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Aliases & Descriptionsfor IL29 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions interleukin 29 (interferon, lambda 1)1 2 IFN-lambda-12 3 IL-291 2 3 interleukin 291 IFNL11 2 3 interleukin-292 Interferon lambda-12 3 interferon, lambda 12 Cytokine Zcyto212 3 ZCYTO213
Export aliases for IL29 gene to outside databases Previous GC identifers: GC19P040178 GC19P044463 GC19P044478 GC19P039786
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Summariesfor IL29 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for IL29 : This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). (provided by RefSeq) UniProtKB/Swiss-Prot: IL29_HUMAN, Q8IU54 Function : Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class Iantigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway
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Genomic Viewsfor IL29 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the IL29 gene promoter: STAT1 STAT1beta STAT1alpha AP-1 c-Jun c-Fos STAT3 Fra-1 JunD JunB Other transcription factors Search SABiosciences Chromatin IP Primers for IL29 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19q13.13 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.13 IL29 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19P036233: view genomic region
(about GC identifiers )
Start:
36,233,484 bp from pter
End:
36,235,831 bp from pter
Size:
2,348 bases
Orientation:
plus strand
1 alternative location : Chr 19+ 39,786,965-39,789,312
RefSeq DNA sequence: NC_000019.9 NT_011109.16
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Proteinsfor IL29 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: IL29_HUMAN, Q8IU54 (See
protein sequence )Recommended Name: Interleukin-29 precursor Size : 200 amino acids; 21898 Da
Subcellular location : Secreted
Secondary accessions : A0AV25 Q17R34Explore the universe of human proteins at neXtProt for IL29: NX_Q8IU54
REFSEQ proteins: NP_742152.1 ENSEMBL proteins: ENSP00000329991 Human Recombinant Proteins 3 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
About this table
IL29 for ontologies About GeneDecksing Antibodies for IL29: Assays for IL29:
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Protein
Domains/ Familiesfor IL29 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q8IU54
UniProtKB/Swiss-Prot: IL29_HUMAN, Q8IU54 Similarity : Belongs to the IL-28/IL-29 family
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Gene Functionfor IL29 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: IL29_HUMAN, Q8IU54 Function : Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class Iantigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway Induction : By viral infections or double-stranded RNA
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view) :
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IL29 for ontologies About GeneDecksing
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Pathways & Interactionsfor IL29 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section
IL29 for pathways About GeneDecksing 2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for IL29 2 Kegg Pathways (Kegg details for IL29) : hsa04060 Cytokine-cytokine receptor interaction hsa04630 Jak-STAT signaling pathway
SABiosciences Pathway-Focused PCR Arrays including IL29 : PAHS-064A PAHS-3803A Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for IL29 SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL29 2 Interacting proteins for IL29 (ENSP00000329991 3 ) via UniProtKB, MINT, and/or STRING About this table 5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7 ):
About this table
IL29 for ontologies About GeneDecksing
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Drugs & Compoundsfor IL29 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section
IL29 for compounds About GeneDecksing Browse Tocris compounds for IL29 1 Novoseek chemical compound relationship for IL29 gene
About this table
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Transcriptsfor IL29 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for IL29 gene: NM_172140.1
Additional cDNA sequence: AY129150.1 AY184372.1 AY336716.1 BC074985.2 BC117482.1 BC126183.1
1 DOTS entry : DT.100013335
6 AceView cDNA sequences :
AY129150 AY336716 AY184372 BC074985 NM_172140 T07139
highest scoring ESTs for IL29 :AY129150 AY184372 AY336716 T07139 BC074985 NM_172140 BC117482 BC126183 Unigene Cluster for IL29:
Interleukin 29 (interferon, lambda 1) Hs.406745 Unigene Representative Sequence: AY129150 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000333625 (uc002okv.2 )
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Expression for IL29 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section IL29 expression in normal and diseased human tissues 1 / 2
1 probe-set matching IL29 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
1552917_at2
U133Plus2
1
0.73
1.00
--
--
--
--
--
--
--
About this table Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GCTGCAGCTT SOURCE GeneReport for Unigene cluster: Hs.406745 SABiosciences Expression via Pathway-Focused PCR Arrays including IL29 : PAHS-064A PAHS-3803A
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Orthologsfor IL29 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section ENSEMBL Gene Tree for IL29 (if available)
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Paralogsfor IL29 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for IL29 gene IL28B 2 IL28A 2
IL29 for paralogs About GeneDecksing
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Genomic Variantsfor IL29 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 19 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for IL29 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for IL29: --
QIAGEN SeqTarget long-range PCR primers for resequencing IL29
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Disorders & Mutationsfor IL29 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
IL29 for disorders About GeneDecksing
OMIM: 607403 5 Novoseek disease relationships for IL29 gene
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
virus infection
37.7
2
12469119 (1), 16537619 (1)
influenza
22.2
9
16014923 (4), 16537619 (2), 19155475 (1), 16797201 (1)
autoimmunity
12.9
1
17027516 (1)
necrosis
0
4
16014923 (1), 16227300 (1), 16603509 (1), 16537619 (1)
tumors
0
5
16650825 (2), 16014923 (1), 16227300 (1), 16537619 (1)
About this table Export disorders and mutations for IL29 gene to outside databases
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Medical Newsfor IL29 gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor IL29 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/63 PubMed articles for IL29 gene, integrated from 7 sources (see all 63 ): (articles sorted by number of sources associating them with IL29) IL-28, IL-29 and their class II cytokine receptor IL-28R. (PubMed id 12469119) 1 , 2 , 7 Sheppard P.... Klucher K.M. (2003) IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. (PubMed id 12483210) 1 , 2 , 7 Kotenko S.V.... Donnelly R.P. (2003) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells. (PubMed id 16539846) 1 , 7 Li M.C....He S.H. (2006) Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection. (PubMed id 19155475) 1 , 7 Wang J....Mason R.J. (2009) Interferon lambda-1 (IFN-lambda1/IL-29) induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner. (PubMed id 17252004) 1 , 7 Pekarek V....Gallagher G. (2007) Interleukin-29 binds to melanoma cells inducing Jak-S TAT signal transduction and apoptosis. (PubMed id 20103601) 1 , 7 Guenterberg K.D....Carson W.E. (2010) Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells. (PubMed id 16014923) 1 , 7 Osterlund P....Julkunen I. (2005) IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression. (PubMed id 16051921) 1 , 7 Brand S....Dambacher J. (2005) Purification, crystallization and preliminary crystal lographic studies of the complex of interferon-lambda1 with its receptor. (PubMed id 20057073) 1 , 7 Magracheva E....Zdanov A. (2010)
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External Searches for IL29 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing IL29 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing IL29 gene
(According to HUGE )
About This Section --
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Specialized Databases showing IL29 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
Wikipedia http://en.wikipedia.org/wiki/Interleukin_29
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About This Section Patent Information for IL29 gene: Search GeneIP for patents involving IL29 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor IL29 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Antibodies & Assays for IL29   (hIL-29)
Search Tocris compounds for IL29
Recombinant Protein for IL29
ELISAs and CLIAs for IL29
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