Aliases &
Descriptions
for IFIT2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| interferon-induced protein with tetratricopeptide repeats 21 2 | | Interferon-induced 54 kDa protein2 3 | | G10P22 3 5 | | IFI-54K2 3 | | IFI542 3 5 | | IFIT-22 3 | | GARG-391 2 | | ISG-54 K2 3 | | cig421 2 | | Interferon, alpha-inducible protein (MW 54kD)2 | | ISG-54K1 2 | | ISG542 | | IFI-541 2 | | interferon-induced protein 542 |
Export aliases for IFIT2 gene to outside databasesPrevious GC identifers: GC10U990034 GC10P090283 GC10P091192 GC10P090726 GC10P091051 |
Summaries
for IFIT2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for IFIT2 |
Genomic Views
for IFIT2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IFIT2 gene promoter:
STAT1alpha STAT1 STAT1beta IRF-1 POU2F1 MEF-2A Pax-6 POU3F2 GCNF-1 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for IFIT2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q23.31 Ensembl cytogenetic band: 10q23.31 HGNC cytogenetic band: 10q23.31IFIT2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P084695: view genomic region
(about GC identifiers)
Start:
|
84,695,886 bp from pter |
End:
|
84,703,213 bp from pter |
Size:
|
7,328 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr10+ 91,061,712-91,069,033 |
RefSeq DNA sequence:- NC_000010.10 NT_030059.13
|
Proteins
for IFIT2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: IFIT2_HUMAN, P09913 (See
protein sequence)Recommended Name: Interferon-induced protein with tetratricopeptide repeats 2 Size: 472 amino acids; 54632 Da
Secondary accessions: Q5T767Explore the universe of human proteins at neXtProt for IFIT2: NX_P09913
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001538.4
ENSEMBL proteins: ENSP00000360891
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
About this table
IFIT2 for ontologies About GeneDecksing
Antibodies for IFIT2:
Assays for IFIT2: |
Protein
Domains/
Families
for IFIT2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IFIT2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P09913ProtoNet protein and cluster: P09913 UniProtKB/Swiss-Prot: IFIT2_HUMAN, P09913Similarity: Belongs to the IFIT familySimilarity: Contains 6 TPR repeats |
Gene Function
for IFIT2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: IFIT2_HUMAN, P09913Induction: By interferons
Genatlas biochemistry entry for IFIT2:interferon alpha-inducible protein,54kDa (clone ISG-54K,IFI-54K),also induced by interferon beta,interleukin 1,retinoicacid,viral infections...2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
IFIT2 for ontologies About GeneDecksing
|
Pathways & Interactions
for IFIT2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
IFIT2 for pathways About GeneDecksing
1  Millipore Pathway for IFIT2
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for IFIT2
SABiosciences Pathway-Focused PCR Array including IFIT2: PAHS-064A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for IFIT2
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IFIT2
1 Interacting protein for IFIT2 (P099132) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | | GO:0035457 | cellular response to interferon-alpha |
-- | -- |
About this table
IFIT2 for ontologies About GeneDecksing
|
Drugs & Compounds
for IFIT2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for IFIT2
|
Transcripts
for IFIT2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for IFIT2 gene: NM_001547.4 Additional cDNA sequence: AF026944.1 AK300431.1 AK312831.1 BC005987.1 BC032839.2 7 DOTS entries: DT.121275540 DT.444085 DT.121275562 DT.100775785 DT.121275545 DT.100775784 DT.95262075 24/101 AceView cDNA sequences (see all 101): CA391802 BU167935 N63988 BU677511 AI338018 BP356603 AI620542 AI140291 CD366645 AI373569 AI446658 BQ946250 BQ893557 AA854597 CA440164 AA866128 AI458848 AW337373 BI494104 BU508131 AA810945 AI301531 CA306219 AI261334
 highest scoring ESTs for IFIT2:AA131041 AA054658 AA056431 AA130252 AA131155 AA134105 AA143609 AA148160 AA484050 AA516150 Unigene Cluster for IFIT2: Interferon-induced protein with tetratricopeptide repeats 2 Hs.437609 [show with all ESTs]Unigene Representative Sequence: NM_001547
