Aliases &
Descriptions
for IFI35 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| interferon-induced protein 351 2 | | FLJ217532 | | IFP351 2 3 | | interferon-induced 35 kDa protein2 | | IFP 352 3 | | Ifi-353 | | ifi-352 | | |
Export aliases for IFI35 gene to outside databasesPrevious GC identifers: GC17M062367 GC17P043320 GC17P041067 GC17P041532 GC17P041533 GC17P038412 GC17P041158 |
Summaries
for IFI35 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: IN35_HUMAN, P80217Function: Not yet known
Gene Wiki entry for IFI35 |
Genomic Views
for IFI35 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IFI35 gene promoter:
IRF-7A PPAR-gamma1 PPAR-gamma2 XBP-1 FOXD1 LCR-F1 GCNF-1 GCNF-2 IRF-1 POU2F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for IFI35
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21IFI35 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P036924: view genomic region
(about GC identifiers)
Start:
|
36,924,533 bp from pter |
End:
|
36,932,236 bp from pter |
Size:
|
7,704 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr17+ 41,158,769-41,166,475 |
RefSeq DNA sequence:- NC_000017.10 NT_010783.15
|
Proteins
for IFI35 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: IN35_HUMAN, P80217 (See
protein sequence)Recommended Name: Interferon-induced 35 kDa protein Size: 286 amino acids; 31546 Da
Subunit: Homodimer. Also interacts with B-ATF
Subcellular location: Nucleus. Note=Nuclear following IFN treatment
Sequence caution: Sequence=AAB61703.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknownorigin in the N-terminal part;
Secondary accessions: Q92984 Q99537 Q9BV98Alternative splicing: 2 isoforms: P80217-1 P80217-2 Explore the universe of human proteins at neXtProt for IFI35: NX_P80217
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005524.2
ENSEMBL proteins: ENSP00000395590 ENSP00000394579 ENSP00000246911
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): About this table
IFI35 for ontologies About GeneDecksing
Antibodies for IFI35:
Assays for IFI35: |
Protein
Domains/
Families
for IFI35 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IFI35 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P80217ProtoNet protein and cluster: P80217 1 Blocks protein family: IPB009909 Nmi/IFP 35
UniProtKB/Swiss-Prot: IN35_HUMAN, P80217Similarity: Belongs to the NMI family |
Gene Function
for IFI35 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: IN35_HUMAN, P80217Function: Not yet knownInduction: By interferon gamma
Genatlas biochemistry entry for IFI35:interferon-induced leucine zipper protein IFI35,may be the same as APRF1 Gene Ontology (GO) molecular function term (GO ID links to tree view): About this table
IFI35 for ontologies About GeneDecksing
|
Pathways & Interactions
for IFI35 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
IFI35 for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for IFI35
SABiosciences Pathway-Focused PCR Array including IFI35: PAHS-064A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for IFI35
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IFI35
1 Interacting protein for IFI35 (P802171) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006955 | immune response |
NAS | -- | | GO:0009615 | response to virus |
NAS | -- |
About this table
IFI35 for ontologies About GeneDecksing
|
Drugs & Compounds
for IFI35 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
IFI35 for compounds About GeneDecksing
 Browse Tocris compounds for IFI35
1  Novoseek chemical compound relationship for IFI35 gene
About this table
|
Transcripts
for IFI35 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for IFI35 gene: NM_005533.4 Additional cDNA sequence: AK025406.1 BC001356.2 U72882.1 7 DOTS entries: DT.455598 DT.100028280 DT.91753253 DT.92389823 DT.75126564 DT.100778859 DT.120983472 24/201 AceView cDNA sequences (see all 201): BQ020479 CB130670 BE276568 CB138771 BM717524 CB110077 BU629908 BX954767 AW082544 AW118002 BM996594 CA748732 BG476389 CA308785 BQ448302 AA864863 BM917187 BQ052205 CB152434 BU627353 AI142433 BF026268 BG479076 AA132931
 highest scoring ESTs for IFI35:AW026462 U72882 AA025690 AA026789 AA088879 AA115662 AA132931 AA195653 AA435595 AA536149 Unigene Cluster for IFI35: Interferon-induced protein 35 Hs.632258 [show with all ESTs]Unigene Representative Sequence: BU539084
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000438323(uc010whj.1) ENST00000415816 ENST00000246911
|
Expression
for IFI35 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| IFI35 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching IFI35 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 626_s_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.95 |
0.94 |
L78833 |
0.20 |
0.25 |
0.23 |
1 |
| 464_s_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.97 |
1.11 |
U72882 |
1.00 |
1.00 |
1.00 |
1 |
| 74908_at2, 3
|
U95-D |
1 |
0.75 |
1.00 |
0.99 |
0.97 |
AW026462 |
1.00 |
1.00 |
1.00 |
1 |
| 209417_s_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
BC001356 |
0.80 |
1.00 |
0.91 |
1 |
| 209417_s_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
IFI35 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ACGTCCTGGA
SOURCE GeneReport for Unigene cluster: Hs.632258
UniProtKB/Swiss-Prot: IN35_HUMAN, P80217Tissue specificity: In a wide range of cell types, including fibroblasts, macrophages, and epithelial cells
SABiosciences Expression via Pathway-Focused PCR Array including IFI35: PAHS-064A
|
Orthologs
for IFI35 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for IFI35 gene from 5/7 species (see all 7)
About this table Species with no ortholog for IFI35
ENSEMBL Gene Tree for IFI35 (if available) |
Paralogs
for IFI35 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for IFI35 gene
- NMI2
IFI35 for paralogs About GeneDecksing
|
Genomic Variants
for IFI35 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for IFI35 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IFI35
1 CNV: 0206 | | QIAGEN SeqTarget long-range PCR primers for resequencing IFI35 |
|
Disorders & Mutations
for IFI35 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IFI35 for disorders About GeneDecksing
OMIM: 600735
1 Novoseek disease relationship for IFI35 gene
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
1 |
17197158 (1) |
About this table
Human Genome Epidemiology (HuGE) Navigator: IFI35 (1 document)
Export disorders and mutations for IFI35 gene to outside databases
|
Medical News
for IFI35 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for IFI35 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/18 PubMed articles for IFI35 gene, integrated from 7 sources (see all 18):
(articles sorted by number of sources associating them with IFI35)- IFP 35 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistribution. (PubMed id 8288566)1, 2, 7 Bange F.-C....Boettger E.C. (1994)
- IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors. (PubMed id 8954125)1, 2, 7 Wang X.... Taparowsky E.J. (1996)
- Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. (PubMed id 8938427)1, 2, 7 Smith T.M.... King M.-C. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling. (PubMed id 17197158)1, 7 Zhang L.... He F. (2007)
- Interferon-alpha induces nmi-IFP35 heterodimeric complex formation that is affected by the phosphorylation of IFP35. (PubMed id 10779520)1, 7 Zhou X....Omary M.B. (2000)
- Intracellular redistribution of interferon-inducible proteins Nmi and IFP 35 in apoptotic cells. (PubMed id 11911807)1, 7 Chen J. and Naumovski L. (2002)
- Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PubMed id 20628624)1 Johnatty S.E.... . (2010)
- IFP35 is involved in the antiviral function of interferon by association with the viral tas transactivator of bovine foamy virus. (PubMed id 18305040)1 Tan J....Geng Y. (2008)
|
External Searches for IFI35 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IFI35 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IFI35 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFI35 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for IFI35 gene:
Search GeneIP for patents involving IFI35
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IFI35 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for IFI35 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for IFI35 |
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