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IL8 Gene

protein-coding GIFtS: 68

GC04P070417

interleukin 8
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
interleukin 8¹ ²		b-ENAP¹
CXCL8¹ ² ³		TSG-1¹
MONAP¹ ² ³		SCYB8¹
GCP-1¹ ² ³		K60¹
MDNCF¹ ² ³		emoctakin²
NAP-1¹ ² ³		NAP1²
LYNAP¹ ²		beta-thromboglobulin-like protein²
LUCT¹ ²		small inducible cytokine subfamily B, member 8²
LECT¹ ²		OTTHUMP00000199825²
NAF¹ ²		interleukin-8²
IL-8¹ ³		neutrophil-activating peptide 1²
Granulocyte chemotactic protein 1² ³		GCP1²
Monocyte-derived neutrophil chemotactic factor² ³		T cell chemotactic factor²
Monocyte-derived neutrophil-activating peptide² ³		lymphocyte-derived neutrophil-activating factor²
C-X-C motif chemokine 8² ³		chemokine (C-X-C motif) ligand 8²
T-cell chemotactic factor² ³		Protein 3-10C³
AMCF-I¹		Emoctakin³
3-10C¹		Neutrophil-activating protein 1³

External Ids:	HGNC: 6025¹	Entrez Gene: 3576²	Ensembl: ENSG00000169429⁷	UniProtKB: P10145³

Export aliases for IL8 gene to outside databases

Previous GC identifers: GC04P074595 GC04P074845 GC04P075006 GC04P075072 GC04P074971

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL8:

The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators

of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and

is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a

common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene

family form a chemokine gene cluster in a region mapped to chromosome 4q. (provided by RefSeq)

UniProtKB/Swiss-Prot: IL8_HUMAN, P10145

Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also

involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus.

IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil

activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively

Gene Wiki entry for IL8 (Interleukin 8)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL8 gene promoter:
         C/EBPalpha   HNF-4alpha2   p300   GR-alpha   p53   GR-beta   c-Rel   RelA   NF-kappaB   NF-kappaB1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for IL8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13-q21 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q13-q21

IL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL8 gene location

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P070417: view genomic region (about GC identifiers)

Start:	70,417,759 bp from pter
End:	70,420,917 bp from pter
Size:	3,159 bases
Orientation:	plus strand

1 alternative location:

Chr4+ 74,606,223-74,609,433

RefSeq DNA sequence:

NC_000004.11 NT_022778.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: IL8_HUMAN, P10145 (See protein sequence)

Recommended Name: Interleukin-8 precursor

Size: 99 amino acids; 11098 Da

Subunit: Homodimer

Subcellular location: Secreted

PDB structures from and Proteopedia :

1ICW (3D)

1IKL (3D)

1IKM (3D)

1IL8 (3D)

1ILP (3D)

1ILQ (3D)

1QE6 (3D)

1ROD (3D)

2IL8 (3D)

3IL8 (3D)

Secondary accessions: B2R4L8 Q6FGF6 Q6LAE6 Q96RG6 Q9C077 Q9UCE1 Q9UCR8 Q9UCR9 Q9UCS0

Alternative splicing: 2 isoforms: P10145-1 P10145-2

Explore the universe of human proteins at neXtProt for IL8: NX_P10145

Post-translational modifications:

Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood

monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is

the most promiment form¹

REFSEQ proteins: NP_000575.1

ENSEMBL proteins:

ENSP00000385908 ENSP00000306512

Human Recombinant Proteins

	Millipore Purified and/or Recombinant IL8 Protein
	Sigma-Aldrich Proteins for IL8
	R&D Systems Recombinant & Natural Proteins for IL8 (CXCL8/IL-8)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: IL8 Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for IL8
	Novus Biologicals Proteins for IL8
	Novus Biologicals Lysate for IL8
	Sino Biological Recombinant Protein for IL8
	ProSpec Recombinant Protein for IL8

