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Aliases & Descriptionsfor IL20RB gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions interleukin 20 receptor beta1 2 IL-20RB2 3 IL-20R21 2 3 IL-20R-beta2 3 DIRS11 2 3 interleukin-20 receptor II2 fibronectin type III domain containing 61 2 interleukin-20 receptor subunit beta2 MGC349231 2 FNDC62 IL-20 receptor subunit beta2 3
Export aliases for IL20RB gene to outside databases Previous GC identifers: GC00U990739 GC03P138161 GC03P136665
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Summariesfor IL20RB gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for IL20RB : IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 (PubMed 11163236)).(supplied by OMIM) UniProtKB/Swiss-Prot: I20RB_HUMAN, Q6UXL0 Function : The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor forIL20 and IL24 Gene Wiki entry for IL20RB (Interleukin 20 receptor, beta subunit)
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Genomic Viewsfor IL20RB gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for IL20RB Other transcription factors Search SABiosciences Chromatin IP Primers for IL20RB Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3q22.3 Ensembl cytogenetic band: 3q22.3 HGNC cytogenetic band: 3q22.3 IL20RB Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03P134052: view genomic region
(about GC identifiers )
Start:
134,052,492 bp from pter
End:
134,105,774 bp from pter
Size:
53,283 bases
Orientation:
plus strand
1 alternative location : Chr 3+ 136,665,072-136,729,927
RefSeq DNA sequence: NC_000003.11 NT_005612.16
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Proteinsfor IL20RB gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: I20RB_HUMAN, Q6UXL0 (See
protein sequence )Recommended Name: Interleukin-20 receptor subunit beta precursor Size : 311 amino acids; 35076 Da
Subunit : Heterodimer with IL20RA and heterodimer with IL22RA1
Subcellular location : Membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions : Q6P438 Q8TAJ7Explore the universe of human proteins at neXtProt for IL20RB: NX_Q6UXL0
REFSEQ proteins: NP_653318.2 ENSEMBL proteins: ENSP00000328133 ENSP00000417437 ENSP00000420725 ENSP00000418637 ENSP00000311979 Human Recombinant Proteins 2 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0016020 membrane
IEA -- GO:0016021 integral to membrane
IEA --
About this table
IL20RB for ontologies About GeneDecksing Antibodies for IL20RB: Assays for IL20RB:
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Protein
Domains/ Familiesfor IL20RB gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
IL20RB for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q6UXL0 ProtoNet protein and cluster: Q6UXL0
UniProtKB/Swiss-Prot: I20RB_HUMAN, Q6UXL0 Similarity : Belongs to the type II cytokine receptor familySimilarity : Contains 2 fibronectin type-III domains
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Gene Functionfor IL20RB gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: I20RB_HUMAN, Q6UXL0 Function : The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor forIL20 and IL24
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0004872 receptor activity
IEA -- GO:0005515 protein binding
IEA --
About this table
IL20RB for ontologies About GeneDecksing Animal Models: 4 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Il20rb) :
IL20RB for phenotypes About GeneDecksing
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Pathways & Interactionsfor IL20RB gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section
IL20RB for pathways About GeneDecksing 2 Kegg Pathways (Kegg details for IL20RB) : hsa04060 Cytokine-cytokine receptor interaction hsa04630 Jak-STAT signaling pathway
SABiosciences Pathway-Focused PCR Array including IL20RB : PAHS-064A SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL20RB 1 Gene Ontology (GO) biological process term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0007596 blood coagulation
IEA --
About this table
IL20RB for ontologies About GeneDecksing
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Drugs & Compoundsfor IL20RB gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for IL20RB
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Transcriptsfor IL20RB gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for IL20RB gene: NM_144717.3
Additional cDNA sequence: AJ431617.1 AK296832.1 AK316084.1 AY358305.1 BC027449.1 BC033292.1 BC063696.1 CR590848.1 CR604488.1
5 DOTS entries : DT.101977165 DT.410873 DT.100021077 DT.99997292 DT.95321065
