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IL29 Gene

protein-coding   GIFtS: 44

GC19P036233
interleukin 29 (interferon, lambda 1)
(Previous name: interleukin 29 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases & Descriptions
interleukin 29 (interferon, lambda 1)1 2     IFN-lambda-12 3
IL-291 2 3     interleukin 291
IFNL11 2 3     interleukin-292
Interferon lambda-12 3     interferon, lambda 12
Cytokine Zcyto212 3     ZCYTO213

External Ids:    HGNC: 183631   Entrez Gene: 2826182   Ensembl: ENSG000001823937   UniProtKB: Q8IU543   

Export aliases for IL29 gene to outside databases

Previous GC identifers: GC19P040178 GC19P044463 GC19P044478 GC19P039786


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL29:
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A
(IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a
chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral
infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that
consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). (provided by RefSeq)

UniProtKB/Swiss-Prot: IL29_HUMAN, Q8IU54
Function: Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I
antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The
ligand/receptor complex seems to signal through the Jak-STAT pathway


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL29 gene promoter:
         STAT1   STAT1beta   STAT1alpha   AP-1   c-Jun   c-Fos   STAT3   Fra-1   JunD   JunB   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for IL29

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.13   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.13

IL29 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL29 gene location

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P036233:  view genomic region     (about GC identifiers)

Start:
36,233,484 bp from pter
End:
36,235,831 bp from pter
Size:
2,348 bases
Orientation:
plus strand

1 alternative location:
Chr19+ 39,786,965-39,789,312     
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: IL29_HUMAN, Q8IU54 (See protein sequence)
Recommended Name: Interleukin-29 precursor  
Size: 200 amino acids; 21898 Da
Subcellular location: Secreted
Secondary accessions: A0AV25 Q17R34

Explore the universe of human proteins at neXtProt for IL29: NX_Q8IU54 

REFSEQ proteins: NP_742152.1  

ENSEMBL proteins: 
ENSP00000329991 


Human Recombinant Proteins 
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Sigma-Aldrich Proteins for IL29
R&D Systems Recombinant & Natural Proteins for IL29 (IL-29/IFN-lambda 1)
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OriGene Protein Over-expression Lysate: IL29
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ProSpec Recombinant Protein for IL29

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IDA12483210
GO:0005615 extracellular space IEA--
GO:0032002 interleukin-28 receptor complex IDA12469119
About this table

IL29 for ontologies           About GeneDecksing



Antibodies for IL29: 
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Uscn ELISAs and CLIAs for IL29 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8IU54

UniProtKB/Swiss-Prot: IL29_HUMAN, Q8IU54
Similarity: Belongs to the IL-28/IL-29 family


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: IL29_HUMAN, Q8IU54
Function: Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I
antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The
ligand/receptor complex seems to signal through the Jak-STAT pathway
Induction: By viral infections or double-stranded RNA

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for IL29
Sigma-Aldrich shRNA Panels and shRNA for IL29
OriGene 29mer shRNA kits in GFP-retroviral vector: IL29
OriGene shRNA RFP: IL29
OriGene basic RS shRNA: IL29
OriGene siRNA: IL29
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IL29 
miRNA:Sigma-Aldrich microRNA Mimics for IL29
Sigma-Aldrich microRNA target validation systems for IL29 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IL29 
1 SABiosciences Assays for microRNA that regulate IL29:
hsa-miR-548n

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: IL29
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: IL29
OriGene untagged cDNA clones in CMV expression vector: IL29
Browse 3'-UTR reporter clones for miRNA target validation 
Browse MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: IL29 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for IL29 

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005102 receptor binding IDA12483210
GO:0005125 cytokine activity IEA--
GO:0032003 interleukin-28 receptor binding IPI12469119
About this table

IL29 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


IL29 for pathways           About GeneDecksing

2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  IL29
    Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
Role of Cytokines in Mediating Communication between Immune Cells

2 Kegg Pathways  (Kegg details for IL29):
    hsa04060 Cytokine-cytokine receptor interaction
hsa04630 Jak-STAT signaling pathway

    SABiosciences Pathway-Focused PCR Arrays including IL29: PAHS-064A PAHS-3803A 

    Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for IL29
    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL29

2 Interacting proteins for IL29 (ENSP000003299913) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
IL10RBENSP000002902003STRING: ENSP00000290200
IL28RAENSP000003278243STRING: ENSP00000327824
About this table

5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7):

GO IDQualified GO termEvidencePubMed IDs
GO:0008285 negative regulation of cell proliferation IDA15166220
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IDA15166220
GO:0045345 positive regulation of MHC class I biosynthetic process IDA12483210
GO:0045941 positive regulation of transcription IDA12483210
GO:0046427 positive regulation of JAK-STAT cascade IDA12483210
About this table

IL29 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

IL29 for compounds           About GeneDecksing

Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL29
1 Novoseek chemical compound relationship for IL29 gene
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
2',5'-oligoadenylate 64.3 2 17006906 (1), 18657576 (1)
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for IL29
Sigma-Aldrich shRNA Panels and shRNA for IL29
OriGene 29mer shRNA kits in GFP-retroviral vector: IL29
OriGene shRNA RFP: IL29
OriGene basic RS shRNA: IL29
OriGene siRNA: IL29
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IL29 
miRNA: Sigma-Aldrich microRNA Mimics for IL29
Sigma-Aldrich microRNA target validation systems for IL29 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IL29 
1 SABiosciences Assays for microRNA that regulate IL29:
hsa-miR-548n
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: IL29
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: IL29
OriGene untagged cDNA clones in CMV expression vector: IL29
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: IL29 
Primers: OriGene genome-wide validated SYBR primer pairs: IL29
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for IL29: PPH05849A

