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IL8 Gene

protein-coding   GIFtS: 68

GC04P070417
interleukin 8
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
interleukin 81 2     b-ENAP1
CXCL81 2 3     TSG-11
MONAP1 2 3     SCYB81
GCP-11 2 3     K601
MDNCF1 2 3     emoctakin2
NAP-11 2 3     NAP12
LYNAP1 2     beta-thromboglobulin-like protein2
LUCT1 2     small inducible cytokine subfamily B, member 82
LECT1 2     OTTHUMP000001998252
NAF1 2     interleukin-82
IL-81 3     neutrophil-activating peptide 12
Granulocyte chemotactic protein 12 3     GCP12
Monocyte-derived neutrophil chemotactic factor2 3     T cell chemotactic factor2
Monocyte-derived neutrophil-activating peptide2 3     lymphocyte-derived neutrophil-activating factor2
C-X-C motif chemokine 82 3     chemokine (C-X-C motif) ligand 82
T-cell chemotactic factor2 3     Protein 3-10C3
AMCF-I1     Emoctakin3
3-10C1     Neutrophil-activating protein 13

External Ids:    HGNC: 60251   Entrez Gene: 35762   Ensembl: ENSG000001694297   UniProtKB: P101453   

Export aliases for IL8 gene to outside databases

Previous GC identifers: GC04P074595 GC04P074845 GC04P075006 GC04P075072 GC04P074971


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL8:
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators
of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and
is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a
common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene
family form a chemokine gene cluster in a region mapped to chromosome 4q. (provided by RefSeq)

UniProtKB/Swiss-Prot: IL8_HUMAN, P10145
Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also
involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus.
IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil
activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively

Gene Wiki entry for IL8 (Interleukin 8)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL8 gene promoter:
         C/EBPalpha   HNF-4alpha2   p300   GR-alpha   p53   GR-beta   c-Rel   RelA   NF-kappaB   NF-kappaB1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for IL8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13-q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13-q21

IL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL8 gene location

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P070417:  view genomic region     (about GC identifiers)

Start:
70,417,759 bp from pter
End:
70,420,917 bp from pter
Size:
3,159 bases
Orientation:
plus strand

1 alternative location:
Chr4+ 74,606,223-74,609,433     
RefSeq DNA sequence:
NC_000004.11  NT_022778.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: IL8_HUMAN, P10145 (See protein sequence)
Recommended Name: Interleukin-8 precursor  
Size: 99 amino acids; 11098 Da
Subunit: Homodimer
Subcellular location: Secreted
PDB structures from and Proteopedia :
1ICW (3D)    1IKL (3D)    1IKM (3D)    1IL8 (3D)    1ILP (3D)    1ILQ (3D)    1QE6 (3D)    1ROD (3D)    
2IL8 (3D)    3IL8 (3D)    
Secondary accessions: B2R4L8 Q6FGF6 Q6LAE6 Q96RG6 Q9C077 Q9UCE1 Q9UCR8 Q9UCR9 Q9UCS0
Alternative splicing: 2 isoforms:  P10145-1   P10145-2   

Explore the universe of human proteins at neXtProt for IL8: NX_P10145 

Post-translational modifications:

  • Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood
  • monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is
    the most promiment form1


    REFSEQ proteins: NP_000575.1  

    ENSEMBL proteins: 
    ENSP00000385908 ENSP00000306512 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant IL8 Protein
    Sigma-Aldrich Proteins for IL8
    R&D Systems Recombinant & Natural Proteins for IL8 (CXCL8/IL-8)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: IL8
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for IL8 
    Novus Biologicals Proteins for IL8
    Novus Biologicals Lysate for IL8
    Sino Biological Recombinant Protein for IL8
    ProSpec Recombinant Protein for IL8

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region TAS--
    GO:0005615 extracellular space IEA--
    About this table

    IL8 for ontologies           About GeneDecksing



    Antibodies for IL8: 
    Millipore Mono- and Polyclonal Antibodies for the study of IL8
    Sigma-Aldrich Antibodies for IL8
    R&D Systems Antibodies for IL8 (CXCL8/IL-8)
    OriGene Antibodies (see all 2): IL8
    GenScript Superior Antibodies for IL8 
    Novus Biologicals Antibodies for IL8
    Epitomics antibodies for IL8

