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HOXA13 Gene

protein-coding   GIFtS: 51

GC07M027203
homeobox A13
(Previous name: homeo box A13 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: HOX1J, HOX1)
Products    

Aliases &
Descriptions
for HOXA13 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
homeobox A131 2     transcription factor HOXA132
HOX1J2 3 5     HOX12
homeo box A131 2     homeo box 1J2
Homeobox protein Hox-1J2 3     homeobox protein Hox-A132
homeobox protein HOXA132     

External Ids:    HGNC: 51021   Entrez Gene: 32092   Ensembl: ENSG000001060317   UniProtKB: P312713   

Export aliases for HOXA13 gene to outside databases

Previous GC identifers: GC07M026880 GC07M026944 GC07M026978 GC07M027009 GC07M027235


Summaries
for HOXA13 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HOXA13:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named
A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during
embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription
factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the
encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. (provided by RefSeq)

UniProtKB/Swiss-Prot: HXA13_HUMAN, P31271
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXA13

Genomic Views
for HOXA13 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXA13 gene promoter:
         AP-1   c-Fos   c-Jun   MyoD   Sp1   YY1   Meis-1   HOXA9B   ATF   ATF-2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for HOXA13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HOXA13 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.2   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15.2

HOXA13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXA13 gene location

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M027203:  view genomic region     (about GC identifiers)

Start:
 27,117,064 bp from pter
End:
 27,152,477 bp from pter
Size:
 35,414 bases
Orientation:
 minus strand

1 alternative location:
Chr7- 27,233,122-27,239,725     
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NT_079592.2  

Proteins
for HOXA13 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: HXA13_HUMAN, P31271 (See protein sequence)
Recommended Name: Homeobox protein Hox-A13  
Size: 388 amino acids; 39727 Da
Subcellular location: Nucleus
Secondary accessions: A4D188 O43371

Explore the universe of human proteins at neXtProt for HOXA13: NX_P31271 

REFSEQ proteins: NP_000513.2  

ENSEMBL proteins: 
ENSP00000222753 


Human Recombinant Proteins 
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
Browse OriGene Protein Over-expression Lysates
GenScript Custom Purified and Recombinant Proteins Services for HOXA13 
Novus Biologicals Protein for HOXA13
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
About this table

HOXA13 for ontologies           About GeneDecksing



Antibodies for HOXA13: 
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for HOXA13
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
GenScript Custom Superior Antibodies Services for HOXA13 
Novus Biologicals Antibody for HOXA13
Browse antibodies at Epitomics

Assays for HOXA13: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for HOXA13 
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for HOXA13 

Protein Domains/
Families
for HOXA13 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HOXA13 for domains           About GeneDecksing

5 InterPro domains/families:
 IPR022067 HoxA13_N
 IPR001356 Homeobox
 IPR017970 Homeobox_CS
 IPR009057 Homeodomain-like
 IPR012287 Homeodomain-rel

Graphical View of Domain Structure for InterPro Entry P31271

ProtoNet protein and cluster: P31271

UniProtKB/Swiss-Prot: HXA13_HUMAN, P31271
Similarity: Belongs to the Abd-B homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


Gene Function
for HOXA13 gene

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: HXA13_HUMAN, P31271
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis

Inhib.
RNA:    		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for HOXA13
Sigma-Aldrich shRNA for HOXA13
OriGene 29mer shRNA kits in GFP-retroviral vector: HOXA13
OriGene shRNA RFP: HOXA13
OriGene basic RS shRNA: HOXA13
OriGene siRNA: HOXA13
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HOXA13 
miRNA:Sigma-Aldrich microRNA Mimics for HOXA13
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HOXA13 
5 SABiosciences Assays for microRNAs that regulate HOXA13:
hsa-miR-612 hsa-miR-27a hsa-miR-128 hsa-miR-1285 hsa-miR-27b

Gene
Editing:		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: HOXA13
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HOXA13
OriGene untagged cDNA clones in CMV expression vector: HOXA13
OriGene 3'-UTR clone: HOXA13 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for HOXA13 
Browse Sino Biological Human cDNA Clones

