Aliases &
Descriptions
for IBTK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| inhibitor of Bruton agammaglobulinemia tyrosine kinase1 2 | | RP1-93K22.12 | | Bruton agammaglobulinemia tyrosine kinase inhibitor1 2 | | BTK-binding protein2 | | BTKI2 3 | | MGC1422582 | | KIAA14172 3 | | inhibitor of Bruton's tyrosine kinase2 | | DKFZP564B1161 | | MGC1422562 | | inhibitor of Bruton's tyrosine kinase-beta2 | | inhibitor of Bruton's tyrosine kinase-alpha2 | | OTTHUMP000002207712 | | inhibitor of Bruton's tyrosine kinase-gamma2 | | inhibitor of Bruton tyrosine kinase2 | | IBtk3 | | OTTHUMP000002207702 | | |
Export aliases for IBTK gene to outside databasesPrevious GC identifers: GC06M082833 GC06M082875 GC06M082936 GC06M082879 |
Summaries
for IBTK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IBTK:
The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. Inaddition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation ofnuclear factor-kappa-B-driven transcription. (provided by RefSeq)
UniProtKB/Swiss-Prot: IBTK_HUMAN, Q9P2D0Function: Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development.Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization andNF-kappa-B-driven transcription
|
Genomic Views
for IBTK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IBTK gene promoter:
Cart-1 STAT1beta STAT1alpha STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 STAT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for IBTK
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for IBTK  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q14.1 Ensembl cytogenetic band: 6q14.1 HGNC cytogenetic band: 6q14.3IBTK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M080097: view genomic region
(about GC identifiers)
Start:
|
80,097,712 bp from pter |
End:
|
80,175,203 bp from pter |
Size:
|
77,492 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr6- 82,879,700-82,957,471 |
RefSeq DNA sequence:- NC_000006.11 NT_007299.13
|
Proteins
for IBTK gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: IBTK_HUMAN, Q9P2D0 (See
protein sequence)Recommended Name: Inhibitor of Bruton tyrosine kinase Size: 1353 amino acids; 150528 Da
Subunit: Interacts with the PH domain of BTK. Isoform 2 does not interact with BTK
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane uponIgM stimulation
Subcellular location: Isoform 2: Nucleus
Sequence caution: Sequence=AAG27170.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BAA92655.2;Type=Erroneous initiation; Sequence=CAI23414.1; Type=Erroneous gene model prediction; Sequence=CAI23416.1;Type=Erroneous gene model prediction;
Secondary accessions: Q2QKU2 Q2QKU3 Q2QKU4 Q5TFD7 Q5TFD9 Q8IUQ9 Q8IUY7 Q8TAI4 Q9HBI8 Q9Y3T8Alternative splicing: 3 isoforms: Q9P2D0-1 Q9P2D0-2 Q9P2D0-3 Explore the universe of human proteins at neXtProt for IBTK: NX_Q9P2D0
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_056340.2
ENSEMBL proteins: ENSP00000424634 ENSP00000422136 ENSP00000305721 ENSP00000426405 ENSP00000422762 ENSP00000405762
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
IBTK for ontologies About GeneDecksing
Antibodies for IBTK:
Assays for IBTK: |
Protein
Domains/
Families
for IBTK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IBTK for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9P2D0ProtoNet protein and cluster: Q9P2D0 2 Blocks protein families: IPB000210 BTB/POZ domain IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: IBTK_HUMAN, Q9P2D0Similarity: Contains 3 ANK repeatsSimilarity: Contains 2 BTB (POZ) domainsSimilarity: Contains 3 RCC1 repeats |
Gene Function
for IBTK gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: IBTK_HUMAN, Q9P2D0Function: Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development.Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization andNF-kappa-B-driven transcription
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
IBTK for ontologies About GeneDecksing
|
Pathways & Interactions
for IBTK gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for IBTK
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IBTK
5/9 Interacting proteins for IBTK (ENSP000003057213 Q9P2D01, 2) via UniProtKB, MINT, and/or STRING (see all 9)About this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001933 | negative regulation of protein phosphorylation |
IDA | 11577348 | | GO:0051209 | release of sequestered calcium ion into cytosol |
IDA | 11577348 |
About this table
IBTK for ontologies About GeneDecksing
|
Drugs & Compounds
for IBTK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for IBTK
|
Transcripts