    Assays for IL8: 
    Millipore Kits and Assays for the Analysis of IL8
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    R&D Systems Flow Cytometry Kits for IL8 (CXCL8/IL-8)         (see all)
    GenScript Custom Assay Services for IL8 
    Enzo Life Sciences assays for IL8
    Uscn ELISAs and CLIAs for IL8 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    IL8 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001089 CXC_chmkine_smll
     IPR018048 Small_chemokine_CXC_CS
     IPR001811 Chemokine_IL8
     IPR002473 C-X-C/Interlkn_8

    Graphical View of Domain Structure for InterPro Entry P10145

    ProtoNet protein and cluster: P10145

    1 Blocks protein family: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: IL8_HUMAN, P10145
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: IL8_HUMAN, P10145
    Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also
    involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus.
    IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil
    activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for IL8
    Sigma-Aldrich shRNA Panels and shRNA for IL8
    OriGene 29mer shRNA kits in GFP-retroviral vector: IL8
    OriGene shRNA RFP: IL8
    OriGene basic RS shRNA: IL8
    OriGene siRNA: IL8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IL8 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IL8 
    8/16 SABiosciences Assays for microRNAs that regulate IL8 (see all 16):
    hsa-miR-1294 hsa-miR-520e hsa-miR-519d hsa-miR-20a hsa-miR-302a hsa-miR-106a hsa-miR-106b hsa-miR-373

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: IL8
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: IL8
    OriGene untagged cDNA clones in CMV expression vector: IL8
    OriGene 3'-UTR clone: IL8 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: IL8 
    Sino Biological Human cDNA Clone for IL8

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for IL8 

    Genatlas biochemistry entry for IL8:
    interleukin 8 (see IMC2@),neutrophil activating peptide 1,monocyte-derived neutrophil chemotactic factor,with a direct
    growth potentiating activity in malignant mesothelioma

    3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005153 interleukin-8 receptor binding IPI1840701
    GO:0005515 protein binding IPI10880251
    GO:0008009 chemokine activity IEA--
    About this table

    IL8 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    IL8 for pathways           About GeneDecksing

    5/8 Millipore Pathways for IL8 (see all 8)
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Role of integrins in NK cells cytotoxicity
    Selected targets of GCR-alpha
    Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF in innate immunity response

    5/15 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  IL8 (see all 15)
        Atherosclerosis Signaling
    Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
    Hepatic Cholestasis
    Role of Cytokines in Mediating Communication between Immune Cells
    Airway Pathology in Chronic Obstructive Pulmonary Disease

    5/13 Kegg Pathways  (Kegg details for IL8) (see all 13):
        hsa04060 Cytokine-cytokine receptor interaction
    hsa04062 Chemokine signaling pathway
    hsa04620 Toll-like receptor signaling pathway
    hsa04621 NOD-like receptor signaling pathway
    hsa04622 RIG-I-like receptor signaling pathway

        SABiosciences Pathway-Focused PCR Arrays including IL8 (see all 16): PAHS-011A PAHS-014A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for IL8
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL8

    5/24 Interacting proteins for IL8 (ENSP000003065123) via UniProtKB, MINT, and/or STRING (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXCR2ENSP000003196353STRING: ENSP00000319635
    CXCL2ENSP000002644923STRING: ENSP00000264492
    CXCL3ENSP000002960263STRING: ENSP00000296026
    CXCL5ENSP000002960273STRING: ENSP00000296027
    CXCL6ENSP000002263173STRING: ENSP00000226317
    About this table

    5/16 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 16):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525 angiogenesis TAS11483765
    GO:0006928 cellular component movement TAS10820279
    GO:0006935 chemotaxis IEA--
    GO:0006954 inflammatory response TAS11483765
    GO:0006955 immune response IEA--
    About this table

