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HOXD9 Gene

protein-coding   GIFtS: 51

GC02P168864
homeobox D9
(Previous name: homeo box D9 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: HOX4C, HOX4)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
homeobox D91 2     homeobox protein Hox-D92
HOX4C2 3 5     Hox-5.22
homeo box D91 2     Hox-4.3, mouse, homolog of2
Homeobox protein Hox-5.22 3     HOX42
Homeobox protein Hox-4C2 3     Hox-4.32

External Ids:    HGNC: 51401   Entrez Gene: 32352   Ensembl: ENSG000001287097   UniProtKB: P283563   

Export aliases for HOXD9 gene to outside databases

Previous GC identifers: GC02P175040 GC02P175648 GC02P176951 GC02P177189 GC02P176812 GC02P176695


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HOXD9:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription
factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar
homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes
arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions
that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital
abnormalities. The exact role of this gene has not been determined. (provided by RefSeq)

UniProtKB/Swiss-Prot: HXD9_HUMAN, P28356
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXD9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXD9 gene promoter:
         PPAR-gamma1   PPAR-gamma2   NF-kappaB   NF-kappaB1   NF-kappaB2   CUTL1   E2F-1   E2F   Max1   FOXL1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for HOXD9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HOXD9 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

HOXD9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXD9 gene location

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P168864:  view genomic region     (about GC identifiers)

Start:
168,864,337 bp from pter
End:
168,866,570 bp from pter
Size:
2,234 bases
Orientation:
plus strand

1 alternative location:
Chr2+ 176,987,413-176,989,665     
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: HXD9_HUMAN, P28356 (See protein sequence)
Recommended Name: Homeobox protein Hox-D9  
Size: 352 amino acids; 36495 Da
Subcellular location: Nucleus
Developmental stage: Expressed in the developing limb buds
Caution: It is uncertain whether Met-1 or Met-11 is the initiator
Sequence caution: Sequence=AAH44855.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAA42016.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q86ST1

Explore the universe of human proteins at neXtProt for HOXD9: NX_P28356 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_055028.3  

    ENSEMBL proteins: 
    ENSP00000397186 ENSP00000249499 ENSP00000376319 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: HOXD9
    OriGene Protein Over-expression Lysate: HOXD9
    GenScript Custom Purified and Recombinant Proteins Services for HOXD9 
    Novus Biologicals Lysate for HOXD9
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    HOXD9 for ontologies           About GeneDecksing



    Antibodies for HOXD9: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for HOXD9
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for HOXD9 
    Novus Biologicals Antibody for HOXD9
    Browse antibodies at Epitomics

    Assays for HOXD9: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HOXD9 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HOXD9 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HOXD9 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR017112 Homeobox_Hox9
     IPR001356 Homeobox
     IPR017970 Homeobox_CS
     IPR020479 Homeobox_eu
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P28356

    ProtoNet protein and cluster: P28356

    2 Blocks protein families:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB006711 Hox9 activation region


    UniProtKB/Swiss-Prot: HXD9_HUMAN, P28356
    Similarity: Belongs to the Abd-B homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: HXD9_HUMAN, P28356
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
    with specific positional identities on the anterior-posterior axis

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for HOXD9
    Sigma-Aldrich shRNA for HOXD9
    OriGene 29mer shRNA kits in GFP-retroviral vector: HOXD9
    OriGene shRNA RFP: HOXD9
    OriGene basic RS shRNA: HOXD9
    OriGene siRNA: HOXD9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HOXD9 
    miRNA:Sigma-Aldrich microRNA Mimics for HOXD9
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HOXD9 
    4 SABiosciences Assays for microRNAs that regulate HOXD9:
    hsa-miR-875-3p hsa-miR-125a-5p hsa-miR-125b hsa-miR-1299

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: HOXD9
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): HOXD9
    OriGene untagged cDNA clones in CMV expression vector: HOXD9
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for HOXD9 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for HOXD9 

    Genatlas biochemistry entry for HOXD9:
    homeo box D9(4C),homologous to mouse Hox-4.4,Drosophila abd-B

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding ----
    GO:0003700 sequence-specific DNA binding transcription factor activity IEA--
    GO:0003702 RNA polymerase II transcription factor activity TAS1756725
    GO:0005515 protein binding IEA--
    GO:0016563 transcription activator activity IEA--
    About this table

    HOXD9 for ontologies           About GeneDecksing

    Animal Models: 9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Hoxd9):

    behavior/neurologicalendocrine/exocrine glandlife span-post-weaning/aginglimbs/digits/tailmuscle
    nervous systemrenal/urinary systemreproductive systemskeleton

    HOXD9 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Pathway-Focused PCR Array including HOXD9: PAHS-083A 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOXD9

