Aliases &
Descriptions
for HOXC9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| homeobox C91 2 | | OTTHUMP000002173912 | | HOX3B2 3 5 | | homeobox protein Hox-C92 | | homeo box C91 2 | | HOX32 | | Homeobox protein Hox-3B2 3 | | |
Export aliases for HOXC9 gene to outside databasesPrevious GC identifers: GC12M054413 GC12P054506 GC12P054110 GC12P052680 GC12P054393 GC12P054388 |
Summaries
for HOXC9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HOXC9:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcriptionfactors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similarhomeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12.(provided by RefSeq)
UniProtKB/Swiss-Prot: HXC9_HUMAN, P31274Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cellswith specific positional identities on the anterior-posterior axis
Gene Wiki entry for HOXC9 |
Genomic Views
for HOXC9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HOXC9 gene promoter:
Sp1 p53 deltaCREB CREB HOXA9B Meis-1 CUTL1 E47 RP58 STAT5A
Other transcription factors
Search SABiosciences Chromatin IP Primers for HOXC9
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HOXC9  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.13HOXC9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P051432: view genomic region
(about GC identifiers)
Start:
|
51,431,589 bp from pter |
End:
|
51,434,833 bp from pter |
Size:
|
3,245 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr12+ 54,388,679-54,397,121 |
RefSeq DNA sequence:- NC_000012.11 NT_029419.12
|
Proteins
for HOXC9 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: HXC9_HUMAN, P31274 (See
protein sequence)Recommended Name: Homeobox protein Hox-C9 Size: 260 amino acids; 29248 Da
Subcellular location: Nucleus
Secondary accessions: B2RCN7 Q9H1I0Explore the universe of human proteins at neXtProt for HOXC9: NX_P31274
REFSEQ proteins: NP_008828.1
ENSEMBL proteins: ENSP00000423861 ENSP00000302836
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
About this table
HOXC9 for ontologies About GeneDecksing
Antibodies for HOXC9:
Assays for HOXC9: |
Protein
Domains/
Families
for HOXC9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HOXC9 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P31274ProtoNet protein and cluster: P31274 2 Blocks protein families: IPB000047 Lambda and other repressor helix-turn-helix signature IPB006711 Hox9 activation region
UniProtKB/Swiss-Prot: HXC9_HUMAN, P31274Similarity: Belongs to the Abd-B homeobox familySimilarity: Contains 1 homeobox DNA-binding domain |
Gene Function
for HOXC9 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: HXC9_HUMAN, P31274Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cellswith specific positional identities on the anterior-posterior axis
Genatlas biochemistry entry for HOXC9:homeo box C9(3B),homologous to mouse Hox-3.2,Drosophila abd-B,involved in mouse posterior limb patterning,expressed inposterior limb4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | 18305892 | | GO:0016563 | transcription activator activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
About this table
HOXC9 for ontologies About GeneDecksing
Animal Models: 3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Hoxc9):
HOXC9 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HOXC9 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
HOXC9 for pathways About GeneDecksing
2  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for HOXC9
SABiosciences Pathway-Focused PCR Array including HOXC9: PAHS-083A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for HOXC9
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOXC9
1 Interacting protein for HOXC9 (P312741) via UniProtKB, MINT, and/or STRING| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
About this table
5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006350 | transcription |
-- | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0009952 | anterior/posterior pattern formation |
-- | -- | | GO:0048704 | embryonic skeletal system morphogenesis |
-- | -- |
About this table
HOXC9 for ontologies About GeneDecksing
|
Drugs & Compounds
for HOXC9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for HOXC9
|
Transcripts
for HOXC9 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for HOXC9 gene: NM_006897.1 Additional cDNA sequence: AK000445.1 AK315194.1 BC032769.1 BC053894.1 CR600750.1 CR617045.1 3 DOTS entries: DT.99957565 DT.99935637 DT.208892 24/51 AceView cDNA sequences (see all 51): AL556826 CR600750 CR617045 AI361560 X99682 NM_006897 AA227856 BQ015349 BF062661 BU625573 AI367169 AI332412 BU621618 BU616567 BE786336 CA429963 CA446202 BQ772563 AL522191 BC032769 AI333355 AI522164 AK000445 BC053894
 highest scoring ESTs for HOXC9:AI522164 AW382790 BE065077 BE091205 X99682 AW379837 AA719162 AI332412 AK000445 BC032769 Unigene Cluster for HOXC9: Homeobox C9 Hs.658823 [show with all ESTs]Unigene Representative Sequence: NM_006897
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000504557 ENST00000508190(uc001sep.2) ENST00000303450(uc001seq.2)
|
Expression
for HOXC9 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| HOXC9 expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching HOXC9 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 45167_at2, 3
|
U95-B |
1 |
0.94 |
1.00 |
0.94 |
1.15 |
AI332412 |
0.60 |
0.75 |
0.68 |
1 |
| 87693_at2, 3
|
U95-D |
1 |
0.81 |
1.00 |
0.97 |
0.86 |
AA719162 |
0.60 |
0.75 |
0.68 |
1 |
| 231936_at2, 3
|
U133-B |
1 |
0.73 |
1.00 |
-- |
-- |
AK000445 |
0.60 |
0.75 |
0.68 |
1 |
| 231936_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
HOXC9 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TACGGCTCGC
SOURCE GeneReport for Unigene cluster: Hs.658823
SABiosciences Expression via Pathway-Focused PCR Array including HOXC9: PAHS-083A
|
Orthologs
for HOXC9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HOXC9 gene from 2 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
mouse
(Mus musculus) |
Hoxc95 |
15 (58.04 cM) |
homeobox C9 |
-- |
X55318 |
zebrafish
(Danio rerio) |
hoxc9a2 |
-- |
homeo box C9a |
77.69(n) |
58043 NM_131528.1 |
About this table Species with no ortholog for HOXC9
ENSEMBL Gene Tree for HOXC9 (if available) |
Paralogs
for HOXC9 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for HOXC9 gene
- HOXA92 HOXD112 HOXC112 HOXD102 HOXA112 HOXB92 HOXC102 HOXD92
- HOXA102
HOXC9 for paralogs About GeneDecksing
|
Genomic Variants
for HOXC9 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 12 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for HOXC9 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HOXC9
1 CNV: 3890 | | QIAGEN SeqTarget long-range PCR primers for resequencing HOXC9 |
|
Disorders & Mutations
for HOXC9 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HOXC9 for disorders About GeneDecksing
OMIM: 142971
Export disorders and mutations for HOXC9 gene to outside databases
|
Medical News
for HOXC9 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for HOXC9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/19 PubMed articles for HOXC9 gene, integrated from 7 sources (see all 19):
(articles sorted by number of sources associating them with HOXC9)- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)1, 2 Kosaki K.... Matsuo N. (2002)
- Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
- Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (1989)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010 Mar 5)
- RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A , DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-smal l cell lung cancer in China. (PubMed id 19506903)1 Lin Q....Zhu J. (2009)
- Search for cellular partners of human papillomavirus type 16 E2 protein. (PubMed id 18305892)1 Olejnik-Schmidt A.K....Gozdzicka-Jozefiak A. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Expression of HOXC9 and E2F2 are up-regulated in CD133(+) cells isolated from human astrocytomas and associate with transformation of human astrocytes. (PubMed id 17588684)1 Okamoto O.K....Nagahashi Marie S.K. (2007)
|
External Searches for HOXC9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HOXC9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HOXC9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HOXC9 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for HOXC9 gene:
Search GeneIP for patents involving HOXC9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HOXC9 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for HOXC9 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for HOXC9 |
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