    IL8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    IL8 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL8
    10/138 Novoseek chemical compound relationships for IL8 gene (see all 138)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 92.7 1369 9723955 (8), 17207890 (7), 10619832 (7), 16413378 (6) (see all 99)
    groalpha 86.1 191 11495082 (7), 9641651 (7), 17922696 (5), 9889409 (4) (see all 81)
    fmlp 79.7 471 7837814 (9), 16249234 (7), 15494208 (5), 9013980 (5) (see all 99)
    leukotriene b4 78.5 560 8003341 (9), 8973284 (5), 9482389 (5), 12149532 (5) (see all 99)
    vegf 76.4 1297 11234901 (9), 10334214 (9), 17349553 (8), 9457313 (8) (see all 99)
    endotoxin 74.4 268 2007851 (5), 11451261 (5), 18485432 (4), 16384605 (4) (see all 99)
    grogamma 72.8 23 8702798 (3), 15832427 (2), 9553055 (2), 10695618 (1) (see all 11)
    grobeta 68 26 10600366 (3), 8702798 (3), 15832427 (2), 9553055 (2) (see all 12)
    il 10 67.4 70 18363812 (4), 9543183 (2), 19723087 (2), 20041183 (2) (see all 56)
    lipoteichoic acid 67.3 89 10570304 (7), 16619004 (4), 8262617 (4), 19250704 (3) (see all 37)
    About this table

    1 PharmGKB drug compound relationship for IL8 gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    glucocorticoidsFA  1370208
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for IL8
    Sigma-Aldrich shRNA Panels and shRNA for IL8
    OriGene 29mer shRNA kits in GFP-retroviral vector: IL8
    OriGene shRNA RFP: IL8
    OriGene basic RS shRNA: IL8
    OriGene siRNA: IL8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IL8 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IL8 
    8/16 SABiosciences Assays for microRNAs that regulate IL8 (see all 16):
    hsa-miR-1294 hsa-miR-520e hsa-miR-519d hsa-miR-20a hsa-miR-302a hsa-miR-106a hsa-miR-106b hsa-miR-373
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: IL8
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: IL8
    OriGene untagged cDNA clones in CMV expression vector: IL8
    OriGene 3'-UTR Clone: IL8 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: IL8 
    Primers: OriGene genome-wide validated SYBR primer pairs: IL8
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for IL8: PPH00568A

    REFSEQ mRNAs for IL8 gene: 

    NM_000584.2  

    Additional cDNA sequence: 

    AK131067.1 AK311874.1 BC013615.1 BT007067.1 CR542151.1 CR594973.1 CR595357.1 CR600500.1 
    CR601533.1 CR601902.1 CR603686.1 CR619554.1 CR623683.1 CR623827.1 M17017.1 M26383.1 
    Y00787.1 Z11686.1 

    22 DOTS entries:

    DT.92451091  DT.452985  DT.121222191  DT.100764374  DT.121222188  DT.100890247  DT.121222199  DT.121222180 
    DT.97822713  DT.100722366  DT.121222165  DT.100890251  DT.92451100  DT.95366903  DT.100890254  DT.121222196 
    DT.92451094  DT.92451101  DT.100890241  DT.100890257  DT.100890262  DT.92451080 

    24/756 AceView cDNA sequences (see all 756):

    AA381700 CR542151 AA362246 CA306746 CR619554 BQ932618 CB851080 CA308318 
    BI962588 BU186293 AA381914 AA362132 AV716793 AA381217 CR600500 CB306060 
    AW662707 BX358167 BQ100994 BE122713 CR623683 AA362358 BU159049 CD367465 

    highest scoring ESTs for IL8:

    AA082747 AA095727 AA102526 AA296403 AA305271 AA360958 AA361981 AA362132 AA362138 AA362139 

    Unigene Cluster for IL8:

    Interleukin 8
    Hs.624  [show with all ESTs]
    Unigene Representative Sequence: NM_000584


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IL8

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
    SP1:                                                
    SP2:                    -                           
    SP3:                                                

    About this scheme

    ECgene alternative splicing isoforms for IL8
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483500 ENST00000401931 ENST00000307407(uc003hhe.2 uc011cbh.1)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    IL8 expression in normal and diseased human tissues

