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IL1B Gene

protein-coding   GIFtS: 71

GC02M106041
interleukin 1, beta
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
interleukin 1, beta1 2     catabolin2
IL1F21 2 3     pro-interleukin-1-beta2
IL-1 beta2 3     OTTHUMP000002036942
IL-1B1     IL1-BETA2
IL-12     preinterleukin 1 beta2
OTTHUMP000002036932     interleukin-1 beta2
OTTHUMP000002036952     Catabolin3

External Ids:    HGNC: 59921   Entrez Gene: 35532   Ensembl: ENSG000001255387   UniProtKB: P015843   

Export aliases for IL1B gene to outside databases

Previous GC identifers: GC02M110793 GC02M111508 GC02M113494 GC02M113682 GC02M113303


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL1B:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by
activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE).
This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular
activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2
(PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain
hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
(provided by RefSeq)

UniProtKB/Swiss-Prot: IL1B_HUMAN, P01584
Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell
maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory
response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and
collagenase from synovial cells

summary for IL1B:
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They
control many different cellular functions including proliferation, differentiation and cell
survival/apoptosis but are also involved in several pathophysiological processes including viral infections
and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the
innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can
be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,
IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.
Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL1B gene promoter:
         AP-1   c-Rel   COUP-TF1   STAT3   HNF-4alpha2   AhR   Sp1   GR-alpha   c-Jun   c-Fos   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for IL1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q14

IL1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1B gene location

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M106041:  view genomic region     (about GC identifiers)

Start:
106,041,964 bp from pter
End:
106,048,983 bp from pter
Size:
7,020 bases
Orientation:
minus strand

1 alternative location:
Chr2- 113,587,328-113,594,480     
RefSeq DNA sequence:
NC_000002.11  NT_022135.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: IL1B_HUMAN, P01584 (See protein sequence)
Recommended Name: Interleukin-1 beta precursor  
Size: 269 amino acids; 30748 Da
Subunit: Monomer
Subcellular location: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that
IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins
PDB structures from and Proteopedia :
1HIB (3D)    1I1B (3D)    1IOB (3D)    1ITB (3D)    1L2H (3D)    1S0L (3D)    1T4Q (3D)    1TOO (3D)    
1TP0 (3D)    1TWE (3D)    1TWM (3D)    21BI (3D)    2I1B (3D)    2KH2 (3D)    2NVH (3D)    31BI (3D)    
3O4O (3D)    41BI (3D)    4I1B (3D)    5I1B (3D)    6I1B (3D)    7I1B (3D)    9ILB (3D)    
Secondary accessions: Q53X59 Q53XX2 Q7M4S7 Q7RU01 Q96HE5 Q9UCT6

Explore the universe of human proteins at neXtProt for IL1B: NX_P01584 

REFSEQ proteins: NP_000567.1  

ENSEMBL proteins: 
ENSP00000407219 ENSP00000263341 ENSP00000409680 ENSP00000400854 


Human Recombinant Proteins 
Millipore Purified and/or Recombinant IL1B Protein
Sigma-Aldrich Proteins for IL1B
R&D Systems Recombinant & Natural Proteins for IL1B (IL-1 beta/IL-1F2)
Enzo Life Sciences proteins for IL1B
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate: IL1B
GenScript Custom Purified and Recombinant Proteins Services for IL1B 
Novus Biologicals Proteins for IL1B
Novus Biologicals Lysate for IL1B
Browse Sino Biological Recombinant Proteins
ProSpec Recombinant Protein for IL1B

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region TAS--
GO:0005615 extracellular space IMP3493774
GO:0005829 cytosol TAS--
GO:0030141 stored secretory granule IEA--
GO:0031982 vesicle IEA--
About this table

IL1B for ontologies           About GeneDecksing



Antibodies for IL1B: 
Millipore Mono- and Polyclonal Antibodies for the study of IL1B
Sigma-Aldrich Antibodies for IL1B
R&D Systems Antibodies for IL1B (IL-1 beta/IL-1F2)
Cell Signaling Technology (CST) Antibodies for IL1B  (IL-1b)
Browse OriGene Antibodies
GenScript Custom Superior Antibodies Services for IL1B 
Novus Biologicals Antibodies for IL1B
Epitomics antibodies for IL1B