Cell
Lines:  		GenScript Custom overexpressing Cell Line Services for HOXA13 

Genatlas biochemistry entry for HOXA13:
homeo box A13(1J),homologous to mouse Hox-1.10 (hypodactyly),expressed in the developing lower genitourinary tract
(abnormal seminal vesicle and prostate development),altered in hypodactyly mutants

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

GO IDQualified GO termEvidencePubMed IDs
GO:0003677 DNA binding TAS9020844
GO:0003700 sequence-specific DNA binding transcription factor activity IEA--
GO:0005515 protein binding IEA--
GO:0010843 promoter binding IEA--
GO:0030528 transcription regulator activity IEA--
About this table

HOXA13 for ontologies           About GeneDecksing

Animal Models: 13 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Hoxa13):

cardiovascular systemdigestive/alimentaryembryogenesisendocrine/exocrine glandgrowth/size
homeostasis/metabolismlethality-prenatal/perinatallimbs/digits/tailrenal/urinary systemreproductive system
skeletonskin/coat/nailsvision/eye

HOXA13 for phenotypes           About GeneDecksing


Pathways & Interactions
for HOXA13 gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for HOXA13 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOXA13

5/20 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 20):

GO IDQualified GO termEvidencePubMed IDs
GO:0001501 skeletal system development TAS9020844
GO:0001570 vasculogenesis IEA--
GO:0001886 endothelial cell morphogenesis IEA--
GO:0001894 tissue homeostasis IEA--
GO:0003281 ventricular septum development IEA--
About this table

HOXA13 for ontologies           About GeneDecksing



Drugs & Compounds
for HOXA13 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

HOXA13 for compounds           About GeneDecksing

Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HOXA13
1 Novoseek chemical compound relationship for HOXA13 gene
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
alanine 13.7 1 17935235 (1)
About this table



Transcripts
for HOXA13 gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section
Inhib.
RNA:     		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for HOXA13
Sigma-Aldrich shRNA for HOXA13
OriGene 29mer shRNA kits in GFP-retroviral vector: HOXA13
OriGene shRNA RFP: HOXA13
OriGene basic RS shRNA: HOXA13
OriGene siRNA: HOXA13
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HOXA13 
miRNA: Sigma-Aldrich microRNA Mimics for HOXA13
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HOXA13 
5 SABiosciences Assays for microRNAs that regulate HOXA13:
hsa-miR-612 hsa-miR-27a hsa-miR-128 hsa-miR-1285 hsa-miR-27b
Clones: Sigma-Aldrich FLAG tag genes for HOXA13
OriGene GFP tagged cDNA clones in CMV expression vector: HOXA13
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HOXA13
OriGene untagged cDNA clones in CMV expression vector: HOXA13
OriGene 3'-UTR Clone: HOXA13 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for HOXA13 
Primers: OriGene genome-wide validated SYBR primer pairs: HOXA13
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for HOXA13: PPH19695A

REFSEQ mRNAs for HOXA13 gene: 

NM_000522.4  

Additional cDNA sequence: 

BC016712.1 BC075791.1 

1 DOTS entry:

DT.443168 

24/47 AceView cDNA sequences (see all 47):

R80259 BF589601 BF221789 BX119246 BQ024387 BE784076 BG260781 BQ025175 
BU617759 NM_000522 AI080175 AI695522 AI659273 BQ022750 BF055200 AW364757 
BG259921 AI800530 AI680626 AA088393 CB129050 AA088276 BX439546 AI680621 

highest scoring ESTs for HOXA13:

AA160421 AI680626 AI680621 AI800530 AL597666 BC016712 BC075791 BE784076 BF793608 BG289306 

Unigene Cluster for HOXA13:

Homeobox A13
Hs.592172  [show with all ESTs]
Unigene Representative Sequence: NM_000522


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000518136 ENST00000222753(uc003szb.1)