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--

About this table

IL8 for ontologies About GeneDecksing

Antibodies for IL8:

	Millipore Mono- and Polyclonal Antibodies for the study of IL8
	Sigma-Aldrich Antibodies for IL8
	R&D Systems Antibodies for IL8 (CXCL8/IL-8)
	OriGene Antibodies (see all 2): IL8
	GenScript Superior Antibodies for IL8
	Novus Biologicals Antibodies for IL8
	Epitomics antibodies for IL8

Assays for IL8:

	Millipore Kits and Assays for the Analysis of IL8
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Flow Cytometry Kits for IL8 (CXCL8/IL-8) (see all)
	GenScript Custom Assay Services for IL8
	Enzo Life Sciences assays for IL8
	Uscn ELISAs and CLIAs for IL8

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL8 for domains About GeneDecksing

4 InterPro domains/families:

IPR001089 CXC_chmkine_smll

IPR018048 Small_chemokine_CXC_CS

IPR001811 Chemokine_IL8

IPR002473 C-X-C/Interlkn_8

Graphical View of Domain Structure for InterPro Entry P10145

ProtoNet protein and cluster: P10145

1 Blocks protein family: IPB002473 Interleukin-8 signature

UniProtKB/Swiss-Prot: IL8_HUMAN, P10145

Similarity: Belongs to the intercrine alpha (chemokine CxC) family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: IL8_HUMAN, P10145

Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also

involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus.

IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil

activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for IL8 Sigma-Aldrich shRNA Panels and shRNA for IL8
		OriGene 29mer shRNA kits in GFP-retroviral vector: IL8 OriGene shRNA RFP: IL8 OriGene basic RS shRNA: IL8 OriGene siRNA: IL8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IL8

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IL8
		8/16 SABiosciences Assays for microRNAs that regulate IL8 (see all 16):
		hsa-miR-1294 hsa-miR-520e hsa-miR-519d hsa-miR-20a hsa-miR-302a hsa-miR-106a hsa-miR-106b hsa-miR-373

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: IL8 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: IL8 OriGene untagged cDNA clones in CMV expression vector: IL8 OriGene 3'-UTR clone: IL8 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: IL8
		Sino Biological Human cDNA Clone for IL8

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for IL8

Genatlas biochemistry entry for IL8:

interleukin 8 (see IMC2@),neutrophil activating peptide 1,monocyte-derived neutrophil chemotactic factor,with a direct

growth potentiating activity in malignant mesothelioma

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005153	interleukin-8 receptor binding	IPI	1840701
GO:0005515	protein binding	IPI	10880251
GO:0008009	chemokine activity	IEA	--

About this table

IL8 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

IL8 for pathways About GeneDecksing

5/8 Millipore Pathways for IL8 (see all 8)

	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
	Immune response Role of integrins in NK cells cytotoxicity
	Selected targets of GCR-alpha
	Immune response MIF-mediated glucocorticoid regulation
	Immune response MIF in innate immunity response

5/15 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for IL8 (see all 15)

	Atherosclerosis Signaling
	Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
	Hepatic Cholestasis
	Role of Cytokines in Mediating Communication between Immune Cells
	Airway Pathology in Chronic Obstructive Pulmonary Disease

5/13 Kegg Pathways (Kegg details for IL8) (see all 13):

	hsa04060 Cytokine-cytokine receptor interaction
	hsa04062 Chemokine signaling pathway
	hsa04620 Toll-like receptor signaling pathway
	hsa04621 NOD-like receptor signaling pathway
	hsa04622 RIG-I-like receptor signaling pathway

SABiosciences Pathway-Focused PCR Arrays including IL8 (see all 16): PAHS-011A PAHS-014A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for IL8