Assays for IL1B: 
Millipore Kits and Assays for the Analysis of IL1B
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
R&D Systems Flow Cytometry Kits for IL1B (IL-1 beta/IL-1F2)         (see all)
GenScript Custom Assay Services for IL1B 
Enzo Life Sciences assays for IL1B
Browse ELISAs and CLIAs at Uscn 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL1B for domains           About GeneDecksing

5/7 InterPro domains/families (see all 7):
 IPR020877 Interleukin-1_CS
 IPR003502 IL1_propep
 IPR002348 IL1_HBGF
 IPR008996 Cytokine_IL1-like
 IPR003296 InterleukinIL1B

Graphical View of Domain Structure for InterPro Entry P01584

ProtoNet protein and cluster: P01584

5 Blocks protein families:
IPB000975 Interleukin-1 precursor family signature
IPB002348 IL1/HBGF family signature
IPB003294 Interleukin-1 alpha/beta precursor family signature
IPB003296 Interleukin-1 beta precursor signature
IPB003502 Interleukin-1 propeptide


UniProtKB/Swiss-Prot: IL1B_HUMAN, P01584
Domain: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet
undefined function
Similarity: Belongs to the IL-1 family


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: IL1B_HUMAN, P01584
Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell
maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory
response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and
collagenase from synovial cells

Inhib.
RNA:
    
Millipore RNAi Products for the Analysis of IL1B Gene knock-down
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for IL1B
Sigma-Aldrich shRNA Panels and shRNA for IL1B
OriGene 29mer shRNA kits in GFP-retroviral vector: IL1B
OriGene shRNA RFP: IL1B
OriGene basic RS shRNA: IL1B
OriGene siRNA: IL1B
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IL1B 
miRNA:Sigma-Aldrich microRNA Mimics for IL1B
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IL1B 
Search SABiosciences for Assays for microRNAs that regulate IL1B

Gene
Editing:
Sigma-Aldrich CompoZr Knockout ZFN for IL1B 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: IL1B
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: IL1B
OriGene untagged cDNA clones in CMV expression vector: IL1B
OriGene 3'-UTR clone: IL1B 
Browse MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: IL1B 
Sino Biological Human cDNA Clone for IL1B

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for IL1B 

Genatlas biochemistry entry for IL1B:
interleukin 1,17.3kDa,beta polypeptide,mainly expressed by macrophages osteoblastic cells and putatively stimulating
osteoclastogenesis,inducing the association of TRAF6 with IRAK1,involved in the inflammatory response,susceptibility
factor for inflammatory bowel diseaes

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005125 cytokine activity IMP2989698
GO:0005149 interleukin-1 receptor binding NAS1919436
GO:0005515 protein binding IPI9062193
GO:0008083 growth factor activity IEA--
GO:0019904 protein domain specific binding IPI16575408
About this table

IL1B for ontologies           About GeneDecksing

Animal Models: 7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Il1b):

cardiovascular systemhomeostasis/metabolismimmune systemlife span-post-weaning/agingnervous system
skeletontumorigenesis

IL1B for phenotypes           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


IL1B for pathways           About GeneDecksing

4 Millipore Pathways for IL1B
    Transcription Role of VDR in regulation of genes involved in osteoporosis
Selected targets of GCR-alpha
Immune response MIF in innate immunity response
Immune response IL-1 signaling pathway

5/30 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  IL1B (see all 30)
    Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
Hepatic Fibrosis / Hepatic Stellate Cell Activation
PPAR Signaling
Atherosclerosis Signaling
FXR/RXR Activation

5/15 Kegg Pathways  (Kegg details for IL1B) (see all 15):
    hsa04010 MAPK signaling pathway
hsa04060 Cytokine-cytokine receptor interaction
hsa04210 Apoptosis
hsa04620 Toll-like receptor signaling pathway
hsa04621 NOD-like receptor signaling pathway

    SABiosciences Pathway-Focused PCR Arrays including IL1B (see all 21): PAHS-003A PAHS-011A  

    Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for IL1B
    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL1B

