916(+) TTTGAC/TGATTA 1 -- ng511Minor allele frequency- T:0.04NA 72
    rs14121251,2
    		C,F,A,H,31041595(+) ACTATC/TGGACT 1 -- ng51102Minor allele frequency- G:0.01NS EA PA EU CA WA NA 6220
    rs18549191,2
    		--31034093(-) AATTTA/TGACTT 1 -- ut310--------
    rs19296061,2
    		C,F,H,31036681(-) AAATAC/TGAAAA 2 Y ref1 syn114Minor allele frequency- T:0.03NS EA NA WA 574
    About this table

    HapMap Linkage Disequilibrium images for HMGB1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HMGB1: --

    QIAGEN SeqTarget long-range PCR primers for resequencing HMGB1 

    Disorders & Mutations
    for HMGB1 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HMGB1 for disorders           About GeneDecksing

    OMIM: 163905

    10/59 Novoseek disease relationships for HMGB1 gene (see all 59)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sepsis 66.6 165 17334246 (6), 17901841 (5), 14620138 (4), 17625012 (4) (see all 70)
    inflammation 62 136 15947118 (3), 16645483 (3), 19679874 (3), 19948257 (3) (see all 90)
    necrosis 50.2 67 19587006 (4), 16855214 (3), 16354107 (3), 17516211 (2) (see all 46)
    systemic inflammatory response syndrome 46.7 8 18577209 (2), 20158885 (1), 17346334 (1), 19819342 (1)
    shock septic 46 19 15753748 (3), 12974876 (2), 18713653 (2), 12297673 (1) (see all 11)
    arthritis 40.6 56 14871458 (5), 18759291 (5), 17203009 (4), 17397533 (3) (see all 22)
    tumors 39.6 130 17667523 (4), 19639200 (4), 18031610 (3), 19876719 (3) (see all 74)
    rheumatoid arthritis 33.9 19 17597834 (2), 18346273 (2), 17172710 (1), 17060363 (1) (see all 17)
    multiple organ failure 31.7 4 19533845 (1), 15877951 (1), 19209785 (1)
    cancer 31.1 51 17611640 (3), 14763124 (3), 19506549 (3), 20044610 (3) (see all 29)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: HMGB1 (5 documents)

    Export disorders and mutations for HMGB1 gene to outside databases

    Medical News
    for HMGB1 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for HMGB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/624 PubMed articles for HMGB1 gene, integrated from 7 sources (see all 624):
    (articles sorted by number of sources associating them with HMGB1)
    1. The active gene that encodes human high mobility group 1 protein (HMG1) contains introns and maps to chromosome 13. (PubMed id 8661151)1, 2, 3 Ferrari S.... Bianchi M.E. (1996)
    2. The genetic variation of the human HMGB1 gene. (PubMed id 17610420)1, 2, 7 Kornblit B....Garred P. (2007)
    3. Expression of high-mobility group-1 mRNA in human gastrointestinal adenocarcinoma and corresponding non-cancerous mucosa. (PubMed id 9036861)1, 2, 7 Xiang Y.Y.... Sugimura H. (1997)
    4. Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. (PubMed id 18655026)1, 2 Tan F....Peng X. (2008)
    5. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)1, 2 Kim S.C.... Zhao Y. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Identity of nuclear high-mobility-group protein, HMG-1, and sulfoglucuronyl carbohydrate-binding protein, SBP-1, in brain. (PubMed id 11279268)1, 3 Chou D.K....Jungalwala F.B. (2001)
    9. Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2. (PubMed id 9150946)1, 2 Rasmussen R.K.... Dorow D.S. (1997)
    10. A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1. (PubMed id 2922262)1, 2 Wen L.... Reeck G.R. (1989)

    External Searches for HMGB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HMGB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3146 HGNC: 4983 AceView: HMGB1 Ensembl:ENSG00000189403 euGenes: HUgn3146
    ECgene: HMGB1 Kegg: 3146 H-InvDB: HMGB1

    Other Databases showing HMGB1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HMGB1 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for HMGB1 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/hmgb1/

    Intellectual Property
    for HMGB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for HMGB1 gene:
    Search GeneIP for patents involving HMGB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HMGB1 gene

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    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
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