Aliases &
Descriptions
for HOXB6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| homeobox B61 2 | | Hox-2.22 | | HOX2B2 3 5 | | HOX22 | | homeo box B61 2 | | OTTHUMP000002169752 | | Homeobox protein Hox-2B2 3 | | homeo box 2B2 | | Homeobox protein Hu-22 3 | | homeobox protein Hox-B62 | | Homeobox protein Hox-2.22 3 | | HU-22 |
Export aliases for HOXB6 gene to outside databasesPrevious GC identifers: GC17M046384 GC17M049153 GC17M047015 GC17M047147 GC17M044028 GC17M046673 |
Summaries
for HOXB6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HOXB6:
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It isincluded in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as asequence-specific transcription factor that is involved in development, including that of lung and skin, and has beenlocalized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellularlocalization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer. (providedby RefSeq)
UniProtKB/Swiss-Prot: HXB6_HUMAN, P17509Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cellswith specific positional identities on the anterior-posterior axis
Gene Wiki entry for HOXB6 |
Genomic Views
for HOXB6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HOXB6 gene promoter:
GR-alpha STAT3 FAC1 Cart-1 Arnt ZID IRF-1 ER-alpha POU2F2 POU2F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HOXB6
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HOXB6  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.3 Ensembl cytogenetic band: 17q21.32 HGNC cytogenetic band: 17q21.32HOXB6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M042041: view genomic region
(about GC identifiers)
Start:
|
42,041,907 bp from pter |
End:
|
42,051,148 bp from pter |
Size:
|
9,242 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr17- 46,673,114-46,682,354 |
RefSeq DNA sequence:- NC_000017.10 NT_010783.15
|
Proteins
for HOXB6 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: HXB6_HUMAN, P17509 (See
protein sequence)Recommended Name: Homeobox protein Hox-B6 Size: 224 amino acids; 25432 Da
Subcellular location: Nucleus
Secondary accessions: A8K835 P09068 Q9HB11 Q9UGH2Alternative splicing: 2 isoforms: P17509-1 P17509-2 Explore the universe of human proteins at neXtProt for HOXB6: NX_P17509
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_061825.2
ENSEMBL proteins: ENSP00000420009 ENSP00000225648
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
NAS | -- |
About this table
HOXB6 for ontologies About GeneDecksing
Antibodies for HOXB6:
Assays for HOXB6: |
Protein
Domains/
Families
for HOXB6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HOXB6 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P17509ProtoNet protein and cluster: P17509 1 Blocks protein family: IPB001827 Homeobox protein
UniProtKB/Swiss-Prot: HXB6_HUMAN, P17509Similarity: Belongs to the Antp homeobox familySimilarity: Contains 1 homeobox DNA-binding domain |
Gene Function
for HOXB6 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: HXB6_HUMAN, P17509Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cellswith specific positional identities on the anterior-posterior axis
Genatlas biochemistry entry for HOXB6:homeo box B6(2B),homologous to mouse Hox-2.2,Drosophila Antp,Ubx,abd-A,expressed during early myelopoiesis3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
NAS | -- | | GO:0030528 | transcription regulator activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
About this table
HOXB6 for ontologies About GeneDecksing
Animal Models: 4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Hoxb6):
HOXB6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HOXB6 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for HOXB6
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOXB6
3 Interacting proteins for HOXB6 (P175092) via UniProtKB, MINT, and/or STRINGAbout this table
5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
NAS | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0008595 | anterior/posterior axis specification, embryo |
NAS | -- | | GO:0009952 | anterior/posterior pattern formation |
IEA | -- | | GO:0034101 | erythrocyte homeostasis |
IEA | -- |
About this table
HOXB6 for ontologies About GeneDecksing
|
Drugs & Compounds
for HOXB6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for HOXB6
|
Transcripts
