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IL1B Gene

protein-coding GIFtS: 71

GC02M106041

interleukin 1, beta
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
interleukin 1, beta¹ ²		catabolin²
IL1F2¹ ² ³		pro-interleukin-1-beta²
IL-1 beta² ³		OTTHUMP00000203694²
IL-1B¹		IL1-BETA²
IL-1²		preinterleukin 1 beta²
OTTHUMP00000203693²		interleukin-1 beta²
OTTHUMP00000203695²		Catabolin³

External Ids:	HGNC: 5992¹	Entrez Gene: 3553²	Ensembl: ENSG00000125538⁷	UniProtKB: P01584³

Export aliases for IL1B gene to outside databases

Previous GC identifers: GC02M110793 GC02M111508 GC02M113494 GC02M113682 GC02M113303

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL1B:

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by

activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE).

This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular

activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2

(PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain

hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

(provided by RefSeq)

UniProtKB/Swiss-Prot: IL1B_HUMAN, P01584

Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell

maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory

response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and

collagenase from synovial cells

summary for IL1B:

Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They

control many different cellular functions including proliferation, differentiation and cell

survival/apoptosis but are also involved in several pathophysiological processes including viral infections

and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the

innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can

be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,

IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.

Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL1B gene promoter:
         AP-1   c-Rel   COUP-TF1   STAT3   HNF-4alpha2   AhR   Sp1   GR-alpha   c-Jun   c-Fos
         Other transcription factors

Search SABiosciences Chromatin IP Primers for IL1B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q14

IL1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1B gene location

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M106041: view genomic region (about GC identifiers)

Start:	106,041,964 bp from pter
End:	106,048,983 bp from pter
Size:	7,020 bases
Orientation:	minus strand

1 alternative location:

Chr2- 113,587,328-113,594,480

RefSeq DNA sequence:

NC_000002.11 NT_022135.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: IL1B_HUMAN, P01584 (See protein sequence)

Recommended Name: Interleukin-1 beta precursor

Size: 269 amino acids; 30748 Da

Subunit: Monomer

Subcellular location: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that

IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins

PDB structures from and Proteopedia :

1HIB (3D)

1I1B (3D)

1IOB (3D)

1ITB (3D)

1L2H (3D)

1S0L (3D)

1T4Q (3D)

1TOO (3D)

1TP0 (3D)

1TWE (3D)

1TWM (3D)

21BI (3D)

2I1B (3D)

2KH2 (3D)

2NVH (3D)

31BI (3D)

3O4O (3D)

41BI (3D)

4I1B (3D)

5I1B (3D)

6I1B (3D)

7I1B (3D)

9ILB (3D)

Secondary accessions: Q53X59 Q53XX2 Q7M4S7 Q7RU01 Q96HE5 Q9UCT6

Explore the universe of human proteins at neXtProt for IL1B: NX_P01584

REFSEQ proteins: NP_000567.1

ENSEMBL proteins:

ENSP00000407219 ENSP00000263341 ENSP00000409680 ENSP00000400854

Human Recombinant Proteins

	Millipore Purified and/or Recombinant IL1B Protein
	Sigma-Aldrich Proteins for IL1B
	R&D Systems Recombinant & Natural Proteins for IL1B (IL-1 beta/IL-1F2)
	Enzo Life Sciences proteins for IL1B
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: IL1B
	GenScript Custom Purified and Recombinant Proteins Services for IL1B
	Novus Biologicals Proteins for IL1B
	Novus Biologicals Lysate for IL1B
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IL1B

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IMP	3493774
GO:0005829	cytosol	TAS	--
GO:0030141	stored secretory granule	IEA	--
GO:0031982	vesicle	IEA	--

About this table

IL1B for ontologies About GeneDecksing

Antibodies for IL1B:

	Millipore Mono- and Polyclonal Antibodies for the study of IL1B
	Sigma-Aldrich Antibodies for IL1B
	R&D Systems Antibodies for IL1B (IL-1 beta/IL-1F2)
	Cell Signaling Technology (CST) Antibodies for IL1B (IL-1b)
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for IL1B
	Novus Biologicals Antibodies for IL1B
	Epitomics antibodies for IL1B