5/35 Interacting proteins for IL1B (P015841, 2 ENSP000002633413) via UniProtKB, MINT, and/or STRING (see all 35)
InteractantInteraction Details
GeneCardExternal ID(s)
IL1R1P147781, 2, ENSP000002339463EBI-1026290,EBI-525905 MINT-24831 STRING: ENSP00000233946
CREBBPENSP000003715023STRING: ENSP00000371502
IL12AENSP000003032313STRING: ENSP00000303231
IL12BENSP000002312283STRING: ENSP00000231228
IL12RB1ENSP000002212703STRING: ENSP00000221270
About this table

5/78 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 78):

GO IDQualified GO termEvidencePubMed IDs
GO:0000187 activation of MAPK activity IDA10748004
GO:0001525 angiogenesis ----
GO:0001934 positive regulation of protein phosphorylation NAS16477012
GO:0002439 chronic inflammatory response to antigenic stimulus IEA--
GO:0002711 positive regulation of T cell mediated immunity IC1919436
About this table

IL1B for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

IL1B for compounds           About GeneDecksing

Sigma-Aldrich Small Molecules for IL1B:
Small Molecule - Inhibitor Small Molecule - Antagonist
Browse drugs & compounds from Enzo Life Sciences

Compounds for IL1B available from Tocris Bioscience
CompoundAction CAS number
AF 12198 Potent, selective human type I IL-1 receptor antagonist [185413-30-3]
About this table


10/136 Novoseek chemical compound relationships for IL1B gene (see all 136)
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pge2 85.5 1669 15135319 (8), 19452719 (8), 17438251 (7), 1668251 (6) (see all 99)
rantes 80.6 362 11600537 (6), 19080516 (6), 15499983 (6), 11063385 (5) (see all 99)
endotoxin 78.9 487 15499983 (6), 9659298 (5), 10908988 (5), 15325407 (5) (see all 99)
il 10 71.4 89 17022949 (3), 18832862 (3), 10645445 (2), 16842617 (2) (see all 63)
dexamethasone 71.1 456 17513787 (6), 9758209 (5), 10657942 (5), 19435930 (4) (see all 99)
nitric oxide 70.8 1245 10025918 (6), 1384465 (6), 11247871 (6), 9160463 (5) (see all 99)
cycloheximide 69.4 155 1384465 (3), 1732280 (2), 9144567 (2), 1918980 (2) (see all 99)
prostaglandin 69.1 243 1641502 (4), 8140125 (3), 9419743 (3), 9047011 (3) (see all 99)
indomethacin 63.5 183 12639911 (4), 9627083 (4), 10772282 (4), 1348040 (4) (see all 99)
sb 203580 63.3 64 12921636 (4), 18348730 (4), 17207362 (2), 20416175 (2) (see all 47)
About this table

2 PharmGKB drug compound relationships for IL1B gene
Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
glucocorticoidsFA  8429822
pravastatinPD  GN  14515062
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Millipore RNAi Products for the Analysis of IL1B Gene knock-down
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for IL1B
Sigma-Aldrich shRNA Panels and shRNA for IL1B
OriGene 29mer shRNA kits in GFP-retroviral vector: IL1B
OriGene shRNA RFP: IL1B
OriGene basic RS shRNA: IL1B
OriGene siRNA: IL1B
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IL1B 
miRNA: Sigma-Aldrich microRNA Mimics for IL1B
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IL1B 
Search SABiosciences for Assays for microRNAs that regulate IL1B
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: IL1B
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: IL1B
OriGene untagged cDNA clones in CMV expression vector: IL1B
OriGene 3'-UTR Clone: IL1B 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: IL1B 
Primers: OriGene genome-wide validated SYBR primer pairs: IL1B
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for IL1B: PPH00171A

REFSEQ mRNAs for IL1B gene: 

NM_000576.2  

Additional cDNA sequence: 

AB451494.1 AF043335.1 AK313983.1 BC008678.1 BT007213.1 CR407679.1 K02770.1 M15330.1 
M54933.1 X02532.1 X56087.1 

8 DOTS entries:

DT.454455  DT.95307325  DT.101987199  DT.100026384  DT.121014363  DT.102824241  DT.121014359  DT.95375716 

24/440 AceView cDNA sequences (see all 440):

