Aliases &
Descriptions
for IL1RAP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| interleukin 1 receptor accessory protein1 2 | | OTTHUMP000002094902 | | C3orf131 2 3 | | OTTHUMP000002094892 | | IL1R31 2 3 | | OTTHUMP000002094882 | | IL-1RAcP1 2 3 | | OTTHUMP000002094912 | | Interleukin-1 receptor 32 3 | | interleukin-1 receptor accessory protein2 | | IL-1 receptor accessory protein2 3 | | OTTHUMP000002094922 | | IL-1R32 3 | | interleukin-1 receptor accessory protein beta2 | | IL-1R-32 3 | | OTTHUMP000002094862 | | FLJ377882 | | OTTHUMP000002094872 |
Export aliases for IL1RAP gene to outside databasesPrevious GC identifers: GC03P187234 GC03P191494 GC03P191633 GC03P191552 GC03P191714 GC03P190231 |
Summaries
for IL1RAP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IL1RAP:
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress,by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodesthe interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complexwhich initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternativesplicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and onesoluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. (provided byRefSeq)
UniProtKB/Swiss-Prot: IL1AP_HUMAN, Q9NPH3Function: Mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form ofthe IL-1 receptor. Signaling involves formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 orIRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancinginterleukin-binding to the decoy receptor
Gene Wiki entry for IL1RAP |
Genomic Views
for IL1RAP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IL1RAP gene promoter:
CUTL1 POU3F1 RORalpha1 Bach1 MEF-2A RSRFC4 Arnt AhR POU2F1 LCR-F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for IL1RAP
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for IL1RAP  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q28 Ensembl cytogenetic band: 3q28 HGNC cytogenetic band: 3q28IL1RAP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P187631: view genomic region
(about GC identifiers)
Start:
|
187,631,658 bp from pter |
End:
|
187,775,020 bp from pter |
Size:
|
143,363 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr3+ 190,231,840-190,375,843 |
RefSeq DNA sequence:- NC_000003.11 NT_005612.16
|
Proteins
for IL1RAP gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: IL1AP_HUMAN, Q9NPH3 (See
protein sequence)Recommended Name: Interleukin-1 receptor accessory protein precursor Size: 570 amino acids; 65418 Da
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
Subcellular location: Isoform 3: Secreted
PDB structures from  and Proteopedia  :3O4O (3D)
Secondary accessions: O14915 Q86WJ7Alternative splicing: 3 isoforms: Q9NPH3-1 Q9NPH3-2 Q9NPH3-3 Explore the universe of human proteins at neXtProt for IL1RAP: NX_Q9NPH3
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (6 alternative transcripts):
NP_001161400.1 NP_001161401.1 NP_001161402.1 NP_001161403.1 NP_002173.1 NP_608273.1
ENSEMBL proteins: ENSP00000389149 ENSP00000314807 ENSP00000390541 ENSP00000412053 ENSP00000345829 ENSP00000391899 ENSP00000409352 ENSP00000387371 ENSP00000416296 ENSP00000398146 ENSP00000412008 ENSP00000414102 ENSP00000408893 ENSP00000072516 ENSP00000401132
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
IL1RAP for ontologies About GeneDecksing
Antibodies for IL1RAP:
Assays for IL1RAP: |
Protein
Domains/
Families
for IL1RAP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IL1RAP for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9NPH3ProtoNet protein and cluster: Q9NPH3 2 Blocks protein families: IPB004074 Interleukin-1 receptor type I and type II family signature IPB004075 Interleukin-1 receptor type I family signature
UniProtKB/Swiss-Prot: IL1AP_HUMAN, Q9NPH3Similarity: Belongs to the interleukin-1 receptor familySimilarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domainsSimilarity: Contains 1 TIR domain |
Gene Function
for IL1RAP gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: IL1AP_HUMAN, Q9NPH3Function: Mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form ofthe IL-1 receptor. Signaling involves formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 orIRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancinginterleukin-binding to the decoy receptorInduction: Isoform 1 is down-regulated by phorbol ester treatment. Isoform 2 is induced by phorbol ester treatment
Genatlas biochemistry entry for IL1RAP:interleukin 1,receptor accessory protein,required for the recruitment of IRAK(1) to the interleukin 1 receptorcomplex,after induction by IL1A or IL1B4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
IL1RAP for ontologies About GeneDecksing
Animal Models: 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Il1rap):
IL1RAP for phenotypes About GeneDecksing
|
Pathways & Interactions
for IL1RAP gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
IL1RAP for pathways About GeneDecksing
2  Millipore Pathways for IL1RAP
3  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for IL1RAP
2  Kegg Pathways (Kegg details for IL1RAP):
SABiosciences Pathway-Focused PCR Arrays including IL1RAP (see all 3): PAHS-052A PAHS-077A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for IL1RAP
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL1RAP
5/14 Interacting proteins for IL1RAP (ENSP000000725163 Q9NPH31, 2) via UniProtKB, MINT, and/or STRING (see all 14)About this table
5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7): About this table
IL1RAP for ontologies About GeneDecksing
|
Drugs & Compounds
for IL1RAP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
IL1RAP for compounds About GeneDecksing
 Browse Tocris compounds for IL1RAP
5  Novoseek chemical compound relationships for IL1RAP gene
About this table
|
Transcripts