Assays for IL1B:

	Millipore Kits and Assays for the Analysis of IL1B
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Flow Cytometry Kits for IL1B (IL-1 beta/IL-1F2) (see all)
	GenScript Custom Assay Services for IL1B
	Enzo Life Sciences assays for IL1B
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL1B for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR020877 Interleukin-1_CS

IPR003502 IL1_propep

IPR002348 IL1_HBGF

IPR008996 Cytokine_IL1-like

IPR003296 InterleukinIL1B

Graphical View of Domain Structure for InterPro Entry P01584

ProtoNet protein and cluster: P01584

5 Blocks protein families:

IPB000975 Interleukin-1 precursor family signature

IPB002348 IL1/HBGF family signature

IPB003294 Interleukin-1 alpha/beta precursor family signature

IPB003296 Interleukin-1 beta precursor signature

IPB003502 Interleukin-1 propeptide

UniProtKB/Swiss-Prot: IL1B_HUMAN, P01584

Domain: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet

undefined function

Similarity: Belongs to the IL-1 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: IL1B_HUMAN, P01584

Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell

maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory

response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and

collagenase from synovial cells

Inhib. RNA:		Millipore RNAi Products for the Analysis of IL1B Gene knock-down
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for IL1B Sigma-Aldrich shRNA Panels and shRNA for IL1B
		OriGene 29mer shRNA kits in GFP-retroviral vector: IL1B OriGene shRNA RFP: IL1B OriGene basic RS shRNA: IL1B OriGene siRNA: IL1B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IL1B

miRNA:		Sigma-Aldrich microRNA Mimics for IL1B Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IL1B
		Search SABiosciences for Assays for microRNAs that regulate IL1B

Gene
Editing:

Sigma-Aldrich CompoZr Knockout ZFN for IL1B

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: IL1B OriGene Myc/DDK tagged cDNA clones in CMV expression vector: IL1B OriGene untagged cDNA clones in CMV expression vector: IL1B OriGene 3'-UTR clone: IL1B Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: IL1B
		Sino Biological Human cDNA Clone for IL1B

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for IL1B

Genatlas biochemistry entry for IL1B:

interleukin 1,17.3kDa,beta polypeptide,mainly expressed by macrophages osteoblastic cells and putatively stimulating

osteoclastogenesis,inducing the association of TRAF6 with IRAK1,involved in the inflammatory response,susceptibility

factor for inflammatory bowel diseaes

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IMP	2989698
GO:0005149	interleukin-1 receptor binding	NAS	1919436
GO:0005515	protein binding	IPI	9062193
GO:0008083	growth factor activity	IEA	--
GO:0019904	protein domain specific binding	IPI	16575408

About this table

IL1B for ontologies About GeneDecksing

Animal Models: 7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Il1b):

cardiovascular system	homeostasis/metabolism	immune system	life span-post-weaning/aging	nervous system
skeleton	tumorigenesis

IL1B for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

IL1B for pathways About GeneDecksing

4 Millipore Pathways for IL1B

	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Selected targets of GCR-alpha
	Immune response MIF in innate immunity response
	Immune response IL-1 signaling pathway

5/30 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for IL1B (see all 30)

	Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
	Hepatic Fibrosis / Hepatic Stellate Cell Activation
	PPAR Signaling
	Atherosclerosis Signaling
	FXR/RXR Activation

5/15 Kegg Pathways (Kegg details for IL1B) (see all 15):

	hsa04010 MAPK signaling pathway
	hsa04060 Cytokine-cytokine receptor interaction
	hsa04210 Apoptosis
	hsa04620 Toll-like receptor signaling pathway
	hsa04621 NOD-like receptor signaling pathway

SABiosciences Pathway-Focused PCR Arrays including IL1B (see all 21): PAHS-003A PAHS-011A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for IL1B

