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IL17F Gene

protein-coding GIFtS: 53

GC06M051932

interleukin 17F
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
interleukin 17F¹ ²		IL-24² ³
IL-17F¹ ² ³		interleukin-17F²
ML1¹ ² ⁵		interleukin-24²
ML-1¹ ²		Interleukin-24³
Cytokine ML-1² ³		IL24³

External Ids:	HGNC: 16404¹	Entrez Gene: 112744²	Ensembl: ENSG00000112116⁷	UniProtKB: Q96PD4³

Export aliases for IL17F gene to outside databases

Previous GC identifers: GC06M052103 GC06M052148 GC06M052209

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL17F:

The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by

activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and

CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells

to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. (provided by RefSeq)

UniProtKB/Swiss-Prot: IL17F_HUMAN, Q96PD4

Function: Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor,

and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL17F gene promoter:
         AP-1   NF-kappaB1   p53   CREB   deltaCREB   c-Fos   STAT3   c-Jun   GATA-1   POU2F1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for IL17F

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12 Ensembl cytogenetic band: 6p12.2 HGNC cytogenetic band: 6p12

IL17F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL17F gene location

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M051932: view genomic region (about GC identifiers)

Start:	51,932,711 bp from pter
End:	51,940,522 bp from pter
Size:	7,812 bases
Orientation:	minus strand

1 alternative location:

Chr6- 52,101,479-52,109,335

RefSeq DNA sequence:

NC_000006.11 NT_007592.15

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: IL17F_HUMAN, Q96PD4 (See protein sequence)

Recommended Name: Interleukin-17F precursor

Size: 163 amino acids; 18045 Da

Subunit: Homodimer; disulfide-linked

Subcellular location: Secreted

Sequence caution: Sequence=AAL14427.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=CAD92646.1;

Type=Erroneous gene model prediction;

PDB structure from and Proteopedia :

1JPY (3D)

3JVF (3D)

Secondary accessions: Q6NSI0 Q7Z6P4 Q96PI8 Q9NUE6

Explore the universe of human proteins at neXtProt for IL17F: NX_Q96PD4

REFSEQ proteins: NP_443104.1

ENSEMBL proteins:

ENSP00000337432

Human Recombinant Proteins

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	Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	11574464
GO:0005615	extracellular space	IEA	--

About this table

IL17F for ontologies About GeneDecksing

Antibodies for IL17F:

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	Browse antibodies at Epitomics

Assays for IL17F:

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	Uscn ELISAs and CLIAs for IL17F

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL17F for domains About GeneDecksing

2 InterPro domains/families:

IPR020440 Interleukin-17_chordata

IPR010345 Interleukin-17_met

Graphical View of Domain Structure for InterPro Entry Q96PD4

ProtoNet protein and cluster: Q96PD4

1 Blocks protein family: IPB010345 Interleukin-17

UniProtKB/Swiss-Prot: IL17F_HUMAN, Q96PD4

Similarity: Belongs to the IL-17 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: IL17F_HUMAN, Q96PD4

Function: Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor,

and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for IL17F Sigma-Aldrich shRNA Panels and shRNA for IL17F
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): IL17F OriGene shRNA RFP (see all 2): IL17F OriGene basic RS shRNA (see all 2): IL17F OriGene siRNA (see all 2): IL17F
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IL17F

miRNA:		Sigma-Aldrich microRNA Mimics for IL17F Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IL17F
		Search SABiosciences for Assays for microRNAs that regulate IL17F

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: IL17F OriGene Myc/DDK tagged cDNA clones in CMV expression vector: IL17F OriGene untagged cDNA clones in CMV expression vector: IL17F Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: IL17F
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for IL17F

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IDA	11591732
GO:0019955	cytokine binding	IDA	11574464
GO:0042803	protein homodimerization activity	IDA	11574464

About this table

IL17F for ontologies About GeneDecksing

Animal Models: 7 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Il17f):

craniofacial	digestive/alimentary	immune system	life span-post-weaning/aging	normal
respiratory system	skeleton

IL17F for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

IL17F for pathways About GeneDecksing

1 Millipore Pathway for IL17F

Immune response IL-23 signaling pathway

3 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for IL17F

	Role of Cytokines in Mediating Communication between Immune Cells
	IL-17 Signaling
	T Helper Cell Differentiation

SABiosciences Pathway-Focused PCR Arrays including IL17F (see all 3): PAHS-072A PAHS-073A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for IL17F

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL17F

1 Interacting protein for IL17F (ENSP00000337432³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STAT3	ENSP00000264657³	STRING: ENSP00000264657

About this table

5/12 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 12):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006029	proteoglycan metabolic process	IDA	11574464
GO:0006954	inflammatory response	IEA	--
GO:0016525	negative regulation of angiogenesis	IDA	11591732
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	IDA	11591732
GO:0042089	cytokine biosynthetic process	IDA	11591732

About this table

IL17F for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL17F

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for IL17F Sigma-Aldrich shRNA Panels and shRNA for IL17F
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): IL17F OriGene shRNA RFP (see all 2): IL17F OriGene basic RS shRNA (see all 2): IL17F OriGene siRNA (see all 2): IL17F
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IL17F

miRNA:		Sigma-Aldrich microRNA Mimics for IL17F Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IL17F
		Search SABiosciences for Assays for microRNAs that regulate IL17F

