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HOXB6 Gene

protein-coding   GIFtS: 53

GC17M042041
homeobox B6
(Previous name: homeo box B6 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: HOX2, HOX2B)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
homeobox B61 2     Hox-2.22
HOX2B2 3 5     HOX22
homeo box B61 2     OTTHUMP000002169752
Homeobox protein Hox-2B2 3     homeo box 2B2
Homeobox protein Hu-22 3     homeobox protein Hox-B62
Homeobox protein Hox-2.22 3     HU-22

External Ids:    HGNC: 51171   Entrez Gene: 32162   Ensembl: ENSG000001085117   UniProtKB: P175093   

Export aliases for HOXB6 gene to outside databases

Previous GC identifers: GC17M046384 GC17M049153 GC17M047015 GC17M047147 GC17M044028 GC17M046673


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HOXB6:
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is
included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a
sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been
localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular
localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer. (provided
by RefSeq)

UniProtKB/Swiss-Prot: HXB6_HUMAN, P17509
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXB6 gene promoter:
         GR-alpha   STAT3   FAC1   Cart-1   Arnt   ZID   IRF-1   ER-alpha   POU2F2   POU2F1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for HOXB6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HOXB6 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.3   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

HOXB6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXB6 gene location

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M042041:  view genomic region     (about GC identifiers)

Start:
42,041,907 bp from pter
End:
42,051,148 bp from pter
Size:
9,242 bases
Orientation:
minus strand

1 alternative location:
Chr17- 46,673,114-46,682,354     
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: HXB6_HUMAN, P17509 (See protein sequence)
Recommended Name: Homeobox protein Hox-B6  
Size: 224 amino acids; 25432 Da
Subcellular location: Nucleus
Secondary accessions: A8K835 P09068 Q9HB11 Q9UGH2
Alternative splicing: 2 isoforms:  P17509-1   P17509-2   

Explore the universe of human proteins at neXtProt for HOXB6: NX_P17509 

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_061825.2  

    ENSEMBL proteins: 
    ENSP00000420009 ENSP00000225648 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HOXB6
    GenScript Custom Purified and Recombinant Proteins Services for HOXB6 
    Novus Biologicals Proteins for HOXB6
    Novus Biologicals Lysate for HOXB6
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus NAS--
    About this table

    HOXB6 for ontologies           About GeneDecksing



    Antibodies for HOXB6: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for HOXB6
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for HOXB6 
    Browse antibodies at Epitomics

    Assays for HOXB6: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HOXB6 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HOXB6 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HOXB6 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR017995 Homeobox_antennapedia
     IPR001827 Homeobox_Antennapedia_CS
     IPR001356 Homeobox
     IPR017970 Homeobox_CS
     IPR020479 Homeobox_eu

    Graphical View of Domain Structure for InterPro Entry P17509

    ProtoNet protein and cluster: P17509

    1 Blocks protein family: IPB001827 Homeobox protein

    UniProtKB/Swiss-Prot: HXB6_HUMAN, P17509
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: HXB6_HUMAN, P17509
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
    with specific positional identities on the anterior-posterior axis

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for HOXB6
    Sigma-Aldrich shRNA for HOXB6
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): HOXB6
    OriGene shRNA RFP (see all 3): HOXB6
    OriGene basic RS shRNA (see all 3): HOXB6
    OriGene siRNA (see all 3): HOXB6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HOXB6 
    miRNA:Sigma-Aldrich microRNA Mimics for HOXB6
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HOXB6 
    3 SABiosciences Assays for microRNAs that regulate HOXB6:
    hsa-miR-196a hsa-miR-196b hsa-miR-376c

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: HOXB6
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HOXB6
    OriGene untagged cDNA clones in CMV expression vector: HOXB6
    OriGene 3'-UTR clone: HOXB6 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for HOXB6 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for HOXB6 

    Genatlas biochemistry entry for HOXB6:
    homeo box B6(2B),homologous to mouse Hox-2.2,Drosophila Antp,Ubx,abd-A,expressed during early myelopoiesis

    3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700 sequence-specific DNA binding transcription factor activity NAS--
    GO:0030528 transcription regulator activity IEA--
    GO:0043565 sequence-specific DNA binding IEA--
    About this table

    HOXB6 for ontologies           About GeneDecksing

    Animal Models: 4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hoxb6):

    hematopoietic systemimmune systemnervous systemskeleton

    HOXB6 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for HOXB6 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOXB6

    3 Interacting proteins for HOXB6 (P175092) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT15P190122MINT-67624
    PLSCR1O151622MINT-66992
    SAT1P216732MINT-66153
    About this table

