Aliases &
Descriptions
for HOXB9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| homeobox B91 2 | | HOX-2.52 | | HOX2E2 3 5 | | homeobox protein Hox-B92 | | homeo box B91 2 | | HOX22 | | Homeobox protein Hox-2.52 3 | | homeo box 2E2 | | Homeobox protein Hox-2E2 3 | | |
Export aliases for HOXB9 gene to outside databasesPrevious GC identifers: GC17M046409 GC17M049179 GC17M047040 GC17M047173 GC17M044053 GC17M046694 |
Summaries
for HOXB9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HOXB9:
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It isincluded in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as asequence-specific transcription factor that is involved in cell proliferation and differentiation. Increasedexpression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. (provided byRefSeq)
UniProtKB/Swiss-Prot: HXB9_HUMAN, P17482Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cellswith specific positional identities on the anterior-posterior axis
Gene Wiki entry for HOXB9 |
Genomic Views
for HOXB9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HOXB9 gene promoter:
MRF-2 POU3F1 E2F-1 E2F-3a E2F-5 E2F E2F-4 E2F-2 STAT1 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for HOXB9
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HOXB9  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.3 Ensembl cytogenetic band: 17q21.32 HGNC cytogenetic band: 17q21.32HOXB9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M042067: view genomic region
(about GC identifiers)
Start:
|
42,067,396 bp from pter |
End:
|
42,072,713 bp from pter |
Size:
|
5,318 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr17- 46,698,518-46,703,720 |
RefSeq DNA sequence:- NC_000017.10 NT_010783.15
|
Proteins
for HOXB9 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: HXB9_HUMAN, P17482 (See
protein sequence)Recommended Name: Homeobox protein Hox-B9 Size: 250 amino acids; 28059 Da
Subcellular location: Nucleus
Developmental stage: Expressed in whole embryos and fetuses at 5-9 weeks from conception
Secondary accessions: B2RDB7 Q9H1I1Explore the universe of human proteins at neXtProt for HOXB9: NX_P17482
REFSEQ proteins: NP_076922.1
ENSEMBL proteins: ENSP00000309439 ENSP00000411988
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
HOXB9 for ontologies About GeneDecksing
Antibodies for HOXB9:
Assays for HOXB9: |
Protein
Domains/
Families
for HOXB9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HOXB9 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P17482ProtoNet protein and cluster: P17482 2 Blocks protein families: IPB000047 Lambda and other repressor helix-turn-helix signature IPB006711 Hox9 activation region
UniProtKB/Swiss-Prot: HXB9_HUMAN, P17482Similarity: Belongs to the Abd-B homeobox familySimilarity: Contains 1 homeobox DNA-binding domain |
Gene Function
for HOXB9 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: HXB9_HUMAN, P17482Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cellswith specific positional identities on the anterior-posterior axis
Genatlas biochemistry entry for HOXB9:homeo box B9(2E),homologous to mouse Hox-2.5,Drosophila abd-B4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
NAS | -- | | GO:0005515 | protein binding |
IPI | 10617598 | | GO:0016563 | transcription activator activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
About this table
HOXB9 for ontologies About GeneDecksing
Animal Models: 6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Hoxb9):
HOXB9 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HOXB9 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
HOXB9 for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for HOXB9
SABiosciences Pathway-Focused PCR Array including HOXB9: PAHS-083A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for HOXB9
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOXB9
4 Interacting proteins for HOXB9 (P174821, 2) via UniProtKB, MINT, and/or STRINGAbout this table
5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006350 | transcription |
-- | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
NAS | -- | | GO:0007275 | multicellular organismal development |
NAS | -- | | GO:0009952 | anterior/posterior pattern formation |
IEA | -- | | GO:0030879 | mammary gland development |
IEA | -- |
About this table
HOXB9 for ontologies About GeneDecksing
|
Drugs & Compounds
for HOXB9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for HOXB9