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL1B

5/35 Interacting proteins for IL1B (P01584^{1, 2} ENSP00000263341³) via UniProtKB, MINT, and/or STRING (see all 35)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL1R1	P14778¹^,², ENSP00000233946³	EBI-1026290,EBI-525905 MINT-24831 STRING: ENSP00000233946
CREBBP	ENSP00000371502³	STRING: ENSP00000371502
IL12A	ENSP00000303231³	STRING: ENSP00000303231
IL12B	ENSP00000231228³	STRING: ENSP00000231228
IL12RB1	ENSP00000221270³	STRING: ENSP00000221270

About this table

5/78 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 78):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	IDA	10748004
GO:0001525	angiogenesis	--	--
GO:0001934	positive regulation of protein phosphorylation	NAS	16477012
GO:0002439	chronic inflammatory response to antigenic stimulus	IEA	--
GO:0002711	positive regulation of T cell mediated immunity	IC	1919436

About this table

IL1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

IL1B for compounds About GeneDecksing

Sigma-Aldrich Small Molecules for IL1B:

Small Molecule - Inhibitor Small Molecule - Antagonist

Browse drugs & compounds from Enzo Life Sciences

Compounds for IL1B available from Tocris Bioscience

Compound	Action	CAS number
AF 12198	Potent, selective human type I IL-1 receptor antagonist	[185413-30-3]

About this table

10/136 Novoseek chemical compound relationships for IL1B gene (see all 136)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pge2	85.5	1669	15135319 (8), 19452719 (8), 17438251 (7), 1668251 (6) (see all 99)
rantes	80.6	362	11600537 (6), 19080516 (6), 15499983 (6), 11063385 (5) (see all 99)
endotoxin	78.9	487	15499983 (6), 9659298 (5), 10908988 (5), 15325407 (5) (see all 99)
il 10	71.4	89	17022949 (3), 18832862 (3), 10645445 (2), 16842617 (2) (see all 63)
dexamethasone	71.1	456	17513787 (6), 9758209 (5), 10657942 (5), 19435930 (4) (see all 99)
nitric oxide	70.8	1245	10025918 (6), 1384465 (6), 11247871 (6), 9160463 (5) (see all 99)
cycloheximide	69.4	155	1384465 (3), 1732280 (2), 9144567 (2), 1918980 (2) (see all 99)
prostaglandin	69.1	243	1641502 (4), 8140125 (3), 9419743 (3), 9047011 (3) (see all 99)
indomethacin	63.5	183	12639911 (4), 9627083 (4), 10772282 (4), 1348040 (4) (see all 99)
sb 203580	63.3	64	12921636 (4), 18348730 (4), 17207362 (2), 20416175 (2) (see all 47)

About this table

2 PharmGKB drug compound relationships for IL1B gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
glucocorticoids	FA	8429822
pravastatin	PD GN	14515062

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Millipore RNAi Products for the Analysis of IL1B Gene knock-down
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for IL1B Sigma-Aldrich shRNA Panels and shRNA for IL1B
		OriGene 29mer shRNA kits in GFP-retroviral vector: IL1B OriGene shRNA RFP: IL1B OriGene basic RS shRNA: IL1B OriGene siRNA: IL1B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IL1B

miRNA:		Sigma-Aldrich microRNA Mimics for IL1B Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IL1B
		Search SABiosciences for Assays for microRNAs that regulate IL1B

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: IL1B OriGene Myc/DDK tagged cDNA clones in CMV expression vector: IL1B OriGene untagged cDNA clones in CMV expression vector: IL1B OriGene 3'-UTR Clone: IL1B Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: IL1B

Primers:		OriGene genome-wide validated SYBR primer pairs: IL1B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for IL1B: PPH00171A

REFSEQ mRNAs for IL1B gene:

NM_000576.2

Additional cDNA sequence:

AB451494.1 AF043335.1 AK313983.1 BC008678.1 BT007213.1 CR407679.1 K02770.1 M15330.1

M54933.1 X02532.1 X56087.1

8 DOTS entries:

DT.454455 DT.95307325 DT.101987199 DT.100026384 DT.121014363 DT.102824241 DT.121014359 DT.95375716

24/440 AceView cDNA sequences (see all 440):