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL8

5/24 Interacting proteins for IL8 (ENSP00000306512³) via UniProtKB, MINT, and/or STRING (see all 24)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CXCR2	ENSP00000319635³	STRING: ENSP00000319635
CXCL2	ENSP00000264492³	STRING: ENSP00000264492
CXCL3	ENSP00000296026³	STRING: ENSP00000296026
CXCL5	ENSP00000296027³	STRING: ENSP00000296027
CXCL6	ENSP00000226317³	STRING: ENSP00000226317

About this table

5/16 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 16):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	TAS	11483765
GO:0006928	cellular component movement	TAS	10820279
GO:0006935	chemotaxis	IEA	--
GO:0006954	inflammatory response	TAS	11483765
GO:0006955	immune response	IEA	--

About this table

IL8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

IL8 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL8
10/138 Novoseek chemical compound relationships for IL8 gene (see all 138)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	92.7	1369	9723955 (8), 17207890 (7), 10619832 (7), 16413378 (6) (see all 99)
groalpha	86.1	191	11495082 (7), 9641651 (7), 17922696 (5), 9889409 (4) (see all 81)
fmlp	79.7	471	7837814 (9), 16249234 (7), 15494208 (5), 9013980 (5) (see all 99)
leukotriene b4	78.5	560	8003341 (9), 8973284 (5), 9482389 (5), 12149532 (5) (see all 99)
vegf	76.4	1297	11234901 (9), 10334214 (9), 17349553 (8), 9457313 (8) (see all 99)
endotoxin	74.4	268	2007851 (5), 11451261 (5), 18485432 (4), 16384605 (4) (see all 99)
grogamma	72.8	23	8702798 (3), 15832427 (2), 9553055 (2), 10695618 (1) (see all 11)
grobeta	68	26	10600366 (3), 8702798 (3), 15832427 (2), 9553055 (2) (see all 12)
il 10	67.4	70	18363812 (4), 9543183 (2), 19723087 (2), 20041183 (2) (see all 56)
lipoteichoic acid	67.3	89	10570304 (7), 16619004 (4), 8262617 (4), 19250704 (3) (see all 37)

About this table

1 PharmGKB drug compound relationship for IL8 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
glucocorticoids	FA	1370208

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for IL8 Sigma-Aldrich shRNA Panels and shRNA for IL8
		OriGene 29mer shRNA kits in GFP-retroviral vector: IL8 OriGene shRNA RFP: IL8 OriGene basic RS shRNA: IL8 OriGene siRNA: IL8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IL8

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IL8
		8/16 SABiosciences Assays for microRNAs that regulate IL8 (see all 16):
		hsa-miR-1294 hsa-miR-520e hsa-miR-519d hsa-miR-20a hsa-miR-302a hsa-miR-106a hsa-miR-106b hsa-miR-373

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: IL8 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: IL8 OriGene untagged cDNA clones in CMV expression vector: IL8 OriGene 3'-UTR Clone: IL8 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: IL8

Primers:		OriGene genome-wide validated SYBR primer pairs: IL8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for IL8: PPH00568A

REFSEQ mRNAs for IL8 gene:

NM_000584.2

Additional cDNA sequence:

AK131067.1 AK311874.1 BC013615.1 BT007067.1 CR542151.1 CR594973.1 CR595357.1 CR600500.1

CR601533.1 CR601902.1 CR603686.1 CR619554.1 CR623683.1 CR623827.1 M17017.1 M26383.1

Y00787.1 Z11686.1

22 DOTS entries:

DT.92451091 DT.452985 DT.121222191 DT.100764374 DT.121222188 DT.100890247 DT.121222199 DT.121222180

DT.97822713 DT.100722366 DT.121222165 DT.100890251 DT.92451100 DT.95366903 DT.100890254 DT.121222196

DT.92451094 DT.92451101 DT.100890241 DT.100890257 DT.100890262 DT.92451080

24/756 AceView cDNA sequences (see all 756):

AA381700 CR542151 AA362246 CA306746 CR619554 BQ932618 CB851080 CA308318

BI962588 BU186293 AA381914 AA362132 AV716793 AA381217 CR600500 CB306060

AW662707 BX358167 BQ100994 BE122713 CR623683 AA362358 BU159049 CD367465

highest scoring ESTs for IL8:

AA082747 AA095727 AA102526 AA296403 AA305271 AA360958 AA361981 AA362132 AA362138 AA362139

Unigene Cluster for IL8:

Interleukin 8

Hs.624 [show with all ESTs]

Unigene Representative Sequence: NM_000584

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for IL8

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b
SP1:
SP2:							-
SP3:

About this scheme

ECgene alternative splicing isoforms for IL8
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000483500 ENST00000401931 ENST00000307407(uc003hhe.2 uc011cbh.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

IL8 expression in normal and diseased human tissues

¹ / ² / ³

6 probe-sets matching IL8 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35372_r_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.95	M28130	0.20	1.00	0.72	1
1369_s_at²^{, 3}	U95-A	1	0.81	1.00	1.00	1.06	M28130	0.20	1.00	0.72	1
211506_s_at²^{, 3}	U133-A	1	0.91	1.00	--	--	AF043337	0.20	1.00	0.72	1
202859_x_at²^{, 3}	U133-A	1	0.91	1.00	--	--	NM_000584	0.60	1.00	0.82	1
211506_s_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--
202859_x_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

IL8 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

About these images

CGAP SAGE TAG: TGGAAGCACT

SOURCE GeneReport for Unigene cluster: Hs.624

Expression variation in blood from EXPOLDB for IL8

Primers:		OriGene genome-wide validated SYBR primer pairs: IL8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for IL8: PPH00568A

SABiosciences Expression via Pathway-Focused PCR Arrays including IL8 (see all 16): PAHS-011A PAHS-014A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IL8 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IL8¹	--	interleukin 8	81.44(n) 77.32(a)	403850 XM_850481.1 XP_855574.1
chimpanzee (Pan troglodytes)	IL8¹	--	interleukin 8	99.33(n) 100(a)	471205 XM_001156432.1 XP_001156432.1
cow (Bos taurus)	IL8¹	--	interleukin 8	83.51(n) 79.38(a)	280828 NM_173925.2 NP_776350.1
chicken (Gallus gallus)	IL8¹	--	interleukin 8	60.76(n) 52.08(a)	396495 NM_205498.1 NP_990829.1

About this table Species with no ortholog for IL8

ENSEMBL Gene Tree for IL8 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IL8 gene

PF4² PPBP² CXCL1² PF4V1² CXCL6² CXCL3² CXCL5² CXCL2²

IL8 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs4073^1,2	C,F,A,	74606024(+)	`ATACAA/TTTGAT`	1	--	ng5¹ tfbs³		33	NS MN EA NA WA	3784
rs12420^1,2	C,H	74608413(+)	`CAAAAA/TACAAC`	1	--	ut3¹		10	MN NS EA	958
rs1126647^1,2	C,F,A,	74609045(+)	`AGATAA/TACAAC`	1	--	ut3¹		11	NS MN NA EA WA	724
rs1803205^1,2	C	74606393(+)	`CTGGCC/TGTGGC`	2	A	ref¹ syn¹ ese³		5	MN	392
rs2227306^1,2	C,F,O,	74607055(+)	`GAAGTC/TGTTCA`	1	--	int¹		22	NS MN EA NA WA	2178
rs2227307^1,2	C,F,	74606669(+)	`TACCAT/GGTAGC`	1	--	int¹		15	NS MN NA EA WA	1666
rs2227527^1,2	F	74604465(+)	`TTTGAT/AGTTGT`	1	--	ng5¹		2	NS	86
rs2227528^1,2	C,F	74604551(+)	`CCTGT-/TATTGT`	1	--	ng5¹ tfbs³		3	NS NA	86
rs2227529^1,2	C	74604771(+)	`TAGAAT/CAAACA`	1	--	ng5¹ tfbs³		2	NS	94
rs2227530^1,2	C	74605053(+)	`TATCAT/GAAGAA`	1	--	ng5¹		2	NS	94