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000371826(uc009xts.2)
|
Expression
for IFIT2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| IFIT2 expression in normal and diseased human tissues
1 / 2 / 3 7 probe-sets matching IFIT2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 909_g_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.91 |
0.67 |
M14660 |
0.20 |
1.00 |
0.72 |
1 |
| 91313_at2, 3
|
U95-E |
1 |
0.88 |
1.00 |
0.80 |
1.46 |
AA131041 |
1.00 |
1.00 |
1.00 |
1 |
| 908_at2, 3
|
U95-A |
1 |
0.75 |
1.00 |
0.84 |
0.89 |
M14660 |
0.20 |
1.00 |
0.72 |
1 |
| 226757_at2, 3
|
U133-B |
1 |
0.82 |
1.00 |
-- |
-- |
AA131041 |
1.00 |
1.00 |
1.00 |
1 |
| 217502_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
BE888744 |
0.80 |
1.00 |
0.91 |
1 |
| 226757_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 217502_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
IFIT2 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GTTTTTTAAA
SOURCE GeneReport for Unigene cluster: Hs.437609
Expression variation in blood from EXPOLDB for IFIT2 SABiosciences Expression via Pathway-Focused PCR Array including IFIT2: PAHS-064A
|
Orthologs
for IFIT2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for IFIT2 gene from 4 species
About this table Species with no ortholog for IFIT2
ENSEMBL Gene Tree for IFIT2 (if available) |
Paralogs
for IFIT2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for IFIT2 gene
- IFIT12 IFIT1B2 IFIT32 IFIT52
IFIT2 for paralogs About GeneDecksing
|
Genomic Variants
for IFIT2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 10 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for IFIT2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IFIT2
1 CNV: 47891 | | QIAGEN SeqTarget long-range PCR primers for resequencing IFIT2 |
|
Disorders & Mutations
for IFIT2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IFIT2 for disorders About GeneDecksing
OMIM: 147040
Human Genome Epidemiology (HuGE) Navigator: IFIT2 (1 document)
Export disorders and mutations for IFIT2 gene to outside databases
|
Medical News
for IFIT2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for IFIT2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/21 PubMed articles for IFIT2 gene, integrated from 7 sources (see all 21):
(articles sorted by number of sources associating them with IFIT2)- The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family. (PubMed id 3360121)1, 2, 3 Wathelet M.G.... Huez G.A. (1988)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Cloning and chromosomal location of human genes inducible by type I interferon. (PubMed id 3175763)1, 3 Wathelet M.G....Szpirer C. (1988)
- Regulation of two interferon-inducible human genes by interferon, poly(rI).poly(rC) and viruses. (PubMed id 2454816)1, 2 Wathelet M.G.... Huez G.A. (1988)
- Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region. (PubMed id 3466167)1, 2 Levy D.... Darnell J.E. Jr. (1986)
- The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24. (PubMed id 1377167)1, 7 Lafage M....Huez G. (1992)
- [Late activation of interferon-induced genes IFI-54k and IFI-56k in human RH cells infected with tick-borne encephalitis virus] (PubMed id 12708317)1, 7 Gavrilov B.G....Sverdlov E.D. (2003)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- IFN-induced protein with tetratricopeptide repeats 2 inhibits migration activity and increases survival of oral squamous cell carcinoma. (PubMed id 18819931)1 Lai K.C....Lee T.C. (2008)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
|
External Searches for IFIT2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IFIT2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IFIT2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IFIT2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for IFIT2 gene:
Search GeneIP for patents involving IFIT2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IFIT2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for IFIT2 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for IFIT2 |
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