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IGHD@ Cluster

gene cluster   GIFtS: 12

GC14U990397
immunoglobulin heavy diversity group
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for IGHD@ gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases & Descriptions
immunoglobulin heavy diversity group1 2
IGHDY12
IGD12

External Ids:    HGNC: 54811   Entrez Gene: 506482   

Export aliases for IGHD@ gene to outside databases


Summaries
for IGHD@ gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IGHD@:
Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy
chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a
light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region
containing the antigen-binding site and a C-terminal constant (C) region, encoded by a C region gene (e.g., IGHG1; MIM
147100), that provides effector or signaling functions. The heavy chain V region is encoded by 3 types of genes: V
genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes. Random selection of just 1 gene
of each type to assemble a V region accounts for the great diversity of V regions among Ig molecules. The heavy chain
locus on chromosome 14 contains approximately 40 functional V genes, followed by approximately 25 functional D genes
and approximately 6 functional J genes. Due to polymorphism, the numbers of functional V, J, and D genes differ among
individuals (Janeway et al., 2005).(supplied by OMIM)


Genomic Views
for IGHD@ gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHD@
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for IGHD@

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Chromosome:14   

Entrez Gene cytogenetic band: 14q32.32-q32.33   HGNC cytogenetic band: 14q32.32-q32.33

GeneLoc gene densities for chromosome 14        


Proteins
for IGHD@ gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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Human Recombinant Proteins 
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Antibodies for IGHD@: 
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Assays for IGHD@: 
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Protein Domains/
Families
for IGHD@ gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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   --

Gene Function
for IGHD@ gene

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
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Inhib.
RNA:    		Browse for Gene Knock-down Tools from Millipore
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miRNA:Browse microRNA Mimics at Sigma-Aldrich
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IGHD@ 
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Gene
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Cell
Lines:  		GenScript Custom overexpressing Cell Line Services for IGHD@ 


Pathways & Interactions
for IGHD@ gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


IGHD@ for pathways           About GeneDecksing

5/7 Millipore Pathways for IGHD@ (see all 7)
    Immune response Classic complement pathway
Immune response BCR pathway
Immune response CD16 signaling in NK cells
Signal transduction IP3 signaling
Immune response IL-4 signaling pathway

    SABiosciences Custom Pathway-Focused PCR Arrays for IGHD@ 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGHD@

Drugs & Compounds
for IGHD@ gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
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Browse Tocris compounds for IGHD@


Transcripts
for IGHD@ gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section
Inhib.
RNA:     		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Browse siRNA at Sigma-Aldrich
Browse shRNA at Sigma-Aldrich
Browse OriGene 29mer shRNA kits
Browse OriGene siRNA
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miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IGHD@ 
Search SABiosciences for Assays for microRNAs that regulate IGHD@
Clones: Browse FLAG tag genes at Sigma-Aldrich
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for IGHD@ 
Primers:Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs 
Search SABiosciences RT2 qPCR Primer Assays for IGHD@

Expression
for IGHD@ gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

IGHD@ expression in normal and diseased human tissues

Data from GNF BioGPS
    About these images

IGHD@ gene expression
IGHD@ gene electronic northern expression
IGHD@ gene sage expression
About these images

CGAP SAGE TAG: --
Primers:Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs 
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Orthologs
for IGHD@ gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
   --

Paralogs
for IGHD@ gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
  --

Genomic Variants
for IGHD@ gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
Search QIAGEN SeqTarget long-range PCR primers for resequencing for IGHD@ 

Disorders & Mutations
for IGHD@ gene

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
IGHD@ for disorders           About GeneDecksing

OMIM: 146910


Export disorders and mutations for IGHD@ gene to outside databases

Medical News
for IGHD@ gene

(Possibly Related Articles in Doctor's Guide)
About This Section

Publications
for IGHD@ gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

2 PubMed articles for IGHD@ gene integrated from 7 sources:
(articles sorted by number of sources associating them with IGHD@)
  1. Identifying highly mutated IGHD genes in the junctions of rearranged human immunoglobulin heavy chain genes. (PubMed id 17553518)1 Jackson K.J....Collins A.M. (2007)
  2. Human immunoglobulin D segments encoded in tandem multigenic families. (PubMed id 7312051)1 Siebenlist U....Leder P. (1981)

External Searches for IGHD@ gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGHD@ gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 50648 HGNC: 5481 euGenes: HUgn50648 ECgene: IGHD@ H-InvDB: IGHD@

Other Databases showing IGHD@ gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGHD@ gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
IMGT entry for IGHD@ The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGHD@ gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for IGHD@ gene:
Search GeneIP for patents involving IGHD@

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for IGHD@ gene

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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