About this table

HapMap Linkage Disequilibrium images for IL8 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IL8: --

QIAGEN SeqTarget long-range PCR primers for resequencing IL8

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL8 for disorders About GeneDecksing

OMIM: 146930

10/98 Novoseek disease relationships for IL8 gene (see all 98)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	91.7	3968	9462219 (9), 8601968 (6), 10740342 (5), 1702929 (4) (see all 99)
inflammation	90.2	1154	12697917 (4), 10680520 (4), 15104334 (4), 15901266 (4) (see all 99)
tumors	81.8	3953	11181444 (8), 8601968 (6), 12471616 (6), 16088182 (5) (see all 99)
bronchoalveolar lavage fluid	72.9	158	7712280 (4), 10933164 (3), 16077402 (3), 15909061 (3) (see all 99)
systemic inflammatory response syndrome	70.3	31	8143477 (2), 9558403 (2), 9038289 (2), 16227031 (2) (see all 21)
pulmonary disease chronic obstructive	68	39	8563494 (2), 12915744 (2), 11108181 (2), 16181530 (2) (see all 27)
sepsis	66.2	233	1612748 (6), 17368039 (5), 15730597 (5), 9120108 (4) (see all 99)
cystic fibrosis	65.2	102	7940424 (6), 7639556 (3), 8476069 (3), 17880760 (2) (see all 65)
rheumatoid arthritis	64.5	130	1932367 (2), 8961381 (2), 14750259 (2), 10437780 (2) (see all 94)
airways disease	63.8	23	7927669 (2), 10417151 (1), 10460760 (1), 9199432 (1) (see all 14)

About this table

Human Gene Mutation Database (HGMD): IL8
Genetic Association Database (GAD): IL8
Human Genome Epidemiology (HuGE) Navigator: IL8 (258 documents)

Export disorders and mutations for IL8 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/6826 PubMed articles for IL8 gene, integrated from 7 sources (see all 6826):
(articles sorted by number of sources associating them with IL8)

The neutrophil-activating proteins interleukin 8 and beta- thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms. (PubMed id 2145175)^{1, 2, 7} van Damme J.... Billiau A. (1990)
Polymorphisms of the IL-8 and CXCR2 genes are not associated with Behcet's disease. (PubMed id 15630732)^{1, 4, 7} Duymaz-Tozkir J....Gul A. (2005)
Genetic variation in the interleukin-8 gene promoter and vaginal concentrations of interleukin-8 are not associated with bacterial vaginosis during pregnancy. (PubMed id 16038986)^{1, 4, 7} Diaz-Cueto L....Arechavaleta-Velasco F. (2005)
Relation of tumor necrosis factor (TNF) gene polymorphisms with serum concentrations and in vitro production of TNF-alpha and interleukin-8 in heavy drinkers. (PubMed id 15902922)^{1, 4, 7} Gonzalez-Quintela A....Perez L.F. (2004)
Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. (PubMed id 15356575)^{1, 4, 7} Heinzmann A....Deichmann K.A. (2004)
Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q. (PubMed id 15708897)^{1, 4, 7} Kawahara C....Loughlin J. (2005)
Influence of cytokine and ICAM-1 gene polymorphisms on susceptibility to chronic pancreatitis. (PubMed id 15917409)^{1, 4, 7} Howell W.M....Bateman A.C. (2005)
Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan. (PubMed id 16284368)^{1, 4, 7} Taguchi A....Goto H. (2005)
Variants of the IL8 and IL8RB genes and risk for gastric cardia adenocarcinoma and esophageal squamous cell carcinoma. (PubMed id 15598788)^{1, 4, 7} Savage S.A....Chanock S.J. (2004)
Interleukin 8 gene polymorphism is associated with increased risk of nephritis in cutaneous vasculitis. (PubMed id 12415593)^{1, 4, 7} Amoli M.M....Gonzalez-Gay M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3576	HGNC: 6025	AceView: IL8	Ensembl:ENSG00000169429	euGenes: HUgn3576
ECgene: IL8	Kegg: 3576	H-InvDB: IL8