    1  / 2  / 3

    6 probe-sets matching IL8 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    35372_r_at2, 3 U95-A 1 1.00 1.00 0.99 0.95 M28130 0.20 1.00 0.72 1
    1369_s_at2, 3 U95-A 1 0.81 1.00 1.00 1.06 M28130 0.20 1.00 0.72 1
    211506_s_at2, 3 U133-A 1 0.91 1.00 -- -- AF043337 0.20 1.00 0.72 1
    202859_x_at2, 3 U133-A 1 0.91 1.00 -- -- NM_000584 0.60 1.00 0.82 1
    211506_s_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    202859_x_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table

    IL8 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    IL8 gene expression
    IL8 gene electronic northern expression
    IL8 gene sage expression
    About these images

    CGAP SAGE TAG: TGGAAGCACT

    SOURCE GeneReport for Unigene cluster: Hs.624

    Expression variation in blood from EXPOLDB for IL8

    Primers: OriGene genome-wide validated SYBR primer pairs: IL8
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for IL8: PPH00568A
        SABiosciences Expression via Pathway-Focused PCR Arrays including IL8 (see all 16): PAHS-011A PAHS-014A  


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for IL8 gene from 4 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    IL81   -- interleukin 8 81.44(n)
    77.32(a)
    403850  XM_850481.1  XP_855574.1 
    chimpanzee
    (Pan troglodytes)
    IL81   -- interleukin 8 99.33(n)
    100(a)
    471205  XM_001156432.1  XP_001156432.1 
    cow
    (Bos taurus)
    IL81   -- interleukin 8 83.51(n)
    79.38(a)
    280828  NM_173925.2  NP_776350.1 
    chicken
    (Gallus gallus)
    IL81   -- interleukin 8 60.76(n)
    52.08(a)
    396495  NM_205498.1  NP_990829.1 
    About this table        Species with no ortholog for IL8

    ENSEMBL Gene Tree for IL8 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for IL8 gene
    PF42  PPBP2  CXCL12  PF4V12  CXCL62  CXCL32  CXCL52  CXCL22  

    IL8 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/79 NCBI SNPs in IL8 are shown (see all 79)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 4 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs40731,2
    C,F,A,74606024(+) ATACAA/TTTGAT 1 -- ng51 tfbs333Minor allele frequency- T:0.48NS MN EA NA WA 3784
    rs124201,2
    C,H74608413(+) CAAAAA/TACAAC 1 -- ut3110Minor allele frequency- T:0.00MN NS EA 958
    rs11266471,2
    C,F,A,74609045(+) AGATAA/TACAAC 1 -- ut3111Minor allele frequency- T:0.29NS MN NA EA WA 724
    rs18032051,2
    C74606393(+) CTGGCC/TGTGGC 2 A ref1 syn1 ese35Minor allele frequency- T:0.00MN 392
    rs22273061,2
    C,F,O,74607055(+) GAAGTC/TGTTCA 1 -- int122Minor allele frequency- T:0.29NS MN EA NA WA 2178
    rs22273071,2
    C,F,74606669(+) TACCAT/GGTAGC 1 -- int115Minor allele frequency- G:0.47NS MN NA EA WA 1666
    rs22275271,2
    F74604465(+) TTTGAT/AGTTGT 1 -- ng512Minor allele frequency- A:0.02NS 86
    rs22275281,2
    C,F74604551(+) CCTGT-/TATTGT 1 -- ng51 tfbs33Minor allele frequency- T:0.07NS NA 86
    rs22275291,2
    C74604771(+) TAGAAT/CAAACA 1 -- ng51 tfbs32Minor allele frequency- C:0.01NS 94
    rs22275301,2
    C74605053(+) TATCAT/GAAGAA 1 -- ng512Minor allele frequency- G:0.01NS 94
    About this table

    HapMap Linkage Disequilibrium images for IL8 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IL8: --

    QIAGEN SeqTarget long-range PCR primers for resequencing IL8 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IL8 for disorders           About GeneDecksing