Expression
for HOXA13 gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

HOXA13 expression in normal and diseased human tissues

1  / 2  / 3

4 probe-sets matching HOXA13 gene

Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
47826_at2, 3 U95-B 2 0.44 0.78 0.94 0.82 AA687604 0.40 1.00 0.76 1
60937_at2, 3 U95-C 1 0.38 1.00 0.90 1.34 AI680626 0.80 1.00 0.91 1
231786_at2, 3 U133-B 1 0.27 1.00 -- -- BG289306 0.60 1.00 0.82 1
231786_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
About this table

HOXA13 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
HOXA13 gene expression
HOXA13 gene electronic northern expression
HOXA13 gene sage expression
About these images

CGAP SAGE TAG: TTTATTGTGT

SOURCE GeneReport for Unigene cluster: Hs.592172
Primers: OriGene genome-wide validated SYBR primer pairs: HOXA13
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for HOXA13: PPH19695A
    SABiosciences Custom PCR Arrays for HOXA13 


Orthologs
for HOXA13 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for HOXA13 gene from 5/6 species (see all 6)
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 HOXA131   -- homeobox A13 94.94(n)
98.88(a)		 482375  XM_539492.2  XP_539492.2 
rat
(Rattus norvegicus)		 Hoxa131   -- homeo box A13 91.02(n)
98.96(a)		 500129  XM_575481.2  XP_575481.1 
mouse
(Mus musculus)		 Hoxa131 , 5 6 (25.41 cM)5
 homeobox A135
homeo box A131		 91.71(n)1
99.22(a)1		 153981  NM_008264.11  NP_032290.11 
 BC1007315  BC1007325  (see all 7)
chicken
(Gallus gallus)		 HOXA131   -- homeobox A13 81.72(n)
85.86(a)		 373934  NM_204139.1  NP_989470.1 
zebrafish
(Danio rerio)		 hoxa13b2   -- homeo box A13b 73.58(n) 30438  NM_131194.1 
About this table        Species with no ortholog for HOXA13

ENSEMBL Gene Tree for HOXA13 (if available)

Paralogs
for HOXA13 gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for HOXA13 gene
HOXD132  HOXC132  HOXC122  HOXB132  HOXD122  

HOXA13 for paralogs           About GeneDecksing



Genomic Variants
for HOXA13 gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/41 NCBI SNPs in HOXA13 are shown (see all 41)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 7 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
----------
rs20670871,2
C,F,A,27241660(+) ACAAAC/GAGACA 1 -- ng5116Minor allele frequency- G:0.38EA NA NS WA 2798
rs20712651,2
C,H,27238691(-) GGTGCC/GTTTCT 1 -- int17Minor allele frequency- G:0.38EA NA WA 1478
rs23913981,2
H27241293(+) CCCCTC/TACACA 1 -- ng514Minor allele frequency- T:0.00NS EA 418
rs38075981,2
C,F,27240482(+) AGACCC/GATAGA 1 -- ng519Minor allele frequency- G:0.43NS EA NA 748
rs102251571,2
C,F,27241230(+) TGGACC/TTGTCC 1 -- ng515Minor allele frequency- T:0.03NS EA WA 464
rs114113591,2
C27240017(+) GAAGG-/GCGGCC 1 -- ng510--------
rs119737581,2
H27240057(+) CCCAGG/TGGGGC 1 -- ng510--------
rs119842971,2
C,F,H,27236493(+) CAGATT/GTTAAT 1 -- ng316Minor allele frequency- G:0.01NS EA NA 578
rs174279241,2
C27236466(+) GCATAG/CGAAAG 1 -- ng311Minor allele frequency- C:0.00NS 116
rs174375791,2
H27240194(+) GCCTAG/TCTCAG 1 -- ng513Minor allele frequency- T:0.00EA NS 288
About this table

HapMap Linkage Disequilibrium images for HOXA13 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for HOXA13: --

QIAGEN SeqTarget long-range PCR primers for resequencing HOXA13 

Disorders & Mutations
for HOXA13 gene

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
HOXA13 for disorders           About GeneDecksing

