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Aliases & Descriptionsfor HOXA6 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions homeobox A61 2 HOX1.22 HOX1B2 3 5 homeobox protein Hox-A62 homeo box A61 2 homeobox protein HOXA62 Homeobox protein Hox-1B2 3 homeo box 1B2 HOX12
Export aliases for HOXA6 gene to outside databases Previous GC identifers: GC07M026827 GC07M026927 GC07M026958 GC07M027151
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Summariesfor HOXA6 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for HOXA6 : In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. (provided by RefSeq) UniProtKB/Swiss-Prot: HXA6_HUMAN, P31267 Function : Sequence-specific transcription factor which is part of a developmental regulatory system that provides cellswith specific positional identities on the anterior-posterior axis Gene Wiki entry for HOXA6
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Genomic Viewsfor HOXA6 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the HOXA6 gene promoter: C/EBPalpha c-Myb GR-beta GR-alpha AP-2alphaA AP-2gamma NF-kappaB1 Sp1 p53 FOXO1a Other transcription factors Search SABiosciences Chromatin IP Primers for HOXA6 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HOXA6
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7p15.2 Ensembl cytogenetic band: 7p15.2 HGNC cytogenetic band: 7p15.2 HOXA6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07M027065: view genomic region
(about GC identifiers )
Start:
27,065,504 bp from pter
End:
27,067,754 bp from pter
Size:
2,251 bases
Orientation:
minus strand
1 alternative location : Chr 7- 27,185,015-27,190,222
RefSeq DNA sequence: NC_000007.13 NT_007819.17 NT_079592.2
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Proteinsfor HOXA6 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: HXA6_HUMAN, P31267 (See
protein sequence )Recommended Name: Homeobox protein Hox-A6 Size : 233 amino acids; 26339 Da
Subcellular location : Nucleus
Secondary accessions : A4D192 Q2M3G3 Q9UPM0Explore the universe of human proteins at neXtProt for HOXA6: NX_P31267
REFSEQ proteins: NP_076919.1 ENSEMBL proteins: ENSP00000222728 Human Recombinant Proteins 1 Gene Ontology (GO) cellular component term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
About this table
HOXA6 for ontologies About GeneDecksing Antibodies for HOXA6: Assays for HOXA6:
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Protein
Domains/ Familiesfor HOXA6 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
HOXA6 for domains About GeneDecksing 5/7 InterPro domains/families (see all 7 ):
Graphical View of Domain Structure for InterPro Entry P31267 ProtoNet protein and cluster: P31267
1 Blocks protein family : IPB001827 Homeobox protein UniProtKB/Swiss-Prot: HXA6_HUMAN, P31267 Similarity : Belongs to the Antp homeobox familySimilarity : Contains 1 homeobox DNA-binding domain
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Gene Functionfor HOXA6 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: HXA6_HUMAN, P31267 Function : Sequence-specific transcription factor which is part of a developmental regulatory system that provides cellswith specific positional identities on the anterior-posterior axis
Genatlas biochemistry entry for HOXA6 :homeo box A6(1B),homologous to mouse Hox-1.2,Drosophila Antp,Ubx,abd-A 4 Gene Ontology (GO) molecular function terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003700 sequence-specific DNA binding transcription factor activity
IEA -- GO:0005515 protein binding
IEA -- GO:0030528 transcription regulator activity
IEA -- GO:0043565 sequence-specific DNA binding
IEA --
About this table
HOXA6 for ontologies About GeneDecksing Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Hoxa6) :
HOXA6 for phenotypes About GeneDecksing
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Pathways & Interactionsfor HOXA6 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for HOXA6 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOXA6 5 Gene Ontology (GO) biological process terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0007275 multicellular organismal development
IEA -- GO:0009952 anterior/posterior pattern formation
IEA -- GO:0048704 embryonic skeletal system morphogenesis
IEA -- GO:0048706 embryonic skeletal system development
-- --
About this table
HOXA6 for ontologies About GeneDecksing
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Drugs & Compoundsfor HOXA6 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for HOXA6
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Transcriptsfor HOXA6 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for HOXA6 gene: NM_024014.2
Additional cDNA sequence: BC069497.1 BC104915.1 BC104917.1
1 DOTS entry : DT.92068629
7 AceView cDNA sequences :
NM_024014 BC069497 BP871526 BE792613 BG749730 BF738660 BF820847
highest scoring ESTs for HOXA6 :BE792613 BM020281 BC069497 BG749730 BC104915 BC104917 DQ655986 AW292647 Unigene Cluster for HOXA6:
Homeobox A6 Hs.679517 [show with all ESTs ] Unigene Representative Sequence: NM_024014 GeneLoc Exon Structure 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000521478 ENST00000222728 (uc003syo.1 )
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Expression for HOXA6 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section HOXA6 expression in normal and diseased human tissues 1 / 2 / 3
2 probe-sets matching HOXA6 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
208557_at2 , 3
U133-A
1
0.91
1.00
--
--
NM_024014
0.20
0.17
0.18
3
208557_at2
U133Plus2
1
0.91
1.00
--
--
--
--
--
--
--
About this table Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.679517 SABiosciences Custom PCR Arrays for HOXA6
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Orthologsfor HOXA6 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for HOXA6 gene from 5/6 species (see all 6 )
About this table Species with no ortholog for HOXA6 ENSEMBL Gene Tree for HOXA6 (if available)
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Paralogsfor HOXA6 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for HOXA6 gene HOXB8 2 HOXC8 2 HOXD8 2 HOXB6 2
HOXA6 for paralogs About GeneDecksing
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Genomic Variantsfor HOXA6 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 7 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for HOXA6 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for HOXA6: --
QIAGEN SeqTarget long-range PCR primers for resequencing HOXA6
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Disorders & Mutationsfor HOXA6 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
HOXA6 for disorders About GeneDecksing
OMIM: 142951 Human Genome Epidemiology (HuGE) Navigator: HOXA6 (1 document)Export disorders and mutations for HOXA6 gene to outside databases
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Medical Newsfor HOXA6 gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor HOXA6 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/13 PubMed articles for HOXA6 gene, integrated from 7 sources (see all 13 ): (articles sorted by number of sources associating them with HOXA6) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Human chromosome 7: DNA sequence and biology. (PubMed id 12690205) 1 , 2 Scherer S.W.... Tsui L.-C. (2003) The DNA sequence of human chromosome 7. (PubMed id 12853948) 1 , 2 Hillier L.W.... Wilson R.K. (2003) Vertebrate homeobox gene nomenclature. (PubMed id 1358459) 1 , 3 Scott M.P. (1992) Nomenclature for human homeobox genes. (PubMed id 1973146) 1 , 3 McAlpine P.J. and Shows T.B. (1990) Organization of human class I homeobox genes. (PubMed id 2576652) 1 , 2 Boncinelli E.... Simeone A. (1989) High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261) 1 Yerges L.M....Zmuda J.M. (2009) Hoxa6 potentiates short-term hemopoietic cell proliferation and extended self-renewal. (PubMed id 19157684) 1 Dickson G.J....Thompson A. (2009) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506) 1 Kosaki K.... Matsuo N. (2002)
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External Searches for HOXA6 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing HOXA6 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing HOXA6 gene
(According to HUGE )
About This Section --
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Specialized Databases showing HOXA6 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for HOXA6 gene: Search GeneIP for patents involving HOXA6 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor HOXA6 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for HOXA6
ELISAs and CLIAs for HOXA6
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