    5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355 regulation of transcription, DNA-dependent NAS--
    GO:0007275 multicellular organismal development IEA--
    GO:0008595 anterior/posterior axis specification, embryo NAS--
    GO:0009952 anterior/posterior pattern formation IEA--
    GO:0034101 erythrocyte homeostasis IEA--
    About this table

    HOXB6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXB6


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for HOXB6
    Sigma-Aldrich shRNA for HOXB6
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): HOXB6
    OriGene shRNA RFP (see all 3): HOXB6
    OriGene basic RS shRNA (see all 3): HOXB6
    OriGene siRNA (see all 3): HOXB6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HOXB6 
    miRNA: Sigma-Aldrich microRNA Mimics for HOXB6
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HOXB6 
    3 SABiosciences Assays for microRNAs that regulate HOXB6:
    hsa-miR-196a hsa-miR-196b hsa-miR-376c
    Clones: Sigma-Aldrich FLAG tag genes for HOXB6
    OriGene GFP tagged cDNA clones in CMV expression vector: HOXB6
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HOXB6
    OriGene untagged cDNA clones in CMV expression vector: HOXB6
    OriGene 3'-UTR Clone: HOXB6 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for HOXB6 
    Primers: OriGene genome-wide validated SYBR primer pairs: HOXB6
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for HOXB6: PPH10715A

    REFSEQ mRNAs for HOXB6 gene: 

    NM_018952.4  

    Additional cDNA sequence: 

    AK292200.1 BC014651.1 M30597.1 S69023.1 

    10 DOTS entries:

    DT.411550  DT.40284863  DT.120919488  DT.100751617  DT.120919546  DT.120919468  DT.95110663  DT.91661718 
    DT.86853413  DT.92434281 

    24/119 AceView cDNA sequences (see all 119):

    AI739272 AW780031 BQ930769 AW079372 AI581159 AI078264 AI262967 AI393078 
    CF127170 BF001683 AI935193 BI764435 BE908889 AA425339 BG470218 BF001449 
    AI887979 NM_156037 AI262637 AW166458 BX115208 AW204721 AW439180 BG430754 

    highest scoring ESTs for HOXB6:

    AW194050 BF811061 NM_156036 NM_156037 AA082985 AI352188 AJ270993 BF813712 BQ323056 X58431 

    Unigene Cluster for HOXB6:

    Homeobox B6
    Hs.98428  [show with all ESTs]
    Unigene Representative Sequence: AK292200


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for HOXB6

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
    SP1:        -           -                 -               
    SP2:                                                      
    SP3:                                                      

    About this scheme

    ECgene alternative splicing isoforms for HOXB6
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470193 ENST00000484302(uc002ins.1 uc010dbh.1 uc002int.1)
    ENST00000225648 ENST00000490419

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    HOXB6 expression in normal and diseased human tissues

    1  / 2  / 3

    7 probe-sets matching HOXB6 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    62769_at2, 3 U95-C 1 0.44 1.00 0.62 1.20 AA416576 0.20 0.50 0.38 1
    83030_at2, 3 U95-E 1 0.44 1.00 0.83 0.70 AI392987 0.40 0.67 0.55 1
    160042_s_at2, 3 U95-A 1 0.31 1.00 0.88 1.11 X58431 0.20 1.00 0.72 1
    205366_s_at2, 3 U133-A 1 0.46 1.00 -- -- NM_018952 0.40 0.67 0.55 1
    205365_at*2, 3 U133-A 1 0.46 1.00 -- -- AA527340 0.60 0.75 0.68 1
    205366_s_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    205365_at*2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    About this table

    HOXB6 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    HOXB6 gene expression
    HOXB6 gene electronic northern expression
    HOXB6 gene sage expression
    About these images

    CGAP SAGE TAG: AAGTGGAAAA

    SOURCE GeneReport for Unigene cluster: Hs.98428
    Primers: OriGene genome-wide validated SYBR primer pairs: HOXB6
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for HOXB6: PPH10715A
        SABiosciences Custom PCR Arrays for HOXB6 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for HOXB6 gene from 5/7 species (see all 7)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    HOXB61   -- homeobox B6 100(n)
    100(a)
    749195  XM_001172963.1  XP_001172963.1 
    cow
    (Bos taurus)
    HOXB61   -- homeobox B6 86.15(n)
    92.27(a)
    539095  XM_882402.2  XP_887495.2 
    rat
    (Rattus norvegicus)
    Hoxb61   -- homeo box B6 91.37(n)
    97.77(a)
    497986  XM_573182.2  XP_573182.1 
    mouse
    (Mus musculus)
    Hoxb61 , 5 11 (59.82 cM)5
    homeobox B65
    homeo box B61
    91.22(n)1
    97.77(a)1
    154141  NM_008269.11  NP_032295.11 
     AK0116225  BC0168935  (see all 8)
    zebrafish
    (Danio rerio)
    hoxb6a2   -- homeo box B6a 73.59(n) 30341  NM_131119.1 
    About this table        Species with no ortholog for HOXB6

