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IGHV3-7 Gene

protein-coding   GIFtS: 19

GC14M086659
immunoglobulin heavy variable 3-7
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for IGHV3-7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
immunoglobulin heavy variable 3-71 2
VH2
IGHV372

External Ids:    HGNC: 56201   Entrez Gene: 284522   UniProtKB: Q9ULB64   

Export aliases for IGHV3-7 gene to outside databases

Previous GC identifers: GC14U990208 GC14M104490 GC14M105589 GC14M106518


Summaries
for IGHV3-7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for IGHV3-7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHV3-7
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for IGHV3-7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   HGNC cytogenetic band: 14q32.32-q32.33

IGHV3-7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHV3-7 gene location

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M086659:  view genomic region     (about GC identifiers)

Start:
 86,659,558 bp from pter
End:
 86,660,013 bp from pter
Size:
 456 bases
Orientation:
 minus strand

1 alternative location:
Chr14- 106,518,398-106,518,853     

Proteins
for IGHV3-7 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/TrEMBL: Q9ULB6 (See protein sequence)
Recommended Name: Imunoglobulin heavy chain  
Size: 95 amino acids; 10527 Da

Explore the universe of human proteins at neXtProt for IGHV3-7: NX_Q9ULB6 


Human Recombinant Proteins 

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Antibodies for IGHV3-7: 
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Assays for IGHV3-7: 
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Protein Domains/
Families
for IGHV3-7 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
IGHV3-7 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR007110 Ig-like
 IPR003596 Ig_V-set_sub
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry Q9ULB6

ProtoNet protein and cluster: Q9ULB6

1 Blocks protein family: IPB003596 Immunoglobulin V-type


Gene Function
for IGHV3-7 gene

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section
Inhib.
RNA:    		Browse for Gene Knock-down Tools from Millipore
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miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IGHV3-7 
Search SABiosciences for Assays for microRNAs that regulate IGHV3-7

Gene
Editing:		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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Cell
Lines:  		GenScript Custom overexpressing Cell Line Services for IGHV3-7 


Pathways & Interactions
for IGHV3-7 gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for IGHV3-7 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGHV3-7

Drugs & Compounds
for IGHV3-7 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGHV3-7


Transcripts
for IGHV3-7 gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section
Inhib.
RNA:     		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Browse siRNA at Sigma-Aldrich
Browse shRNA at Sigma-Aldrich
Browse OriGene 29mer shRNA kits
Browse OriGene siRNA
Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IGHV3-7 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IGHV3-7 
Search SABiosciences for Assays for microRNAs that regulate IGHV3-7
Clones: Browse FLAG tag genes at Sigma-Aldrich
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for IGHV3-7 
Primers:Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs 
Search SABiosciences RT2 qPCR Primer Assays for IGHV3-7

24/64 AceView cDNA sequences (see all 64):

AF471184 AB067237 CD704592 U96282 AF471177 AJ627231 U00584 AJ579234 
AF103221 AB063892 AW403163 AF115120 AF062138 AW401910 AY423165 AJ579233 
X65896 AJ579198 AJ579269 AB067099 AY003828 BX357384 AJ579217 U85243 

highest scoring ESTs for IGHV3-7:

BG538010 BM007416 CD685697 CD687015 CD690429 CD694129 CD706567 DA432637 DA918056 DB242475 


GeneLoc Exon Structure


Expression
for IGHV3-7 gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

IGHV3-7 expression in normal and diseased human tissues

1  / 2  / 3

18 probe-sets matching IGHV3-7 gene

Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
216557_x_at*2 U133-A 244 0.82 0.01 -- -- -- -- -- -- --
211878_at*2, 3 U133-A 122 0.64 0.01 -- -- M26463 0.20 0.00 0.14 2
217384_x_at*2 U133-A 167 0.46 0.01 -- -- -- -- -- -- --
217198_x_at*2 U133-A 202 0.46 0.01 -- -- -- -- -- -- --
234419_x_at*2 U133-B 176 0.46 0.01 -- -- -- -- -- -- --
217360_x_at*2 U133-A 169 0.36 0.01 -- -- -- -- -- -- --
211638_at*2, 3 U133-A 158 0.36 0.01 -- -- L23517 0.20 0.00 0.14 2
211636_at*2 U133-A 145 0.27 0.01 -- -- -- -- -- -- --
217169_at*2 U133-A 124 0.27 0.01 -- -- -- -- -- -- --
216557_x_at*2 U133Plus2 244 0.82 0.01 -- -- -- -- -- -- --
211878_at*2 U133Plus2 122 0.64 0.01 -- -- -- -- -- -- --
217384_x_at*2 U133Plus2 167 0.46 0.01 -- -- -- -- -- -- --
217198_x_at*2 U133Plus2 202 0.46 0.01 -- -- -- -- -- -- --
234419_x_at*2 U133Plus2 176 0.46 0.01 -- -- -- -- -- -- --
217360_x_at*2 U133Plus2 169 0.36 0.01 -- -- -- -- -- -- --
211638_at*2 U133Plus2 158 0.36 0.01 -- -- -- -- -- -- --
211636_at*2 U133Plus2 145 0.27 0.01 -- -- -- -- -- -- --
217169_at*2 U133Plus2 124 0.27 0.01 -- -- -- -- -- -- --
About this table
Data from Genenote  (Publications) and GNF BioGPS
    About these images
IGHV3-7 gene expression
IGHV3-7 gene electronic northern expression
IGHV3-7 gene sage expression
About these images

CGAP SAGE TAG: --
Primers:Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs 
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    SABiosciences Custom PCR Arrays for IGHV3-7 


Orthologs
for IGHV3-7 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
   --

Paralogs
for IGHV3-7 gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
  --

Genomic Variants
for IGHV3-7 gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
Search QIAGEN SeqTarget long-range PCR primers for resequencing for IGHV3-7 

Disorders & Mutations
for IGHV3-7 gene

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Medical News
for IGHV3-7 gene

(Possibly Related Articles in Doctor's Guide)
About This Section
   --

Publications
for IGHV3-7 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

2 PubMed articles for IGHV3-7 gene integrated from 7 sources:
(articles sorted by number of sources associating them with IGHV3-7)
  1. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. (PubMed id 9841928)1 Matsuda F....Honjo T. (1998)
  2. Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy-chain locus. (PubMed id 8490662)1 Matsuda F....Anand R. (1993)

External Searches for IGHV3-7 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGHV3-7 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28452 HGNC: 5620 AceView: IGHV3-7 euGenes: HUgn28452 ECgene: IGHV3-7
H-InvDB: IGHV3-7

Other Databases showing IGHV3-7 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGHV3-7 gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
IMGT entry for IGHV3-7 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGHV3-7 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for IGHV3-7 gene:
Search GeneIP for patents involving IGHV3-7

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for IGHV3-7 gene

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IGHV3-7
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