    5/15 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 15):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription ----
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0007275 multicellular organismal development IEA--
    GO:0007519 skeletal muscle tissue development IEA--
    GO:0008344 adult locomotory behavior IEA--
    About this table

    HOXD9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    HOXD9 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXD9
    1 Novoseek chemical compound relationship for HOXD9 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 31.9 2 7501971 (2)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for HOXD9
    Sigma-Aldrich shRNA for HOXD9
    OriGene 29mer shRNA kits in GFP-retroviral vector: HOXD9
    OriGene shRNA RFP: HOXD9
    OriGene basic RS shRNA: HOXD9
    OriGene siRNA: HOXD9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HOXD9 
    miRNA: Sigma-Aldrich microRNA Mimics for HOXD9
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HOXD9 
    4 SABiosciences Assays for microRNAs that regulate HOXD9:
    hsa-miR-875-3p hsa-miR-125a-5p hsa-miR-125b hsa-miR-1299
    Clones: Sigma-Aldrich FLAG tag genes for HOXD9
    OriGene GFP tagged cDNA clones in CMV expression vector: HOXD9
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): HOXD9
    OriGene untagged cDNA clones in CMV expression vector: HOXD9
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for HOXD9 
    Primers: OriGene genome-wide validated SYBR primer pairs: HOXD9
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for HOXD9: PPH14792A

    REFSEQ mRNAs for HOXD9 gene: 

    NM_014213.3  

    Additional cDNA sequence: 

    BC044855.1 X59372.1 

    1 DOTS entry:

    DT.412550 

    24/76 AceView cDNA sequences (see all 76):

    AW292591 NM_014213 AI127062 BG171365 AA886779 AI394644 BE219356 AI306148 
    AI972688 AI818195 AI239897 AI480371 AI201249 AA938529 AI972635 AI401822 
    AI420400 AW419056 AW075573 BI761261 AI275516 BC044855 AW152267 BX374409 

    highest scoring ESTs for HOXD9:

    AI264311 X59372 AA418987 AA424747 AA424871 AA426396 AA478764 AA479985 AA626196 AA733216 

    Unigene Cluster for HOXD9:

    Homeobox D9
    Hs.236646  [show with all ESTs]
    Unigene Representative Sequence: NM_014213


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000433989(uc010zex.1) ENST00000249499 ENST00000392535

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    HOXD9 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching HOXD9 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    413_at2, 3 U95-A 2 0.56 0.90 0.98 0.93 X59372 1.00 1.00 1.00 1
    36882_at2, 3 U95-A 1 0.44 1.00 0.98 0.77 X59372 1.00 1.00 1.00 1
    87925_at2, 3 U95-E 1 0.38 1.00 0.98 1.34 AI264311 1.00 1.00 1.00 1
    205604_at2, 3 U133-A 1 0.55 1.00 -- -- AI432470 0.80 1.00 0.91 1
    205604_at2 U133Plus2 1 0.55 1.00 -- -- -- -- -- -- --
    About this table

    HOXD9 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    HOXD9 gene expression
    HOXD9 gene electronic northern expression
    HOXD9 gene sage expression
    About these images

    CGAP SAGE TAG: TTTCTGAAAA

    SOURCE GeneReport for Unigene cluster: Hs.236646

    Expression variation in blood from EXPOLDB for HOXD9

    Primers: OriGene genome-wide validated SYBR primer pairs: HOXD9
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for HOXD9: PPH14792A
        SABiosciences Expression via Pathway-Focused PCR Array including HOXD9: PAHS-083A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for HOXD9 gene from 5/7 species (see all 7)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    HOXD91   -- homeobox D9 91.39(n)
    89.01(a)
    609984  XM_847350.1  XP_852443.1 
    cow
    (Bos taurus)
    HOXD91   -- homeobox D9 91.69(n)
    92.08(a)
    540250  XM_592660.3  XP_592660.2 
    rat
    (Rattus norvegicus)
    Hoxd91   -- homeo box D9 64.76(n)
    60.51(a)
    688999  XM_001069122.1  XP_001069122.1 
    mouse
    (Mus musculus)
    Hoxd91 , 5 2 (44.13 cM)5
    homeobox D95
    homeo box D91
    90.04(n)1
    89.94(a)1
    154381  NM_013555.21  NP_038583.11 
     AK1344275  AK1447465  (see all 8)
    chicken
    (Gallus gallus)
    HOXD91   -- homeobox D9 65.16(n)
    58.27(a)
    771214  XM_001234506.1  XP_001234507.1 
    About this table        Species with no ortholog for HOXD9