BP335911 BP336610 BP336924 BP336896 BP337439 BP337036 BP335673 CA307234

BP336766 BP335163 CD370914 AA382166 CD370442 AA381609 CA309582 BP336709

BP336476 BP335514 BP335646 BP337240 AA381800 CA307004 BP336765 AA381476

highest scoring ESTs for IL1B:

M15330 AA362068 AA362191 AA381178 AA381266 AA381270 AA381298 AA381321 AA381339 AA381407

Unigene Cluster for IL1B:

Interleukin 1, beta

Hs.126256 [show with all ESTs]

Unigene Representative Sequence: AK313983

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for IL1B (see all 6)

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	^	7	^	8
SP1:					-		-		-						-				-
SP2:							-		-						-				-
SP3:									-						-				-
SP4:					-		-		-						-
SP5:															-				-

About this scheme

ECgene alternative splicing isoforms for IL1B
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000418817 ENST00000491056 ENST00000263341(uc002tih.1 uc002tii.1)

ENST00000477398 ENST00000487639 ENST00000432018 ENST00000416750 ENST00000496280

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

IL1B expression in normal and diseased human tissues

¹ / ² / ³

6 probe-sets matching IL1B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1520_s_at²^{, 3}	U95-A	1	0.75	1.00	0.99	0.94	X04500	0.20	1.00	0.72	1
39402_at²^{, 3}	U133-A	1	0.69	1.00	0.95	1.07	M15330	1.00	1.00	1.00	1
205067_at²^{, 3}	U133-A	1	0.73	1.00	--	--	NM_000576	0.60	1.00	0.82	1
39402_at²^{, 3}	U133-A	1	0.69	1.00	--	--	M15330	1.00	1.00	1.00	1
205067_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--
39402_at²	U133Plus2	1	0.69	1.00	--	--	--	--	--	--	--

About this table

IL1B for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

IL1B gene electronic northern expression

About these images

CGAP SAGE TAG: CAATTTGTGT

SOURCE GeneReport for Unigene cluster: Hs.126256

Expression variation in blood from EXPOLDB for IL1B

Primers:		OriGene genome-wide validated SYBR primer pairs: IL1B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for IL1B: PPH00171A

SABiosciences Expression via Pathway-Focused PCR Arrays including IL1B (see all 21): PAHS-003A PAHS-011A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IL1B gene from 5/6 species (see all 6)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IL1B¹	--	interleukin 1, beta	78.28(n) 65.15(a)	403974 XM_849577.1 XP_854670.1
chimpanzee (Pan troglodytes)	IL1B¹	--	interleukin 1, beta	99.5(n) 99.26(a)	450200 XM_001146864.1 XP_001146864.1
cow (Bos taurus)	IL1B¹	--	interleukin 1, beta	75.38(n) 62.12(a)	281251 NM_174093.1 NP_776518.1
rat (Rattus norvegicus)	Il1b¹	--	interleukin 1 beta	76.07(n) 68.05(a)	24494 NM_031512.1 NP_113700.1
mouse (Mus musculus)	Il1b^{1 , 5}	2 (62.97 cM)⁵	interleukin 1 beta^{1, 5}	78.57(n)¹ 69.55(a)¹	16176¹ NM_008361.3¹ NP_032387.1¹ AK156396⁵ AK157245⁵ (see all 12)

About this table Species with no ortholog for IL1B

ENSEMBL Gene Tree for IL1B (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

QIAGEN SeqTarget long-range PCR primers for resequencing IL1B

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL1B for disorders About GeneDecksing