BP335911 BP336610 BP336924 BP336896 BP337439 BP337036 BP335673 CA307234 
BP336766 BP335163 CD370914 AA382166 CD370442 AA381609 CA309582 BP336709 
BP336476 BP335514 BP335646 BP337240 AA381800 CA307004 BP336765 AA381476 

highest scoring ESTs for IL1B:

M15330 AA362068 AA362191 AA381178 AA381266 AA381270 AA381298 AA381321 AA381339 AA381407 

Unigene Cluster for IL1B:

Interleukin 1, beta
Hs.126256  [show with all ESTs]
Unigene Representative Sequence: AK313983


GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for IL1B (see all 6)

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1:              -     -     -                 -           -                                       
SP2:                    -     -                 -           -                                       
SP3:                          -                 -           -                                       
SP4:              -     -     -                 -                                                   
SP5:                                            -           -                                       

About this scheme

ECgene alternative splicing isoforms for IL1B
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000418817 ENST00000491056 ENST00000263341(uc002tih.1 uc002tii.1)
ENST00000477398 ENST00000487639 ENST00000432018 ENST00000416750 ENST00000496280


(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

IL1B expression in normal and diseased human tissues

1  / 2  / 3

6 probe-sets matching IL1B gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
1520_s_at2, 3 U95-A 1 0.75 1.00 0.99 0.94 X04500 0.20 1.00 0.72 1
39402_at2, 3 U133-A 1 0.69 1.00 0.95 1.07 M15330 1.00 1.00 1.00 1
205067_at2, 3 U133-A 1 0.73 1.00 -- -- NM_000576 0.60 1.00 0.82 1
39402_at2, 3 U133-A 1 0.69 1.00 -- -- M15330 1.00 1.00 1.00 1
205067_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
39402_at2 U133Plus2 1 0.69 1.00 -- -- -- -- -- -- --
About this table

IL1B for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
IL1B gene expression
IL1B gene electronic northern expression
IL1B gene sage expression
About these images

CGAP SAGE TAG: CAATTTGTGT

SOURCE GeneReport for Unigene cluster: Hs.126256

Expression variation in blood from EXPOLDB for IL1B

Primers: OriGene genome-wide validated SYBR primer pairs: IL1B
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for IL1B: PPH00171A
    SABiosciences Expression via Pathway-Focused PCR Arrays including IL1B (see all 21): PAHS-003A PAHS-011A  


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IL1B gene from 5/6 species (see all 6)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
IL1B1   -- interleukin 1, beta 78.28(n)
65.15(a)
403974  XM_849577.1  XP_854670.1 
chimpanzee
(Pan troglodytes)
IL1B1   -- interleukin 1, beta 99.5(n)
99.26(a)
450200  XM_001146864.1  XP_001146864.1 
cow
(Bos taurus)
IL1B1   -- interleukin 1, beta 75.38(n)
62.12(a)
281251  NM_174093.1  NP_776518.1 
rat
(Rattus norvegicus)
Il1b1   -- interleukin 1 beta 76.07(n)
68.05(a)
24494  NM_031512.1  NP_113700.1 
mouse
(Mus musculus)
Il1b1 , 5 2 (62.97 cM)5
interleukin 1 beta1, 5 78.57(n)1
69.55(a)1
161761  NM_008361.31  NP_032387.11 
 AK1563965  AK1572455  (see all 12)
About this table        Species with no ortholog for IL1B

ENSEMBL Gene Tree for IL1B (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
  --

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
QIAGEN SeqTarget long-range PCR primers for resequencing IL1B 

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL1B for disorders           About GeneDecksing

OMIM: 147720   disorders: 137215  

10/94 Novoseek disease relationships for IL1B gene (see all 94)