REFSEQ mRNAs for IL29 gene: 

NM_172140.1  

Additional cDNA sequence: 

AY129150.1 AY184372.1 AY336716.1 BC074985.2 BC117482.1 BC126183.1 

1 DOTS entry:

DT.100013335 

6 AceView cDNA sequences:

AY129150 AY336716 AY184372 BC074985 NM_172140 T07139 

highest scoring ESTs for IL29:

AY129150 AY184372 AY336716 T07139 BC074985 NM_172140 BC117482 BC126183 

Unigene Cluster for IL29:

Interleukin 29 (interferon, lambda 1)
Hs.406745
Unigene Representative Sequence: AY129150


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000333625(uc002okv.2)

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

IL29 expression in normal and diseased human tissues

1  / 2

1 probe-set matching IL29 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
1552917_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
About this table
Data from Genenote  (Publications) and GNF BioGPS
    About these images
IL29 gene expression
IL29 gene electronic northern expression
IL29 gene sage expression
About these images

CGAP SAGE TAG: GCTGCAGCTT

SOURCE GeneReport for Unigene cluster: Hs.406745
Primers: OriGene genome-wide validated SYBR primer pairs: IL29
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for IL29: PPH05849A
    SABiosciences Expression via Pathway-Focused PCR Arrays including IL29: PAHS-064A PAHS-3803A 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
ENSEMBL Gene Tree for IL29 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for IL29 gene
IL28B2  IL28A2  

IL29 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/56 NCBI SNPs in IL29 are shown (see all 56)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 19 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs304611,2
C,F,O,A,39789115(-) CAGGTT/CCCCAT 2 /N /D ref1 mis1 ese314Minor allele frequency- C:0.22MN NS EA NA WA 1238
rs8568391,2
--39785684(-) ggtggC/Ttcacg 1 -- ng510--------
rs72468511,2
C,F,39785877(+) ccttaC/Ttcagt 1 -- ng518Minor allele frequency- T:0.16NS EA NA WA 632
rs72470861,2
C,F,39786019(+) AACTAC/TTCAGA 1 -- ng518Minor allele frequency- T:0.19NS EA NA WA 542
rs72470971,2
C,39786099(+) TggccA/Gggagc 1 -- ng513Minor allele frequency- G:0.06NA WA 76
rs72473611,2
C,A39786284(+) aggccG/Aaggca 1 -- ng512Minor allele frequency- A:0.50NA WA 4
rs104192681,2
--39788145(+) gcagaA/Gacggg 1 -- int10--------
rs106794471,2
--39785211(+) agaga-/GAgagag 1 -- ng51 trp30--------
rs285886951,2
--39788348(+) CCAGAA/GAACTT 1 -- int10--------
rs285911001,2
--39788346(+) CCCCAA/GAGAAC 1 -- int10--------
About this table

HapMap Linkage Disequilibrium images for IL29 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for IL29: --

QIAGEN SeqTarget long-range PCR primers for resequencing IL29 

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL29 for disorders           About GeneDecksing

OMIM: 607403

5 Novoseek disease relationships for IL29 gene

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
virus infection 37.7 2 12469119 (1), 16537619 (1)
influenza 22.2 9 16014923 (4), 16537619 (2), 19155475 (1), 16797201 (1)
autoimmunity 12.9 1 17027516 (1)
necrosis 0 4 16014923 (1), 16227300 (1), 16603509 (1), 16537619 (1)
tumors 0 5 16650825 (2), 16014923 (1), 16227300 (1), 16537619 (1)
About this table


Export disorders and mutations for IL29 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10/63 PubMed articles for IL29 gene, integrated from 7 sources (see all 63):
(articles sorted by number of sources associating them with IL29)
  1. IL-28, IL-29 and their class II cytokine receptor IL-28R. (PubMed id 12469119)1, 2, 7 Sheppard P.... Klucher K.M. (2003)
  2. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. (PubMed id 12483210)1, 2, 7 Kotenko S.V.... Donnelly R.P. (2003)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells. (PubMed id 16539846)1, 7 Li M.C....He S.H. (2006)
  5. Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection. (PubMed id 19155475)1, 7 Wang J....Mason R.J. (2009)
  6. Interferon lambda-1 (IFN-lambda1/IL-29) induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner. (PubMed id 17252004)1, 7 Pekarek V....Gallagher G. (2007)
  7. Interleukin-29 binds to melanoma cells inducing Jak-S TAT signal transduction and apoptosis. (PubMed id 20103601)1, 7 Guenterberg K.D....Carson W.E. (2010)
  8. Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells. (PubMed id 16014923)1, 7 Osterlund P....Julkunen I. (2005)
  9. IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression. (PubMed id 16051921)1, 7 Brand S....Dambacher J. (2005)
  10. Purification, crystallization and preliminary crystal lographic studies of the complex of interferon-lambda1 with its receptor. (PubMed id 20057073)1, 7 Magracheva E....Zdanov A. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
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Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 282618 HGNC: 18363 AceView: IL29 Ensembl:ENSG00000182393 euGenes: HUgn282618
ECgene: IL29 Kegg: 282618 H-InvDB: IL29

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
Wikipedia http://en.wikipedia.org/wiki/Interleukin_29

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for IL29 gene:
Search GeneIP for patents involving IL29

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 microRNA Target Validation Systems for IL29 Browse CompoZr Knockout ZFN at Sigma-Aldrich
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 miRNA Expression Plasmids

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IL29
 SeqTarget long-range PCR primers for resequencing IL29
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IL29
 GenScript Custom Purified and Recombinant Proteins Services for IL29 GenScript cDNA clones with any tag delivered in your preferred vector for IL29
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 Recombinant Protein for IL29

 ELISAs and CLIAs for IL29
       

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