|
Transcripts
for HOXB9 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for HOXB9 gene: NM_024017.4 Additional cDNA sequence: AK026084.1 AK056123.1 AK315480.1 BC015565.1 3 DOTS entries: DT.309741 DT.100749432 DT.100749433 24/82 AceView cDNA sequences (see all 82): AW078582 BX114117 BF478046 AW973279 BF063337 BM987589 BE350818 NM_024017 BC015565 BM784270 BF305592 AA447441 BF205444 AI695505 BG830524 AI763257 BI113866 AI828957 AK026084 AI343498 AI352287 BF939270 AW881257 AK056414
 highest scoring ESTs for HOXB9:AA204719 AA211845 AK056123 BF205444 BF305592 BG830524 BI113866 BM748115 BM784270 AA447441 Unigene Cluster for HOXB9: Homeobox B9 Hs.463350 [show with all ESTs]Unigene Representative Sequence: NM_024017
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000311177(uc002inx.2) ENST00000442657
|
Expression
for HOXB9 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| HOXB9 expression in normal and diseased human tissues
1 / 2 / 3 7 probe-sets matching HOXB9 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 62959_at2, 3
|
U95-C |
1 |
0.75 |
1.00 |
1.00 |
1.00 |
AA204719 |
0.80 |
1.00 |
0.91 |
1 |
| 216417_x_at2
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 216201_at2
|
U133-A |
1 |
0.36 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 226461_at2, 3
|
U133-B |
1 |
0.27 |
1.00 |
-- |
-- |
AA204719 |
0.80 |
1.00 |
0.91 |
1 |
| 216417_x_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 216201_at2
|
U133Plus2 |
1 |
0.36 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 226461_at2
|
U133Plus2 |
1 |
0.27 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
HOXB9 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GGCCTGGATG
SOURCE GeneReport for Unigene cluster: Hs.463350
SABiosciences Expression via Pathway-Focused PCR Array including HOXB9: PAHS-083A
|
Orthologs
for HOXB9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HOXB9 gene from 5/9 species (see all 9)
About this table Species with no ortholog for HOXB9
ENSEMBL Gene Tree for HOXB9 (if available) |
Paralogs
for HOXB9 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for HOXB9 gene
- HOXA92 HOXC92 HOXD112 HOXC112 HOXD102 HOXA112 HOXC102 HOXD92
- HOXA102
HOXB9 for paralogs About GeneDecksing
|
Genomic Variants
for HOXB9 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for HOXB9 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for HOXB9
2 CNVs: 53230 4040 | | QIAGEN SeqTarget long-range PCR primers for resequencing HOXB9 |
|
Disorders & Mutations
for HOXB9 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HOXB9 for disorders About GeneDecksing
OMIM: 142964
Human Genome Epidemiology (HuGE) Navigator: HOXB9 (1 document)
Export disorders and mutations for HOXB9 gene to outside databases
|
Medical News
for HOXB9 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for HOXB9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/29 PubMed articles for HOXB9 gene, integrated from 7 sources (see all 29):
(articles sorted by number of sources associating them with HOXB9)- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)1, 2 Kosaki K.... Matsuo N. (2002)
- Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
- Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
- Differential expression of human HOX-2 genes along the anterior- posterior axis in embryonic central nervous system. (PubMed id 2570724)1, 2 Giampaolo A.... Peschle C. (1989)
- Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (1989)
- HOXB9, a gene overexpressed in breast cancer, promote s tumorigenicity and lung metastasis. (PubMed id 20080567)1 Hayashida T....Maheswaran S. (2010)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010 Mar 5)
- Do HOXB9 and COL1A1 genes play a role in congenital dislocation of the hip? Study in a Caucasian population. (PubMed id 19341834)1 Rouault K....FAcrec C. (2009)
|
External Searches for HOXB9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HOXB9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HOXB9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HOXB9 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for HOXB9 gene:
Search GeneIP for patents involving HOXB9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HOXB9 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for HOXB9 |
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 | | | ELISAs and CLIAs for HOXB9 |
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