    ENSEMBL Gene Tree for HOXD9 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for HOXD9 gene
    HOXA92  HOXC92  HOXD112  HOXC112  HOXD102  HOXA112  HOXB92  HOXC102  
    HOXA102  

    HOXD9 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/40 NCBI SNPs in HOXD9 are shown (see all 40)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs6982581,2
    C,F,A,176988412(-) TAGGCA/C/G/
            
    TCTAG
    1 -- int15NA EA WA 272
    rs7118191,2
    C,F,A,H,176985696(-) ACCTCG/AGGTAA 1 -- ng5113Minor allele frequency- A:0.34NS EA NA WA 594
    rs7118201,2
    C,F,A,H,176987112(-) CGGCGC/AGTCCA 1 -- ng513Minor allele frequency- A:0.33NA 6
    rs7118211,2
    C,176988015(-) GAGGCG/TGCCGT 2 A syn1 ref1 ese31Minor allele frequency- T:0.50WA 2
    rs7118221,2
    C,F,A,176989023(-) AAAAAA/GAAGAA 1 -- ut31 trp311Minor allele frequency- G:0.35MN NS EA NA WA 812
    rs37317941,2
    C,H176986429(+) TCGGCC/AGAATT 1 -- ng514Minor allele frequency- A:0.00NS EA 418
    rs104457651,2
    C,176987220(+) GATGCT/GGTCGC 1 -- ng51 ese33Minor allele frequency- G:0.37NA 76
    rs106652651,2
    --176988293(+) CCGCA-/GCAGCAGC 3 Q RK fra1 ref10--------
    rs116754081,2
    H176986526(+) GCTGAA/GGCGGC 1 -- ng510--------
    rs133849921,2
    --176985624(+) GCCCAA/GACTTA 1 -- ng510--------
    About this table

    HapMap Linkage Disequilibrium images for HOXD9 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HOXD9: --

    QIAGEN SeqTarget long-range PCR primers for resequencing HOXD9 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HOXD9 for disorders           About GeneDecksing

    OMIM: 142982

    1 Novoseek disease relationship for HOXD9 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 19.6 3 11352232 (1), 10211882 (1)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: HOXD9 (2 documents)

    Export disorders and mutations for HOXD9 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/33 PubMed articles for HOXD9 gene, integrated from 7 sources (see all 33):
    (articles sorted by number of sources associating them with HOXD9)
    1. HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities. (PubMed id 1756725)1, 2, 7 Zappavigna V.... Duboule D. (1991)
    2. Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)1, 2 Kosaki K.... Matsuo N. (2002)
    3. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    4. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    5. The human HOX gene family. (PubMed id 2574852)1, 2 Acampora D.... Boncinelli E. (1989)
    6. Complementary homeo protein gradients in developing limb buds. (PubMed id 2568311)1, 2 Oliver G.... De Robertis E.M. (1989)
    7. Immunocytochemical detection of HoxD9 and Pbx1 homeodomain protein expression in Chinese esophageal squamous cell carcinomas. (PubMed id 15770739)1, 7 Liu D.B....Li J.Y. (2005)
    8. HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation. (PubMed id 8890171)1, 7 Zappavigna V....Bianchi M.E. (1996)
    9. PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins. (PubMed id 10523646)1, 7 Shanmugam K....Featherstone M.S. (1999)
    10. Specificity of HOX protein function depends on DNA-protein and protein-protein interactions, both mediated by the homeo domain. (PubMed id 7926763)1, 7 Zappavigna V....Mavilio F. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3235 HGNC: 5140 AceView: HOXD9 Ensembl:ENSG00000128709 euGenes: HUgn3235
    ECgene: HOXD9 H-InvDB: HOXD9

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for HOXD9 gene:
    Search GeneIP for patents involving HOXD9

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for HOXD9 Antibodies for HOXD9
     Super-pooled esiRNAs for HOXD9 Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for HOXD9 microRNA Mimics for HOXD9
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     FLAG tag genes for HOXD9 Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HOXD9
     SeqTarget long-range PCR primers for resequencing HOXD9
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HOXD9
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HOXD9
     GenScript Custom Purified and Recombinant Proteins Services for HOXD9 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for HOXD9
     GenScript Custom Assay Services for HOXD9 GenScript Custom Superior Antibodies Services for HOXD9
     GenScript Custom overexpressing Cell Line Services for HOXD9 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HOXD9 promoter
     Search Chromatin IP Primers for HOXD9
     RT2 qPCR Primer Assay for HOXD9
     GNC Network for HOXD9
     Assays for microRNAs that regulate HOXD9
     SABiosciences PCR Arrays including HOXD9
     Search Tocris compounds for HOXD9
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for HOXD9
     Lysates for HOXD9
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for HOXD9
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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