    ENSEMBL Gene Tree for HOXB6 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for HOXB6 gene
    HOXB82  HOXA62  HOXC82  HOXD82  

    HOXB6 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/108 NCBI SNPs in HOXB6 are shown (see all 108)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs92211,2
    C,F,A,H,46675813(-) TGGGGA/GGAGAG 1 -- int1 trp316Minor allele frequency- G:0.28MN NS EA NA WA 1008
    rs9191091,2
    C,F,A,H,46675977(+) TAATTG/CTGTTT 1 -- int112Minor allele frequency- C:0.21NA EA MN WA 836
    rs10600301,2
    --46683662(+) TCCCCA/CCCCCC 1 -- ng511Minor allele frequency- C:0.00MN 184
    rs10647391,2
    --46683655(+) ATTCCC/TTTCCC 1 -- ng51 trp31Minor allele frequency- T:0.00MN 184
    rs27407541,2
    C,F,46683060(-) CGGGAG/TAAGCC 1 -- ng511Minor allele frequency- T:0.06NA 72
    rs32095441,2
    --46676569(-) GGTACG/TGGAGT 1 -- int10--------
    rs37447751,2
    C,F,46677716(-) CTCACC/TAGATC 1 -- int110Minor allele frequency- T:0.05EA NS NA 2344
    rs42861471,2
    C46676841(+) GAGAAG/AGTCGT 1 -- int1 trp34Minor allele frequency- A:0.00NS EA 416
    rs46469931,2
    C,F,46681604(-) GAGACC/GAGCTC 1 -- int111Minor allele frequency- G:0.17EU NS EA NA WA 728
    rs47939511,2
    C,46678814(+) GGCCCT/CGAAGT 1 -- int15Minor allele frequency- C:0.08NA EA WA 166
    About this table

    HapMap Linkage Disequilibrium images for HOXB6 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for HOXB6
         2 CNVs: 53230 4040

    QIAGEN SeqTarget long-range PCR primers for resequencing HOXB6 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HOXB6 for disorders           About GeneDecksing

    OMIM: 142961

    Human Gene Mutation Database (HGMD): HOXB6
    Human Genome Epidemiology (HuGE) Navigator: HOXB6 (2 documents)

    Export disorders and mutations for HOXB6 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/38 PubMed articles for HOXB6 gene, integrated from 7 sources (see all 38):
    (articles sorted by number of sources associating them with HOXB6)
    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    3. Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues. (PubMed id 1672751)1, 2 Shen W.-F....Largman C. (1991)
    4. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    5. Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines. (PubMed id 2573064)1, 2 Shen W.-F.... Lawrence H.J. (1989)
    6. Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila. (PubMed id 6091895)1, 2 Levine M.... Tjian R. (1984)
    7. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010 Mar 5)
    8. Induction of HoxB transcription by retinoic acid requ ires actin polymerization. (PubMed id 19477923)1 Ferrai C....Blasi F. (2009)
    9. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    10. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3216 HGNC: 5117 AceView: HOXB6 Ensembl:ENSG00000108511 euGenes: HUgn3216
    ECgene: HOXB6 H-InvDB: HOXB6

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for HOXB6 gene:
    Search GeneIP for patents involving HOXB6

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    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for HOXB6 Antibodies for HOXB6
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for HOXB6 microRNA Mimics for HOXB6
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     FLAG tag genes for HOXB6 Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HOXB6
     SeqTarget long-range PCR primers for resequencing HOXB6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HOXB6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HOXB6
     GenScript Custom Purified and Recombinant Proteins Services for HOXB6 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for HOXB6
     GenScript Custom Assay Services for HOXB6 GenScript Custom Superior Antibodies Services for HOXB6
     GenScript Custom overexpressing Cell Line Services for HOXB6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HOXB6 promoter
     Search Chromatin IP Primers for HOXB6
     RT2 qPCR Primer Assay for HOXB6
     GNC Network for HOXB6
     Assays for microRNAs that regulate HOXB6
     SABiosciences Custom PCR Arrays for HOXB6
     Search Tocris compounds for HOXB6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Proteins for HOXB6
     Lysates for HOXB6
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for HOXB6
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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