Aliases &
Descriptions
for HOXC10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| homeobox C101 2 | | MGC52592 | | homeo box C101 2 | | homeobox protein Hox-C102 | | Homeobox protein Hox-3I2 3 | | homeoprotein C102 | | HOX3I2 3 | | |
Export aliases for HOXC10 gene to outside databasesPrevious GC identifers: GC12M054414 GC12P054491 GC12P054095 GC12P052665 GC12P054378 |
Summaries
for HOXC10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HOXC10:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcriptionfactors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similarhomeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. Theprotein level is controlled during cell differentiation and proliferation, which may indicate this protein has a rolein origin activation. (provided by RefSeq)
UniProtKB/Swiss-Prot: HXC10_HUMAN, Q9NYD6Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cellswith specific positional identities on the anterior-posterior axis
Gene Wiki entry for HOXC10 |
Genomic Views
for HOXC10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HOXC10 gene promoter:
FOXC1 C/EBPalpha CHOP-10 Arnt AhR FAC1 FOXO1a E47 RP58 NRSF form 1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HOXC10
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HOXC10  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.13HOXC10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P051416: view genomic region
(about GC identifiers)
Start:
|
51,416,659 bp from pter |
End:
|
51,421,773 bp from pter |
Size:
|
5,115 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr12+ 54,378,849-54,384,063 |
RefSeq DNA sequence:- NC_000012.11 NT_029419.12
|
Proteins
for HOXC10 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: HXC10_HUMAN, Q9NYD6 (See
protein sequence)Recommended Name: Homeobox protein Hox-C10 Size: 342 amino acids; 38073 Da
Subcellular location: Nucleus
Secondary accessions: O15219 O15220 Q9BVD5Explore the universe of human proteins at neXtProt for HOXC10: NX_Q9NYD6
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_059105.2
ENSEMBL proteins: ENSP00000421946 ENSP00000307321
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | | GO:0019907 | colocalizes with cyclin-dependent protein kinase activating kinase holoenzyme complex |
IDA | 11445587 |
About this table
HOXC10 for ontologies About GeneDecksing
Antibodies for HOXC10:
Assays for HOXC10: |
Protein
Domains/
Families
for HOXC10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HOXC10 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NYD6ProtoNet protein and cluster: Q9NYD6 UniProtKB/Swiss-Prot: HXC10_HUMAN, Q9NYD6Similarity: Belongs to the Abd-B homeobox familySimilarity: Contains 1 homeobox DNA-binding domain |
Gene Function
for HOXC10 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: HXC10_HUMAN, Q9NYD6Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cellswith specific positional identities on the anterior-posterior axis
Genatlas biochemistry entry for HOXC10:homeo box C10(3I),homologous to mouse Hox-3.6,involved in mouse posterior limb patterning,expressed in posterior limb4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0003702 | RNA polymerase II transcription factor activity |
TAS | 10835276 | | GO:0005515 | protein binding |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
About this table
HOXC10 for ontologies About GeneDecksing
Animal Models: 7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Hoxc10):
HOXC10 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HOXC10 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Pathway-Focused PCR Array including HOXC10: PAHS-083A
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOXC10
5 Interacting proteins for HOXC10 (ENSP000003073213) via UniProtKB, MINT, and/or STRINGAbout this table
5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001501 | skeletal system development |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0008284 | positive regulation of cell proliferation |
TAS | 10835276 | | GO:0009952 | anterior/posterior pattern formation |
IEA | -- |
About this table
HOXC10 for ontologies About GeneDecksing
|
Drugs & Compounds
for HOXC10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for HOXC10
|
Transcripts
for HOXC10 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for HOXC10 gene: NM_017409.3 Additional cDNA sequence: AF255675.1 AK313759.1 BC001293.1 BT009921.1 CR600861.1 CR622939.1 X99685.1 4 DOTS entries: DT.448032 DT.91692757 DT.95307803 DT.91909674 24/228 AceView cDNA sequences (see all 228): AI174335 BF434131 BE396026 BE464190 BF057562 BQ890449 NM_014620 AL558161 AI631879 AI200419 AI159844 BM127627 NM_018953 AA629181 AI215607 BF434950 BX280842 AW299598 AA827833 T28272 BF591158 AW000987 BC074845 AA158947
 highest scoring ESTs for HOXC10:AI670876 AW024474 BE545448 BE813426 AA112396 AA190344 AA190345 AA307551 AA411006 AA502954 Unigene Cluster for HOXC10: Homeobox C10 Hs.44276 [show with all ESTs]Unigene Representative Sequence: NM_017409
GeneLoc Exon Structure
5 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000515593 ENST00000303460(uc001sen.2) ENST00000511575 ENST00000514415
ENST00000513413
|
Expression
for HOXC10 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| HOXC10 expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching HOXC10 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 57830_s_at2, 3
|
U95-C |
1 |
0.94 |
1.00 |
0.98 |
1.16 |
AW024474 |
1.00 |
0.85 |
0.93 |
1 |
| 52117_at2, 3
|
U95-B |
1 |
0.88 |
1.00 |
0.98 |
0.85 |
AI670876 |
1.00 |
0.85 |
0.93 |
1 |
| 218959_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
NM_017409 |
0.60 |
0.75 |
0.68 |
1 |
| 218959_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
HOXC10 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TAGCTTCCTT
SOURCE GeneReport for Unigene cluster: Hs.44276
SABiosciences Expression via Pathway-Focused PCR Array including HOXC10: PAHS-083A
|
Orthologs
for HOXC10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HOXC10 gene from 5/6 species (see all 6)
About this table Species with no ortholog for HOXC10
ENSEMBL Gene Tree for HOXC10 (if available) |
Paralogs
for HOXC10 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for HOXC10 gene
- HOXA92 HOXA112 HOXB92 HOXC92 HOXD112 HOXD92 HOXC112 HOXD102
- HOXA102
HOXC10 for paralogs About GeneDecksing
|
Genomic Variants
for HOXC10 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 12 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for HOXC10 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HOXC10
1 CNV: 3890 | | QIAGEN SeqTarget long-range PCR primers for resequencing HOXC10 |
|
Disorders & Mutations
for HOXC10 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HOXC10 for disorders About GeneDecksing
OMIM: 605560
Export disorders and mutations for HOXC10 gene to outside databases
|
Medical News
for HOXC10 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for HOXC10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/16 PubMed articles for HOXC10 gene, integrated from 7 sources (see all 16):
(articles sorted by number of sources associating them with HOXC10)- Selection of homeotic proteins for binding to a human DNA replication origin. (PubMed id 10835276)1, 2, 7 de Stanchina E.... Biamonti G. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines. (PubMed id 9357979)1, 2 Flagiello D.... Malfoy B. (1997)
- Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
- Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion. (PubMed id 17974957)1, 7 Zhai Y....Cho K.R. (2007)
- HOXC10 as a potential marker for discriminating betwe en amnion- and decidua-derived mesenchymal stem cells. (PubMed id 19522674)1 Hwang J.H....Lee J.K. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Dynamic profiling of the post-translational modificat ions and interaction partners of epidermal growth factor receptor signaling aft er stimulation by epidermal growth factor using Extended Range Proteomic Analys is (ERPA). (PubMed id 16799092)1 Wu S.L....Karger B.L. (2006)
- Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression. (PubMed id 12853486)1 Gabellini D....Peverali F.A. (2003)
|
External Searches for HOXC10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HOXC10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HOXC10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HOXC10 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for HOXC10 gene:
Search GeneIP for patents involving HOXC10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HOXC10 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for HOXC10 |
| |  |  |  |  | | | | |
 | | |
|
|