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: IL17F OriGene Myc/DDK tagged cDNA clones in CMV expression vector: IL17F OriGene untagged cDNA clones in CMV expression vector: IL17F Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: IL17F

Primers:		OriGene genome-wide validated SYBR primer pairs: IL17F Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for IL17F: PPH01680A

REFSEQ mRNAs for IL17F gene:

NM_052872.3

Additional cDNA sequence:

AF332389.1 AF384857.1 BC070124.1

2 DOTS entries:

DT.97802452 DT.97784418

6 AceView cDNA sequences:

NM_052872 NM_172343 AF384857 BC070124 AF332389 CD639406

highest scoring ESTs for IL17F:

AF384857 BC070124 CD639406 AF332389 NM_052872 NM_172343

Unigene Cluster for IL17F:

Interleukin 17F

Hs.272295 [show with all ESTs]

Unigene Representative Sequence: AF332389

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000336123(uc003pam.1) ENST00000478427(uc003pal.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

IL17F expression in normal and diseased human tissues

¹ / ²

2 probe-sets matching IL17F gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
234408_at²	U133-B	1	0.91	1.00	--	--	--	--	--	--	--
234408_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table
Data from Genenote (Publications) and GNF BioGPS
About these images

IL17F gene electronic northern expression

About these images

CGAP SAGE TAG: TGCAGTAAGA

SOURCE GeneReport for Unigene cluster: Hs.272295

UniProtKB/Swiss-Prot: IL17F_HUMAN, Q96PD4

Tissue specificity: Expressed in activated, but not resting, CD4+ T-cells and activated monocytes

Primers:		OriGene genome-wide validated SYBR primer pairs: IL17F Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for IL17F: PPH01680A

SABiosciences Expression via Pathway-Focused PCR Arrays including IL17F (see all 3): PAHS-072A PAHS-073A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IL17F gene from 5/6 species (see all 6)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IL17F¹	--	interleukin 17F	74.51(n) 60.13(a)	481838 XM_538959.1 XP_538959.1
chimpanzee (Pan troglodytes)	IL17F¹	--	interleukin 17F	98.98(n) 98.16(a)	472030 XM_527409.2 XP_527409.2
cow (Bos taurus)	IL17F¹	--	interleukin 17F	72.19(n) 56.05(a)	506030 XM_582420.3 XP_582420.1
rat (Rattus norvegicus)	Il17f¹	--	interleukin 17F	73.73(n) 60.26(a)	301291 NM_001015011.1 NP_001015011.1
mouse (Mus musculus)	Il17f^{1 , 5}	1 (6.49 cM)⁵	interleukin 17F^{1, 5}	73(n)¹ 56.96(a)¹	257630¹ NM_145856.2¹ NP_665855.2¹ AB116259⁵ AF458064⁵ (see all 10)

About this table Species with no ortholog for IL17F

ENSEMBL Gene Tree for IL17F (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IL17F gene

IL17A² IL17D² IL17B² IL17C²

IL17F for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs597506^1,2	C,F,	52109621(-)	`TGACAA/GGGGTG`	1	--	ng5¹ tfbs³		13	NS EA NA EU WA	992
rs612242^1,2	C,F,O,A,H,	52103160(-)	`ATTCAG/CTCAGA`	1	--	int¹		93	NS NA EU EA PA CA WA	4804
rs641701^1,2	C,F,O,A,	52101165(-)	`CATATG/CGAAGG`	1	--	ng3¹		14	NS EA NA EU WA	770
rs677901^1,2	C,F,	52111101(-)	`GGTAAT/CGGGCA`	1	--	ng5¹		8	NS EA NA EU WA	562
rs721430^1,2	C,F,A,H,	52102640(-)	`ttctcA/Ggtggc`	1	--	int¹		11	NS EA NA WA	552
rs722323^1,2	C,F,A,H,	52106860(-)	`CTGCTC/TTGTAT`	1	--	int¹		17	NS EA NA EU WA	1136
rs763780^1,2	C,F,O,	52101739(+)	`GCACAC/TGGTGG`	2	H R	ref¹ mis¹ ese³		26	NS MN EA NA EU	1918
rs766748^1,2	C,F,A,H,	52102899(-)	`gtagtG/Accccc`	1	--	int¹		8	NS EA NA	584
rs1266828^1,2	C,F,O,A,	52108062(-)	`AATCCT/CGCATC`	1	--	int¹		24	NS EA NA EU WA	1292
rs1889570^1,2	C,F,A,	52110734(-)	`agctgG/Accata`	1	--	ng5¹ tfbs³		10	NA EU EA WA	312

About this table

HapMap Linkage Disequilibrium images for IL17F (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IL17F: --

QIAGEN SeqTarget long-range PCR primers for resequencing IL17F

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL17F for disorders About GeneDecksing