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis 94.6 6807 8908543 (6), 2239094 (5), 9223915 (5), 10958731 (5) (see all 99)
inflammation 87.4 725 11776404 (4), 8777275 (4), 8990190 (4), 10444264 (3) (see all 99)
tumors 85.7 5675 8908543 (6), 1966551 (6), 1752785 (5), 9223915 (5) (see all 99)
rheumatoid arthritis 79 217 7608561 (3), 2057724 (2), 8135776 (2), 15304675 (2) (see all 99)
osteoarthritis 72 126 19835118 (3), 2057724 (2), 1616355 (2), 7586981 (2) (see all 95)
response acute phase 67.1 37 8354339 (2), 11250916 (1), 12177794 (1), 18262272 (1) (see all 30)
arthritis 67 126 1616355 (2), 11120857 (2), 17397533 (2), 8275587 (2) (see all 88)
periodontal diseases 66.4 98 16570465 (3), 9203094 (2), 17378884 (2), 15002890 (2) (see all 63)
sepsis 63.9 142 9773833 (4), 17877801 (3), 18274637 (2), 8945019 (2) (see all 99)
systemic inflammatory response syndrome 59.9 34 8379598 (2), 7680670 (2), 10101684 (1), 16736416 (1) (see all 21)
About this table

7 PharmGKB disease relationships for IL1B gene
Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
Cardiovascular DiseasesCO  GN  11472429
Coronary ArteriosclerosisCO  GN  11472429
Coronary DiseaseCO  GN  11472429
Heart Failure, CongestiveCO  GN  11472429
InflammationCO  GN  11472429
Leukemia, Lymphocytic, Acute, L1FA  GN  12086872
OsteoarthritisGN  12801479
About this table

Human Gene Mutation Database (HGMD): IL1B
Genetic Association Database (GAD): IL1B
Human Genome Epidemiology (HuGE) Navigator: IL1B (1121 documents)

Export disorders and mutations for IL1B gene to outside databases

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
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10/6705 PubMed articles for IL1B gene, integrated from 7 sources (see all 6705):
(articles sorted by number of sources associating them with IL1B)
  1. Human interleukin-1 beta gene. (PubMed id 2954882)1, 2, 3 Bensi G.... Melli M. (1987)
  2. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. (PubMed id 2989698)1, 2, 3 March C.J.... Cosman D. (1985)
  3. Lack of association with interleukin 1 receptor antagonist and interleukin-1beta gene polymorphisms in sarcoidosis patients. (PubMed id 11127488)1, 4, 7 Niimi T....Ueda R. (2000)
  4. Interleukin 1 and nuclear factor-kappaB polymorphisms in ankylosing spondylitis in Canada and Korea. (PubMed id 16206345)1, 4, 7 Kim T.H....Inman R.D. (2005)
  5. Lack of association of genetic polymorphisms in the interleukin-1beta, interleukin-1 receptor antagonist, interleukin-4 and interleukin-10 genes with mitral valve prolapse in Taiwan Chinese. (PubMed id 12578333)1, 4, 7 Chou H.T....Tsai F.J. (2003)
  6. Absence of a genetic association between IL-1RN and IL-1B gene polymorphisms in ulcerative colitis and Crohn disease in multiple populations from northeast England. (PubMed id 11686217)1, 4, 7 Craggs A....Mansfield J. (2001)
  7. The role of arginine residues in interleukin 1 receptor binding. (PubMed id 1837236)1, 2, 7 Nanduri V.B.... Stern A.S. (1991)
  8. Association of IL-1Ra gene polymorphism, but no association of IL-1beta and IL-4 gene polymorphisms, with Kawasaki disease. (PubMed id 15900570)1, 4, 7 Wu S.F....Tsai F.J. (2005)
  9. A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand. (PubMed id 16098232)1, 4, 7 Ohashi J....Tokunaga K. (2005)
  10. Association of IL-1 RN*2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer's disease. (PubMed id 15201366)1, 4, 7 Bosco P....Gueant J.L. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3553 HGNC: 5992 AceView: IL1B Ensembl:ENSG00000125538 euGenes: HUgn3553
ECgene: IL1B Kegg: 3553 H-InvDB: IL1B

(According to HUGE)
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  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
ATLAS Chromosomes in Cancer entry for IL1B Genetics and Cytogenetics in Oncology and Haematology
Wikipedia http://en.wikipedia.org/wiki/Interleukin_1
SeattleSNPshttp://pga.gs.washington.edu/data/il1b/
SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL1B

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
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Patent Information for IL1B gene:
Search GeneIP for patents involving IL1B

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