OMIM: 147720 disorders: 137215

10/94 Novoseek disease relationships for IL1B gene (see all 94)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	94.6	6807	8908543 (6), 2239094 (5), 9223915 (5), 10958731 (5) (see all 99)
inflammation	87.4	725	11776404 (4), 8777275 (4), 8990190 (4), 10444264 (3) (see all 99)
tumors	85.7	5675	8908543 (6), 1966551 (6), 1752785 (5), 9223915 (5) (see all 99)
rheumatoid arthritis	79	217	7608561 (3), 2057724 (2), 8135776 (2), 15304675 (2) (see all 99)
osteoarthritis	72	126	19835118 (3), 2057724 (2), 1616355 (2), 7586981 (2) (see all 95)
response acute phase	67.1	37	8354339 (2), 11250916 (1), 12177794 (1), 18262272 (1) (see all 30)
arthritis	67	126	1616355 (2), 11120857 (2), 17397533 (2), 8275587 (2) (see all 88)
periodontal diseases	66.4	98	16570465 (3), 9203094 (2), 17378884 (2), 15002890 (2) (see all 63)
sepsis	63.9	142	9773833 (4), 17877801 (3), 18274637 (2), 8945019 (2) (see all 99)
systemic inflammatory response syndrome	59.9	34	8379598 (2), 7680670 (2), 10101684 (1), 16736416 (1) (see all 21)

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7 PharmGKB disease relationships for IL1B gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Cardiovascular Diseases	CO GN	11472429
Coronary Arteriosclerosis	CO GN	11472429
Coronary Disease	CO GN	11472429
Heart Failure, Congestive	CO GN	11472429
Inflammation	CO GN	11472429
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872
Osteoarthritis	GN	12801479

About this table

Human Gene Mutation Database (HGMD): IL1B
Genetic Association Database (GAD): IL1B
Human Genome Epidemiology (HuGE) Navigator: IL1B (1121 documents)

Export disorders and mutations for IL1B gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

CHEST: Short Course of Tobramycin Nebulized Solution Significantly Reduces Chronic Obstructive Pulmonary Disease Exacerbations in Patients Colonized with Pseudomonas Aeruginosa

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/6705 PubMed articles for IL1B gene, integrated from 7 sources (see all 6705):
(articles sorted by number of sources associating them with IL1B)

Human interleukin-1 beta gene. (PubMed id 2954882)^{1, 2, 3} Bensi G.... Melli M. (1987)
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. (PubMed id 2989698)^{1, 2, 3} March C.J.... Cosman D. (1985)
Lack of association with interleukin 1 receptor antagonist and interleukin-1beta gene polymorphisms in sarcoidosis patients. (PubMed id 11127488)^{1, 4, 7} Niimi T....Ueda R. (2000)
Interleukin 1 and nuclear factor-kappaB polymorphisms in ankylosing spondylitis in Canada and Korea. (PubMed id 16206345)^{1, 4, 7} Kim T.H....Inman R.D. (2005)
Lack of association of genetic polymorphisms in the interleukin-1beta, interleukin-1 receptor antagonist, interleukin-4 and interleukin-10 genes with mitral valve prolapse in Taiwan Chinese. (PubMed id 12578333)^{1, 4, 7} Chou H.T....Tsai F.J. (2003)
Absence of a genetic association between IL-1RN and IL-1B gene polymorphisms in ulcerative colitis and Crohn disease in multiple populations from northeast England. (PubMed id 11686217)^{1, 4, 7} Craggs A....Mansfield J. (2001)
The role of arginine residues in interleukin 1 receptor binding. (PubMed id 1837236)^{1, 2, 7} Nanduri V.B.... Stern A.S. (1991)
Association of IL-1Ra gene polymorphism, but no association of IL-1beta and IL-4 gene polymorphisms, with Kawasaki disease. (PubMed id 15900570)^{1, 4, 7} Wu S.F....Tsai F.J. (2005)
A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand. (PubMed id 16098232)^{1, 4, 7} Ohashi J....Tokunaga K. (2005)
Association of IL-1 RN*2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer's disease. (PubMed id 15201366)^{1, 4, 7} Bosco P....Gueant J.L. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3553	HGNC: 5992	AceView: IL1B	Ensembl:ENSG00000125538	euGenes: HUgn3553
ECgene: IL1B	Kegg: 3553	H-InvDB: IL1B

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for IL1B	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Interleukin_1
SeattleSNPs	http://pga.gs.washington.edu/data/il1b/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL1B

Intellectual Property for IL1B gene
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Patent Information for IL1B gene:
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Antibodies & Assays for IL1B (IL-1b)

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IL1B Gene

protein-coding GIFtS: 71

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CINCA SYNDROME
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IL1B Gene

protein-coding GIFtS: 71

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