OMIM: 606496

10 Novoseek disease relationships for IL17F gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
autoimmune diseases	50.8	2	19034630 (1)
autoimmunity	48.4	1	18280574 (1), 19144313 (1)
inflammation	46.8	10	18992745 (2), 20375986 (1), 15972674 (1), 16630936 (1) (see all 10)
necrosis	29.5	6	14601514 (1), 18061474 (1), 15657292 (1), 20519880 (1) (see all 6)
asthma	18.7	20	15703761 (5), 16630936 (4), 16961709 (1), 19361847 (1) (see all 5)
bronchoalveolar lavage fluid	15.7	1	15703761 (1)
tumors	15.7	20	20210523 (3), 17352237 (2), 17292626 (2), 14601514 (1) (see all 10)
pneumonia	0	1	15477493 (1)
cancer	0	3	14601514 (1), 7779151 (1), 17644350 (1), 19904747 (1)
hyperplasia	0	1	15477493 (1)

About this table

Human Gene Mutation Database (HGMD): IL17F
Genetic Association Database (GAD): IL17F
Human Genome Epidemiology (HuGE) Navigator: IL17F (21 documents)

Export disorders and mutations for IL17F gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/107 PubMed articles for IL17F gene, integrated from 7 sources (see all 107):
(articles sorted by number of sources associating them with IL17F)

Identification of a novel cytokine, ML-1, and its expression in subjects with asthma. (PubMed id 11591768)^{1, 2, 3, 7} Kawaguchi M.... Huang S.-K. (2001)
IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. (PubMed id 11591732)^{1, 2, 3, 7} Starnes T.... Hromas R. (2001)
Polymorphisms in the interleukin 17F gene (IL17F) and asthma. (PubMed id 15703761)^{1, 4, 7} Ramsey C.D....Celedon J.C. (2005)
IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. (PubMed id 11574464)^{1, 2, 7} Hymowitz S.G.... Starovasnik M.A. (2001)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity. (PubMed id 16630936)^{1, 7} Kawaguchi M....Adachi M. (2006)
Interleukin-17F suppresses hepatocarcinoma cell growt h via inhibition of tumor angiogenesis. (PubMed id 20210523)^{1, 7} Xie Y....Yang J. (2010)
Interleukin-17F signaling requires ubiquitination of interleukin-17 receptor via TRAF6. (PubMed id 17346928)^{1, 7} Rong Z....Chang Z. (2007)
Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. (PubMed id 15972674)^{1, 7} McAllister F....Kolls J.K. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 112744	HGNC: 16404	AceView: IL17F	Ensembl:ENSG00000112116	euGenes: HUgn112744
ECgene: IL17F	H-InvDB: IL17F

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for IL17F	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Interleukin_17

Intellectual Property for IL17F gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for IL17F gene:
Search GeneIP for patents involving IL17F

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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	Predesigned and custom siRNAs for IL17F		Antibodies for IL17F
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	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
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	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies for IL17F (IL-17F)		Cell Culture Products
	ELISAs for IL17F (IL-17F)		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for IL17F (IL-17F)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IL17F
	SeqTarget long-range PCR primers for resequencing IL17F
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IL17F

	GenScript Custom Purified and Recombinant Proteins Services for IL17F		GenScript cDNA clones with any tag delivered in your preferred vector for IL17F
	GenScript Custom Assay Services for IL17F		GenScript Custom Superior Antibodies Services for IL17F
	GenScript Custom overexpressing Cell Line Services for IL17F		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in IL17F promoter
	Search Chromatin IP Primers for IL17F
	RT² qPCR Primer Assay for IL17F
	GNC Network for IL17F
	Search for Assays for microRNAs that regulate IL17F
	SABiosciences PCR Arrays including IL17F

Search Tocris compounds for IL17F

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for IL17F
	Proteins for IL17F
	Lysates for IL17F

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for IL17F

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

IL17F gene at Home site.

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IL17F Gene

protein-coding GIFtS: 53

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Export list of displayed genes

IL17F Gene

protein-coding GIFtS: 53

Aliases & Descriptionsfor IL17F gene

Summariesfor IL17F gene

Genomic Viewsfor IL17F gene

Proteinsfor IL17F gene

Protein Domains/Familiesfor IL17F gene

Gene Functionfor IL17F gene

Pathways & Interactionsfor IL17F gene

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Transcriptsfor IL17F gene

Expression for IL17F gene

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Genome Databases showing IL17F gene

Other Databases showing IL17F gene

Specialized Databases showing IL17F gene

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Aliases &
Descriptions
for IL17F gene

Summaries
for IL17F gene

Genomic Views
for IL17F gene

Proteins
for IL17F gene

Protein Domains/
Families
for IL17F gene

Gene Function
for IL17F gene

Pathways & Interactions
for IL17F gene

Drugs & Compounds
for IL17F gene

Transcripts
for IL17F gene

Expression
for IL17F gene

Orthologs
for IL17F gene

Paralogs
for IL17F gene

Genomic Variants
for IL17F gene

Disorders & Mutations
for IL17F gene

Medical News
for IL17F gene

Publications
for IL17F gene

Intellectual Property
for IL17F gene

Products
for IL17F gene