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Aliases & Descriptionsfor IGK@ gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions immunoglobulin kappa locus1 2 MGC404262 IGK1 2 FLJ262962 MGC273762 MGC226452 MGC719902
Export aliases for IGK@ gene to outside databases Previous GC identifers: GC02U990232 GC02M089561 GC02M089890
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Summariesfor IGK@ gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Gene Wiki entry for IGK@
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Genomic Viewsfor IGK@ gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for IGK@ Other transcription factors Search SABiosciences Chromatin IP Primers for IGK@ Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2p12 HGNC cytogenetic band: 2p11.2 IGK@ Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02P089891: view genomic region
(about GC identifiers )
Start:
89,890,568 bp from pter
End:
90,274,235 bp from pter
Size:
383,668 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000002.11 NT_022184.15 NT_032994.6
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Proteinsfor IGK@ gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/TrEMBL: Q6P5S8 (See
protein sequence )Recommended Name: IGK@ protein Size : 236 amino acids; 25773 Da
PDB structures from and Proteopedia : 2NXY (3D)
 2NY1 (3D)
 2NY3 (3D)
 2NY6 (3D)
 UniProtKB/TrEMBL: Q6PIL8 (See
protein sequence )
Recommended Name: IGK@ protein Size : 236 amino acids; 25834 Da
PDB structures from and Proteopedia : 3DVN (3D)
 UniProtKB/TrEMBL: Q6PJF2 (See
protein sequence )
Recommended Name: IGK@ protein Size : 235 amino acids; 25521 Da
PDB structures from and Proteopedia : 2AGJ (3D)
 Explore the universe of human proteins at neXtProt for IGK@: NX_Q6PJF2 Human Recombinant Proteins
Antibodies for IGK@: Assays for IGK@:
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Protein
Domains/ Familiesfor IGK@ gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
IGK@ for domains About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry Q6P5S8 Graphical View of Domain Structure for InterPro Entry Q6PIL8 Graphical View of Domain Structure for InterPro Entry Q6PJF2 ProtoNet protein and cluster: Q6P5S8
2 Blocks protein families : IPB003596 Immunoglobulin V-type IPB003599 Immunoglobulin subtype
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Gene Functionfor IGK@ gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section
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Pathways & Interactionsfor IGK@ gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section
IGK@ for pathways About GeneDecksing 5/7 Millipore Pathways for IGK@ (see all 7 ) SABiosciences Custom Pathway-Focused PCR Arrays for IGK@ Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGK@
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Drugs & Compoundsfor IGK@ gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for IGK@
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Transcriptsfor IGK@ gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section Additional cDNA sequence: AB006847.1 AB022651.1 AB022653.1 AB022654.1 AB022656.1 AB027444.1 AB030640.1 AB063935.1 AB063948.1 AB063953.1 AB063955.1 AB063960.1 AB064043.1 AB064044.1 AB064046.1 AB064049.1 AB064053.1 AB064054.1 AB064056.1 AB064062.1 AB064064.1 AB064074.1 AB064082.1 AB064084.1 AB064085.1 AB064089.1 AB064091.1 AB064092.1 AB064093.1 AB064121.1 AB084082.1 AB095273.1 AB095283.1 AB245096.1 AB274407.1 AB274411.1 AB363262.1 AB363267.1 AB363271.1 AB363306.1 AB363308.1 AF029989.1 AF039298.1 AF078947.1 AF078948.1 AF082203.1 AF090357.1 AF098363.1 AF098365.1 AF103384.1 AF103390.1 AF103406.1 AF103412.1 AF103423.1 AF103443.1 AF103461.1 AF103494.1 AF103502.1 AF103535.1 AF103540.1 AF103550.1 AF103552.1 AF103553.1 AF103575.1 AF115362.1 