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for IL8	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Interleukin_8
SeattleSNPs	http://pga.gs.washington.edu/data/il8/

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IL8 Gene

protein-coding GIFtS: 68

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IL8 (Gene Symbol)
interleukin 8
CXCL8
MONAP
GCP-1
MDNCF
NAP-1
LYNAP
LUCT
LECT
NAF
IL-8
Granulocyte chemotactic protein 1
Monocyte-derived neutrophil chemotactic factor
Monocyte-derived neutrophil-activating peptide
C-X-C motif chemokine 8
T-cell chemotactic factor
AMCF-I
3-10C
b-ENAP
TSG-1
SCYB8
K60
emoctakin
NAP1
beta-thromboglobulin-like protein
small inducible cytokine subfamily B, member 8
OTTHUMP00000199825
interleukin-8
neutrophil-activating peptide 1
GCP1
T cell chemotactic factor
lymphocyte-derived neutrophil-activating factor
chemokine (C-X-C motif) ligand 8
Protein 3-10C
Emoctakin
Neutrophil-activating protein 1

Chronic sinusitis
Bronchiectasis
preterm delivery
sepsis
SCCMS
Endometriosis
Dermatitis Atopic
Cystic Fibrosis
Colitis Ulcerative
Allergic Reaction
AIRWAYS DISEASE
Keratoconjunctivitis Vernal
Meningitis Viral
Nasal Epithelium
Skin Diseases
Atherosclerosis
Respiratory Distress Syndrome
TRANSFUSION REACTION
Neovascularization
Chronic prostatitis
Rhinitis Allergic Seasonal
Pulmonary Eosinophilia
Asthma
ALVEOLITIS
Allergic rhinitis
cell damage
Bronchopulmonary Dysplasia
GASTRITIS CHRONIC
Periodontal Diseases
Meningitis
Nasal Polyps
Bronchoalveolar Lavage Fluid
Osteolysis
effusion
acute pancreatitis
Alcoholic Cirrhosis
Bacterial Vaginosis
Dermatitis Toxicodendron
Inflammation
HNSCC
Monocytic leukemia
Psoriasis
Hepatitis Alcoholic
Pulmonary Disease Chronic Obstructive
Rheumatoid Arthritis
METAL FUME FEVER
Pneumonia
Tumors
Metastasis
Pneumonitis Hypersensitivity
Necrosis
Rhinitis
Bronchiolitis
Asthma allergic
Glioblastoma
virus infection
Peptic Ulcer
FIBROSIS IDIOPATHIC PULMONARY
Escherichia coli Infections
Shock Septic
Colitis
Gastric Cancer
Melanoma
Pulmonary Fibrosis
inflammatory joint disease
Common Cold
Meningitis Bacterial
atherosclerotic plaque
Systemic Inflammatory Response Syndrome
Lung Diseases Interstitial
Leukocytosis
Bacterial Infections
Osteoarthritis
SEPSIS NEONATAL
Bronchitis Chronic
Pancreatic Cancer
Inflammatory Bowel Diseases
Multiple Organ Failure
Respiratory Tract Infections
CYSTIC FIBROSIS LUNG
Response Acute Phase
Proliferative diabetic retinopathy
Eosinophilia
Liver Diseases Alcoholic
Chronic periodontitis
BEHCET DISEASE
Gastritis
Lung diseases
Acute respiratory distress
Chorioamnionitis
Bronchiolitis Obliterans
acute alcoholic hepatitis
Respiratory Distress Syndrome Adult
Infection chronic
Pleurisy Tuberculous
Synovitis
Duodenal Ulcer
Arthritis

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IL8 Gene

protein-coding GIFtS: 68

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