OMIM: 142959   disorders: 140000  176305  

UniProtKB/Swiss-Prot: HXA13_HUMAN, P31271

  • Defects in HOXA13 are the cause of hand-foot-genital syndrome (HFGS) [MIM:140000]; also known as
    • hand-foot-uterus syndrome. The clinical features include small feet with unusually short great toes and abnormal
    thumbs. Females with the disorder have duplication of the genital tract
  • Defects in HOXA13 are the cause of Guttmacher syndrome [MIM:176305]. Guttmacher syndrome is a dominantly
    • inherited combination of distal limb and genital tract abnormalities. It has several features in common with
    hand-foot-genital syndrome, including hypoplastic first digits and hypospadias. Typical features not seen in
    hand-foot-genital syndrome include postaxial polydactyly of the hands and uniphalangeal second toes with absent nails

    3 Novoseek disease relationships for HOXA13 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hand-foot-genital syndrome 97.6 8 9020844 (2), 10839976 (1), 12676922 (1), 15643670 (1) (see all 7)
    hypospadias 63.5 4 14675924 (4)
    cancer 0 1 19491265 (1)
    About this table

    GeneTests: HOXA13
    Hand-Foot-Genital Syndrome

    Human Gene Mutation Database (HGMD): HOXA13
    Human Genome Epidemiology (HuGE) Navigator: HOXA13 (4 documents)

    Export disorders and mutations for HOXA13 gene to outside databases

    Medical News
    for HOXA13 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for HOXA13 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/65 PubMed articles for HOXA13 gene, integrated from 7 sources (see all 65):
    (articles sorted by number of sources associating them with HOXA13)
    1. Novel HOXA13 mutations and the phenotypic spectrum of hand-foot- genital syndrome. (PubMed id 10839976)1, 2, 7 Goodman F.R.... Scambler P.J. (2000)
    2. A HOXA13 allele with a missense mutation in the homeobox and a dinucleotide deletion in the promoter underlies Guttmacher syndrome. (PubMed id 11968094)1, 2, 7 Innis J.W.... Guttmacher A.E. (2002)
    3. Mutation of HOXA13 in hand-foot-genital syndrome. (PubMed id 9020844)1, 2, 7 Mortlock D.P. and Innis J.W. (1997)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    6. A novel stable polyalanine [poly(A)] expansion in the HOXA13 gene associated with hand-foot-genital syndrome: proper function of poly(A)-harbouring transcription factors depends on a critical repeat length? (PubMed id 12073020)1, 2 Utsch B....Ludwig M. (2002)
    7. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    8. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    9. The human HOX gene family. (PubMed id 2574852)1, 2 Acampora D.... Boncinelli E. (1989)
    10. HOXA13 promotes cancer cell growth and predicts poor survival of patients with esophageal squamous cell carcinoma. (PubMed id 19491265)1, 7 Gu Z.D....Chen K.N. (2009)

    External Searches for HOXA13 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HOXA13 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3209 HGNC: 5102 AceView: HOXA13 Ensembl:ENSG00000106031 euGenes: HUgn3209
    ECgene: HOXA13 H-InvDB: HOXA13

    Other Databases showing HOXA13 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HOXA13 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for HOXA13 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/HOXA13

    Intellectual Property
    for HOXA13 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for HOXA13 gene:
    Search GeneIP for patents involving HOXA13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HOXA13 gene

    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for HOXA13 Antibodies for HOXA13
     Super-pooled esiRNAs for HOXA13 Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for HOXA13 microRNA Mimics for HOXA13
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     FLAG tag genes for HOXA13 Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HOXA13
     SeqTarget long-range PCR primers for resequencing HOXA13
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HOXA13
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HOXA13
     GenScript Custom Purified and Recombinant Proteins Services for HOXA13 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for HOXA13
     GenScript Custom Assay Services for HOXA13 GenScript Custom Superior Antibodies Services for HOXA13
     GenScript Custom overexpressing Cell Line Services for HOXA13 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HOXA13 promoter
     Search Chromatin IP Primers for HOXA13
     RT2 qPCR Primer Assay for HOXA13
     Search GNC Networks for HOXA13
     Assays for microRNAs that regulate HOXA13
     SABiosciences Custom PCR Arrays for HOXA13
     Search Tocris compounds for HOXA13
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for HOXA13
     Proteins for HOXA13
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for HOXA13
           

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