highest scoring ESTs for IL20RB :BF913926 BI014492 BI015283 BI060935 BI061285 BI061485 CV029830 CV030325 CV319979 CV357151 Unigene Cluster for IL20RB:
Interleukin 20 receptor beta Hs.61232 [show with all ESTs ] Unigene Representative Sequence: AY358305 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for IL20RB ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 SP1 :                       SP2 :     -         -           SP3 :             -     -      
About this scheme ECgene alternative splicing isoforms for IL20RB 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000329582 (uc003eri.1 ) ENST00000491483 ENST00000475972 (uc010hud.1 )ENST00000469964 ENST00000309741 (uc003erj.1 ) ENST00000484501
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Expression for IL20RB gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section IL20RB expression in normal and diseased human tissues 1 / 2 / 3
3 probe-sets matching IL20RB gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
46172_at2 , 3
U95-B
1
0.94
1.00
1.00
1.00
AI142832
0.40
0.40
0.40
2
228575_at2 , 3
U133-B
1
1.00
1.00
--
--
AL578102
0.20
0.25
0.23
2
228575_at2
U133Plus2
1
1.00
1.00
--
--
--
--
--
--
--
About this table
IL20RB for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TTTGTTGTGC SOURCE GeneReport for Unigene cluster: Hs.61232 UniProtKB/Swiss-Prot: I20RB_HUMAN, Q6UXL0 Tissue specificity : Widely expressed with highest levels in skin and testis. Highly expressed in psoriatic skin
SABiosciences Expression via Pathway-Focused PCR Array including IL20RB : PAHS-064A
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Orthologsfor IL20RB gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for IL20RB gene from 5/6 species (see all 6 )
About this table Species with no ortholog for IL20RB ENSEMBL Gene Tree for IL20RB (if available)
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Paralogsfor IL20RB gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section --
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Genomic Variantsfor IL20RB gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 3 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for IL20RB (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for IL20RB: --
QIAGEN SeqTarget long-range PCR primers for resequencing IL20RB
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Disorders & Mutationsfor IL20RB gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
IL20RB for disorders About GeneDecksing
OMIM: 605621 Human Genome Epidemiology (HuGE) Navigator: IL20RB (1 document)Export disorders and mutations for IL20RB gene to outside databases
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Medical Newsfor IL20RB gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor IL20RB gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/17 PubMed articles for IL20RB gene, integrated from 7 sources (see all 17 ): (articles sorted by number of sources associating them with IL20RB) Interleukin 20: discovery, receptor identification, and role in epidermal function. (PubMed id 11163236) 1 , 2 , 3 Blumberg H.... Chandrasekher Y.A. (2001) IL-20: biological functions and clinical implications . (PubMed id 16703417) 1 , 3 Wei C.C....Chang M.S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161) 1 , 2 Zhang Z. and Henzel W.J. (2004) Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20. (PubMed id 14580208) 1 , 2 Pletnev S.... Zdanov A. (2003) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 Clark H.F.... Gray A.M. (2003) Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. (PubMed id 12351624) 1 , 2 Parrish-Novak J.... Chandrasekher Y.A. (2002) STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. (PubMed id 11564763) 1 , 2 Dumoutier L.... Renauld J.-C. (2001) Expression pattern of mda-7/IL-24 receptors in liver cancer cell lines. (PubMed id 19666410) 1 Zhu H. and Yang Z.B. (2009) Association analysis of IL20RA and IL20RB genes in psoriasis. (PubMed id 18480827) 1 Kingo K....Koks S. (2008)
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External Searches for IL20RB gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing IL20RB gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing IL20RB gene
(According to HUGE )
About This Section --
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Specialized Databases showing IL20RB gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for IL20RB gene: Search GeneIP for patents involving IL20RB GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor IL20RB gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for IL20RB
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