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IGLV4-3 Gene

protein-coding   GIFtS: 25

GC22P023213
immunoglobulin lambda variable 4-3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for IGLV4-3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
immunoglobulin lambda variable 4-31 2
V5-12 4
IGLV432

External Ids:    HGNC: 59191   Entrez Gene: 287862   Ensembl: ENSG000002116727   UniProtKB: Q5NV614   

Export aliases for IGLV4-3 gene to outside databases

Previous GC identifers: GC22U990138 GC22P021538 GC22P021108 GC22P021294 GC22P021543


Summaries
for IGLV4-3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for IGLV4-3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGLV4-3
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for IGLV4-3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

IGLV4-3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLV4-3 gene location

GeneLoc gene densities for chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P023213:  view genomic region     (about GC identifiers)

Start:
 23,213,686 bp from pter
End:
 23,214,214 bp from pter
Size:
 529 bases
Orientation:
 plus strand

1 alternative location:
Chr22+ 6,181,526-6,182,022     

Proteins
for IGLV4-3 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/TrEMBL: Q5NV61 (See protein sequence)
Recommended Name: V5-1 protein  
Size: 103 amino acids; 11181 Da

Explore the universe of human proteins at neXtProt for IGLV4-3: NX_Q5NV61 



ENSEMBL proteins: 
ENSP00000374853 


Human Recombinant Proteins 
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Antibodies for IGLV4-3: 
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Assays for IGLV4-3: 
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Protein Domains/
Families
for IGLV4-3 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
IGLV4-3 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR007110 Ig-like
 IPR003596 Ig_V-set_sub
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry Q5NV61

ProtoNet protein and cluster: Q5NV61

2 Blocks protein families:
IPB003596 Immunoglobulin V-type
IPB013106 Immunoglobulin V-set



Gene Function
for IGLV4-3 gene

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section
Inhib.
RNA:    		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
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Browse shRNA at Sigma-Aldrich
Browse OriGene 29mer shRNA kits
Browse OriGene siRNA
Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IGLV4-3 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IGLV4-3 
Search SABiosciences for Assays for microRNAs that regulate IGLV4-3

Gene
Editing:		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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Cell
Lines:  		GenScript Custom overexpressing Cell Line Services for IGLV4-3 


Pathways & Interactions
for IGLV4-3 gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for IGLV4-3 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGLV4-3

5/41 Interacting proteins for IGLV4-3 (ENSP000003748533) via UniProtKB, MINT, and/or STRING (see all 41)
InteractantInteraction Details
GeneCardExternal ID(s)
C1QAENSP000003412713STRING: ENSP00000341271
C1QBENSP000003139673STRING: ENSP00000313967
C1QCENSP000003637703STRING: ENSP00000363770
C1SENSP000003281733STRING: ENSP00000328173
ENSG00000211637ENSP000003748173STRING: ENSP00000374817
About this table

Drugs & Compounds
for IGLV4-3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGLV4-3


Transcripts
for IGLV4-3 gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section
Inhib.
RNA:     		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Browse siRNA at Sigma-Aldrich
Browse shRNA at Sigma-Aldrich
Browse OriGene 29mer shRNA kits
Browse OriGene siRNA
Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IGLV4-3 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IGLV4-3 
Search SABiosciences for Assays for microRNAs that regulate IGLV4-3
Clones: Browse FLAG tag genes at Sigma-Aldrich
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Browse 3'-UTR reporter clones for miRNA target validation 
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Primers:Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs 
Search SABiosciences RT2 qPCR Primer Assays for IGLV4-3

24/97 AceView cDNA sequences (see all 97):

AF194679 CR605950 CR623617 AF194648 AF063703 CR592011 CR623132 CR593480 
AF064507 AF194643 AF194645 AF194669 L35920 L25296 AF194698 AY573191 
AF194642 AF058069 AF194783 AJ319669 AF194714 BC033102 BG757949 AY043110 

highest scoring ESTs for IGLV4-3:

DQ098710 DQ098712 D84140 DQ098759 DQ098783 DQ098826 DQ098701 DQ098785 AF103634 AB064024 


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390318

Expression
for IGLV4-3 gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

IGLV4-3 expression in normal and diseased human tissues

1  / 2  / 3

11 probe-sets matching IGLV4-3 gene

Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
31460_f_at*2 U95-A 93 0.56 0.01 1.00 1.00 -- -- -- -- --
31459_i_at*2 U95-A 82 0.54 0.01 0.11 0.32 -- -- -- -- --
216430_x_at*2 U133-A 94 0.73 0.01 -- -- -- -- -- -- --
217235_x_at*2, 3 U133-A 95 0.55 0.03 -- -- D84140 0.40 0.06 0.29 1
216846_at*2, 3 U133-A 34 0.36 0.03 -- -- AF234254 0.20 0.01 0.14 2
234381_at*2 U133-B 21 0.27 0.06 -- -- -- -- -- -- --
216430_x_at*2 U133Plus2 94 0.73 0.01 -- -- -- -- -- -- --
217235_x_at*2 U133Plus2 95 0.55 0.03 -- -- -- -- -- -- --
1558176_at*2 U133Plus2 73 0.55 0.01 -- -- -- -- -- -- --
216846_at*2 U133Plus2 34 0.36 0.03 -- -- -- -- -- -- --
234381_at*2 U133Plus2 21 0.27 0.06 -- -- -- -- -- -- --
About this table

IGLV4-3 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
IGLV4-3 gene expression
IGLV4-3 gene electronic northern expression
IGLV4-3 gene sage expression
About these images

CGAP SAGE TAG: --
Primers:Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs 
Search SABiosciences RT2 qPCR Primer Assays for IGLV4-3
    SABiosciences Custom PCR Arrays for IGLV4-3 


Orthologs
for IGLV4-3 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
 ENSEMBL Gene Tree for IGLV4-3 (if available)

Paralogs
for IGLV4-3 gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for IGLV4-3 gene
ENSG000002116372  ENSG000002116432  IGLV5-372  VPREB32  IGLV11-552  IGLV5-482  IGLV9-492  VPREB12  
LOC6515362  IGLV4-602  

IGLV4-3 for paralogs           About GeneDecksing



Genomic Variants
for IGLV4-3 gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
Search QIAGEN SeqTarget long-range PCR primers for resequencing for IGLV4-3 

Disorders & Mutations
for IGLV4-3 gene

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Medical News
for IGLV4-3 gene

(Possibly Related Articles in Doctor's Guide)
About This Section
   --

Publications
for IGLV4-3 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

5 PubMed articles for IGLV4-3 gene integrated from 7 sources:
(articles sorted by number of sources associating them with IGLV4-3)
  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  2. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (2002)
  3. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1 Kawasaki K....Shimizu N. (1997)
  4. Activation of C1r by proteolytic cleavage. (PubMed id 1249422)1 Ziccardi R.J. and Cooper N.R. (1976)
  5. Physicochemical and functional characterization of the C1r subunit of the first complement component. (PubMed id 814163)1 Ziccardi R.J. and Cooper N.R. (1976)

External Searches for IGLV4-3 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGLV4-3 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28786 HGNC: 5919 AceView: IGL_ Ensembl:ENSG00000211672 euGenes: HUgn28786
ECgene: IGLV4-3 H-InvDB: IGLV4-3

Other Databases showing IGLV4-3 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGLV4-3 gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
IMGT entry for IGLV4-3 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGLV4-3 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for IGLV4-3 gene:
Search GeneIP for patents involving IGLV4-3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for IGLV4-3 gene

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IGLV4-3
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