AF234256.1 AF301488.1 AF301489.1 AF306387.1 AF338917.1 AF338918.1 AF338920.1 AF338921.1 AF394738.1 AF402948.1 AF417849.1 AF485468.1 AJ005976.1 AJ241396.1 AJ241402.1 AJ241411.1 AJ294735.1 AJ388645.1 AJ388654.1 AK129779.1 AK129807.1 AM040513.1 AM040531.1 AM040584.1 AM181157.1 AM181162.1 AY043095.1 AY043126.1 AY043144.1 AY043163.1 AY043165.1 AY050707.1 AY180390.1 AY180393.1 AY247652.1 AY247654.1 AY281339.1 AY365334.1 AY365338.1 AY422529.1 AY422537.1 AY423217.1 AY423218.1 AY423219.1 AY423220.1 AY423221.1 AY423254.1 AY466501.1 AY505541.1 AY515005.1 AY539809.1 AY560603.1 AY621625.1 AY685276.1 AY685280.1 AY685357.1 AY685359.1 AY866998.1 AY867037.1 AY867052.1 AY867053.1 AY867079.1 AY867102.1 AY867131.1 AY867162.1 AY867181.1 AY867190.1 AY867195.1 AY867249.1 AY867271.1 AY867273.1 AY867280.1 AY867314.1 AY867339.1 AY867374.1 AY867379.1 AY867380.1 AY867383.1 AY867391.1 AY867396.1 AY867400.1 AY867417.1 AY882580.1 AY894695.1 AY941996.1 AY942011.1 AY942012.1 AY942018.1 AY942042.1 AY942064.1 AY942093.1 AY942118.1 AY942129.1 AY942133.1 AY955071.1 AY960866.1 AY960871.1 AY998683.1 AY998689.1 BC018761.1 BC062704.1 BC070336.1 CR607699.1 DQ100616.1 DQ100618.1 DQ100621.1 DQ100629.1 DQ100632.1 DQ100635.1 DQ100643.1 DQ100644.1 DQ100650.1 DQ101015.1 DQ101022.1 DQ101024.1 DQ101025.1 DQ101026.1 DQ101029.1 DQ101031.1 DQ101039.1 DQ101056.1 DQ101057.1 DQ101060.1 DQ101064.1 DQ101071.1 DQ101078.1 DQ101102.1 DQ101104.1 DQ101115.1 DQ101133.1 DQ101148.1 DQ101159.1 DQ187507.1 DQ187522.1 DQ187527.1 DQ187566.1 DQ187687.1 DQ187692.1 DQ187727.1 DQ187737.1 DQ322817.1 DQ322833.1 DQ322855.1 DQ322856.1 DQ322857.1 DQ322858.1 DQ322963.1 DQ322982.1 DQ497188.1 EF058278.1 EF589401.1 EF589409.1 EF589411.1 EF589419.1 EF589421.1 EF589425.1 EF589443.1 EF589452.1 EF589464.1 EF589472.1 EF589483.1 EF589509.1 EF589548.1 EF710807.1 EF710808.1 EF710933.1 EF710934.1 EF710935.1 EU117416.1 EU599323.1 EU599328.1 EU599329.1 EU599336.1 EU599338.1 FJ208778.1 FJ385487.1 FJ481092.1 FJ773247.1 HM214898.1 HM451463.1 HM451465.1 L01413.1 L02267.1 L03168.1 L03172.1 L03555.1 L08899.1 L09099.1 L09101.1 L10150.1 L12066.1 L22157.1 L26891.1 L26893.1 L28047.1 L39957.1 L40650.1 L40654.1 L40667.1 L40668.1 L40670.1 L40676.1 L40683.1 L40695.1 L40700.1 L40708.1 L40716.1 L40726.1 L43086.2 M95721.1 M97805.1 M99597.1 S56182.1 S64995.1 S79919.1 U03484.1 U07990.1 U21248.1 U43767.1 U43768.1 U86794.1 X53612.1 X58083.1 X58089.1 X58091.1 X58092.1 X58094.1 X58095.1 X72423.1 X72443.1 X72460.1 X72471.1 X84341.1 X87445.1 X93707.1 X93708.1 X93710.1 X93712.1 X93716.1 X93720.1 X93777.1 X98965.1 X98966.1 X98968.1 X98971.1 X98977.1 X98979.1 X98981.1 X98982.1 X98983.1 Y12697.1 Y14868.1 Y14869.1 Y14871.1 Y17788.1 Z14247.1 Z15074.1 Z15075.1 Z15077.1 Z15078.1 Z15080.1 Z18838.1 Z18842.1 Z27175.1 Z68944.1 Z68949.1 Z68952.1 Z68967.1
24/235 DOTS entries (see all 235 ): DT.95322415 DT.305209 DT.100033319 DT.95339737 DT.95244015 DT.99944076 DT.95261924 DT.100061049
DT.100709879 DT.95324819 DT.91705797 DT.120984208 DT.97759703 DT.95243710 DT.95243711 DT.95244004 DT.92004244 DT.92475934 DT.91705794 DT.91970838 DT.100855511 DT.100709865 DT.95144795 DT.95243999
highest scoring ESTs for IGK@ :AA455672 AA455729 AI699390 AW469787 BE439582 BE504798 BF334063 BF509891 BG925198 BU431503 Unigene Cluster for IGK@:
Immunoglobulin kappa locus Hs.707648 [show with all ESTs ] Unigene Representative Sequence: BM923616 GeneLoc Exon Structure
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Expression for IGK@ gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section IGK@ expression in normal and diseased human tissues 1 / 2
4 probe-sets matching IGK@ gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
211644_x_at2
U133-A
10
0.73
0.44
--
--
--
--
--
--
--
211643_x_at2
U133-A
8
0.27
0.26
--
--
--
--
--
--
--
211644_x_at2
U133Plus2
10
0.73
0.44
--
--
--
--
--
--
--