for IL1RAP gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for IL1RAP gene (6 alternative transcripts): NM_001167928.1 NM_001167929.1 NM_001167930.1 NM_001167931.1 NM_002182.3 NM_134470.3 Additional cDNA sequence: AB006537.1 AF029213.1 AF167343.1 AF487335.1 AF538732.1 AF538733.1 AF538734.1 AK095107.1 AK291669.1 BC016141.1 BC053621.1 CR591396.1 EF591790.1 FJ998418.1 11 DOTS entries: DT.95370121 DT.99928349 DT.451695 DT.101984015 DT.97811801 DT.99936756 DT.100784427 DT.100773382 DT.97838473 DT.100701028 DT.100784426 24/116 AceView cDNA sequences (see all 116): CA441160 NM_002182 BU189361 BG562435 AF538730 BF589698 AL135064 AA404531 BF059542 BU188227 BX496958 AF029213 CR591396 AF487335 BU194356 AA256257 AV650065 AI082664 NM_134470 BM760155 AB006537 AI086058 AA256132 AV654169
 highest scoring ESTs for IL1RAP:AB006537 AA256132 AA256257 AA344485 AA401290 AA404284 AA404531 AI039647 AI141264 AI189680 Unigene Cluster for IL1RAP: Interleukin 1 receptor accessory protein Hs.478673 [show with all ESTs]Unigene Representative Sequence: NM_001167928
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for IL1RAP (see all 11)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | | | - | | | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | - | | | | - | | | | - | | - | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for IL1RAP
18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20): ENST00000422625 ENST00000317757(uc003fsq.2) ENST00000447382(uc003fsm.1 uc010hzg.1 uc003fsn.1)
ENST00000461629 ENST00000465496 ENST00000412504 ENST00000342550 ENST00000434491
ENST00000482913 ENST00000422485(uc003fsk.2 uc003fsl.2 uc010hzf.2)
ENST00000473566 ENST00000422940 ENST00000413869 ENST00000435897 ENST00000453359
ENST00000412080 ENST00000476929 ENST00000443369
|
Expression
for IL1RAP gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| IL1RAP expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching IL1RAP gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 38546_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.86 |
1.19 |
AB006537 |
1.00 |
0.90 |
0.95 |
1 |
| 51136_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
0.97 |
0.85 |
AI189680 |
0.80 |
1.00 |
0.91 |
1 |
| 205227_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_002182 |
0.60 |
1.00 |
0.82 |
1 |
| 210233_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AF167343 |
0.60 |
1.00 |
0.82 |
1 |
| 205227_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 210233_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
IL1RAP for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AACTTTTGTA
SOURCE GeneReport for Unigene cluster: Hs.478673
Expression variation in blood from EXPOLDB for IL1RAP UniProtKB/Swiss-Prot: IL1AP_HUMAN, Q9NPH3Tissue specificity: Detected in liver, skin, placenta, thymus and lung
SABiosciences Expression via Pathway-Focused PCR Arrays including IL1RAP (see all 3): PAHS-052A PAHS-077A
|
Orthologs
for IL1RAP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for IL1RAP gene from 5 species
About this table Species with no ortholog for IL1RAP
ENSEMBL Gene Tree for IL1RAP (if available) |
Paralogs
for IL1RAP gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for IL1RAP gene
- IL1RAPL22 IL1RAPL12 IL18RAP2 IL18R12 SIGIRR2
IL1RAP for paralogs About GeneDecksing
|
Genomic Variants
for IL1RAP gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 3 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for IL1RAP (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for IL1RAP
5 CNVs: 98570 91771 47999 43475 91772
8 Indels: 40586 12364 91773 27252 46353 12365 42740 60447 | | QIAGEN SeqTarget long-range PCR primers for resequencing IL1RAP |
|
Disorders & Mutations
for IL1RAP gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IL1RAP for disorders About GeneDecksing
OMIM: 602626
8 Novoseek disease relationships for IL1RAP gene
About this table
Genetic Association Database (GAD): IL1RAP
Human Genome Epidemiology (HuGE) Navigator: IL1RAP (14 documents)
Export disorders and mutations for IL1RAP gene to outside databases
|
Medical News
for IL1RAP gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for IL1RAP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/156 PubMed articles for IL1RAP gene, integrated from 7 sources (see all 156):
(articles sorted by number of sources associating them with IL1RAP)- The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping. (PubMed id 9479509)1, 2, 3, 7 Dale M.... Nicklin M.J.H. (1998)
- The interleukin-1 receptor accessory protein (IL-1RAc P) is essential for IL-1-induced activation of interleukin-1 receptor-associate d kinase (IRAK) and stress-activated protein kinases (SAP kinases). (PubMed id 9065432)1, 3, 7 Wesche H....Martin M.U. (1997)
- Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. (PubMed id 9371760)1, 2, 7 Huang J.... Cao Z. (1997)
- IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein. (PubMed id 10799889)1, 2, 7 Jensen L.E.... Whitehead A.S. (2000)
- Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis. (PubMed id 12781872)1, 2, 7 Jensen L.E. and Whitehead A.S. (2003)
- The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action. (PubMed id 12530978)1, 2, 7 Smith D.E.... Sims J.E. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of a cascade of protein interactions initiated at the IL-1 receptor. (PubMed id 12659850)1, 2 Boch J.A....Auron P.E. (2003)
- Host defense and inflammatory gene polymorphisms are associated with outcomes after HLA-identical sibling bone marrow transplantation. (PubMed id 12393699)1, 4 Rocha V....Gluckman E. (2002)
- The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness. (PubMed id 9862719)1, 7 Lang D....Martin M.U. (1998)
|
External Searches for IL1RAP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IL1RAP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IL1RAP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IL1RAP gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for IL1RAP gene:
Search GeneIP for patents involving IL1RAP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IL1RAP gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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