for HOXB6 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for HOXB6 gene: NM_018952.4 Additional cDNA sequence: AK292200.1 BC014651.1 M30597.1 S69023.1 10 DOTS entries: DT.411550 DT.40284863 DT.120919488 DT.100751617 DT.120919546 DT.120919468 DT.95110663 DT.91661718 DT.86853413 DT.92434281 24/119 AceView cDNA sequences (see all 119): AI739272 AW780031 BQ930769 AW079372 AI581159 AI078264 AI262967 AI393078 CF127170 BF001683 AI935193 BI764435 BE908889 AA425339 BG470218 BF001449 AI887979 NM_156037 AI262637 AW166458 BX115208 AW204721 AW439180 BG430754
 highest scoring ESTs for HOXB6:AW194050 BF811061 NM_156036 NM_156037 AA082985 AI352188 AJ270993 BF813712 BQ323056 X58431 Unigene Cluster for HOXB6: Homeobox B6 Hs.98428 [show with all ESTs]Unigene Representative Sequence: AK292200
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for HOXB6
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b |
|---|
|
| SP1: | | | - | | | | - | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for HOXB6
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000470193 ENST00000484302(uc002ins.1 uc010dbh.1 uc002int.1)
ENST00000225648 ENST00000490419
|
Expression
for HOXB6 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| HOXB6 expression in normal and diseased human tissues
1 / 2 / 3 7 probe-sets matching HOXB6 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 62769_at2, 3
|
U95-C |
1 |
0.44 |
1.00 |
0.62 |
1.20 |
AA416576 |
0.20 |
0.50 |
0.38 |
1 |
| 83030_at2, 3
|
U95-E |
1 |
0.44 |
1.00 |
0.83 |
0.70 |
AI392987 |
0.40 |
0.67 |
0.55 |
1 |
| 160042_s_at2, 3
|
U95-A |
1 |
0.31 |
1.00 |
0.88 |
1.11 |
X58431 |
0.20 |
1.00 |
0.72 |
1 |
| 205366_s_at2, 3
|
U133-A |
1 |
0.46 |
1.00 |
-- |
-- |
NM_018952 |
0.40 |
0.67 |
0.55 |
1 |
| 205365_at*2, 3
|
U133-A |
1 |
0.46 |
1.00 |
-- |
-- |
AA527340 |
0.60 |
0.75 |
0.68 |
1 |
| 205366_s_at2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 205365_at*2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
HOXB6 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AAGTGGAAAA
SOURCE GeneReport for Unigene cluster: Hs.98428
SABiosciences Custom PCR Arrays for HOXB6
|
Orthologs
for HOXB6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HOXB6 gene from 5/7 species (see all 7)
About this table Species with no ortholog for HOXB6
ENSEMBL Gene Tree for HOXB6 (if available) |
Paralogs
for HOXB6 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for HOXB6 gene
- HOXB82 HOXA62 HOXC82 HOXD82
HOXB6 for paralogs About GeneDecksing
|
Genomic Variants
for HOXB6 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for HOXB6 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for HOXB6
2 CNVs: 53230 4040 | | QIAGEN SeqTarget long-range PCR primers for resequencing HOXB6 |
|
Disorders & Mutations
for HOXB6 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HOXB6 for disorders About GeneDecksing
OMIM: 142961
Human Gene Mutation Database (HGMD): HOXB6
Human Genome Epidemiology (HuGE) Navigator: HOXB6 (2 documents)
Export disorders and mutations for HOXB6 gene to outside databases
|
Medical News
for HOXB6 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for HOXB6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/38 PubMed articles for HOXB6 gene, integrated from 7 sources (see all 38):
(articles sorted by number of sources associating them with HOXB6)- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
- Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues. (PubMed id 1672751)1, 2 Shen W.-F....Largman C. (1991)
- Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
- Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines. (PubMed id 2573064)1, 2 Shen W.-F.... Lawrence H.J. (1989)
- Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila. (PubMed id 6091895)1, 2 Levine M.... Tjian R. (1984)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010 Mar 5)
- Induction of HoxB transcription by retinoic acid requ ires actin polymerization. (PubMed id 19477923)1 Ferrai C....Blasi F. (2009)
- Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
- Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
|
External Searches for HOXB6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HOXB6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HOXB6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HOXB6 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for HOXB6 gene:
Search GeneIP for patents involving HOXB6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HOXB6 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for HOXB6 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for HOXB6 |
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