211643_x_at2
U133Plus2
8
0.27
0.26
--
--
--
--
--
--
--
About this table Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.707648 SABiosciences Custom PCR Arrays for IGK@
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Orthologsfor IGK@ gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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--
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Paralogsfor IGK@ gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section --
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Genomic Variantsfor IGK@ gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
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Disorders & Mutationsfor IGK@ gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
IGK@ for disorders About GeneDecksing 2 Novoseek disease relationships for IGK@ gene
About this table Genetic Association Database (GAD): IGK@ Human Genome Epidemiology (HuGE) Navigator: IGK@ (2 documents) Export disorders and mutations for IGK@ gene to outside databases
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Medical Newsfor IGK@ gene (Possibly Related Articles in
Doctor's Guide )
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Publicationsfor IGK@ gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/17 PubMed articles for IGK@ gene, integrated from 7 sources (see all 17 ): (articles sorted by number of sources associating them with IGK@) Immunoglobulin KM and GM gene polymorphisms modify the clinical presentation of primary Sjogren's syndrome. (PubMed id 15517630) 1 , 4 Pertovaara M....Pandey J.P. (2004) Analysis of expressed and non-expressed IGK locus rearrangements in chronic lymphocytic leukemia. (PubMed id 16622520) 1 , 7 Belessi C....Laoutaris N. (2005) Ig-free light chains play a crucial role in murine ma st cell-dependent colitis and are associated with human inflammatory bowel dise ases. (PubMed id 20505143) 1 Rijnierse A....Kraneveld A.D. (2010 Jul 1) The polymorphisms on Igkappa gene are related to susceptibility of breast cancer and gastric cancer. (PubMed id 19072568) 1 Hu D....Ya C. (2008) Analysis of immunoglobulin variable kappa gene mutations in cutaneous B-cell lymphoma. (PubMed id 17600686) 1 Bortoletto G....Alaibac M. (2007) Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus. (PubMed id 17546032) 1 Fraenkel S....Bergman Y. (2007) Four crystal forms of a Bence-Jones protein. (PubMed id 16508097) 1 Makino D.L....McPherson A. (2005) Unraveling the consecutive recombination events in the human IGK locus. (PubMed id 15356136) 1 Langerak A.W....van Dongen J.J. (2004) A significant fraction of conserved noncoding DNA in human and mouse consists of predicted matrix attachment regions. (PubMed id 12615002) 1 Glazko G.V....Shabalina S.A. (2003) A monoclonal V kappa l light chain responsible for incomplete proximal tubulopathy. (PubMed id 12552516) 1 Decourt C....Cogne M. (2003)
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External Searches for IGK@ gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing IGK@ gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing IGK@ gene
(According to HUGE )
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Specialized Databases showing IGK@ gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
ATLAS Chromosomes in Cancer entry for IGK@ Genetics and Cytogenetics in Oncology and Haematology IMGT entry for IGK@ The international I mM unoG eneT ics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
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About This Section Patent Information for IGK@ gene: Search GeneIP for patents involving IGK@ GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor IGK@ gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for IGK@
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