    OMIM: 146930

    10/98 Novoseek disease relationships for IL8 gene (see all 98)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 91.7 3968 9462219 (9), 8601968 (6), 10740342 (5), 1702929 (4) (see all 99)
    inflammation 90.2 1154 12697917 (4), 10680520 (4), 15104334 (4), 15901266 (4) (see all 99)
    tumors 81.8 3953 11181444 (8), 8601968 (6), 12471616 (6), 16088182 (5) (see all 99)
    bronchoalveolar lavage fluid 72.9 158 7712280 (4), 10933164 (3), 16077402 (3), 15909061 (3) (see all 99)
    systemic inflammatory response syndrome 70.3 31 8143477 (2), 9558403 (2), 9038289 (2), 16227031 (2) (see all 21)
    pulmonary disease chronic obstructive 68 39 8563494 (2), 12915744 (2), 11108181 (2), 16181530 (2) (see all 27)
    sepsis 66.2 233 1612748 (6), 17368039 (5), 15730597 (5), 9120108 (4) (see all 99)
    cystic fibrosis 65.2 102 7940424 (6), 7639556 (3), 8476069 (3), 17880760 (2) (see all 65)
    rheumatoid arthritis 64.5 130 1932367 (2), 8961381 (2), 14750259 (2), 10437780 (2) (see all 94)
    airways disease 63.8 23 7927669 (2), 10417151 (1), 10460760 (1), 9199432 (1) (see all 14)
    About this table

    Human Gene Mutation Database (HGMD): IL8
    Genetic Association Database (GAD): IL8
    Human Genome Epidemiology (HuGE) Navigator: IL8 (258 documents)

    Export disorders and mutations for IL8 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/6826 PubMed articles for IL8 gene, integrated from 7 sources (see all 6826):
    (articles sorted by number of sources associating them with IL8)
    1. The neutrophil-activating proteins interleukin 8 and beta- thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms. (PubMed id 2145175)1, 2, 7 van Damme J.... Billiau A. (1990)
    2. Polymorphisms of the IL-8 and CXCR2 genes are not associated with Behcet's disease. (PubMed id 15630732)1, 4, 7 Duymaz-Tozkir J....Gul A. (2005)
    3. Genetic variation in the interleukin-8 gene promoter and vaginal concentrations of interleukin-8 are not associated with bacterial vaginosis during pregnancy. (PubMed id 16038986)1, 4, 7 Diaz-Cueto L....Arechavaleta-Velasco F. (2005)
    4. Relation of tumor necrosis factor (TNF) gene polymorphisms with serum concentrations and in vitro production of TNF-alpha and interleukin-8 in heavy drinkers. (PubMed id 15902922)1, 4, 7 Gonzalez-Quintela A....Perez L.F. (2004)
    5. Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. (PubMed id 15356575)1, 4, 7 Heinzmann A....Deichmann K.A. (2004)
    6. Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q. (PubMed id 15708897)1, 4, 7 Kawahara C....Loughlin J. (2005)
    7. Influence of cytokine and ICAM-1 gene polymorphisms on susceptibility to chronic pancreatitis. (PubMed id 15917409)1, 4, 7 Howell W.M....Bateman A.C. (2005)
    8. Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan. (PubMed id 16284368)1, 4, 7 Taguchi A....Goto H. (2005)
    9. Variants of the IL8 and IL8RB genes and risk for gastric cardia adenocarcinoma and esophageal squamous cell carcinoma. (PubMed id 15598788)1, 4, 7 Savage S.A....Chanock S.J. (2004)
    10. Interleukin 8 gene polymorphism is associated with increased risk of nephritis in cutaneous vasculitis. (PubMed id 12415593)1, 4, 7 Amoli M.M....Gonzalez-Gay M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3576 HGNC: 6025 AceView: IL8 Ensembl:ENSG00000169429 euGenes: HUgn3576
    ECgene: IL8 Kegg: 3576 H-InvDB: IL8

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for IL8 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_8
    SeattleSNPshttp://pga.gs.washington.edu/data/il8/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for IL8 gene:
    Search GeneIP for patents involving IL8

    GeneCards and IP:
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