for IBTK gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for IBTK gene: NM_015525.2 Additional cDNA sequence: AB037838.2 AF235049.1 AJ420588.1 AJ420593.1 AK123460.1 AL050018.1 BC012551.1 BC027483.1 BC027490.1 BC035860.1 BC038244.2 BC042171.1 BC092410.1 BC112929.1 BC113696.1 BC113698.1 BC143736.1 BC143745.1 BC143748.1 CR600707.1 DQ005633.1 DQ005634.1 DQ005635.1 9 DOTS entries: DT.215574 DT.100660747 DT.101964877 DT.100664129 DT.121309204 DT.100027305 DT.101982561 DT.95179867 DT.95179878 24/207 AceView cDNA sequences (see all 207): AK126777 CB266563 BI793295 BX955988 T50258 AW673064 BM670666 AL555905 BG680523 BU178341 AI669354 CB851543 AI140997 CR600707 AI827319 CA424504 CB306037 AA236615 BM142101 CB044949 BM126966 BM718167 Z41214 BC038244
 highest scoring ESTs for IBTK:AI445866 AL050018 BC012551 BF795627 CA407936 AA007318 AA007454 AA194627 AA224232 AA224233 Unigene Cluster for IBTK: Inhibitor of Bruton agammaglobulinemia tyrosine kinase Hs.306425 [show with all ESTs]Unigene Representative Sequence: DQ005633
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for IBTK (see all 6)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | ^ | 30 |
|---|
|
| SP1: | | | | | | | - | | | | - | | | | | | |
| SP2: | | | | | | | - | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | |
About this scheme
ECgene alternative splicing isoforms for IBTK
10 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369751(uc003pjm.2) ENST00000445419(uc011dyu.1) ENST00000471036
ENST00000505222 ENST00000503400 ENST00000306270(uc011dyv.1 uc011dyw.1 uc003pjl.1 uc010kbi.1)
ENST00000510291 ENST00000503631 ENST00000508381 ENST00000451512
|
Expression
for IBTK gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| IBTK expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching IBTK gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 36875_at2, 3
|
U95-A |
1 |
0.94 |
1.00 |
0.65 |
1.27 |
AL050018 |
0.80 |
1.00 |
0.91 |
1 |
| 52482_at2, 3
|
U95-B |
1 |
0.88 |
1.00 |
0.93 |
0.76 |
AI445866 |
0.80 |
1.00 |
0.91 |
1 |
| 210970_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AF235049 |
0.40 |
1.00 |
0.76 |
1 |
| 215086_at2, 3
|
U133-A |
1 |
0.46 |
1.00 |
-- |
-- |
AB037838 |
0.60 |
0.75 |
0.68 |
1 |
| 210970_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 215086_at2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
IBTK for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TAAGCAGATG
SOURCE GeneReport for Unigene cluster: Hs.306425
Expression variation in blood from EXPOLDB for IBTK UniProtKB/Swiss-Prot: IBTK_HUMAN, Q9P2D0Tissue specificity: Expressed in DeFew, 293T, Hela and in Jurkat, MC3 and NB4 lymphoid cells (at protein level).Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietictissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or notexpressed in other tissues
SABiosciences Custom PCR Arrays for IBTK
|
Orthologs
for IBTK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for IBTK gene from 5/10 species (see all 10)
About this table Species with no ortholog for IBTK
ENSEMBL Gene Tree for IBTK (if available) |
Paralogs
for IBTK gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for IBTK gene
- RCC22 RCC12 RPGR2
IBTK for paralogs About GeneDecksing
|
Genomic Variants
for IBTK gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 6 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for IBTK (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for IBTK
3 CNVs: 36572 36571 4499 | | QIAGEN SeqTarget long-range PCR primers for resequencing IBTK |
|
Disorders & Mutations
for IBTK gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IBTK for disorders About GeneDecksing
OMIM: 606457
Export disorders and mutations for IBTK gene to outside databases
|
Medical News
for IBTK gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for IBTK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/14 PubMed articles for IBTK gene, integrated from 7 sources (see all 14):
(articles sorted by number of sources associating them with IBTK)- Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein. (PubMed id 11577348)1, 2, 3, 7 Liu W.... Scala G. (2001)
- Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk. (PubMed id 18596081)1, 2, 7 Spatuzza C....Scala G. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
- Computational analysis and in vivo validation of a mi croRNA encoded by the IBTK gene, a regulator of B-lymphocytes differentiation a nd survival. (PubMed id 19782003)1 Fiume G....Quinto I. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
|
External Searches for IBTK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IBTK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IBTK gene
(According to HUGE)
About This Section
| |
Specialized Databases showing IBTK gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for IBTK gene:
Search GeneIP for patents involving IBTK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IBTK gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
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| | | |
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| | |
 |  |  |  | |
| |  | Search Tocris compounds for IBTK |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for IBTK |
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